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Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

 

 VOLUME. 43B NUMBER 3

MARCH 2004

 

CONTENTS

 

 

Rapid Communication
 

590

 

Preparation of a-iodoacetates from alkenes by Co(OAc)2 catalysed Woodward-Prevost reaction

IPC: Int.Cl.7 C 07 C 11/02

Woodward-Prevost reaction of alkenes with iodine and cobalt(II) acetate in acetic acid is reported. The reaction is facile and a-iodoacetates are obtained from both acyclic and cyclic alkenes in high yields within 15-55 min.
 

Yi Yi Myint & M A Pasha*

593

Reduction of nitrosoarenes into anilines by Al/NH4Cl in refluxing methanol

IPC: Int.Cl.7 C 07  C 211/46

A simple, cost-effective method for the reduction of nitrosoarenes by Al/NH4Cl in refluxing methanol to give anilines is reported.
 
D Nagaraja & M A Pasha*
 
Papers
 
595

A convenient synthesis of 4-diarylmethyl-, 4-(a-hydroxy- a-aryl/naphthyl)methyl- and 4-(benzoyl/naphthanoyl)-1-(2H)-phthalazinones from ninhydrin

IPC: Int.Cl.7 C 07  D 237/30

 
 

Sandip kumar kundu & Animesh Pramanik*

604

Facile acid-catalyzed condensation of ninhydrin with enols and aromatic compounds and microwave enhanced condensa­tion of ninhydrin with hydroxy aromatic systems in solid state

IPC: Int.Cl.7 C 07 C 15/20

 

 

 

 

 

Sandip Kumar Kundu, Amarendra Patra* & Animesh Pramanik*

 

 

612

Synthesis, characterization and structure of drum hexameric benzyloxotin hetero­aro­matic carboxylates

IPC: Int.Cl.7 C 07 D 209/04, C 07 D 207/00,
C 07 D 211/00, C 07 D 307/00, C07 D 275/00

The ten drum hexameric benzyloxotin heteroaromatic carboxylates have been synthesized by the reaction of [(PhCH2)3Sn]2O with heteroaromatic carboxylic acids in 1:2 molar ratio. The crystal structures of hexameric benzyloxotin 2-pyridinylcarboxylate and hexameric benzyloxotin 2-oxazolylcarboxylate are determined by X-ray single crystal diffraction.

 

Handong Yin*, Chuanhua Wang &

Yong Wang

 

618

Synthesis of new 2-(2¢-pyridylidene)-1-oxo-1,2,3,4-tetrahydrocarbazoles and 4,5-dihy­dro-2-(2¢-pyridyl)isoxazolo[3,4-a]carbazoles

IPC: Int.Cl.7 C 07 D 209/00

 

 

 

 

 

 

I Antony Danish & K J Rajendra Prasad*

 

 

 

624

Synthesis of benzofuro-4-anilino-2H-1-benzo­pyran-2-one and benzofuro-pyrano–2H-1-benzopyran-2-one

IPC: Int.Cl.7 C 07 D 311 / 00

 

 

 

 

 

Shubhangi S Soman*

 

 

 

629

g-Oxo carboxylic acids in heterocyclic synthesis: Part IV–Synthesis of some pyridazines containing phthalyl and tosyl amino acids using DCC as the condensing agent

IPC: Int.Cl.7 C 07 D 237 / 00

3 (2H)-Oxo-, 3-mercapto- or 3-amino-pyridazine deri­vatives 3, 5 and 6 have been coupled with N-phthalyl- or N-tosyl-amino acids in one-step at room temperature by using N,N¢-dicyclo-hexylcarbodiimide as the condensing agent to furnish the corresponding 3-N-(phthalyl- or tosyl-amino acids)pyridazine derivatives (7-9)a-h, respectively. Hydrazinolysis of the N-phthalyl derivatives (7-9)a-d in methanol yield the corresponding unprotected derivatives (7-9)i-l. The antibacterial activity of the prepared compounds has been tested.

 

 

 

 

A A Aly & A A F Wasfy*

 

 

 

 

 

 

 

636

Glycolamide esters of 4–biphenylacetic acid as potential prodrugs–synthetic and spectral studies

IPC: Int.Cl.7 C 07 C 63/00

Prodrug approach for the development of safer NSAIDs.

 

 

 

 

Pritam Dev Sharma,* Kamal Jit Singh, Shivali Gupta & Senthilkumar Chandiran

 

 

 

 

 

 

643

Synthesis and bioactivity of isoxazolyl thiazoles, isoxazolyl thiazolyl chromen-2-ones, isoxazolyl thiazinanes and isoxazolyl thiazolidinones

IPC: Int.Cl.7 C 07 D 261/00 // A 61 P 31/10, 31/04

A series of substituted methyl/phenyl-[4-methyl/carbo­thoxy/3 - 3-methyl-5-styryl-isoxazol-4-yl) -3H-thiazol-2-yl­dene]amines 3, substituted 3-[2-methyl/phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl)-2,3-dihydrothiazol-4-yl)-chro­­men-2-ones 4, substituted 5-methyl-2-methyl/phenyl-imino-3-(3-methyl-5-styryl-isoxazol-4-yl)thiazolidin-4-ones
5 and substituted methyl / phenyl [3-(3-methyl-5-styryl-isoxazol-4-yl)[1,3]thiazinan-2-ylidene]amines 6 have been synthesized by the reaction of substituted 1-methyl/phenyl-3-(3-methyl-5-styryl-isoxazol-4-yl)thioureas 2 with chloro-acetone or ethyl bromopyruvate, 3-(
w-bromo­acetyl)­coumarin, ethyl 2-bromopropionate and 1,3-dibromo­propane, respectively.

