Indian Journal of Chemistry

 

Sect. B: Organic Chemistry including Medicinal Chemistry

http://www.niscair.res.in; http://nopr.niscair.res.in

Total visitors: 8246 since 06-02-2013

 

VOL. 52B

NUMBER 2

February 2013

 

CONTENTS

 

Papers

 

 

 

 

245

d-Camphor-10-sulfonic acid: A water compatible organocatalyst for Friedel-Crafts reaction of indoles with electron deficient olefins

 

A recyclable natural product derived Brønsted acid (d-CSA) catalyzes the Friedel-Crafts addition of indole derivatives to nitroalkenes and enones in water at room temperature in good to excellent yield (71-98%).

 

 

 

 

 

 

 

 

Pankaj Chauhan, Sarbjit Singh & Swapandeep Singh Chimni*

 

Department of Chemistry, Guru Nanak Dev University, Amritsar 143 005, India

 

 

 

 

 

 

252

Electrochemical synthesis of 2-amino-5-substituted-1,3,4-oxadiazole derivatives and evaluation of anti­bacterial activity

 

2-Amino-5-substituted-1,3,4-oxadiazoles have been synthesized at platinum electrode through the electrochemical oxidation of semicarbazone at room temperature and studied for their anti­bacterial activity.

 

 

 

 

 

 

 

 

Sanjeev Kumar* & H N Pandey

 

Department of Chemistry, Faculty of Science, Iswar Saran Degree College

(University of Allahabad), Allahabad 211 004, India

 

 

 

 

 

 

 

 

 

 

 

 

 

259

Synthesis and antimicrobial evaluation of novel lipophilic derivatives of pyrazolylisoxazolines

 

A series of novel 3′-(3-phenyl-3,4-dihydro-2H-pyrazol-5-yl)-2,2-dimethylspiro{bicyclo[2.2.1]heptan-3,5′-isoxazoline-2′}, 3′-(2,3-di­phenyl-3,4-dihydropyrazol-5-yl)-2,2-dimethylspiro{bi­cyclo[2.2.1]­heptan-3,5′-isoxazoline-2′} and 5-Octyl-3-(3-phenyl-3,4-dihydro-2H-pyrazol-5-yl)isoxazoline-2,5-decyl-3-(2,3-diphenyl--3,4-dihy­dro­pyrazol-5-yl)isoxazoline-2 have been  prepared  and screened for their antibacterial and antifungal activity.

 

 

 

 

 

Shally Chadha, Rajni Khajuria, Satya Paul & Kamal K Kapoor*

 

Department of Chemistry, University of Jammu, Jammu 180 006, India

 

 

 

 

 

 

 

266

Microwave irradiated synthesis of some substituted imidazole derivatives as potential antibacterial and anticancer agents

 

A comparative study between the developed microwave methods and conventional methods is described. The synthesized compounds have been evaluated for their antibacterial and short term anticancer activity.

 

 

 

 

 

  1b-10b

 

 

Gyanendra Kumar Sharma*, Naveen Kumar Sharma & Devender Pathak

 

Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura 281 001, India

 

 

 

 

 

 

 

 

 

 

273

A reinvestigation of reaction of 2-hydrazino-3-phenylquinoxaline with 1,3-diketones: Synthesis and characterization of regioisomeric 1-(3'-phenyl­quino­xalin-2'-yl)-3,5-disubstitutedpyrazoles and 1,2,4-tria­zolo[4,3-a]quinoxalines

 

The present study reports some interesting findings of a reinvestigation into the reaction of 2-hydrazino-3-phenyl­quino­xa­line, 1 with several 1,3-diketones 2a-g.

 

 

 

 

 

Eakta, Ranjana Aggarwal* & Garima Sumran

 

Department of Chemistry, Kurukshetra University, Kurukshetra 136 119, India

 

 

 

 

 

 

 

282

Synthesis, characterisation, docking analysis and biological evaluation of a,a′-bis(p-dimethylamino­benzylidene)-g-methylcyclohexanone

 

α,α′-bis(p-Dimethylamino­benzylidene)-g-methylcyclohexanone (BMABMC) C25H30ON2, has been synthesised and characterised by elemental analysis, spectral data and XRD studies. The compound has also been screened for antibacterial and antifungal activity. Molecular docking analysis has been performed to evaluate the antiviral activity against HIV-1 integrase.

 

 

 

 

S Shalini, C R Girija*, Prashantha Karunakar, M M Jotani, K N Venugopala & T V Venkatesha

 

Chemistry Research Centre, SSMRV College, 4th ‘T’ Block, Jayanagar, Bangalore 560 041, India

 

 

 

 

 

 

 

 

 

Notes

 

 

 

 

 

289

Mukaiyama aldol reaction of trimethylsilyl enolate with aldehyde catalyzed by CuI

 

 

 

 

 

 

Hima Rani Kalita, Arun Jyoti Borah & Prodeep Phukan*

 

Department of Chemistry, Gauhati University, Guwahati 781 014, India

 

 

 

 

 

 

 

293

Synthesis, antimicrobial and antitubercular activity of some novel [3-isonicotinoyl-5-(4-substituted)-2,3-dihydro-1,3,4-oxadiazol-2-yl] and substituted 5-(pyridin-4-yl)-1,3,4-oxadiazole-2-thiol derivatives

 

 

 

 

   

 

4a-f

 

 

Shashikant Pattan*, Deepak Musmade,  Rekha Muluk, Sonali Pawar, Aarati Daithankar,
Nikita Wabale, Sanjay Bhawar & Jayashri Pattan

 

 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni 413 736, India

 

 

 

 

 

 

300

Oxidation of aryl and heteroaryl methyl ketone to aryl and heteroarylglyoxals by using CuCl2-DMSO

 

The oxidation of aryl methyl ketone and heteroaryl methyl ketone to arylglyoxals and heteroaryl glyoxal respectively has been carried out by using the cheap and easily available, non toxic, Lewis acid CuCl2 in DMSO solvent at 70-80°C within 1-2 hr. The reaction can be performed in air without loss of variety of oxidisable fuctional group like phenolic OH, hetroaryl ring, aryl substituted methyl, halo, nitro group, etc.

 

 

 

 

 

Pradeep D Lokhande*, Smita R Waghmare, Harsh Gaikwad & P P Hankare

 

Department of Chemistry, University of Pune, Pune 411 007, India

 

 

 

 

 

 

 

 

 

 

 

 

306

Convenient synthesis of 5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyrans using LiCl /Al2O3 under microwave irradiation

 

2-Amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-1-benzo­pyran-3-carbonitriles 3 have been synthesized conveniently by treating dimedone (5,5-dimethyl-1,3-cyclohexanedione) 1 with arylidenemalononitriles 2 in the presence of lithium chloride in dry media using basic alumina as solid support under microwave irradiation with very good yields.

 

 

 

 

 1 2 3

 

 

K Mogilaiah*, A Vinay Chandra, N Srivani & K Shiva Kumar

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

Authors for correspondence are indicated by (*)