Indian Journal of Chemistry

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Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 49B

NUMBER 11

November 2010

CONTENTS

Papers

 

 

 

1499

Design, synthesis and in vivo hypoglycemic activity of tetrazole-bearing N-glycosides as SGLT2 inhibitors

 

Novel tetrazole-bearing N-glycosides have been  designed and synthesized, and in vivo hypoglycemic  activity has also been evaluated.

 

 

 

 

 

 

Y L Gao, G L Zhao, W Liu , H Shao, Y L Wang,

W R Xu, L D Tang & J W Wang *

 

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China

 

 

 

 

 

 

 

1509

Synthesis of N1-(3-chloro-4-flourophenyl)-N4-sub­sti­tuted semicarbazones as novel anticonvul­sant agents

Several 3-chloro-4-flourophenyl substituted semicarbazones have been synthesized in three steps involving aryl urea and aryl semicarbazide formation. The structures have been confirmed by spectral and elemental analyses. Some selected compounds have been evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) test. The compounds have also been screened for their neurotoxicity and CNS depressant activity.

 

 

 

 

 

 

Mohd Amir*, Mohd J Ahsan & Israr Ali

 

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1515

Synthesis and antimicrobial activity of certain benzimidazole and fused benzimidazole deri­vatives

 

New series of benzimidazoles have been prepared and evaluated for their antimicrobial activity. Some of them show promising antimicrobial activity.  

 

 

 

 

Hassan M Eisa, Alaa-eldin M Barghash,

Sahar M Badr* & Abdelbasset A Farahat

 

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy,

University of Mansoura, Mansoura 35516, Egypt

 

 

Notes

 

 

 

1526

Chemoselective hydrazine addition to diethyl 2-(2,3-dioxo-1,3-diarylpropyl)malonates and a tan­dem deesterification

 

The structural features of the product of the chemoselective reaction of hydrazine on only one of the ketones in a gem diester system with two keto groups by hydrazinium sulfate and hydrazine hydrate are described. A tandem deesterification has also been noticed during the reaction with hydrazine hydrate.

 

 

 

 

Sivaperuman Saravanan, Santhanagopalan Purushothaman &

Shanmugam Muthusubramanian*

 

Department of Organic Chemistry, Madurai Kamaraj University, Madurai 625 021, India

 

 

 

 

 

 

 

1531

2-Amino-5-sulphanyl-1,3,4-thiadiazole derivatives as anticonvulsant agents: Synthesis and evaluation

 

2-Amino-5-sulphanyl-1,3, 4-thiadiazole derivatives bearing different substituents have been synthesized and screened pharmacologically in order to evaluate their central nervous system activity.

 

 

 

 

Priyabrata Pattanayak* & Rajesh Sharma

 

Jeypore College of Pharmacy, Rondapalli, Jeypore,  Koraput 764 002, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1535

A novel versatile strategy for synthesis of new series of 4(3H)-quinazolinone N-nucleosides

 

An integrated protocol for one-pot synthesis of 4(3H)-quinazolinone N-nucleoside analogues under microwave irradiation using montmorilloite K 10 as catalyst and solid support in solvent-free conditions has been reported.

 

 

 

 

 

 

 

 

I R Siddiqui*, Pravin K Singh, Vishal Srivastava,

Sanjay Yadav & J Singh

 

Laboratory of Green Technology, Department of Chemistry, University of Allahabad, Allahabad 211 002, India

 

 

 

 

 

 

 

1542

Synthesis of Gossypin derivatives as potential anticancer and anti-inflammatory agents

 

A new series of gossypin derivatives SGGOS 1-9 have been synthesized from the combination of naturally occurring flavonol glycoside gossypin and substituted aromatic aldehydes, which exhibit significant anticancer and anti-inflammatory activities.

 

 

 

 

 

 

 

 

 

Vijay Kotra, S Ganapaty * & Srinivas R Adapa

 

University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1547

Synthesis and antibacterial properties of some novel 2-substituted-6-(4-methyl-6-substituted­cin­no­line-3-yl)imidazo[2,1-b][1,3,4]thiadiazoles

 

A series of 2-substituted-6-(4-methyl-6-substitutedcinnoline-3-yl)imidazo[2,1-b][1,3,4] thiadiazoles 5a-k have been synthe­sized by reacting 3-(2-bromoacetyl)-4-methyl-6-substituted­cinnolines 3 with various 2-amino-5-substituted-1,3,4-thia­diazoles 4 taking absolute ethanol as solvent. The structures of the newly synthesized compounds have been characterized by elemental analysis, IR, 1H NMR spectral data. All the newly synthesized compounds have been tested for their antibacterial properties against gram-positive and gram-negative bacteria.

 

 

 

 

Anshu Jakhar & J K Makrandi*

 

Department of Chemistry, M. D. University, Rohtak 124 001 India

 

 

 

 

 

 

 

1552

Microwave-assisted zeolite catalyzed Claisen rearrangement of allyl aryl ethers under solvent-free conditions

 

Claisen rearrangement of allyl aryl ethers has been studied extensively over various zeolites under microwave activation and solvent free conditions at 80°C. Hβ-zeolite is found to be an efficient catalyst for the rearrangement. The reaction gives o-rearranged product selectively instead of expected further cyclized dihydrobenzofuran derivative.

 

 

 

 

Deepak K Deodhar, Amol S Tipnis &

Shriniwas D Samant*

 

Department of Chemistry, Institute of Chemical Technology, N M Parekh Marg, Matunga, Mumbai 400 019, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1556

Solid state synthesis of ring-substituted amino­benzenesulphonic acids

 

 

 


R1 = H, R2 = o- OCH3

R1 and R2 = m- Cl

 

 

Inder Pal Singh Kapoor, Manisha Kapoor, Gurdip Singh*, & Roland Fröhlich

 

Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273 009, India

 

 

 

 

 

 

 

1561

An excellent protocol for the synthesis of benzopyrans using basic resin under MWI

 

 

 

 

 

A K Tripathi*, S Koul & Subhash C Taneja

 

Bio-Organic Chemistry Section, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu 180 001, India

 

 

 

 

 

 

 

1565

Recombination of propargyl radicals to form benzene: A computational study

 

Present study involves QCISD(T)/6-311G(d,p) level calculations to analyze reaction pathways during the recombination of propargyl radicals leading to the formation of benzene. Geometries of all the species are optimized at HF/6-31G(d) level. Intrinsic Reaction Coordinate (IRC) calculation has been performed in order to ascertain the existence of the transition states.

 

 

 

Hari Ji Singh* & Nand Kishor Gour

Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273 009, India

 

 

 

 

 

Authors for correspondence are indicated by (*)