Indian Journal of Chemistry

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Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 49B

NUMBER 6

June 2010

CONTENTS

Papers

 

 

 

771

A fast and highly efficient method for the synthesis of tertiary amines in aqueous medium

 

A facile and highly efficient method for the synthesis of tertiary amines by the reaction of secondary amines with benzylic bromides and 1,1˘-dibromo p/o- xylenes in aqueous dioxane and NaOH have been developed. The reactions dually promoted by the base in short time (15 min.) at ambient conditions in aqueous medium.

 

 

 

 

Subbarayappa Adimurthy* & Girdhar Joshi

 

Analytical Science Division, Central Salt and Marine Chemicals Research Institute (CSIR),
Gijubhai Badheka Marg, Bhavnagar 364 002, India

 

 

 

 

 

 

 

776

Enantiospecific total synthesis of ent-5-senecioyl­oxy-10,11-epoxythapsan-10-ol

 

Enantiospecific synthesis of the optical antipode of
5-senecioyloxy-10,11-epoxythapsan-10-ol has been reported.

 

 

 

 

 

A Srikrishna* & K Anebouselvy

 

Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

789

High stereoselectivity in the Diels-Alder reaction of substituted anthracenes: Reactions of 1-succini- midoanthracene and 1-phthalimidoanthracene with maleic anhydride

 

1-Succinimidoanthracene undergoes Diels-Alder  reaction with maleic  anhydride to give mainly the anti adduct suggesting that the steric factors play dominant role in deciding the anti/syn stereoselectivity.1-phthalimido-anthracene also gives mainly the anti adduct with maleic anhydride. The configurations of the compounds have been established by preparing the corresponding imide derivatives of the anhydride adducts and observing the interactions between the imide substituent and the 1-substituent.

 

 

M Dhaneshwar Singh* & Anjana Ningombam

 

Department of Chemistry, Manipur University, Canchipur, Imphal 795 003, India

 

 

 

 

 

 

 

795

A simple and an efficient indium trichloride catalyzed benzyl etherification

 

An efficient method  has been developed for the synthesis of benzyl ethers of alkyl, allyl and propargyl alchols by simple, direct coupling of alcohols in the presence of catalytic amount of InCl3 under solvent-free condition.

 

 

 

 

 

G Bhaskar, M Solomon, G Babu, D Muralidharan & Paramasivan T Perumal*

 

Organic Chemistry Division, Central Leather Research Institute, Adyar, Chennai 600 020, India

 

 

 

 

 

Notes

 

 

 

802

Synthesis, characterization and biological screening of some novel tetrahydroquinazoline derivatives

 

Synthesis of series of novel 4-aryl-5,5-dimethyl-7-(2′-piperi­din-1′-yl-ethyl)-2-hydroxy-3,4,5,6-tetrahydroquina­zo­lines 2a-i is described.

 

 

 

 

D K Dodiya, S J Vaghasia, A R Trivedi, H K Ram, & V H Shah*

 

Department of Chemistry, Saurashtra University, Rajkot 360 005, India

 

 

 

 

 

 

 

 

 

 

 

 

807

Constituents of Nepeta clarkei Hook.f. and their antioxidant activity

 

Six compounds coleon U 12-methyl ether 1, p-benzochinone 2, labda-14-en-8,13-diol 3, β-sitosterol, stigmasterol and ursolic acid have been isolated and identified from roots of Nepeta clarkei Hook.f. The antioxidant activities of four of them have been determined.

 

 

 

 

1

2

3

 

 

 

 

 

D S Bisht, R C Padalia, S C Joshi, A Tewari &  C S Mathela*

 

Department of Chemistry ,Kumaun University, Nainital 263 002, India

 

 

 

 

 

 

 

812

Facile one step synthesis of acyl azides and
Nα–Fmoc/Boc/Z protected amino acid azides employing benzotriazole-1-yl-oxy-tris-(dimethyl­amino)-phosphonium hexafluorophosphate (BOP)

 

Preparation of acyl azides from the corresponding carboxylic acids employing the peptide-coupling agent BOP is described.

