Indian Journal of Chemistry;

Total visitors:7360 since 8-11-2010

Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 49B


November 2010







Design, synthesis and in vivo hypoglycemic activity of tetrazole-bearing N-glycosides as SGLT2 inhibitors


Novel tetrazole-bearing N-glycosides have been  designed and synthesized, and in vivo hypoglycemic  activity has also been evaluated.







Y L Gao, G L Zhao, W Liu , H Shao, Y L Wang,

W R Xu, L D Tang & J W Wang *


School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China









Synthesis of N1-(3-chloro-4-flourophenyl)-N4-sub­sti­tuted semicarbazones as novel anticonvul­sant agents

Several 3-chloro-4-flourophenyl substituted semicarbazones have been synthesized in three steps involving aryl urea and aryl semicarbazide formation. The structures have been confirmed by spectral and elemental analyses. Some selected compounds have been evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) test. The compounds have also been screened for their neurotoxicity and CNS depressant activity.







Mohd Amir*, Mohd J Ahsan & Israr Ali


Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, India















Synthesis and antimicrobial activity of certain benzimidazole and fused benzimidazole deri­vatives


New series of benzimidazoles have been prepared and evaluated for their antimicrobial activity. Some of them show promising antimicrobial activity.  





Hassan M Eisa, Alaa-eldin M Barghash,

Sahar M Badr* & Abdelbasset A Farahat


Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy,

University of Mansoura, Mansoura 35516, Egypt








Chemoselective hydrazine addition to diethyl 2-(2,3-dioxo-1,3-diarylpropyl)malonates and a tan­dem deesterification


The structural features of the product of the chemoselective reaction of hydrazine on only one of the ketones in a gem diester system with two keto groups by hydrazinium sulfate and hydrazine hydrate are described. A tandem deesterification has also been noticed during the reaction with hydrazine hydrate.





Sivaperuman Saravanan, Santhanagopalan Purushothaman &

Shanmugam Muthusubramanian*


Department of Organic Chemistry, Madurai Kamaraj University, Madurai 625 021, India









2-Amino-5-sulphanyl-1,3,4-thiadiazole derivatives as anticonvulsant agents: Synthesis and evaluation


2-Amino-5-sulphanyl-1,3, 4-thiadiazole derivatives bearing different substituents have been synthesized and screened pharmacologically in order to evaluate their central nervous system activity.





Priyabrata Pattanayak* & Rajesh Sharma


Jeypore College of Pharmacy, Rondapalli, Jeypore,  Koraput 764 002, India















A novel versatile strategy for synthesis of new series of 4(3H)-quinazolinone N-nucleosides


An integrated protocol for one-pot synthesis of 4(3H)-quinazolinone N-nucleoside analogues under microwave irradiation using montmorilloite K 10 as catalyst and solid support in solvent-free conditions has been reported.









I R Siddiqui*, Pravin K Singh, Vishal Srivastava,

Sanjay Yadav & J Singh


Laboratory of Green Technology, Department of Chemistry, University of Allahabad, Allahabad 211 002, India









Synthesis of Gossypin derivatives as potential anticancer and anti-inflammatory agents


A new series of gossypin derivatives SGGOS 1-9 have been synthesized from the combination of naturally occurring flavonol glycoside gossypin and substituted aromatic aldehydes, which exhibit significant anticancer and anti-inflammatory activities.










Vijay Kotra, S Ganapaty * & Srinivas R Adapa


University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, India















Synthesis and antibacterial properties of some novel 2-substituted-6-(4-methyl-6-substituted­cin­no­line-3-yl)imidazo[2,1-b][1,3,4]thiadiazoles


A series of 2-substituted-6-(4-methyl-6-substitutedcinnoline-3-yl)imidazo[2,1-b][1,3,4] thiadiazoles 5a-k have been synthe­sized by reacting 3-(2-bromoacetyl)-4-methyl-6-substituted­cinnolines 3 with various 2-amino-5-substituted-1,3,4-thia­diazoles 4 taking absolute ethanol as solvent. The structures of the newly synthesized compounds have been characterized by elemental analysis, IR, 1H NMR spectral data. All the newly synthesized compounds have been tested for their antibacterial properties against gram-positive and gram-negative bacteria.





Anshu Jakhar & J K Makrandi*


Department of Chemistry, M. D. University, Rohtak 124 001 India









Microwave-assisted zeolite catalyzed Claisen rearrangement of allyl aryl ethers under solvent-free conditions


Claisen rearrangement of allyl aryl ethers has been studied extensively over various zeolites under microwave activation and solvent free conditions at 80°C. Hβ-zeolite is found to be an efficient catalyst for the rearrangement. The reaction gives o-rearranged product selectively instead of expected further cyclized dihydrobenzofuran derivative.





Deepak K Deodhar, Amol S Tipnis &

Shriniwas D Samant*


Department of Chemistry, Institute of Chemical Technology, N M Parekh Marg, Matunga, Mumbai 400 019, India















Solid state synthesis of ring-substituted amino­benzenesulphonic acids




R1 = H, R2 = o- OCH3

R1 and R2 = m- Cl



Inder Pal Singh Kapoor, Manisha Kapoor, Gurdip Singh*, & Roland Fröhlich


Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273 009, India









An excellent protocol for the synthesis of benzopyrans using basic resin under MWI






A K Tripathi*, S Koul & Subhash C Taneja


Bio-Organic Chemistry Section, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu 180 001, India









Recombination of propargyl radicals to form benzene: A computational study


Present study involves QCISD(T)/6-311G(d,p) level calculations to analyze reaction pathways during the recombination of propargyl radicals leading to the formation of benzene. Geometries of all the species are optimized at HF/6-31G(d) level. Intrinsic Reaction Coordinate (IRC) calculation has been performed in order to ascertain the existence of the transition states.




Hari Ji Singh* & Nand Kishor Gour

Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273 009, India






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