Indian Journal of Chemistry

 

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 51B

NUMBER 4

April 2012

 

CONTENTS

 

Papers

 

 

 

 

 

605

Facile synthesis of various 4-carboxylic acid derivatives and their amide analogues of benzopyrans

 

 

 

 

 

 

 

Anil K Tripathi*, Debaraj Mukherjee, S Koul & Subhash C Taneja

 

Indian Institute of Integrative Medicines (CSIR), Canal Road, Jammu 180 001, India

 

 

 

 

 

 

 

 

 

 

611

Effect of some pyridinium based compounds on the hydrolysis of carboxylate ester

 

The three pyridinium compounds 4-(-1-amino­hydroxy­iminomethyl)-1-dodecylpyridinium bromide (4-AHIDDPB), 3-hydroxy-1-dodecylpyridinium bromide (3-HDDPB) and 3-hydroxyiminomethyl-1-dodecyl­pyridinium bromide (3-HIDDPB) have been synthesized and nucleophilic reactivities of these compounds studied.

 

 

 

               

(4-AHIDDPB)           (3-HIDDPB)

 

 

 

Namrata Singh & Kallol K Ghosh*

School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur 492 010, India

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

617

Quantitative structure activity relationship analysis of bisbenzofuran cations as antimalarial agents employing multivariate statistical approach

 

A 2D QSAR study has been conducted on 43-bisbenzofuran derivatives with anti malarial activity using multiple linear regression (MLR) and partial least squares (PLS) methods.

 

 

 

 

 

 

 

Sarvesh Paliwal*, Jyoti Sharma & Shailendra Paliwal

 

Department of Pharmacy, Banasthali University, Banasthali 304 022, India

 

 

 

 

 

 

Notes

 

 

 

 

 

 

 

 

 

631

An efficient total synthesis of (±)-pregabalin

 

The synthesis of (±)-pregabalin has been accomplished by oxidation and reduction of 2-benzyl-4-methyl­pentanenitrile.

 

 

 

 

 

 

 

 

 

 

Shivaji H Shelke, Pravin C Mhaske & Vivek D Bobade*

 

Department of Chemistry, H.P.T. Arts and R.Y.K. Science College, Nashik 422 005, India

 

 

 

 

 

 

 

 

 

 

635

Antiviral activity of a new flavone glycoside from Emilia sonchifolia DC.

 

A new flavone glycoside has been isolated from seeds of Emilia sonchifolia DC. It has been characterized as 3,7,3′,4′-tetrahydroxy-flavone-3-O-β-d-xylopyranosyl-(1→3)-O-β-d-gal­actopyranosyl-(1→4)-O-α-l-rhamno­pyranoside by various chemical degradations and spectral analysis.

 

 

 

 

 

 

R N Yadava * & Mamta Raj

 

Natural Products Laboratory, Department of Chemistry,  Dr. H. S. Gour Central University,

Sagar 470 003, India

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

639

Synthesis, characterization and potential anti­convulsant activity of various 3-(substituted)-benzylidene-7-chloro-5-phenyl-1,3-dihydro-benzo­[e]­[1,4]diazepin-2-one

 

Some new 3-(substituted)-benzylidene derivatives of 7-chloro-5-phenyl-1,3-dihydro-benzo [e][1,4] diazepin-2-one have been synthesized and their anticonvulsant activity tested through Maximal Electroshock (M.E.S.) model and PTZ animal model by using Phenytoin and Diazepam as reference drugs respectively. The five compounds 4a, 4b, 4d, 4h and 4j have shown significant anticonvulsant activity as compared to reference drugs.

 

 

 

 

 

 

 

 

 

 

 

4a: R= 4-Cl

4b: R= 2-Cl

4d: R= 3-OH

4h: R= 4-N(CH3)2

4j : R= 4-F

 

 

 

 

 

 

 

Bahar Ahmad*, Mohd Rashid, Asif Husain & Ravinesh Mishra

 

Antihepatotoxic Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy,

Jamia Hamdard University, New Delhi 110 062, India

 

 

 

 

 

 

 

 

 

 

646

Effects of phenols, amines and alcohols on the reactivity of triphenyltin hydride towards alkyl cinnamates

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Pankaj Kalita, Diganta Choudhury & Dibakar Chandra Deka*

 

Department of Chemistry, Gauhati University, Guwahati 781 014, India

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

650

A mild protocol for the synthesis of 2-aryl­benzo­xazoles from phenolic Schiff bases promoted by superoxide

 

An easy and efficient oxidative cyclization of Schiff bases, derived from the condensation of o-aminophenol with aromatic aldehydes, to 2-arylbenzoxazoles is described using in situ generated tetraethylammonium superoxide in aprotic solvent, at room temperature.

 

 

1a-g                                                 2a-g

a : R = H, R1 = C6H5

 

e : R = H, R1 =

b : R = H, R1 = 4-CH3C6H4

c : R = H, R1 = 4-CH3OC6H4

d : R = H, R1 = 2-CH3OC6H4

 

f : R = H, R1 =

g : R = NO2, R1 = 4-NO2C6H4

 

 

Raghvendra Singh Raghuvanshi & Krishna Nand Singh*

 

Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India

 

 

 

 

 

 

 

 

 

 

653

Microwave accelerated synthesis of 2-amino­thiophenes in ionic liquid via three component Gewald reaction

 

Microwave accelerated synthesis of substituted 2-aminothiophenes by a three-component Gewald reaction using a basic ionic liquid, 1,1,3,3-tetramethylguanidine lactate [TMG] [Lac] as solvent as well as catalyst has been developed. The products are obtained in good to high yields and the ionic liquid is reusable over several cycles without significant loss in catalytic activity.

 

 

 

 

 

 

Sunil S Chavan, Yogesh Y Pedgaonkar, Ananda J Jadhav & Mariam S Degani*

 

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology,

 N. Parekh Marg, Matunga, Mumbai 400 019, India

 

 

 

 

 

 

 

 

 

 

658

Sleek synthesis of 2,3-dihydrobenzofurans

 

2-Benzoyl-3-phenacyl-2,3-dihydrobenzofurans are synthesized by the reaction between 2-hydroxychalcones and 2-bromoacetophenones with potassium carbonate in boiling acetone in good yield.

 

 

 

 

 

 

 

 

T S S P N S Sanath Kumar*, A Prasant, G L David Krupadanam & K Akshaya Kumar

 

Department of Chemistry, Osmania University, Hyderabad 500 007, India

 

 

 

 

 

 

 

Authors for correspondence are indicated by (*)