Indian Journal of Chemistry

 

Sect. B: Organic Chemistry including Medicinal Chemistry

http://www.niscair.res.in; http://nopr.niscair.res.in

Total visitors: 4895 since 13-04-2013

 

VOL. 52B

NUMBER 4

April 2013

 

CONTENTS

 

Papers

 

 

 

 

511

An expedient and green protocol for the Michael addition of malonates, diketones and β-keto esters to the nitrostyrenes

 

A simple and efficient method for the Michael addition of carbon nucleophiles like malonate esters, acetylacetone and ethyl acetoacetate to electron-deficient trans-β-nitrostyrenes in presence of triethylamine under solvent free conditions is described. The current protocol provides access for the synthesis of various Michael adducts in high to near quantitative yields in very short time.

 

 

 

 

Jyoti Agarwal, Ram Tilak Naganaboina & Rama Krishna Peddinti*

 

Department of Chemistry, Indian Institute of Technology, Roorkee 247 667, India

 

 

 

 

 

 

 

519

An elegant synthesis of isoxazolyl 1-oxa-6-thia-4,9-diazaspiro[4.4]non-2-en-8-ones and 1,6-dithia-4,9-diazaspiro[4.4]non-7-en-3-ones

 

 

 

 

 

 

E Rajanarendar*, K Thirupathaiah & S Ramakrishna

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

 

 

 

 

 

 

 

526

Synthesis of glycosyl cyanamides from azides: Application for the synthesis of N-hydroxy­guanidine­glycosides

 

A novel class of cyanamides and N-hydroxyguanidines in carbohydrate scaffolds starting from the corresponding azides is described. The protocol has been evaluated for primary and secondary azides of a range of monosaccharides and disaccharides in satisfactory yields under mild conditions.

 

 

 

 

 

 

Girish Prabhu & Vommina V Sureshbabu*

 

Peptide Research Laboratory, Department of Studies in Chemistry

Central College Campus, Bangalore University, Bangalore 560 001, India

 

 

 

 

 

 

 

535

Synthesis of some novel thiosemicarbazone deri­vatives having anti-cancer, anti-HIV as well as anti-bacterial activity

 

Some new thiosemicarbazones containing benzimidazole moiety have been synthesized and their various biological activities have been evaluated.

 

 

 

 

 

 

Hitesh Dahyabhai Patel*, Saavani Malove Divatia & Erik de Clercq

 

Department of Chemistry, Gujarat University, Ahmedabad 380 009, India

 

 

 

 

 

 

 

 

 

 

 

 

 

546

Synthetic studies on compounds related to aminoimidazolecarboxamide: Synthesis of angularly fused purine derivatives and a solid phase ring transformation (ANRORC) to imidazo [1,5-a] pyrazine

 

1-Benzyl-5-aminoimidazole-4-carboxamide 1a has been used as convenient precursor for the synthesis of new triazolo [3,4-i] purines 6 and the corresponding tetrazolo analogue 7. A mesoionic isomer 8 seems to exits along with 7. Interesting heteroaryl-purine motifs have also been prepared via suitably substituted 9-benzylpurines. Imidazo [1,5-a] pyrazine derivative 13 has been prepared in a solid phase exploitation of imidazolium salt of 1 via ANRORC.

 

 

 

 

Gautam Chattopadhyay* & Partha Sinha Ray

 

Department of Chemistry and Biochemistry, Presidency University, Kolkata 700 073, India

 

 

 

 

 

 

 

553

Diethylaminosulfurtrifluoride-catalyzed efficient one-pot three-component aza-Diels-Alder reactions: A facile synthesis of substituted hexahydrofurano[3,2-c]quinolines

 

The aza-Diels-Alder reactions of anilines in combination with substituted benzaldehydes and electron-rich cyclic alkenes in the presence of catalytic amount of diethylaminosulfurtrifluoride are reported.

 

 

 

Ramu Dhanapal, Paramasivan T Perumal* & Damodiran Munusamy

 

CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, India

 

 

 

 

 

 

 

 

 

 

 

 

 

560

Synthesis of anticancer compounds 2-(4-amino-2-arylaminothiazol-5-oyl)-N-methylbenzimidazoles

 

2-(2,4-Diaminothiazol-5-oyl)-N-methylbenzimidazoles have been synthesized and characterized by elemental analysis, IR, NMR and mass spectral data. The novel compounds show very good anticancer activity and moderate antibacterial activity.

 

 

 

 

 

S Selvin Pragalath Paul, A Yardily, K N Rajasekharan & T F Abbs Fen Reji*

 

Department of Chemistry & Research Centre, Nesamony Memorial Christian College, Marthandam 629 165, India

 

 

 

 

 

 

 

Notes

 

 

 

 

 

 

565

Anti-inflammatory and anti-diabetic naphtha­quinones from an endophytic fungus Dendryphion nanum (Nees) S. Hughes

 

Two naphthoquinones namely herbarin and herbaridine A, have been isolated based on bioactivity guided fractionation from an endophytic fungus Dendryphion nanum, isolated from the leaves of Ficus religiosa (Peepal) collected from Goregaon Mumbai. Herbarin shows very good anti-inflammatory and anti-diabetic activities, but herbaridine A is found to be inactive.

 

 

 

 

 

P D Mishra, S A Verekar, A Kulkarni-Almeida, S K Roy, S Jain,

A Balakrishnan, R Vishwakarma & S K Deshmukh*

 

Piramal Enterprises Limited, 1-Nirlon Complex, Goregaon (E), Mumbai 400 063, India

 

 

 

 

 

 

 

 

 

 

 

 

 

568

Design, synthesis and neuropharmacological activity of dihydro imidazole derivatives

 

A new series of dihydro imidazole derivatives have been synthesized and characterized. All the compounds have shown prominent anticonvulsant and CNS depressant activity.

 

 

 

 

G Mariappan*, Sadrul Alam, L Sutharson, P K Haldar & Shyamalendu Nath

 

Department of Pharmaceutical Chemistry, Himalayan Pharmacy Institute, Majhitar 737 136, India

 

 

 

 

 

 

 

573

Method development and validation of testosterone in muscle by using LC-MS/MS in positive ESI mode

 

A simple, accurate and precise LC-MS/MS method has been developed and validated for determination of testosterone in muscle. The method is useful for the estimation of testosterone in muscle sample and other food products of animal origin with accuracy and reproducibility.

 

 

 

 

Meenakshi Dahiya*, Nidhi Dubey, Prabha Singh & G N Singh

 

D. A. V. College, Muzaffarnagar 251 001, India

 

 

 

 

 

Authors for correspondence are indicated by (*)