Indian Journal of Chemistry

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Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 50B

NUMBER 9

September 2011

CONTENTS

Papers

 

 

 

1157

Effect of substituents on enantioselectivity in chiral oxazaborolidine mediated asymmetric ketone reduction reaction

Various new chiral ligands have been synthesized from l-Valine in order to find the most effective catalyst for the enantioselective ketone reduction.

 

 

 

 

U Balakrishnan, N Ananthi & S Velmathi*

 

Organic and Polymer Synthesis Lab, Department of Chemistry, National Institute of Technology, Tiruchirappalli 620 015, India

 

 

 

 

 

 

1165

Design, facile synthesis and biological evaluation of quinazoline containing pyrazolothiazolyl, triazinone and their ethoxyphthalimide derivatives

 

3-(4-Substituted benzylidene)-4-N-ethoxy phthalimido-6-phenyl-3,4-dihydro-2H-[1,2,4] triazino[2,3-c]quinazolin-2-one 6a-d and 3-[3-(4-substitutedbenzylidene-5-phenyl-2-N-ethoxyphthalimido-3,3a-dihydro-2H-pyrazolo[3,4-d][1,3]thiazol-6(5H)-yl)]-2-phenylquinazolin-4(3H)-one 11a-d have been synthesized from benzoxazine 1 and 3-amino-2-phenylquinazolin-4(3H)-one 2 through multiple step approach. Synthesized compounds are characterized by analytical and spectral studies.

 

 

 

 

 

Raja Ram Dangi, Nasir Hussain, Ajit Joshi, Gangotri Pemawat & Ganpat Lal Talesara*

Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, M. L. Sukhadia University,
Udaipur 313 001, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1173

Synthesis of ethoxyphthalimido derivatized thia­zolodihydropyridines assembled with pyrazole and isoxazole systems from common intermediate chalcone and evaluation of their antibacterial activity

8-[(1N-ethoxyphthalimido-2-oxo-1,2-dihydro-3H-indol-3-ylidene)­amino]-3,6-bis(substitutedphenyl)-1,3,3a,9a-tetra-hydro-6H-iso­xa­z­olo[3',4':4,5][1,3]thiazolo[3,2-a]pyridine-5,7-dicarbonitrile 4a-e and N-(5,7-dicyano-3,6-bis(substituted phenyl)-2N-ethoxyphthalimido-2H,6H-pyrazolo[3',4':4,5][1,3]thiazolo[3,2-a]pyridine-8-yl)benz­ami­de 7a-e have been synthesized from common intermediate 5-amino-3-oxo-7- substitutedphenyl-2-substitutedarylidene-2,3-dihydro-7H-[1,3]thiazolo[3,2-a]pyridine-6,8-dicarbonitrile 1a-e. Synthesized compounds have been evaluated for antibacterial activity.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Gangotri Pemawat & Ganpat L Talesara*

 

Synthetic Organic Chemistry Laboratory, Department of Chemistry, M. L. Sukhadia University,

Udaipur 313 001, India

 

 

 

 

 

 

 

 

 

 

 

 

1181

Synthesis and antimicrobial activity of linked heterocyclics containing pyrazole-pyrimidine rings

 

 

New series of 4-(aryl/hetaryl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine 5a-j has been prepared and confirmed by IR, NMR, MS and elemental analyses. All the synthesized compounds have been tested for their antimicrobial activity against bacteria and fungi. Among the synthesized compounds, the compounds containing 4-nitrophenyl 5c, 2-furyl 5h and 2-thiazolyl 5j at 6-position of pyrimidine ring are highly active against all the organisms employed.

 

 

 

 

 

 

 

 

 

Ch Sanjeeva Reddy*,  M Vani Devi, G Rajesh Kumar, L Sanjeeva Rao & A Nagaraj

 

Department of Chemistry, University College, Kakatiya University, Warangal 506 009, India

 

 

 

 

Notes

 

 

 

 

1187

Green synthesis of 1,2,4-triazolo[4,3-a][1,8]

naphthyridines using PhI(OAc)2-Al2O3

under microwave irradiation

 

Alumina-supported iodobenzene diacetate  [PhI(OAc)2-Al2O3] is a highly efficient reagent for the oxidative cyclization of N-arylidene-N’–[3-(4-fluorophenyl)-[1,8]naphthyridin-2-yl]- hydrazines 7 to 1 aryl-4-[4-fluoro phenyl]-1,2,4-triazolo[4,3-a][1,8]naphthyridines 8

in solvent-free conditions under microwave irradiation.

 

 

 

 

 

 

 

 

 

 

 

 

K Mogilaiah*, A Vinay Chandra & N Srivani

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

 

 

 

 

 

 

1192

Ultrasound assisted Friedel-Crafts acylation of aromatics using ferric sulphate as catalyst

 

A facile and simple synthesis of aromatic ketones using catalytic amount of ferric sulphate has been reported under ultrasonication.

 

 

 

 

 

Anandhi Sridharan* & Geetha Gopalakrishnan

Department of Chemistry, Christ University, Hosur Road, Bangalore 560 029, India

 

 

 

 

 

 

1196

Synthesis and antibacterial activities of new dibenzothiazepine derivatives

 

 

 

 

R1H =  imidazole, 2-methyl imidazole, 4-methy imidazole, pyrolidine, triazole, 2-mercapto-5-methyl 1, 3, 4 thiadiazole, 2-mercapto benzimidazole, 4-methoxy-2-mercapto benzimidazole, 2-aminoethanol, benzyl amine, cyclopropyl amine

 

 

Ganesh D Mahale, Yogesh M Kolekar,  Ashok Kumar,  Dharmendra Singh,  Kisan M Kodam &
Suresh B Waghmode*

Department of Chemistry, University of Pune, Pune 411 007, India

 

 

 

 

 

 

1202

Synthesis and characterization and anti-inflammatory and antibacterial evaluation of 3-arylidene-7-methoxychroman-4-ones

 

3-Arylidene-7-methoxychroman-4-ones 3a-k have been prepared from 7-methoxy-chroman-4-one 1 and heterocyclic aldehydes 2 and have been evaluated for anti-inflammatory and antibacterial activities. All of them have registered moderate anti-inflammatory and antibacterial activities.

 

 

 

 

T Shankar, R Gandhidasan* & S Venkataraman

Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1208

Synthesis and antibacterial activity of some novel N-substituted 3-[4-(1-alkyl/acyl/aroyl-1H-benzi­mi­dazol-2-yl)phenyl]acrylate derivatives

 

Synthesis of a series of novel 3-[4-(1-alkyl/acyl/aroyl-1H-benzimid­a­zol-2-yl)phenyl]acrylate derivatives and their antibacterial activity has been reported.

 

 

 

 

(i) Pd(OAc)2, tris(o-Tollyl)phosphine, Triethylamine, DMF

 

 

 

Raju B Chaudhari, Sanjay D Vaidya, B K Karale, P Y Pawar & Sahebrao S Rindhe*

New Arts, Commerce and Science College, Ahmednagar 414 001, India

 

 

 

 

 

 

 

 

 

 

1216

Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives

 

A series of 2-ethyl benzimidazole deri­vatives have been synthesized and characterized. All the compounds have shown significant analgesic and anti-inflammatory activity.

 

 

 

 

 

G Mariappan*, N R Bhuyan, Pradeep Kumar, Deepak Kumar & K Murali

Department of Pharmaceutical Chemistry, Himalayan Pharmacy Institute, Majhitar, Rangpo 737 136, India

 

 

 

 

 

Authors for correspondence are indicated by (*)