Indian Journal of Chemistry

Sect. B : Organic Chemistry including Medicinal Chemistry

VOL. 42B

NUMBER 2

FEBRUARY 2003

 

CONTENTS

 

Rapid Communications

 

343

A facile synthesis of 5-arylpyrazolo[4,3-d]-pyrimidin-7-ones

A series of 1-methyl-3-propylpyrazolo[4,3-d]-pyrimidin-7-ones substituted in the 5-position with various aryl substituents has been synthesized by the reaction of corresponding Schiff bases with 4-amino-1-methyl-3-propylpyrazole-5-carboxamide in the presence of acetic acid.

 

 

 

 

T V Maruthikumar & P Hanumantha Rao*

 

 

 

 

 

 

Papers

 

 

 

 

 

346

Polymer supported palladium (II) complexes as hydrogenation catalysts

An approach towards immobilization of soluble palladium(II) complexes in polymer matrices  and their behaviour as hydrogenation catalysts are reported.

 

 

 

 

Debkumar Mukherjee

 

 

 

 

 

 

 

353

Synthesis of isoxazolyl pyrimidine diones and isoxazolyl thiazolidinones

 

A series of 3-phenyl/methyl-1-(3-methyl-5-styryl/ substituted styryl-4-isoxazolyl)-2,3-dihydro-2-thioxo-4,6 (1H, 5H) pyrimidinediones 3 and 3-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl)-2-phenyl/methyl-imino-4-thiazolidinones 4 have been prepared from isoxazolyl thioureas 2 on treatment with malonic acid and chloroacetic acid respectively.

 

 

 

 

E Rajanarendar*, Md Afzal & D Karunakar

 

 

 

358

Synthesis and reactions of pyranoquino­lines

Novel hetrocyclic compounds 6a-c, 7a-c, 8a-c and 9a-c have been prepared starting from 6-amino­cou­marins.and ethyl benzoylacetate.

 

 

V V Mulwad* & M B Dalvi

 

 

 

 

 

 

363

Synthesis, characterization and electrochemical behaviour of some substituted 3-arylazo-8-aldehydo-4-methylcoumarins at dropping mercury and glassy carbon electrode

 

Synthesis, characterization and comprehensive electrochemical studies on 3-arylazo-8-aldehydo-4-methyl cou­marins have been reported.

 

 

Ashok Kumar*, Partibha Sharma & Ravi Sharma

 

 

 

 

 

 

369

Copper (II)-b-cyclodextrin aided oxidation of eugenol

The reaction with eugenol [3-(4-hydroxy-3-methoxy­phenyl)-prop-1-ene] in presence of Cu(II)-b-CD or b-CD or HPb-CD or CuSO4 is carried out in acetic acid solvent to which H2SO2 is added at room temperature. Cu(II)-b-CD gives the highest yield of an oxidized product.

 

H H Pattekhan & S Divakar*

 

 

 

 

 

372

Azole compounds designed by molecular modell­ing show antifungal activity as pre­dicted

Several azole compouns have been designed .by molecular modeling techniques and synthesized and tested for antifungal activity. Some compounds show excellent activity in vitro. The results are consistent with the computational findings.

 

Rajeshri G Karki, Vijay M Gokhale,
Prashant S Kharkar & Vithal M Kulkarni*

 

 

 

 

 

 

 

382

Synthesis and biological activity of cyanopyridine, isoxazole and pyrazoline derivatives having thymol

Several new 4-acetoacetamido thymol 1, 4-(substi­­tuted benzal aceto acetamido) thymols 2a-j, 4-(2˘-amino-3˘-cyano-4˘-aryl-pyridin-6˘-yl- acetamido)­thy­mols 3a-j, 4-(5˘-aryl-isoxazol-3˘-yl-acetamido)­thy­mols 4a-j, and 4-(1˘-N(H)/N-acetyl-5˘-aryl-pyra­zolin-2˘-yl-acetamido) thymols 5a-t have been synthesized.

 

J M Desai & V H Shah*

 

 

 

 

 

 

 

386

Triterpenoid saponin from Abrus precatorius (Fabaceae)

New triterpenoid saponins isolated from the aerial parts of Abrus precatorius and identified as olean-12-ene-3b, 23, 28-trihydroxy-3-O-{[b-d-glu­­co­pyr­a­­no­syl-(1®4)-b-d-gluco­pyranosyl-(1®3)]-b-d-glu­­­­­co­­pyranosyl-(1®2)]-b-d-fucopyranoside 1 and olean-12-ene-3b, 16b, 23, 28-tetrahydroxy-3-O-{[b-d-glucopyranosyl-(1®4)-b-d-gluco­pyranosyl-(1®3)]-[b-d-glucopyranosyl-(1®2)]-b- d-fuco­pyranoside} 2.

 

Edet M Anam

 

 

Notes

 

 

 

390

One-pot synthesis of dimethyl 2-[acyl(1-naph­thyl)­amino]-3-(1,1,1-triphenyl-λ5-phos­pha­nyli­dene)succinates

A  single-step synthesis of highly stabilized ylides 7 is described.

 

Ali Ramazani*, Leila Karimi-Avargani & Farideh Gouranlou

 

 

 

 

 

 

 

393

Synthesis of 2-quinazolinonylimidazoli­dinones

A linear synthesis of 2-quinazolinonylimida­zolidi­no­nes 5 from 2-chloromethyl-3-methyl­quinazolin-4(3H)-ones 1 is reported.

 

P S N Reddy*, P Pratap Reddy & T Vasantha

 

 

 

 

 

 

 

397

Synthesis and structural studies of novel 1,3,4-oxadiazolophanes

The title compounds have been prepared in moderate yields from 2,5-bis-(2-hydroxyphenyl)-1,3,4-oxadia-zole 2. The title compounds have also been studied for their use as PTC agents.

