Total visitors:3,925 since 17-9-03

Indian Journal of Chemistry

Sect. B : Organic Chemistry including Medicinal Chemistry

 

VOLUME 42B

NUMBER 9

SEPTEMBER 2003

 

CONTENTS

Rapid Communications

 

 

 

2045

Lanthanum chloride medicated-regeneration of carbonyl compounds from oximes in water

 

 

 

 

 

 

 

A Venkat Narsaiah & K Nagaiah*

 

 

 

 

 

 

 

 

2048

Photoreactivity of donor – acceptor ethenes

 

 

         

 

 

 

 

 

 

Anil K Singh* & Prasanta K Hota

 

 

Papers

 

 

 

2054

Synthesis and reactions of new N-bridged heterocycles derived from 3-substituted- 4,5-diamino-1,2,4-triazoles

The synthesis of 3-aryloxymethyl-4,5-diamino-1,2,4-triazoles 1 and their condensations with benzil, phenyl pyruvic acid, ethyl acetoacetate and carbon  disulphide to yield various triazolotriazines 3, triazolo-triazinones 4, triazolotriazepinones 5 and triazolotriazoles 8 are reported. Also the rearrangement of triazolotriazapinones 5 to pyrazolotriazoles 6,7 has been carried out.

 

 

 

 

 

 

B Shivarama Holla*, B K Sarojini,
B Sooryanarayana Rao & Boja Poojary

 

 

 

 

 

 

 

 

 

2059

Synthesis of (±)trans-2-[3-methoxy-4-(4-chlo­ro­­phenylthioethoxy)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl) tetrahydrofuran

 

 

B Balram, B Ram* & S Raghu Ram

 

 

 

 

 

 

 

2063

Synthesis of (±)-trans-2-[3-methoxy-4-(4-chlo­ro­phenylthioethoxy)-5-(N-methyl-N-hyd­ro­xy­ureidyl)methyl­phenyl]-5-(3,4,5-trime­tho­xy­phe­­nyl)­tetra­­hydrofuran

The synthesis of (±)-trans-2-[3-methoxy-4-(4-chloro­phenylthioethoxy)-5-(N-methyl-N-hydroxy­ureidyl)methyl­phenyl]-5-(3,4,5-trimethoxyphenyl) tetrahydrofuran from commercially available vanillin acetate and 3,4,5-trimethoxybenzaldehyde is described.

 

 

B Ram, B Balram* & S Raghu Ram

 

 

 

 

 

 

 

2069

Vilsmeier-Haack reaction on quinaldines

The study of the Vilsmeier-Haack reaction on 4-hydroxy- quinaldines results with the preparation of rarely existing 4-chloro-3-formyl-2-(vinyl-1-ol)quinolines.

 

 

R Nandha Kumar, T Suresh & P S Mohan*

 

 

 

 

 

 

 

2074

Stereochemical studies of some t-3-methyl-r-2,c-6-diphenylpiperidin-4-one azine derivatives

Six heterocyclic azines derived from t-3-methyl-r-2,c-6-di­phenyl­piperidin-4-one are prepared and characterised through NMR techniques.

 

 

 

A Manimekalai*, J Jayabharathi,
Lancy Rufina & R Mahendhiran

 

 

 

 

 

 

 

 

2080

Synthesis of biologically active 3,8-dioxo-10-hydroxypyrano[2,3-f]quinoline and its reactions

Facile synthesis of 3H-7,8-dihydro-3,8-dioxo-10-hy­droxy­pyrano[2,3-]quinoline 2 and its Pechmann condensation with various acyclic, cyclic, aromatic, heterocyclic b-keto esters is described.

 

 

B P Choudhari  & V V Mulwad*

 

 

 

 

 

 

 

2086

Synthesis and evaluation of antiinflammatory and analgesic activity of some new 1,3-diphenyl-2-aryltetrahydroimidazoles

 

Several new 1,3-diphenyl-2-aryltetrahydroimidazoles have been synthesized from various aryl aldehydes and 1,2-dianilinoethane. The two monochloro derivatives show antiinflammatory and analgesic activity comparable to indomethacin and aspirin respectively.

 

 

 

M S Y Khan* & Monica Gupta

 

 

 

 

 

 

 

2091

Synthesis of some antibacterial compounds from 4-hydroxycoumarin

A facile synthesis of some antibacterial isoxazole, pyrimidine and benzothiazepine derivatives is described.

 

 

V V Mulwad* & Rupesh B Pawar

 

 

 

 

Notes

 

 

 

2097

Synthesis of coumarin by Yb(OTf)3 catalyzed Pechmann reaction under the solvent-free conditions

A simple and high yielding environmentally friendly method has been developed for the synthesis of coumarin derivatives via Pechmann condensation reaction using Yb(OTf)3 as a catalyst under solvent-free conditions.

 

 

 

 

Limin Wang*, Jianjun Xia,
He Tian, Changtao Qian & Yun Ma

 

 

 

 

 

 

 

 

2100

Synthesis of some 3-aryloxymethyl-3,4-di­hydro­­isocoumarins

The lithiation of N-methyl benzamides 1a-c with n-BuLi followed by alkylation with oxiranes 3a-d afford the title compounds 5a-l.

