Indian Journal of Chemistry

 

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 51B

NUMBER 9

September 2012

 

CONTENTS

 

Papers

 

 

 

 

1
SCCB 1706

Synthesis of novel 5-substituted isoxazole-3-carboxamide derivatives and cytotoxicity studies on lung cancer cell line

 

A series of novel 5-substituted isoxazole-3-carboxamide derivatives 6a-l have been prepared and screened against A549 lung cancer cell line.

 

 

 

 

 

B Veeraswamy, C Kurumurthy, G Santhosh Kumar, P Sambasiva Rao,

Kavya Thelakkat, Srigiridhar Kotamraju & B Narsaiah*

 

Fluoroorganics Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India

 

 

 

 

 

 

 

2
OC 1448

A simple and convenient chemoenzymatic approach for the synthesis of valuable triacylglycerol-based dendritic building blocks

 

An approach towards synthesis of triacylglycerol-based dendritic building blocks via a highly efficient chemoenzymatic route has been reported.

 

 

 

 

 

Shilpi Gupta, Sarah Jalal, Sumit Kumar, Rainer Haag & Sunil K Sharma*

 

Department of Chemistry, University of Delhi, Delhi 110 007, India

 

 

 

 

 

 

 

 

 

 

 

 

 

3
OC 1336

A three component one-pot synthesis and biological studies of some new octahydroacridine-1,8-dione deri­vatives containing tetrazolo[1,5-a]quinoline moiety

A series of octahydroacridine-1,8-diones have been synthesized in good yield via one-pot synthesis of corresponding tetrazolo[1,5-a]quinoline-4-carbaldehyde, 3-(4-fluorophenylamino)-5,5-dimethylcyclohex-2-enones and dimedone or cyclohexane-1,3-dione in acetic acid. All the synthesized compounds have been screened for antimicrobial and anti-tubercular activities.

 

 

 

 

Sandip V Bhuva & Manish P Patel*

 

Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, India

 

 

 

 

 

 

 

4
OC 1401

PEG-600 mediated one-pot synthesis of quino­linylidinethiazolidine-2,4-diones as potential anti-hyperglycemic agents

 

 

 

 

 

 

 

Sd Riyaz*, A Naidu & P K Dubey

 

Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad College of Engineering,
Kukatpally, Hyderabad 500 085, India

 

 

 

 

 

 

 

5
OC 1384

Synthesis, characterization, antimicrobial, insecticidal and anthelmintic screening of some new s-triazine derivatives of pyrazoline, pyrimidine, isoxazoline and isothiazoline moiety

 

1-(4-(4,6-Bis(4'-chlorophenylamino)-1,3,5-triazin-2-ylamino)-phen­yl)-3-(aryl substituted) prop-2-en-1-one 3 has been used as precursor to synthesize some new pyrimidine, pyrazoline, isoxazoline and isothiazoline derivatives. They have been evaluated for their anti­microbial, antifungal, insecticidal and anthelmintic efficacy.

 

 

 

Nidhi Gautam* & O P Chourasia

 

Department of Chemistry, Dr. H. S. Gour Central University, Sagar 470 003, India

 

 

 

 

 

 

 

 

 

 

 

 

 

Notes

 

 

 

6
SCCB 1614

Synthesis and cytotoxicity of new quinoline deri­vatives

 

New 2,8-bis(trifluoromethyl)-4-substituted quinolines have been synthesized from 4-haloquinoline following the Suzuki protocol and N-arylation.

 

 

 

 

 

 

 

 

 

H M Meshram*, B Chennakesava Reddy, D Aravind Kumar, M Kalyan, P Ramesh,

P Kavitha & J Venkateswara Rao

 

Organic Division-I, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India

 

 

 

 

 

 

 

7
SCCB 1732

One-pot synthesis of coumarin substituted dihydrofurans

 

A sequential one-pot two-step tandem reaction for an efficient synthesis of 2,3-dihydrofurans substituted with 2H-benzopyrans has been developed. One-pot reaction of in situ formed benzopyran substituted pyridinium ylides with aromatic aldehydes and dimedone gives corresponding 2,3-dihydro furans in good yields.

 

 

 

 

 

 

 

 

 

Venkata Sreenivasa Rao Chunduru & Rajeswar Rao Vedula*

 

Department of Chemistry, National Institute of Technology, Warangal 506 004, India

 

 

 

 

 

 

 

 

 

 

 

 

 

8
SCCB 1597

Synthesis and evaluation of some novel 2,4-thia­zoli­dinedione derivatives for antibacterial, anti­tubercular and antidiabetic activities

 

 

 

 

1a-c

2a-c

 

Shashikant Pattan*, Manisha Kedar, Jayashri Pattan, Santosh Dengale, Manjusha Sanap,

Utkarsha Gharate, Punam Shinde & Sushma Kadam

 

Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar 413 736, India

 

 

 

 

 

 

 

9
SCCB 1712

Facile synthesis of spiro-fused heterocyles by multi­component reactions under solvent-free conditions

 

A facile synthesis of spiro-fused heterocycles by using three component cyclocondensations of aromatic aldehydes, Meldrum’s acid and urea/thiourea in the presence of catalytic amount of stannous chloride dihydrate under solvent-free conditions is reported.

 

 

 

Laishram Ronibala Devi & Okram Mukherjee Singh*

 

Department of Chemistry, Manipur University, Canchipur 795 003, India

 

 

 

 

 

 

10
SCCB 1584

Synthesis of racemic and chiral Carvedilol starting from corresponding 5-(chloromethyl)oxazolidin-2-one

 

The synthesis of racemic Carvedilol has been achieved starting from 2-(chloromethyl) oxirane in a four-step sequence with 17.3% overall yield. This approach is useful for the preparation of pharmaceutically important moieties containing β-amino alcohols without formation of bis impurity.

 

 

 

 

B Anand Kumar, K Veera Babu, Rama Koteshwar Rao, Kumbam Srinivas, G Madhusudhan* & K Mukkanti

 

Inogent Laboratories Private Limited, A GVK BIO Company, 28A, IDA, Nacharam, Hyderabad 500 076, India

 

 

 

 

Authors for correspondence are indicated by (*)