Indian Journal of Chemistry
Sect. B: Organic Chemistry including Medicinal Chemistry http://www.niscair.res.in; http://nopr.niscair.res.in Total visitors:3297 since 12-10-2010
VOL. 49B		NUMBER 10		October 2010
CONTENTS
Papers
1363	Total synthesis of enokipodins A-D and cuparene-1,4-diol		Details of the first total synthesis of enokipodins A and B, and formal total synthesis of enokipodins C and D, cuparene-1,4-diol and cuparene-1,4-dione have been described.
	A Srikrishna* & M Srinivasa Rao Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India
1372	Simple and efficient synthesis of Fmoc/Boc/Cbz-protected-b-amino alcohols and peptidyl alcohols employing Boc2O		A facile method for the synthesis b-amino alcohols using sodium borohydride is demonstrated. Further, the protocol is also extended for the conversion of N-urethane protected peptide acids to their corresponding alcohols.
	Pg : Fmoc, Boc, Cbz R: CH3, CH2C6H5 , CH(CH3)2, CH2CH(CH3)2, CH2COO^tBu, CH2CH2COO^tBu, CH2C6H4 O^tBu, CH2OBzl, (CH2)4NHCbz, CH2(CH3)OBzl
	Lalithamba H S & Vommina V Sureshbabu* Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore 560 001, India
1379	Michael adduct: Synthons for a new class of heterocycles		The Michael adduct, ethyl 3,4-diarylsulfonyl-2-cyanobutyrate has been used as synthon to develop amino-pyrazolones, amino-isoxazolones, amino-hydroxypyrimidinones, amino-mercaptopyrimidinones and imino-pyrimidinediones.
	A Padmaja*, T Payani, A Muralikrishna & V Padmavathi Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India
	Notes
1384	Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones		A series of diphenyl hydrazones and semicarbazones have been synthesized and their antibacterial and antituberculosis properties are reported.
	A S Raja*, A K Agarwal, N Mahajan, S N Pandeya & S Ananthan ^1Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221 005, India
1389	Synthesis and characterisation of novel starburst phase transfer catalyst		Phase transfer catalyst, 3,5-bis[(2-methyl-naphthylene-1-yl)phenylamino-phenyl]-butyl-(2-methoxy-naphthalene-1-yl)phenylammoniumbromide (BPBPB) has been synthesized. The application studies of BPBPB as a Phase Transfer Catalyst (PTC) is studied by utilizing common organic reactions. BPBPB is an efficient catalyst for certain organic reactions and it is regenerative to about 95% in weight.
	Siji Mathew, Divia N, T D Radhakrishnan Nair & Karickal R Haridas* School of Chemical Sciences, Kannur University, Payyanur Campus, Edat P.O. 670 327, India
1394	A facile multicomponent synthesis of tetrasubstituted imidazoles using Fe^3+-K10 catalyst under solvent-free microwave conditions		An efficient, microwave assisted, multi-component synthesis of 1,2,4,5-tetrasubstituted imidazoles has been described.
	D S Raghuvanshi & Krishna Nand Singh* Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India
1398	Synthesis and antiparkinsonian activity of some new adamantyl thiazolidinonyl/azetidinonyl indole derivatives		Synthesis and antiparkinsonian activity of new adamantyl thiazolidinonyl/azetidinonylindole derivatives are reported herein. The compound 4a exhibits the most potent antiparkinsonian activity.
	4a
	Sunil Kumar, Hemlata Kaur, K K Saxena, Monica Sharma, Pinki Vishwakarma & Ashok Kumar* Medicinal Chemistry Division, Department of Pharmacology, L.L.R.M. Medical College, Meerut 250 004, India
1406	Synthesis and in-vitro biological evaluation of some quinazolin substituted pyrazoles, pyrazolones and 1,3,4-oxadiazoles		In the present study, a new series of pyrazoles 6a,b, pyrazolones 7a,b and 1,3,4-oxadiazoles 8-10a,b having the quinazolinone ring in the molecular framework have been synthesized from hydrazides 5a,b, possessing potent antibacterial and insecticidal activities.
	Pramilla Sah* & Vasudha Kaul Department of Chemistry, J.N.V. University, Jodhpur 342 005, India
1413	A one-pot synthesis of isoxazolyl benzo[b] [1,4] oxazin-3(4H)-ones via Smiles rearrangement		A one-pot synthesis of isoxazolyl benzo[b] [1,4]oxazin-3(4H)-ones has been achieved by interaction of 2-chlorophenols, chloroacetyl chloride and different isoxazole amines involving Smiles rearrangement from readily available starting materials.
	E Rajanarendar*, M Nagi Reddy & K Rama Murthy Department of Chemistry, Kakatiya University, Warangal 506 009, India
1417	Microwave-assisted synthesis and antibacterial activity of 1-[3-(3-fluorophenyl) [1,8]naphthyridn-2-yl]-3-(2-oxo-2H-chromenyl)-1H-4-pyrazolecarbaldehydes using solid support		A simple and efficient method for the synthesis of 1-[3-(3-fluorophenyl)[1,8]naphthyridn-2-yl]-3-(2-oxo-2H-chromenyl)-1H-4-pyrazolecarbaldehydes 4 in the presence of DMF-POCl3 (Vilsmeier-Haack reagent) using silica gel as solid support under microwave irradiation is described. The compounds 4 have been screened for their antibacterial activity.
	K Mogilaiah*, R Shiva Prasad & K Shiva Kumar Department of Chemistry, Kakatiya University, Warangal 506 009, India
1422	An elegant one-pot synthesis of isoxazolo[2,3-a]pyrimidines		An elegant one-pot synthesis of isoxazolo [2,3-a]pyrimidines has been achieved by reaction of 3-amino-5-methylisoxazole with 4-arylidene-2-phenyl-5-oxazolones. Treatment of 3-amino-5-methylisoxazole with chalcones also resulted in the formation of isoxazolo [2,3-a]pyrimidines in a single step.The structure of the products have been elucidated by spectral and analytical data.
	E Rajanarendar*, S Raju, M Nagi Reddy & K Rama Murthy Department of Chemistry, Kakatiya University, Warangal 506 009, India
1428	Sodium carbonate: A versatile catalyst for Knoevenagel condensation		Catalytic amounts of sodium carbonate (Na2CO3) catalyze the condensation of aromatic aldehydes with active methylene compounds to afford arylmethylidene products under the grindstone method. The reactions go to completion within 1–5 min. at 26ºC and give products in excellent yields.
	M A Pasha*, Krishnappa Manjula & V P Jayashankara Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore 560 001, India
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