 

 

 

 

 

 

D I Brahmbhatt* & Urvish R Pandya

 

 

 

 

 

 

 

2104

Synthesis of b-casomorphin employing Fmoc-amino acid chlorides and t-butyl­dimethyl­silyl­oxy benzotriazole (TBDMS-OBt)

 

 

 

 

 

 

Subramanyam J Tantry,
Raveendra I Mathad &
Vommina V Suresh Babu*

 

 

 

 

 

 

 

2109

Synthesis of novel pyrazolino[3˘,4˘:5,4]cyclo­pent[b]indoles

 

 

 

 

 

V Sangeetha & K J Rajendra Prasad*

 

 

 

 

 

 

 

 

2112

Reaction of amines with ortho halo carbonyl compounds and its derivatives : A novel one pot syntheses of pyrazolo, benzodiazepino, cyclodecano and cyclotridecano  derivatives of naphthalene at room temperature

Reaction of 1-chloro-6-methoxy-3, 4- dihydronaph­thlene 1 and its derivatives with different poly amines is described.

 

 

 

 

Monalisa Boruah , Dilip Konwar* &
Dipak Kr Dutta

 

 

 

 

 

 

 

2115

Syntheses of 1-alkyl-2-(substituted-2-pyri­d­yl)­­­­­benzi­midazoles

1-a-Pyridiniumacetophenone chloride 2 on reaction with 1-alkyl-2-cinnamoylbenzimidazoles 6 in the presence of ammonium acetate in refluxing acetic acid gives 2-(substituted-2-pyridyl)benzimidazoles 5 in accordance with the Kröhnke’s pyridine synthesis.

 

 

 

 

P K Dubey*, C Ravi Kumar &
P V V Prasada Reddy

 

 

 

 

 

 

 

2119

Synthesis of a new heterocycle, 1H-4-aryl­[1,2,4]-oxadiazino[5,4-b]quinazolinone

The synthesis of a new heterocycle, 1H-4-aryl[1,2,4] oxadiazino[5,4-b]quinazolin-5-one, is reported.

 

 

 

 

L Manmohan Reddy, P Pratap Reddy &
P S N Reddy*

 

 

 

 

 

 

 

 

2121

A novel synthesis of diallyloxymethanes

Allylic alcohols on heating with sodium hydride and dihalomethanes furnish corresponding diallyloxy­methanes  in good yields.

 

 

Mukund G Kulkarni*, Saryu I Davawala, Aniruddha K Doke & Ajit V Doke

 

 

 

 

 

 

 

2124

Microwave assisted heterocyclization: A rapid and efficient synthesis of 1,8-naphthy­ridinyl-1,3,4-oxadiazoles

A rapid and efficient method for the synthesis of 1,8-naphthyridinyl-1,3,4-oxadiazoles 4 under microwave irradiation is reported.

 

 

K Mogilaiah* & N Vasudeva Reddy

 

 

 

 

 

 

 

2126

Solid support Erlenmeyer synthesis of azlactones using microwaves

An efficient synthesis of azlactones 2 under microwave irradiation in dry media in open borosil vessels using unmodified domestic microwave oven is described.

 

 

K Mogilaiah*, M Prashanthi &
Ch Srinivas Reddy

 

 

 

 

 

 

 

2129

Kinetics and mechanism of the oxidation of methionine by benzyltrimethylammonium tribromide

Kinetics and mechanism of the oxidation of methionine by benzyltrimethylammonium tribromide is described.

 

 

 

 

Archana Goyal & Seema Kothari*

 

 

 

 

 

 

 

2133

Synthesis, characterization and antimicrobial activities of 4-phenyl-3-thiopyrimido[4,5-b] quinolines

A facile one-step synthesis of substituted pyrimido [4,5-b]quinolines 3a-e has been achieved from 2 – chloro– 3-formylquinolines 1 and N-phenyl thiourea 2 in glacial acetic acid. All the synthesized compounds have been screened for their antibacterial and antifungal activities.

 

 

 

 

T Suresh, R Nandha Kumar, S Magesh &
P S Mohan*

 

 

 

 

 

 

 

 

2136

Synthetic approaches towards 3-pyridine­carbonitrile derivatives and their anti­microbial properties

 

 

 

 

Mona M Kamel* & Manal M M Hussein

 

 

 

 

 

 

 

2142

Newer potential quinazolinones as hypo­ten­sive agents

A series of 3-(substitutedarylidene)hydrazinoacetylamino-2-methyl-6-bromo-quinazolin-4(3H)-ones 4a-e has been synthesized from 3-amino-2-methyl-6-bromoquinazolin-4(3H)-one 1. These on condensation with ClCOCH2Cl give azetidinones 5a-e, which undergo mannich reaction to yield mannich bases 6a-e. Some of the compounds show potential hypotensive activity.

 

 

Ashok Kumar*, Mirdula Tyagi &

V K Srivastava

 

 

 

 

 

Announcement

 

 

 

2146

IUPAC International Conference on Biodiversity and Natural Products: Chemistry and Medical Applications

 

 

 

 

Authors for correspondence are indicated by (*)