 

 

 

E Rajanarendar*, D Karunakar &

M Srinivas

 

   

 

 

 

 

649

Selective antifungal activity of shorter active analogues of Bactenecin 7 against Fusarium moniliforme

IPC: Int.Cl.7 C 12 P 21/00 // A 61 P 31/10

Several active tetrapeptide fragments of Bactenecin 7, a proline/arginine rich antimicrobial peptide, have been synthesized by classical solution phase method. All the synthetic analogues exhibit potent antifungal activity selectively against Fusarium moniliforme.

 

 

 

 

 

K Abiraj, M K Sachidananda,

A S Prakasha Gowda & D Channe Gowda*

 

 

 

 

 

 

 

655

phytoconstituents from saussurea lappa roots

IPC: Int.Cl.7 A 61 K 31/00

Phytochemical investigation on the roots of Saussurea lappa results in two new phytosterols (24S)-stigmasta-5,9(11)-dien-20,28-endo-3 b-ol(lappasterol) 1, (24S)-stig­masta-5, 9(11)-dien-20, 28-endo-3a-ol (3-epi-lap­pasterol) 2 and one ureported lanostane type triterpene, lanostan-20 (22), 24-dien-2-one- 3b, 9a, 12a-triol-21-al (lappalan­asterol) 3 along with b-sitosterol-d-glucopyranoside.

 

 

        

1 3b –OH                                                                                        3

2 3a -OH

 

Vijender Singh & Mohd Ali*

 

 

Notes

 

 

 

660

Synthesis of new 1-hydroxyindole derivatives

IPC: Int.Cl.7 C 07  D 209/04

Syntheses of new 1-hydroxyindole derivatives are reported.

 

 

 

 

 

Hadiétou Diadié Camara, Khalid Attar, Mohamed Benchidmi, El Mokhtar Essassi & Bernard Garriques*

 

 

 

 

 

 

 

 

 

 

 

667

Synthesis of triazolo-pyrimidine, tetrazolo-pyrimidine and pyrimido-triazepine

IPC: Int.Cl.7 C 07 D 253/00

Some 4-substituted aryl-6-(2,4-dialkoxypheyl)-1,2,4-tria­zolo[4, 3-a]pyrimidine, 4-substitutedaryl-6-(2,4-dialkoxy­phenyl)tet­razolo[1,5-a]pyrimidine and 4-substitutedaryl-6-(2,4-dialkoxy­phenyl)pyrimido[2,1-c][1,2,4]triazepine have been synthesized from 4-substitutedaryl-6-(2,4-dialkoxyphenyl)-2-hydrozino­pyri­midine.

 

 

C S Andotra* & Sukhbinder Kaur

 

670

Regioselective synthesis of novel heterophanes from 4-amino-triazoles

IPC: Int.Cl.7 C 07 D 251/00

The title compounds have been prepared in moderate yields from 4-amino-1, 2, 4-triazole and structures of the compounds have been studied for their stereochemistry. Some of the title compounds have also been studied for their use as PTC agents.

 

 

Madhukar S Chande*, Shailesh S Athalye & Ajit A Godbole

 

674

Chemoselective reduction of a,b-unsaturated carbonyl compounds by sodium hydrogen telluride: Part I

IPC: Int.Cl.7 C 07 C 57/00

Sodium hydrogen telluride is used for the selective reduction of C=C bonds in various chalcones. The reduction proceeds smoothly in good yields.

 

R = aryl / heteroaryl

R' = alkyl / aryl

 

G Geethamalika*, A Suguna Sundari, P Shanmugam & S P Rajendran

 

677

 

A simple and efficient method for the dehydrogenation of symmetric hydrazo compounds with NaNO2-Ac2O

IPC: Int.Cl.7 C 07 C 251/72

Rapid oxidation of eighteen symmetric hydrazo compounds to corresponding azo compounds using NaNO2-acetic anhydride as a novel oxidizing agent under mild condition is reported for the first time.

 

 

Xiaochuan Li, Yulu Wang* & Jinye Wang

679

Microwave irradiation in solvent-free conditions: Preparation of 2-substituted- 4(3H)-quinazolinones by heterocyclisation of 2-aminobenzamide with carboxylic acids

IPC: Int.Cl.7 C 07 D 215/00

A simple and fast preparation of 2-substituted -4(3H)-quinazolinones in high yields has been developed by microwave induced heterocyclisation of 2-aminob­enza­mide with carboxylic acids in solvent-free conditions.

 

2a-f                                                       3a-f

 

M Rahimizadeh, Z Tavallai & M Bakavoli*

682

Synthesis of 4,10-dihydro-5/7-substituted-9-oxo-quinolino[2,3-e]-2-amino-1,3,4-thiadiazine and schiff base by microwave irradiation

IPC: Int.Cl.7 C 07 D 285/16

4,10-Dihydro-5/7-substituted-9-oxo-quinolino[2,3-e]-2-amino-1,3,4-thiadiazine and its Schiff base synthesized by using MWI technique in excellent yield than conventional method.

Vijay V Dabholkar* & Govind D More

 

Authors for correspondence are indicated by (*)

IPC: International Patent Classification

Int. Cl.7: International Classification 7th edition, 1999