CONTENTS

Rapid Communications

2523

A new protocol for synthesis of a,b-unsaturated ketones using zirconium tetrachloride under microwave irradiation

IPC: Int.Cl.⁷ C 07 C

Utpal Bora, Anil Saikia & Romesh C Boruah*

Papers

2527

A study on the reactivity of 1,3-dimethyl-2,6-diphenyl-4-piperidone : Synthesis of some novel heterocycles

IPC: Int.Cl.⁷ C 07 D

Some interesting heterocycles, viz.: tetrahydro­pyridine, diazepanone, oxazepanone, pyridoindole, thiazolopyridine, furanylmethylenepiperidone, pyrido­pyrimidone and pyridopyrimidinethione are prepared from piperidin-4-one by exploiting ketomethylene functionality using microwave, ultrasound and conventional methods.

V Padmavathi*, T V Ramana Reddy,

K Audisesha Reddy, A Padmaja &

D Bhaskar Reddy

2532

Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of 3,5-dimethyl pyrazoles, 3-methyl pyrazol-5-ones and 3,5-disubstituted pyrazolines

IPC: Int.Cl.⁷ C 07 D

Pyrazole derivatives of diclofenac, ibuprofen, flurbiprofen and 2,4-dichlorophenoxy acetic acid have been synthesized with the aim of reducing their ulcerogenic activity. Moreover, pyrazoline derivatives of ibuprofen have also been synthesized.

Mohd Amir* & Shikha Kumar

2538

Beibersteneolide-a and -b: Two new sesquiterpene lactones from Achillea beiberstenii

IPC: Int.Cl.⁷ C 07 D

Two new sesquiterpene lactones obtained from Achillea beiberstenii have been characterized as 3a, 9b- diacetoxy- 1b, 10-epoxy 5(4)-en-germacran -6b, 12-olide, named as beibersteneolide-a 1, and 4, 9b-dihydroxy-2(1), 6(5), 11(13) triene-guaian–7a, 12-olide, designated as beibersteneolide-b 2.

Tawfeq A Al-Howiriny , Jaber S Mossa &

Bahar Ahmed*

2545

Condensation of reactive phenols with aromatic 1,2-diketones: A single step protocol for synthesis of benzo-fused g-lactones

IPC: Int.Cl.⁷ C 07 C

Condensation of certain reactive phenols with 1,2-diketones under acid/Lewis acid catalysis affords benzofused g-lactones in reasonable yields.

Sabir H Mashraqui^*, Mamta B Patil, Hitesh D Mistry, Mohamed Ashraf & Subramanian Sundaram

2550

Synthesis and characterization of di(p-fluoro­benzyl)tin bis(heteroaromatic carboxylate) and crystal structure of di(p-fluorobenzyl)tin bis(3-pyridinecarboxylate)

IPC: Int.Cl.⁷ C 07 D

Reaction of di(p-fluorobenzyl)tin oxide with heteroaromatic carboxylic acid in 1:2 stoichiometry yields compounds of the type (4-F-Bz)₃Sn(OOCR)₂ [R=3-pyridinyl 1, 4-pyridinyl 2, 2-pyridinyl 3, 2-indolyl 4, 2-furanyl 5, 2-thiophenyl 6, 3-indolyl 7, 3-indolmethyl 8]. These compounds have been characterized by elemental analysis, IR, ¹H and ¹¹⁹Sn NMR spectra. The crystal and molecular structure of compound 1 has been determined by X-ray single crystal diffraction.

Han DongYin*, Qi Bao Wang & Sheng Cai Xue

2555

Polymer-bound cationic Rh(I) phosphine catalyst for homogeneous asymmetric hydrogenation

IPC: Int.Cl.⁷ C 07 D

Facile synthesis of polymer bound Rh(I) phosphine catalyst for homogeneous asymmetric hydrogenation is described.  Polymer bound Pyrphos Rh(I) complex catalyses hydrogenation of prochiral Z-a-acetamido cinnamic acid to S-N-acetyl phenyl alanine with 76% ee.  The polymer bound catalyst is cleanly separated from the product by membrane osmodialysis. 

Nirmal Koshti*, Shubhangi Naik & Bharat Parab

2560

Improved synthesis of an energetic material, 1,3,3-trinitroazetidine (TNAZ) exploiting 2-iodoxy benzoic acid (IBX) as an oxidising agent

IPC: Int.Cl.⁷ C 07 D

The synthesis and characterisation of a powerful strained ring energetic compound which is of considerable interest to military agency, has been discussed. Most of the effort for producing the next generation of energetic materials is currently centered around the production of TNAZ. The advent of this new high energy explosive presents the possibility of increased performance with reduced sensitivity.

Alok Singh, Nirmala Sikder & Arun K Sikder*

2564

Single crystal XRD structural elucidation of
1-oxopyridinium-2-thioacetic acid

IPC: Int.Cl.⁷ C 07 D

Sudalaiandi Kumaresan*, Palani Ramadevi, Balasingh Ravindran Durainayagam & Rosa Walsh

2569

Michael addition of active methylene compounds to a,b–unsaturated sulfones

IPC: Int.Cl.⁷ C 07 D

The Michael addition of dimethyl malonate and ethyl cyanoacetate to a,b-unsaturated sulfones in the presence of Triton-B and K₂CO₃ is studied.

