Indian Journal of Chemistry

 

Sect. B: Organic Chemistry including Medicinal Chemistry

http://www.niscair.res.in; http://nopr.niscair.res.in

Total visitors: 5949 since 06-06-2012

 

 

VOL. 51B

NUMBER 6

June 2012

 

CONTENTS

 

Papers

 

 

 

 

843

A highly efficient catalytic system for microwave-assisted Suzuki–Miyaura reactions as well as room temperature homocoupling reactions of arylboronic acids in aqueous media

 

Development of a highly efficient catalytic system for Suzuki-Miyaura cross-coupling reactions of aryl halides as well as homocoupling reactions of arylboronic acids in aqueous media is reported.

 

 

 

 

 

Archana Tairai, Chandan Sarmah & Pankaj Das*

 

Department of Chemistry, Dibrugarh University, Dibrugarh 786 004, India

 

 

 

 

 

 

 

849

First stereoselective total synthesis of (3R, 3aS, 6aR)-hexahydrofuro[2,3-b]furan-3-yl (2R,3S)-4-(4-amino-N-isobutyl phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl-carbamate (diastereomer of Darunavir)

 

 

 

 

 

 

Kilaru Ravendra Babu, Valasani Koteswara Rao, Yellapu Sudhakar & Chamarthi Naga Raju*

 

Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India

 

 

 

 

 

 

 

 

 

 

 

 

 

855

l-Proline as an efficient catalyst for synthesis of N-heterocyclic chalcones as potential antibacterial agents

 

The condensation of 4-hydroxy-3-acetyl-1H-quinoline-2-one 1 and substituted benzaldehydes 2a-i in DMSO solution at room temperature yields quinolone chalcone derivatives 3a-i. l-Proline has been found to be an efficient catalyst for this condensation between 1 and 2. Only 5 mol % of the catalyst is necessary to achieve good yield of the products. Reactions proceed smoothly with variation of the substituents.

 

 

 

 

 

 

 

 

Raja S Bhupathi *, B Rama Devi & P K Dubey

 

Department of Chemistry,  Jawaharlal Nehru Technological University, College of Engineering, Kukatpally,
Hyderabad 500 085, India

 

 

 

 

 

 

860

Microwave assisted eco-friendly protocol for one pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones in water

 

An efficient one pot l-proline catalyzed multicomponent synthesis of 2,3-dihydro-4(1H)-quinazolinones has been achieved involving isatoic anhydride, aldehyde and amine or ammonium acetate in water under microwave. The use of l-proline, water and MW has promising reaction response, such as environmentally benign conditions, short reaction time, excellent product yields, and simple work-up of the products. 

 

 

 

 

 

 

 

 

Kumkum Kumari, D S Raghuvanshi & Krishna Nand Singh*

 

Department of Chemistry, Faculty of Science, Banaras Hindu University,

Varanasi 221 005, India

 

 

 

 

 

 

 

 

 

 

 

 

866

Efficient synthesis of 13- to 20-membered Schiff base macrocycles via non-template method

 

A set of hitherto unreported 13- to 20-membered Schiff base macrocycles have been synthesized by the reaction of Schiff base with dielectrophiles via the intermediacy of remote dianion in non-template method.

 

 

 

 

 

 

 

 

 

 

 

M S Singh *, R K Verma, Shweta Singh & Ashutosh Gupta

 

Department of Chemistry (Center of Advanced Study),
Faculty of Science,  Banaras Hindu University, Varanasi 221 005, India

 

 

 

 

 

 

 

871

A novel versatile strategy for synthesis of new series of  thiazolo-triazine N-nucleosides

 

An efficient protocol associated with readily available starting materials, mild conditions, excellent yields, and a broad range of products in synthetic chemistry has been established for synthesis of thiazolo-triazine N-nucleoside derivatives. Result obtained showed considerable enhancement of yields and reduction in time. Furthermore, integrated process minimizes the mechanical loss of the intermediate during process for isolation.

 

 

 

 

 

 

 

 

 

 

I R Siddiqui*, Pravin K Singh, Vishal Srivastava, Shayna Shamim & J Singh

 

Laboratory of Green Technology, Department of Chemistry, University of Allahabad, Allahabad 211 002, India

 

 

 

 

 

 

 

 

 

 

 

 

 

880

Synthesis, characterization and microbial assay of new pyridoquinolone-3-carboxamides

 

Synthesis of new pyrido quinolone carboxamide has been carried out and all the compounds have been screened for their antibacterial and antifungal activity.

 

 

 

 

Navin B Patel*, Kunal K Pathak, Jignesh N Patel & Sandip H Modi

 

Department of Chemistry, Veer Narmad South Gujarat University

Surat 395 007, India

 

 

 

 

 

 

 

 

Notes

 

 

 

 

 

 

891

Conventional and microwave-assisted synthesis of 1,5-diaryl-2-thiohydantoins

 

A simple and fast method for the synthesis of new 1,5-diaryl-2- thiohydantoins by using  microwave radiation has been standardized. The  compounds have been synthesized from phenylacetic  acid by esterification, bromination, amination and  cyclization using conventional as well as microwave  irradiation methods.

 

 

 

 

M B Baile & S S Mahajan *

 

C. U. Shah College of Pharmacy, Sir Vithaldas Vidya Vihar,

Juhu Tara Road, Santacruz (W), Mumbai 400 049, India

 

 

 

 

 

 

 

 

 

 

 

 

 

895

Photochemical synthesis of 9-methoxy-5-thiophenyl-12H-benzo[a] xanthene-12-one

 

Photochemical oxidation of 7-methoxy-3-phenyl-2-[(E)-2-(thiophen-2-yl)ethenyl]-4H-chromen-4-one 4 in methanol containing iodine in the presence of air afforded 9-methoxy-5-thiophenyl-12H-benzo[a] xanthene 5. The structure of the photo-products has been confirmed by IR, UV-Vis, 1H NMR and mass spectra. A suitable mechanism has been proposed.

 

 

 

 

 

Mohd Basheer Miya, Y Jayaprakash Rao & G L David Krupadanam*

 

Department of Chemistry, Osmania University, Hyderabad 500 007, India

 

 

 

 

 

 

 

899

Synthesis and antiulcer activity study of disubsti­tuted alkyl 4-(substituted)-2,6-dimethyl-1-((4-oxo-3-(4-sulfamoylphenyl)-2-thioxo-3,4-dihydroquinazo­lin-1(2H)-yl)methyl)-1,4-dihydropyridine-3,5 dicar­bo­xylate

 

A series of disubstituted alkyl 4-(substituted)-2,6-dimethyl-1-((4-oxo-3-(4-sulfamoylphenyl)-2-thioxo-3,4-dihydroquinazolin-1(2H)-yl) me­thyl)-1,4-dihydropyridine-3,5 dicarboxylate 3a-h have been prepared by reaction of 4-(4-oxo-2-thioxo-1,2-dihydroquinazolin-3(4H)-yl) benzene sulfonamide with para-formaldehyde and 1,4-dihydro­pyridine derivatives. The compounds are characterized and screened for their antiulcer activities.

 

 

 

 

B B Subudhi*, S K Panda, G Ghosh & P K Panda

 

School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneshwar 751 030, India

 

 

 

 

 

Authors for correspondence are indicated by (*)