Indian Journal of Chemistry

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Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 50B

NUMBER 3

March 2011

CONTENTS

Papers

 

 

 

275

Novel class of hybrid natural products derived from Lupeol/Lupenone (Part-II)

 

Triterpene lupeol (1)/lupenone isolated from plant Crataeva nurvala have been chemically modified and its different prototype hybrid forms 2, 3, 4 and 5 have been prepared.

 

 

 

Namita Misra, Satish Kumar & Kanwal Raj*

 

Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226 001 India

 

 

 

 

 

 

 

284

Synthesis and biological evaluation of pyrido(2, 3-d)pyrimidine-carboxylate derivatives

 

Ethyl-5-amino-8-(4-halophenyl)-2-methyl-4,7-dioxo-3,4,5,6,7,8-hexahydro pyrido(2,3-d) pyrimidine-6-carboxylate and ethyl-5-amino-8-(4-halophenyl)-2-amino-4,7 dioxo-3,4,5,6,7,8 hexa­hydro­pyrido(2,3-d)pyrimidine-6-carboxylate derivatives have been synthesized through nucleophilic substitution reactions. These novel derivatives have been screened for antibacterial, antifungal and antitumor activity.

 

 

 

P Shanmugasundaram*, N Harikrishnan, M Vijey Aanandini, M Sathish Kumar & J N Sateesh

 

Department of Pharmaceutical Chemistry, Vels College of Pharmacy, Chennai 600 117, India

 

 

 

 

 

 

 

 

 

 

 

 

 

290

Studies on the synthesis of bis-quaternary ammonium salts of geometrical isomers and its potential as bioregulators

 

 

 

 

 

 

 

   

 

 

 

 

 

Anubhuti Seth*, Simmi Rani, Anita Garg & M L Sharma

 

Department of Chemistry, Punjab Agricultural University, Ludhiana 141 004, India

 

 

 

 

 

 

 

 

Notes

 

 

 

 

 

 

299

Short and general method for the synthesis of
2-halocycloalk-1-enecarboxylic esters from 2-hal- ocycloalk-1-enecarbaldehydes

 

One step general method for the synthesis of methyl 2-halocycloalk-1-enecarboxylate derivatives is described by oxidative esterification of 2-halocycloalk-1-enecarbaldehydes withV2O5 -H2O2, HClO4 (Cat.), in methanol.

 

 

 

 

 

 

 

 

 

 

 

Rumpa Das, Faruk H Shaik & Gandhi K Kar*

 

Department of Chemistry & Biochemistry, Presidency College, 86/1 College Street, Kolkata 700 073, India

 

 

 

 

 

 

 

 

 

 

 

 

304

Catalyst-free and solventless Hantzsch ester mediated reduction of nitroolefins at elevated temperature

 

A catalyst-free and solventless protocol for the reduction of nitroolefins to the corresponding nitroalkanes at 100°C has been developed.

 

 

 

 

 

 

 

 

Pankaj Chauhan, Kirandeep Kaur, Neeraj Bala,  Vikas Kumar & Swapandeep Singh Chimni*

 

Department of Chemistry, Guru Nanak Dev University, Amritsar 143 005, India

 

 

 

 

 

 

 

310

Zinc(II) chloride catalysed one pot synthesis of some new 4-thiazolidinone derivatives as biologically potent agents

 

New derivatives of thiazolidin-4-ones have been synthesised by the cyclocondensation of thioglycolic acid/thiolacticacid, 2-amino benzothiazole and 2-chloro-3-formyl quinoline in the presence of ZnCl2.. All the compounds have been screened for their antimicrobial and antifungal activity against various microbes.

 

 

 

 

3 a-l and 4 a-l

 

Where

R1 = H, CH3, OCH3

R2 = H, CH3, OCH3, Cl

R3 = H, CH3

 

 

 

 

 

Pushpak M Shah & Manish P Patel*

 

Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, India

 

 

 

 

 

 

 

 

 

 

 

 

 

315

Studies on synthesis of various N-substituted derivatives with different heterocycles and their herbicidal activity

 

Coumarin 4-methyl acetates are oxidized to coumarin-4-methyl glyoxalate using SeO2. The oxidation is very selective for active methylene group, without affecting the COOH group protected with ester function. The product formed is analogous to the phenyl glyoxalic acid methyl ester and can be a useful moiety for various synthetic manipulations of heterocycles substituted at 4-position of the coumarin. Different hetero­cycles substituted at 4-position of the coumarin moiety have been synthesized. The herbicidal activity of these compounds has been evaluated using Zea Mays and Green Gram.

 

 

 

U C Mashelkar*, Shefali S Tungare & Sachin Bhagat

 

Organic Research Laboratory, SS & LS Patkar College, Goregaon (West), Mumbai 400 062, India

 

 

 

 

 

 

 

321

Synthesis of thiazolyltriazole substituted azetidinones as antimicrobial agents

 

Ethyl 2-amino-4-methylthiazole-5-carboxylate 1 reacts with acetic anhydride and hydrazine hydrate to yield ethyl 2-acetamido-4-methylthiazole-5-carboxylate 2 and N-(5-(hyd- razinecarbonyl)-4-methylthiazol-2-yl)acetamide 3. Reaction of 3 with alcoholic potassium hydroxide-carbon disulphide followed by hydrazine hydrate gives N-(5-(4-amino-5-mer- capto-4H-1,2,4-triazol-3-yl)-4-methylthiazol-2-yl)acetamide 5. This is then condensed with aromatic aldehydes to offer 6a-h which on cyclization with chloroacetyl chloride furnish 7a-h.

 

 

B A Baviskar*, M R Shiradkar, S S Khadabadi, S L Deore & K G Bothara

 

Department of Pharmaceutical Chemistry, Government College of Pharmacy, Kathora Naka, Amravati 444 604, India

 

 

 

 

 

 

 

 

 

 

 

 

 

326

Spectral and single crystal X-ray diffraction studies of (E)-4-chloro-N(2-hydroxybenzyli­dene)­benzohydrazide

 

The structure and types of hydrogen bonding present in crystalline form of (E)-4-chloro-N(2-hydroxybenzyli­dene)­benzohydrazide are envisaged from single crystal X-ray diffraction studies. The topological analysis of hydrogen bonds indicates both inter and intramolecular hydrogen bonding. The presence of water molecule in crystal structure indicates mono hydrated form of the title compound.

 

 

 

A Padmaja, Aliya Begum, P Ragavaiah & Ch Sarala Devi*

 

Department of Chemistry, Nizam College, Osmania University, Hyderabad 500 001, India

 

 

 

 

 

 

 

330

Synthesis and antimicrobial activity of 1-amino­methyl-3-[4′-(4″-nitrobenzyloxy)-benzohydra­zo­no]isatins

A new series of 1-aminomethyl-3-[4′-(4″-nitrobenzyloxy)-benzohydrazono]isatins (Mannich bases) have been synthesized and screened for their antimicrobial potential against human pathogenic bacteria and fungi. The structures of the compounds have been established by means of elemental analysis and spectral data.

 

 

Nisheeth Rastogi*, Darwin Anil Harrison & Akriti Agarwal

 

Department of Chemistry, Lucknow Christian Post-Graduate College, Lucknow 226 018, India

 

 

 

 

334

Book Review

 

 

 

 

 

Authors for correspondence are indicated by (*)