Indian Journal of Chemistry

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Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 49B

NUMBER 7

July 2010

CONTENTS

Papers

 

 

 

917

1H and 13C NMR studies of some 1,1-bis(carbethoxy)-2-aryl-4-phenyl/(4-chlorophenyl)-4-oxobutane and their derivatives

 

The 1H and 13C NMR spectral features of 1,1-bis(carbethoxy)-2-aryl-4-phenyl/(4-chlorophenyl)-4-oxobutane 1a-j and their carbonyl derivatives 2a-e are discussed in the light of their diastereotopic characteristics and preferred conformational structures for 1 and 2 are proposed.

 

 

 

 

Sivaperuman Saravanan & Shanmugam Muthusubramanian*

 

Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India

 

 

 

 

 

 

923

Synthesis of 2-(4-substitutedsulfonyl piperazin-1-yl-methyl)-3-aryl-quinazolin-4(3H)-one

 

Reaction of 2-(chloromethyl)-3-arylquinazolin-4 (3H)-one 3 with N-BOC piperazine 4 in acetonitrile using K2CO3 and KI followed by deprotection of BOC group in IPA HCl, gives 3-aryl-2-(piperazin-1-yl)quinazolin-4(3H)-one 6. The latter on treatment with benzene/methane sulfonyl chloride in DCM in the presence of TEA at RT, results in the formation of 2-(4-benzene/methanesulfonyl piperazin-1-yl-methyl)-3-aryl-quinazolin-4(3H)-one 7. Alternatively, 7 can also be prepared from the reaction of 4-benzene/methane sulfonylpiperazine 9 with 3, in the presence of K2CO3 and KI.

 

 

 

 

 

 

 

 

Palle V R Acharyulu, P K Dubey*, P V V Prasada Reddy & Thatipally Suresh

 

Department of Chemistry, College of Engineering, J N T University, Kukatpally, Hyderabad 500 085, India

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

929

Synthesis, characterization and in vitro antimicrobial studies of new 2,3-disubstitutedquinazolin-4(3H)ones of 2-[2-(2,6-dichlorophenyl)amino]phenyl acetic acid

 

Synthesis of new 2,3-disubstituted quinazolin-4(3H)ones of 2-[2-(2,6-dichlorophenyl)-amino]phenyl acetic acid have been carried out and all the compounds are screened for antibacterial and antifungal activities.

 

 

 

 

 

 

 

 

 

 

 

 

Navin B Patel* & Asif R Shaikh

 

Department of Chemistry, Veer Narmad South Gujarat University, Surat 395 007, Gujarat, India

 

 

 

 

 

 

937

Synthesis of novel benzimidazole β-keto sulfones and β-hydroxy sulfones and their regiospecific alkylation studies

 

 

 

 

 

 

 

 

 

 

 

 

 

 

P K Dubey*, N D Mahesh Kumar, M V S R K Chaitanya, A Naidu & B George Vineel

 

Department of Chemistry, JNT University, Kukatpally, Hyderabad 500 085, India

 

 

 

 

Notes

 

 

 

944

An efficient synthesis of bio-active fluorescent benzylidine tetralones

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

R Kamakshi, S Swarna Latha & B S R Reddy*

 

Industrial Chemistry Laboratory, Central Leather Research Institute, Adyar, Chennai 600 020. India.

 

 

 

 

 

 

948

Synthesis and QSAR of 16-(3-methoxy-4-substituted benzylidene)androstene derivatives as anticancer agents

 

Chemical synthesis of various 16-(3-methoxy-4-substituted benzylidene)androstene derivatives has been reported, along with their in vitro anticancer activity. The QSAR models have also been developed (R2 value ranging from 0.9692-0.8225).

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Sonal Dubey*, Parmeet Kaur, Dharam Paul Jindal, Yalamanchili Darji Satyanarayan & Poonam Piplani

 

K.L.E. College of Pharmacy, II-Block Rajajinagar, Bangalore 560 010, India

 

 

 

 

 

 

956

Synthesis, antimicrobial and insecticidal activity of some  4H-1,2,4 triazole derivatives

 

1-(Substituted benzylidene) semicarbazide has been used as a precursor to synthesize some important biologically active 3-substituted phenyl, 4H-1,2,4 triazole derivatives. Reaction of ethanolic solution of schiff's base of substituted aromatic aldehyde 1 with ethanolic solution of FeCl3.6H2O (1 mole FeCl3.6H2O in 10 mL ethanol)  yields the 4H-1,2,4 triazole-3-derivative 2. Several derivatives have been synthesized and screened for their antibacterial, antifungal and insecticidal activity.