 

Madhukar S Chande*, Ajit A Godbole,
Evans Coutinho & Prashant Desai

 

 

 

 

 

 

 

401

Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and bioactivity of 3-(2-thienyl)-s-triazolo[3,4-b][1, 3, 4]thia­dia­zole, 2-(2-thienyl)thiazolo[3,2-b]-s-­triazole and isomeric 3-(2-thienyl)thiazolo[2,3-c]-s-triazole

The synthesis of 2-(2-thienyl)-5-p-bromophenyl­thiazolo[3,2-b-]-s-triazole 5,5-(p-bromophenyl)-3-(2-thienyl)thiazolo[2,3-c]-s-triazole 7 and 3-(2-thienyl)-s-triazolo[3,4-b][1,3,4]thiadiazole-6(5H)-thione 9 has been achieved.

 

Jag Mohan

 

 

 

 

 

 

 

 

405

Quinolinium chlorochromate as an efficient reagent for oxidative cleavage of oximes via the use of microwave irradiation and pestle/mortar

Microwave radiation and pestle/mortar techniques have been employed successfully in the presence of quinolinium chlorochromate for the regeneration of carbonyl compounds from the corresponding oximes.

 

 

 

Jasvinder Singh*, Monica Bhandari,
Jasamrit Kaur & Goverdhan L Kad

 

 

 

 

 

408

Montmorillonite K10 – AlCl3 catalyzed enolization: A bifunctional system for selective bromination of hydroxy­aceto­phenones

 

 

 

Vinod Rama Uchil & Vidya Joshi*

 

 

 

 

 

 

 

412

Stereoisomeric synthesis of oxazolidinone and fused pyrrolidine derivatives via azomethine ylides and their antimicrobial activity

The reaction of isatin with 1,2,3,4-isoquinoline-3-carboxylic acid gives rise to azomethine ylide which undergoes [3+2] cycloaddition with various dipolarophiles to afford spiro oxazolidinone and pyrrolidine derivatives.

 

 

P Pardasani*, R T Pardasani,
V Chaturvedi & A Saxena

 

 

 

 

 

 

 

 

416

Synthesis and antimicrobial screening of N-substituted –3-chloro-4-dithiocarbamato azetidin-2-ones

Synthesis and antibacterial screening studies of  substituted 3-chloro-4-dithiocarbomatoazetidin-2-ones.

 

Ashok Kumar*, Pratibha Sharma,
Ravi Sharma & Pankaj Mohan

 

 

 

 

 

 

 

421

Synthesis of isoxazoles and quinoxalines as potential anticancer agents

Preparation of isoxazoles 2a-l and quinoxalines 3a-l from different chalcones 1a-l , has been reported. The compounds have been evaluated for their anticancer and antimicrobial activity.

 

N A Vekariya, M  D Khunt & A R Parikh*

 

 

 

 

 

 

 

425

Synthesis of biologically active angularly fused bisaroylbenzodifurans by PTC and solvent free microwave irradiation

 

 

 

K S Krishna Murthy, B Rajitha &
M Kanakalingeswara Rao*

 

 

 

 

 

429

Microwave assisted acetylation and deacetyla­tion studies on the triterpenes isolated from Dysoxylum malabaricum and Dysoxylum beddomei

Conventional acetylation and  deacetylation in triterpenes are found to give good yields within a mater of seconds when conducted in the presence of microwave radiation. Lupane,cycloartane and tirucallane triterpenes are examined.

 

G Jayakumar*, M D Ajithabai, B Santhosh,
C S Veena & Mangalam S Nair

 

 

 

 

 

 

 

432

1-(2˘,6˘-Dihydroxyphenyl) -b-d-glucopyrano­side, a  novel C-glycoside from  Pterocarpus marsupium

Isolation and  characterisation of a novel  C-glycoside, 1-(2˘,6˘-dihydroxyphenyl) -b-d-glucopyranoside 1 from Pterocarpus  marsupium  Roxb. is reported.

 

K A Suri* , N K Satti, B D Gupta & O P Suri

 

 

 

 

 

 

 

434

New flavonoid glycosides from Cassia occidentalis

From ethanolic extract of whole plant of Cassia accidentalis, 3,2˘-dihydroxy-7,8,4˘-trimethoxy­flavvone-5 O-{-b-d-glucopyranosyl(1→2)}-b-d-galacto­pyrano­side 1 and apigenin-7-O-b-d-allopy-ranoside 2 have been isolated. The structures have been established on the basis of chemical evidences and spectroscopic
methods.

1   R1 = R5 = OH,   R3 = R6 = CH3,   R4 = OCH3

   R2 = d-glucose-d-galactose sugar

2   R1 = R2 = R4 = R5 = R6 = H,   R3 = d-allose sugar

 

Chhavi Purwar*, Renu Rai,
Nidhi Srivastava & J Singh

 

 

 

 

 

 

 

 

 

 

 

437

Isolation and characterization of pectic polysaccharides from the fruits of Naringi crenulata

From the fruits of Naringi crenulata, the title polysaccharides have been isolated and their structures determined by various chemical and physical methods of analysis.

 

 

→4)GalAp(1→4)GalAp(1→4)GalAp(1→2)Rhap(1→4)

                                                                                                                                                                                             

                                                                                                                                                                                              R

R=Galactan and/or arabinan or arabinogalactan side-chains

 

 

 

Saro Mondal, Bimalendu Ray*,
Swapnadip Thakur & Pradyot K Ghosal

 

 

 

 

 

 

 

Authors for correspondence are indicated by (*)