Indian Journal of Chemistry

Sect. B. Organic Chemistry including Medicinal Chemistry

 

VOL. 42B

NUMBER 1

JANUARY 2003

 

CONTENTS

 

Papers

1

Stereochemistry of the marine sesquiterpene 2‑thiocyanatoneopupukeanane: Crystal struc­ture of neopupukean-2-yl 4‑nitrobenzoate

Single crystal X-ray diffraction analysis of neopupukean-2-yl 4‑nitrobenzoate unambiguously confirm the structure of the marine sesquiterpene 2-thiocyanatoneopupukeanane.

 

 

 

 

A Srikrishna*, Santosh J Gharpure &
P Venugopalan

 

 

 

 

 

 

 

 

 

 

2

A rapid one-pot synthesis of 2,4,6-triaryl-3-aroyl-4-hydroxy-1,1-cyclohexanedicarbonitriles and 2-aminoisophthalonitriles under microwave activation

 

 

 

 

Dhrubojyoti D Laskar, Dipak Prajapati* &
Jagir S Sandhu

 

 

 

 

 

 

 

3

Microwave assisted one pot synthesis of novel 11-amino-3-phenyl-2-thioxo-10-oxo-imidazolo­[5˛,4˛:5˘,6˘] pyrano[4˘, 3˘: 3,4]furo[2,3-b]indoles

A facile one pot synthesis of 6 is reported under microwave irradiation

 

 

 

 

 

Anshu Dandia*, Harshita Sachdeva, Ruby Singh & CS Sharma

 

 

 

 

 

 

 

 

 

 

4

Synthesis of some 3-(4-styryl-6-aryl-pyridin-2-yl)- and 3-(6-styryl-4-aryl-pyridin-2-yl) cou­ma­rins

The reaction of 3-coumarinoyl methyl pyridinium salt 1 with pentadienones 2a-f and 3a-f in the presence of NH4OAc in refluxing acetic acid affords the title compounds 4a-f and 5a-f respectively..

 

 

 

D I Brahmbhatt* & Urvish R Pandya

 

 

 

 

 

 

 

 

 

5

Chiral 1,3-oxazolidines as the ligands for the enantioselective addition of diethylzinc to aryl aldehydes

 

 

 

 

K R K Prasad & N N Joshi*

 

 

 

 

 

 

 

 

 

6

Imminium ion chemistry at C-2 of pyro­gluta­mates: Unexpected formation of 1,4-Methano-3-oxa-6-t-butyl-7-azabicyclo[7.3.0]decan-2,8-dione

a- Bromination of the cyclically protected S-pyroglutamic acid and its subsequent reactions with nucleophillic reagents via corresponding N-acylimminium intermediate is described.

 

 

 

Anjana Maheshwari, Lalit N. Goswami Dinesh, Dikshit* B. S. Joshi & Raja Roy

 

 

 

 

 

 

 

 

7

Spectral and electrochemical investigations of ketorolac tromethamine

Spectral and electrochemical studies of ketorolac tromethamine, 1 along with its interaction with Cu(II) ion to form 3 are reported

 

 

 

G S Moses, M Sunil Kumar,
A Ramachandraiah* & K M Rao

 

 

 

 

 

 

 

 

 

 

8

Azole compounds designed by molecular model­ling show antifungal activity as pre­dicted

Several azole compouns have been designed .by molecular modeling techniques and synthesized and tested for antifungal activity. Some compounds show excellent activity in vitro. The results are consistent with thecomputational findings

 

 

 

R G Karki, V M Gokhale, P S Kharkar & V M Kulkarni*

 

 

 

 

 

 

 

 

 

 

9

Synthesis and biological activity of 16-arylidene derivatives of estrone and estrone methyl ether

The synthesis of 16-arylidene derivatives is described

 

 

 

 

 

 

 

Maninder Minu Dharam Paul Jindal G Leclercq &M Borras

 

 

 

 

 

 

10

Synthesis and reactions of some new 2,3-dihydro-5H-5,6-diaryl-thiazolo[3,2-a]pyrimidin-3-one derivatives and their antibacterial and fungicidal activity

 

 

 

 

M A Salama* & S A El-Essa

 

 

 

 

 

 

 

 

 

Notes

 

 

 

 

 

11

Zinc/hydrazine: A low cost-facile system for the reduction of nitro compounds.

Nitro compounds are selectively and rapidly reduced to their corresponding amines in the presence of other functional groups, by employing commercial zinc dust and 99-100% hydrazine hydrate.

 

Zn/H2N-NH2

R-NO2                                                       R-NH2

MeOH, r.t

 

R= alkyl or aryl

 

 

 

Shankare Gowda* & D. Channe Gowda

 

 

 

 

 

 

 

 

 

 

12

Synthesis of novel benzopyrano pyrano pyri­midines and benzopyrano pyrano thiopyri­midines

Treatment of 1,3-diphenylbarbituric acid/1,3-diphenyl-2-thiobarbituric acid and 4-hydroxy thiopyrimidines coumarin with vinyl acetate in alkaline media affords benzopyrano pyrano pyrimidines and thiopyrimidines 3a-e

 

 

 

 

 

R Nandha kumar, T Suresh, S Magesh
& P S Mohan*

 

 

 

 

 

 

 

 

 

 

13

Reactions of heterocyclic quinone methides: A facile entry to synthesize the alkaloid, flindersine and its analogues

 

 

 

 

R Nandha kumar, S Thamarai selvi, T Suresh & P S Mohan*

 

 

 

 

 

 

 

 

 

 

14

Synthesis of newer selenadiazoles and thia­dia­zoles from their chroman-4-one precursors

Newer, a separate series of 13 compounds each of 2-aryl-3,4-dihydrobenzopyrano [3, 4-d]-1, 2, 3-selenadia­zoles 3 and 2-aryl-3,4-dihydrobenzopyrano [3,4-d]-1, 2, 3-thiadiazoles 4 have been synthesized from their chroman-4-one precursors.

