Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 49B

NUMBER 10

October 2010

CONTENTS

Papers

 

 

 

1363

Total synthesis of enokipodins A-D and cuparene-1,4-diol

 

Details of the first total synthesis of enokipodins A and B, and formal total synthesis of enokipodins C and D, cuparene-1,4-diol and cuparene-1,4-dione have been described.

 

 

 

 

 

A Srikrishna* & M Srinivasa Rao

 

Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India

 

 

 

 

 

 

 

1372

Simple and efficient synthesis of Fmoc/Boc/Cbz-protected-b-amino alcohols and peptidyl alcohols employing Boc2O

 

A facile method for the synthesis b-amino alcohols using sodium borohydride is demonstrated. Further, the protocol is also extended for the conversion of N-urethane protected peptide acids to their corresponding alcohols.

 

 

 

Pg : Fmoc, Boc, Cbz

R: CH3, CH2C6H5 , CH(CH3)2, CH2CH(CH3)2, CH2COOtBu,

CH2CH2COOtBu, CH2C6H4 OtBu, CH2OBzl, (CH2)4NHCbz,

CH2(CH3)OBzl

 

 

 

Lalithamba H S & Vommina V Sureshbabu*

 

Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University,
Dr. B. R. Ambedkar Veedhi, Bangalore 560 001, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1379

Michael adduct: Synthons for a new class of heterocycles

 

The Michael adduct, ethyl 3,4-diarylsulfonyl-2-cyanobutyrate has been used as synthon to develop amino-pyrazolones, amino-isoxazolones, amino-hydroxypyrimidinones, amino-mercaptopyrimidinones and imino-pyrimidinediones.

 

 

 

 

 

 

 

 

 

 

 

A Padmaja*, T Payani, A Muralikrishna & V Padmavathi

 

Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India

 

 

 

 

 

 

 

 

Notes

 

 

 

 

 

 

1384

Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones

 

A series of diphenyl hydrazones and semicarbazones have been synthesized and their antibacterial and antituberculosis properties are reported.

 

 

 

 

 

 

 

 

 

 

 

A S Raja*, A K Agarwal, N Mahajan, S N Pandeya & S Ananthan

 

1Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221 005, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1389

Synthesis and characterisation of novel starburst phase transfer catalyst

 

Phase transfer catalyst, 3,5-bis[(2-methyl-naphthylene-1-yl)­phe­nyl­amino-phenyl]-butyl-(2-methoxy-naphthalene-1-yl)­phe­nyl­ammonium­bromide (BPBPB) has been synthesized. The application studies of BPBPB as a Phase Transfer Catalyst (PTC) is studied by utilizing common organic reactions. BPBPB is an efficient catalyst for certain organic reactions and it is regenerative to about 95% in weight.

 

 

 

 

 

 

 

 

 

 

Siji Mathew, Divia N, T D Radhakrishnan Nair & Karickal R Haridas*

 

School of Chemical Sciences, Kannur University, Payyanur Campus, Edat P.O. 670 327, India

 

 

 

 

 

 

 

1394

A facile multicomponent synthesis of tetra­substituted imidazoles using Fe3+-K10 catalyst under solvent-free microwave conditions

 

An efficient, microwave assisted, multi-component synthesis of 1,2,4,5-tetrasubstituted imidazoles has been described.

 

 

 

 

 

 

 

 

 

D S Raghuvanshi & Krishna Nand Singh*

 

Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1398

Synthesis and antiparkinsonian activity of some new adamantyl thiazolidinonyl/azeti­dinonyl in­dole derivatives

 

Synthesis and antiparkinsonian activity of new adamantyl thiazolidinonyl/azetidinonylindole derivatives are reported herein. The compound 4a exhibits the most potent anti­parkinsonian activity.

 

 

4a

 

 

Sunil Kumar, Hemlata Kaur, K K Saxena, Monica Sharma, Pinki Vishwakarma & Ashok Kumar*

 

Medicinal Chemistry Division, Department of Pharmacology, L.L.R.M. Medical College, Meerut 250 004, India

 

 

 

 

 

 

 

1406

Synthesis and in-vitro biological evaluation of some quinazolin substituted pyrazoles, pyrazol­ones and 1,3,4-oxadiazoles

 

In the present study, a new series of pyrazoles 6a,b, pyra­zolones 7a,b and 1,3,4-oxadiazoles 8-10a,b having the quina­zolinone ring in the molecular framework have been synthe­sized from hydrazides 5a,b, possessing potent antibacterial and insecticidal activities.

 

 

 

 

 

Pramilla Sah* & Vasudha Kaul

 

Department of Chemistry, J.N.V. University, Jodhpur 342 005, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1413

A one-pot synthesis of isoxazolyl benzo[b] [1,4] oxazin-3(4H)-ones via Smiles rearrangement

 

A one-pot synthesis of isoxazolyl benzo[b] [1,4]oxazin-3(4H)-ones has been achieved by interaction of 2-chloro­phenols, chloroacetyl chloride and different isoxazole amines involving Smiles rearrangement from readily available starting materials.

 

 

 

 

E Rajanarendar*, M Nagi Reddy & K Rama Murthy

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

 

1417

Microwave-assisted synthesis and antibacterial activity of 1-[3-(3-fluorophenyl) [1,8]naphthyridn-2-yl]-3-(2-oxo-2H-chromenyl)-1H-4-pyrazole­carb­aldehydes using solid support

 

A simple and efficient method for the syn­­the­­sis of 1-[3-(3-fluorophenyl)[1,8]naphthyridn-2-yl]-3-(2-oxo-2H-chromenyl)-1H-4-pyrazolecarbaldehydes 4 in the presence of DMF-POCl3 (Vilsmeier-Haack reagent) using silica gel as solid support under microwave irradiation is described. The compounds 4 have been screened for their antibacterial activity.

 

 

 

 

K Mogilaiah*, R Shiva Prasad & K Shiva Kumar

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

 

1422

An elegant one-pot synthesis of isoxazolo[2,3-a]pyrimidines

 

An elegant one-pot synthesis of isoxazolo [2,3-a]pyrimidines has been achieved by reaction of 3-amino-5-methylisoxazole with 4-arylidene-2-phenyl-5-oxazolones. Treatment of 3-amino-5-methylisoxazole with chalcones also resulted in the formation of isoxazolo [2,3-a]pyrimidines in a single step.The structure of the products have been elucidated by spectral and analytical data.

 

 

 

 

E Rajanarendar*, S Raju, M Nagi Reddy & K Rama Murthy

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1428

Sodium carbonate: A versatile catalyst for Knoevenagel condensation

 

Catalytic amounts of sodium carbonate (Na2CO3) catalyze the condensation of aromatic aldehydes with active methylene compounds to afford arylmethylidene products under the grindstone method. The reactions go to completion within 1–5 min. at 26ºC and give products in excellent yields.

 

 

 

 

M A Pasha*, Krishnappa Manjula & V P Jayashankara

 

Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore 560 001, India

 

 

 

 

 

Authors for correspondence are indicated by (*)