Indian Journal of Chemistry

 

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 51B

NUMBER 7

July 2012

 

CONTENTS

 

Papers

 

 

 

 

969

Synthesis of novel α-amino acid functionalized 6-fluoro quinolones, their anti-bacterial activity and molecular docking studies

 

A series of novel α-amino acid functionalized 6-fluoro quinolones have been prepared and screened for antibacterial activity in-vitro. Promising compound 6e has been identified for all strains.

 

 

 

 

6e

 

 

 

B P Venkat Lingaiah, T Yakaiah, A Chandra Shekhar, A Ravi Kumar,

G Sathaiah, K Raju, P Shanthan Rao*, B Narsaiah, K Pranay Kumar,

U S N Murthy , U Purushotham & G Narahari Sastry

 

Fluoroorganic Division, Biology Division (Bioinformatics), Molecular Modeling Group,

Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India

 

 

 

 

 

 

 

981

Synthesis and anti-inflammatory activity of imidazo[1,2-a] pyridinyl/pyrazinyl benzamides and acetamides

 

A series of the imidazo[1,2-a]pyridin-2-one and imidazo[1,2-a]pyrazin-2-one acetamide/benzamide derivatives have been synthesized, characterized and their anti-inflammatory activities evaluated.

 

 

 

 

 

 

S Hemasrilatha, K Sruthi, A Manjula, V Harinadha Babu & B Vittal Rao*

 

Crop Protection Chemicals Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India

 

 

 

 

 

 

 

 

 

 

 

 

 

988

Eco-friendly method for catalytic aerial oxidation of Aloe-emodin to rheinal: An intermediate for diacerein

 

An eco-friendly process for the synthesis of 4,5-dihydro-9,10-dioxo-9,10- dihydroanthracene-2-carbalaldehyde (rheinal) from 1,8-dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione (aloe-emodin) via aerial oxidation in presence of catalysts such as oxovanadium, copper(II) salen or enzymes containing copper(II) i.e. laccase is described.

 

 

 

 

 

 

 

 

Bhairab Nath Roy*, Girij Pal Singh & Piyush Suresh Lathi

 

Lupin Research Park, Lupin Ltd, Survey No 46/A & 47/A,
Nande Village, Mulshi Taluka, Dist. Pune 411 042, India

 

 

 

 

 

 

 

992

Stereoselective bioreduction of chalcone and β diketone by Saccharomyces cerevisiae in biphasic solvent system: A mechanistic study

 

The utility and versatility of Baker’s yeast as a biocatalyst in effecting biotransformations such as stereoselective reductions of chalcones and diketones in biphasic system is exemplified by delineation of a green procedure.

 

 

 

 

 

 

 

Naziyanaz B Pathan, Anjali M Rahatgaonkar & Mukund S Chorghade*

 

Chemistry Department, Institute of Science, Civil lines, R. T. Road, Nagpur 440 001, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1002

Facile synthesis of new substituted aryl and heteroarylflavones by thermal and microwave assisted Suzuki-Miyaura coupling reaction

 

Synthesis of aryl and heteroarylflavones has been carried out using Suzuki-Miyaura coupling reaction by thermal heating, separately with catalysts, Pd(OCOCH3)2 and Pd[(Ph)3P]4.  Microwave heating with Pd[(Ph)3P]4 catalyst reduced time of heating, and gave highest yield.

 

 

 

 

 

 

 

 

 

 

Vidya Joshi* & Jaywant Govind Hatim

 

C. C. Shroff Research Institute, 13/14 Aradhana Industrial Development Corporation,

Near Virwani Industrial Estate, Goregaon (East), Mumbai, 400 063, India

 

 

 

 

 

 

 

1011

Synthesis, characterization and antimicrobial screening of some quinoline based dihydropyridine and 2-oxo-azetidine derivatives

 

 

 

 

 

 

 

 

 

 

 

N C Desai* & J P Harsora

 

Division of Medicinal Chemistry, Department of Chemistry,
Mahatma Gandhi Campus, Bhavnagar University, Bhavnagar 364 002, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1020

Synthesis, antimicrobial, insecticidal and anthelmintic activity studies of some new alkyl/aryl 6-(4-(4-(4-methyl-1H-1,2,3-triazol-1-yl)phenyl amino)phenyl)-N2,N4-bis(4-methoxyphenyl)-1,3,5-triazin-2,4-diamine carbamic acid ester derivatives

 

New carbamic acid ester derivatives containing 1,2,3-triazole nucleus have been synthesized and their antimicrobial, insecticidal and anthelmintic activity investigated.

 

 

 

 

Nidhi Gautam* & O P Chourasia

 

Department of Chemistry, Dr. H. S. Gour University, Sagar 470 003, India

 

 

 

 

 

Notes

 

 

 

1027

Studies on the reaction of N-bromo­succinimide in dimethylsulphoxide: Part X — Action on cholest-4-en-3,6-dione

 

The reaction of cholest-4-en-3,6-dione 1 with NBS in DMSO furnishes three compounds which have been identified as 2,7α-dibromocholest-1,4-dien-3,6-dione 2, 2,2,7α- tribromo cholest-4-en-3,6-dione 3 and 2α,7α-dibromo cholest-4-en-3,6-dione 4 by various spectroscopic methods.

 

 

 

 

B P Pradhan, Utpal Debnath, Nagendra Narayan Pradhan & Pranab Ghosh*

 

Natural Product and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal,
Darjeeling, West Bengal 734 013, India

 

 

 

 

 

 

 

1032

Fuller’s earth catalyzed a rapid synthesis of bis(indolyl)methanes under solvent free condition

 

A rapid and highly efficient synthesis of various bis(indolyl)­methanes with high yield by the reaction of indoles and arylaldehydes in presence of Fuller’s earth is demonstrated.

 

 

 

Naval Kapuriya, Rajesh Kakadiya, Mahesh M Savant, Akshay M Pansuriya,

Chirag V Bhuva, Anil S Patel , Piyush V Pipaliya, Vipul B Audichya, Sarala Gangadharaiah,

Sridhar M Anandalwar, Javaregowda S Prasad, Anamik Shah & Yogesh T Naliapara*

 

Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot 360 005, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1039

Potassium phosphate catalyzed efficient synthesis of 3-carboxycoumarins

 

 

 

 

Kedar A Undale, Dipak S Gaikwad, Tarannum S Shaikh, Uday V Desai & Dattaprasad M Pore*

 

Department of Chemistry, Shivaji University, Kolhapur 416 004, India

 

 

 

 

 

Authors for correspondence are indicated by (*)