Indian Journal of Chemistry


Sect. B: Organic Chemistry including Medicinal Chemistry;

Total visitors: 6421 since 06-06-2012



VOL. 51B


June 2012










A highly efficient catalytic system for microwave-assisted Suzuki–Miyaura reactions as well as room temperature homocoupling reactions of arylboronic acids in aqueous media


Development of a highly efficient catalytic system for Suzuki-Miyaura cross-coupling reactions of aryl halides as well as homocoupling reactions of arylboronic acids in aqueous media is reported.






Archana Tairai, Chandan Sarmah & Pankaj Das*


Department of Chemistry, Dibrugarh University, Dibrugarh 786 004, India









First stereoselective total synthesis of (3R, 3aS, 6aR)-hexahydrofuro[2,3-b]furan-3-yl (2R,3S)-4-(4-amino-N-isobutyl phenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl-carbamate (diastereomer of Darunavir)







Kilaru Ravendra Babu, Valasani Koteswara Rao, Yellapu Sudhakar & Chamarthi Naga Raju*


Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, India















l-Proline as an efficient catalyst for synthesis of N-heterocyclic chalcones as potential antibacterial agents


The condensation of 4-hydroxy-3-acetyl-1H-quinoline-2-one 1 and substituted benzaldehydes 2a-i in DMSO solution at room temperature yields quinolone chalcone derivatives 3a-i. l-Proline has been found to be an efficient catalyst for this condensation between 1 and 2. Only 5 mol % of the catalyst is necessary to achieve good yield of the products. Reactions proceed smoothly with variation of the substituents.









Raja S Bhupathi *, B Rama Devi & P K Dubey


Department of Chemistry,  Jawaharlal Nehru Technological University, College of Engineering, Kukatpally,
Hyderabad 500 085, India








Microwave assisted eco-friendly protocol for one pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones in water


An efficient one pot l-proline catalyzed multicomponent synthesis of 2,3-dihydro-4(1H)-quinazolinones has been achieved involving isatoic anhydride, aldehyde and amine or ammonium acetate in water under microwave. The use of l-proline, water and MW has promising reaction response, such as environmentally benign conditions, short reaction time, excellent product yields, and simple work-up of the products. 









Kumkum Kumari, D S Raghuvanshi & Krishna Nand Singh*


Department of Chemistry, Faculty of Science, Banaras Hindu University,

Varanasi 221 005, India














Efficient synthesis of 13- to 20-membered Schiff base macrocycles via non-template method


A set of hitherto unreported 13- to 20-membered Schiff base macrocycles have been synthesized by the reaction of Schiff base with dielectrophiles via the intermediacy of remote dianion in non-template method.












M S Singh *, R K Verma, Shweta Singh & Ashutosh Gupta


Department of Chemistry (Center of Advanced Study),
Faculty of Science,  Banaras Hindu University, Varanasi 221 005, India









A novel versatile strategy for synthesis of new series of  thiazolo-triazine N-nucleosides


An efficient protocol associated with readily available starting materials, mild conditions, excellent yields, and a broad range of products in synthetic chemistry has been established for synthesis of thiazolo-triazine N-nucleoside derivatives. Result obtained showed considerable enhancement of yields and reduction in time. Furthermore, integrated process minimizes the mechanical loss of the intermediate during process for isolation.











I R Siddiqui*, Pravin K Singh, Vishal Srivastava, Shayna Shamim & J Singh


Laboratory of Green Technology, Department of Chemistry, University of Allahabad, Allahabad 211 002, India















Synthesis, characterization and microbial assay of new pyridoquinolone-3-carboxamides


Synthesis of new pyrido quinolone carboxamide has been carried out and all the compounds have been screened for their antibacterial and antifungal activity.





Navin B Patel*, Kunal K Pathak, Jignesh N Patel & Sandip H Modi


Department of Chemistry, Veer Narmad South Gujarat University

Surat 395 007, India

















Conventional and microwave-assisted synthesis of 1,5-diaryl-2-thiohydantoins


A simple and fast method for the synthesis of new 1,5-diaryl-2- thiohydantoins by using  microwave radiation has been standardized. The  compounds have been synthesized from phenylacetic  acid by esterification, bromination, amination and  cyclization using conventional as well as microwave  irradiation methods.





M B Baile & S S Mahajan *


C. U. Shah College of Pharmacy, Sir Vithaldas Vidya Vihar,

Juhu Tara Road, Santacruz (W), Mumbai 400 049, India















Photochemical synthesis of 9-methoxy-5-thiophenyl-12H-benzo[a] xanthene-12-one


Photochemical oxidation of 7-methoxy-3-phenyl-2-[(E)-2-(thiophen-2-yl)ethenyl]-4H-chromen-4-one 4 in methanol containing iodine in the presence of air afforded 9-methoxy-5-thiophenyl-12H-benzo[a] xanthene 5. The structure of the photo-products has been confirmed by IR, UV-Vis, 1H NMR and mass spectra. A suitable mechanism has been proposed.






Mohd Basheer Miya, Y Jayaprakash Rao & G L David Krupadanam*


Department of Chemistry, Osmania University, Hyderabad 500 007, India









Synthesis and antiulcer activity study of disubsti­tuted alkyl 4-(substituted)-2,6-dimethyl-1-((4-oxo-3-(4-sulfamoylphenyl)-2-thioxo-3,4-dihydroquinazo­lin-1(2H)-yl)methyl)-1,4-dihydropyridine-3,5 dicar­bo­xylate


A series of disubstituted alkyl 4-(substituted)-2,6-dimethyl-1-((4-oxo-3-(4-sulfamoylphenyl)-2-thioxo-3,4-dihydroquinazolin-1(2H)-yl) me­thyl)-1,4-dihydropyridine-3,5 dicarboxylate 3a-h have been prepared by reaction of 4-(4-oxo-2-thioxo-1,2-dihydroquinazolin-3(4H)-yl) benzene sulfonamide with para-formaldehyde and 1,4-dihydro­pyridine derivatives. The compounds are characterized and screened for their antiulcer activities.





B B Subudhi*, S K Panda, G Ghosh & P K Panda


School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneshwar 751 030, India






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