 

 

 

 

 

 

 

 

Nidhi Gautam* & O P Chourasia

 

Heterocyclic Research Laboratory, Department of Chemistry, Dr. H. S. Gour University,  Sagar  470 003, India

 

 

 

 

 

 

960

Synthesis and characterization of some sulfonamide based bis-sydnones and their in vitro antimicrobial activity

 

4-Sulfonamide substituted novel sydnones have been synthesized. All new compounds have been characterized by spectral data as well as elemental analysis and have been tested for their antibacterial activity against gram positive S. pneumoniae and S. aureus, and gram negative bacteria E. coli and P.aeruginosa. Some of the synthesized compounds show excellent antimicrobial activity.

 

 

 

 

 

 

 

 

 

 

 

Shahrukh T Asundaria & Keshav C Patel*

 

Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat 395 007, India

 

 

 

 

 

 

965

Synthetic and biological studies on some fused pyrazoles and their ethoxyphthalimide derivatives

 

Various 2-N-ethoxyphthalimido-6-nicotinoyl-4-methyl-3-(4-substituted phenyl)-3,3a-dihydro pyrazolo[3,4-c] pyrazoles
6a-d have been prepared from nicotinicacid hydrazide through multi step procedure and tested for antimicrobial and antiviral  activity.

 

 

 

 

Ajit Joshi, Devendra K Sain, Bhawana Thadhaney, Swati Ojha, Nasir Hussain & Ganpat L Talesara*

 

Synthetic Organic Chemistry Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur 313 001, India

 

 

 

 

 

 

971

Synthesis and antimicrobial screening of some 3-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] and 4-methyl-3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins

 

Various 3-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins 4a-l and 4-methyl-3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl]coumarins 5a-f  have been synthesized by reacting 3-coumarinoyl methyl pyridinium bromide 1a,b and 4-methyl-3-phenyl-6-coumarinoylmethyl pyridinium bromide 2 with pyrazolyl chalcones 3a-f respectively under Krohnke’s reaction conditions. All the synthesized compounds 4a-l and 5a-f have been fully characterized and screened for their antimicrobial activity.

 

 

                                       4a-l                                                                                     5a-f

 

D I Brahmbhatt*, Ankit R Kaneria, Anil K Patel & Niraj H Patel

 

Department of Chemistry, Sardar Patel University, Vallabh Vidhyanagar 388 120, India

 

 

 

 

 

 

978

A facile Ph3P/CO2 mediated, one-pot synthesis of 2-oxazolidinones from 1,2-azido alcohols via phosphazene and isocyanate intermediates

A facile, efficient and convenient method has been developed for the one-pot synthesis of 2-oxazolidinones from the corresponding 1,2-azido alcohols via phosphazene and isocyanate intermediates in presence of Ph3P/CO2 in toluene.

 

 

 

 

 

 

 

G Madhusudhan*, M Srinivasa Reddy, Y Narayana Reddy, V Vijayalakshmi, M Suribabu & V Balraju

                                                                               

Inogent Laboratories Pvt. Ltd., A GVK BIO Company, 28A, IDA, Nacharam, Hyderabad 500 076, India

 

 

 

 

 

 

 

985

Designing hydroxy-functionalized chiral salen ligand and its use in the synthesis of dioxadiazasilamacroheterocycles

 

Synthesis of dioxadiazasilamacroheterocycles is described.

 

 

 

 

 

 

 

 

M S Singh *, Pratibha Singh & Ashutosh Gupta

 

Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India

 

 

 

989

Microwave assisted transformation of benzimidazolyl chalcones into N1  -substituted pyrazolines and evaluation of their antimicrobial activities

 

 

 

 

 

 

Jayanti Rajora, Janardan  Yadav, Ravindra Kumar  & Yogendra K Srivastava

 

Synthetic Organic Chemistry Laboratory, Department of Chemistry, M. P. Govt (PG) College, Chittorgarh 312 001 Rajasthan, India

 

 

 

 

 

Authors for correspondence are indicated by (*)