V Padmavathi*, D R C Venkata Subbaiah,

A Balaiah, B Chandra Obula Reddy & A Padmaja

2575

Synthesis of isoflavones containing naturally occurring substitution pattern by oxidative rearrangement of respective flavanones using thallium(III) p-tosylate

IPC: Int.Cl.⁷ C 07 D

Om V Singh*, M Muthukrishnan &

M Sunderavadivelu

2582

Design, synthesis and characterisation of a novel anticancer prodrug having antiproliferative activity against prostrate tumour

IPC: Int.Cl.⁷ C 07 C

5'-O-Curcuminyl-diglycinoyl-DNA had antipro­li­fera­tive activity against prostrate tumor derived DU145 cells. It acts by hybridisation with target telomerase sequence.

Satyendra Mishra, Snehlata Tripathi, Roli Mishra & Krishna Misra*

2589

Rapid and convenient synthetic strategy for
2-amino-4-aryl-5-aryl-sulfonyl thiazoles

IPC: Int.Cl.⁷ C 07 D

A convenient one pot synthetic strategy for 2-amino-4-aryl-5-aryl sulfonyl thiazoles has been first time introduced.

V E Bhingolikar, S R Mahalle, S P Bondge &

R A Mane*

Notes

2594

Synthesis and biological screening of some new novel indole derivatives

IPC: Int.Cl.⁷ C 07 D

Synthesis of some novel indole derivatives has been undertaken by the reaction of 1,4-benzoquinone with ethyl-b-(arylamino)-crotonates in the presence of nitrogen atmosphere or in the absence of nitrogen atmosphere.

D S Mehta, K H Sikotra & V H Shah*

2598

Base induced carbon-nitrogen (C=N) double bond migration in Schiff bases

IPC: Int.Cl.⁷ C 07 C

Various Schiff bases are prepared to study base induced carbon-nitrogen double bond migrations. Schiff bases derived from aliphatic aldehydes display highest selectivity. Hydrolysis of the resulting rearranged Schiff base provides an entry to make amines from aldehydes.

B Gangadasu, P Narender, B China Raju* &

V Jayathirtha Rao

2601

Reaction of 2'-hydroxy-5'-acetamido chalcones with dimethyl sulfoxide-iodine, pyridine-mercuric (II) acetate and triethanolamine

IPC: Int.Cl.⁷ C 07 D

Reaction of 2'-hydroxy-5'-acetamido chalcones with catalytic amount of iodine in DMSO affords flavone, molar amount of mercuric acetate in pyridine gives aurones while with phenylhydrazine and hydrazine hydrate gives pyrazoline in triethanolamine medium.

Nitin N Agrawal* & P A Soni

2604

Two dimeric flavonoids from Bauhinia purpurea

IPC: Int.Cl.⁷ C 07 D

Bauhinia purpurea leaves yield two new dimeric flavonoids namely, bis [3¢,4¢-dihydroxy-6-methoxy-7,8-furano-5¢,6¢-monomethylallyloxy]-5-C-5-biflavonyl 1 and (4¢-hydroxy-7-methyl-3-C-a-l-rhamnopyrano­syl)-5-C-5-(4¢-hydroxy-7-methyl-3-C-a-glucopyrano­syl) biflavonoid 2 with protein precipitating capacity 214.4 and 199.24 mgBSA/g, respectively.

SurabhiYadav & Brijesh K Bhadoria*

2608

A facile synthesis of 1-hydroxy-5-chloro-benzo­[f]­[2,7]naphthyridines

IPC: Int.Cl.⁷ C 07 D

Synthesis of the titled compounds from 2-chloro-3-formyl quinolines is reported.

N Sampathkumar, S Thiruvaranga Ramalingam & S P Rajendran*

2611

Wolff rearrangement of N^α- Boc-/Z-protected aminodiazoketones to the corresponding β-amino acids under microwave irradiation

IPC: Int.Cl.⁷ C 07 C

The  Wolff  rearrangement  of  N^a-Boc-/Z-protected    aminodiazoketones assisted by microwave irradiation is described. All the resulting b-amino acids have been isolated in good yield and purity.

X= Boc-/Z- group

Kantharaju, Basanagoud S Patil & Vommina V Suresh Babu*

2614

Synthesis and antimicrobial activity of some 3-alkyl-
4-(arylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones

IPC: Int.Cl.⁷ C 07 D

Eight new ethyl N^ı-(3-methyl-4-arylmethyleneamino-4,5-dihydro-1H-1,2,4-triazolyl-5-one)acetates 2 and N^ı - (3-methyl-4-arylmethyleneamino-4, 5-dihydro-1H-1,2,4-tria­zolyl-5-one)acetylhydrazines 3 have been synthesized. The compounds show some antimicrobial activities.

Bahittin Kahveci*, Olcay Bekircan &

Şengül Alpay Karaoğlu

Announcements

2618

Second International Symposium On Green/ Sustainable Chemistry

2619

Annual Index

Authors for correspondence are indicated by (*)

IPC: International Patent Classification

Int. Cl⁷.: International Classification, 7th Edition, 1999