 

 

 

 

 

 

 

 

 

 

 

B Vasantha & Vommina V Sureshbabu*

 

Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Dr. B. R. Ambedkar Veedhi, Bangalore University, Bangalore 560 001, India

 

 

 

 

 

 

 

 

 

 

 

818

Synthesis, characterization and biological evaluation of some heterocyclic compounds containing ethoxyphthalimide moiety via key intermediate 6-chloro 1,3 benzothiazole 2-amine

 

Some ethyl 8-chloro-4(4-substitutedphenyl)-2-[(N-ethoxy­phthali­mido)amino]-4H-pyrimido[2, 1-b][1,3]benzothiazole-3-carboxylate 5a-d and 6-chloro-N-[3-{2-(4-substitute­dphenyl)­ethenyl}-1-N-ethoxyphthalimidoquinoxalin-2(1H)-ylidene]-1, 3-ben­zothiazol-2-amine 10a-d have been synthesized from a common intermediate 6-chloro-1,3-benzothiazol-2-amine 2. Synthesized compounds have been characterized by analytical and spectral studies.

 

 

Devendra Kr Sain, Bhawana Thadhaney, Ajit Joshi, Nasir Hussain & Ganpat L Talesara*

 

Synthetic Organic Chemistry Laboratory, Department of Chemistry,  M L Sukhadia University,

Udaipur 313 001, India

 

 

 

 

 

 

 

826

An efficient mono-mode MW controlled multi­component synthesis of polysubstituted benzenes under solvent-free conditions

 

Microwave-assisted, solvent-free one-step multicomponent and efficient synthesis of polysubstituted benzene derivatives has been achieved in reasonably good yield from ethyl­chloro­acetate, aromatic aldehydes and malononitrile in the presence of pyridine.

 

 

 

 

 

Krishna Nand Singh* & Satish Kumar Singh

 

Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India

 

 

 

 

 

 

 

 

 

 

 

 

 

830

Synthesis, antimicrobial and insecticidal activity of some new cinnoline based chalcones and cinnoline based pyrazoline derivatives

 

4-Methyl-3-acetyl cinnoline has been used as a precursor to synthesize some new cinnoline based chalcones 3a-l. Reaction of chalcone with hydrazine hydrate in acetic acid yields the cinnoline based pyrazoline derivatives 4a-l. The compounds have been evaluated for their antimicrobial and insecticidal activity.

 

 

 

 

Nidhi Gautam* & O P Chourasia

 

Heterocyclic Research Laboratory,Department of Chemistry, Dr. H.S. Gour University,

Sagar 470 003, India

 

 

 

 

 

 

 

836

Zinc chloride-catalyzed one pot synthesis of 3-[2-(3-methyl-4,5-dihydro-furo[2,3-c]­pyrazol-1-yl)­thi­a­zol-4-yl]-chromen-2-ones via a three component reaction

 

 

 

 

 

P Vijaya Kumar, K Manoher Reddy & V Rajeswar Rao*

 

Department of Chemistry, National Institute of Technology, Warangal 506 004, India

 

 

 

 

 

 

 

840

Efficient synthesis of 1,3,4-oxadiazolyl-1,8-naph­thy­ridines using iodobenzene diacetate in the solid state

 

A simple and highly efficient procedure for the synthesis of 1-(5-aryl-[1,3,4] oxadiazol-2-ylmethyl)-3-(3-methyl­phenyl)-1H-[1,8]naphthyridin-2-ones 5 is achieved by the oxidation of the corresponding [2-oxo-3-(3-methyl­phenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid arylidene­hydra­zides 4 with iodobenzene diacetate [PhI(OAc)2] in solid state

 

 

 

K Mogilaiah*, K Shiva Kumar, J Kumara Swamy & A Vinay Chandra

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

Authors for correspondence are indicated by (*)