 

 

3 ; X = Se

4 ; X = S

 

 

M S Gaikwad, A S Mane, R V Hangarge,
V P Chavan & M S Shingare*

 

 

 

 

 

 

 

 

15

Synthesis of some novel bridgehead nitrogen heterocyclic systems containing 1,8-naphthyri­dine moiety

Synthesis of quinazolino[3,2-a][1,8]naphthyridin-13-ones 4, benzimidazo[1,2-a][1,8]naphthyridines 5 and tetrazolo[1,5-a][1,8]naphthyridines 6 is reported.

 

 

 

 

K Mogilaiah* & G Kankaiah

 

 

 

 

 

 

 

 

 

 

16

Efficient and highly selective oxidation of primary and secondary alcohols by butyltri­phenyl­phosphonium chlorochromate under non-aqueous conditions

Butyltriphenylphosphonium chlorochromate is used as a new and selective reagent for the oxidation of benzylic and allylic alcohols to the corresponding carbonyl compounds in refluxing acetonitrile.

 

 

 

Abdol R Hajipour*, Shadpour E Mallakpour,
& Morteza Malakoutikhah

 

 

 

 

 

 

 

 

 

 

17

Studies on the cyclisation of two Key allyl phenol intermediates of bromo tyrosine based natural products.

Cyclisation of two key allyl phenol intermediates has been studied under a variety of acidcatalysts and found cationic montmorillonite clays very effective for quantitative and regioselctive conversion to five membered coumarans.

 

 

 

Uppuluri V Mallavadhani* & K Narasimhan

 

 

 

 

 

 

 

 

 

 

18

Synthesis and activity of a new series of Chalc­ones as antibacterial agents

A new series of 2’-hydroxychalcones has been synthesised. They have been characterised by physical and spectral data (IR, 1H NMR and MS). All these chalcones have been tested for antibacterial activity. Their ability to inhibit different plant pathogens and animal pathogens is assessed. Except few, all the chalcones display antibacterial activity to a remarkable extent.

 

 

 

Y B Vibhute* & M A Baseer

 

 

 

 

 

 

 

 

 

 

19

Synthesis and biological activity of some new benzophenothiazines

Thiadiazolyl benzophenothiazines 6 have been prepared synthetically from appropriate b-(p-anisi­dino)­naphthalenes 5 and sulphur in the presence of iodine. 5 have been synthesized by the diazotisation of thiadiazoles followed by coupling with b-naphthol and finally treatment with p-anisidine. The antiviral and antifungal activities of 6 have also been reported.

 

 

 

V K Pandey*, H S Negi, M N Joshi, &
Ms S K Bajpai

 

 

 

 

 

 

 

 

 

 

20

One Pot Reaction; Synthesis, Characterization and biological activity of 3-alkyl/aryl-9-substi­tuted-1,2,4-triazolo [3,4-b][1,3,4] quinolino thiadiazepines

The formation of an unexpected novel 3- alkyl/aryl-9-substituted-1,2,4-triazolo[3,4-b] [1,3,4]quinolino thia­dia­zepine is described.The new compounds have also showed significant biological activity

 

 

 

Balakrishna Kalluraya*, R Gururaja & Ganesha Rai.

 

 

 

 

 

 

 

 

 

 

21

Synthesis and bioevaluation of some novel nucleosides as antiherptic agents

N1 -(5-Aryl-1,3,4-oxadiazolo-2-yl)-ureas on cyclo­condensa­tion with CS2/KOH afford 2-aryl-1,3,4-oxadiazole[3,2-a]-s-tria­zine-5,7-(6H) dithione nucleo­base which on glycosylation with different sugars gives nucleoside analogues.

 

 

 

deepa Chauhan*, J S Chauhan & J Singh S K Bajpai & M N Joshi

 

 

 

 

 

 

 

 

 

 

22

New flavonoid glycosides from Cassia occidentalis

From ethanolic extract of whole plant of Cassia accidentalis, 3,2˘-dihydroxy-7,8,4˘-trimethoxyflavvon-5 O-{-b-D-allopyranoside 2 have been isolated. The structures have been established on the basis of chemical evidences and spectroscopic methods

 

 1R1 = R5 = OH, R3 = R6 = CH3, R4 = OCH3

R  2 = D-glucose-D-galactose sugar

 2R1 = R2 = R4 = R5 = R6 = H, R3 = D-allose sugar

 

 

Chhavi Purwar*, Renu Rai, Nidhi Srivastava & J Singh

 

 

 

Authors for correspondence are indicated by (*)