Indian Journal of Chemistry

 

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 1,369  since 23-08-06

 

VOL. 45B

NUMBER 8

August 2006

CONTENTS

Papers

 

 

 

1871

Synthesis of heterocyclic and non-heterocyclic entities as antibacterial and anti-HIV agents

IPC Code: Int.Cl.8 C07D

 

3,4-Dimethoxy-1-[{(2-aryl/alkyl amino)-2-oxoethyl} amino]-ethyl benzene and 2-[{2-(3,4-dimethoxy phenyl ethyl amino)-2-oxoethyl}amino]-4,6-diaryl pyrimidines have been synthesized and tested for their antibacterial and anti-HIV activities.

 

 

R B Patel & K H Chikhalia*

 

 

 

 

 

 

 

1880

Synthesis of Fmoc-protected β-amino alcohols and peptidyl alcohols from Fmoc-amino acid / peptide acid azides

 

IPC Code: Int.Cl.8 C07D

An efficient method for the synthesis of Nα-9H-fluoren-9-ylmethoxycarbonyl (Fmoc)-β-amino alcohols by the reduction of Fmoc-α-amino acid azides employing aqueous NaBH4 as a reducing agent has been described. All the   Fmoc-β-amino alcohols prepared are characterized by using 1H and 13C NMR and mass spectrometry.

 

 

 

 

 

Vommina V Suresh Babu*, Kantharaju &
Naremaddepalli S Sudarshan

 

 

 

 

 

 

 

 

 

 

1887

Synthesis of N-hydroxy-r-2,c-6-diphenylpiperidines using DMD and their stereochemical studies by NMR spectra and semiempirical MO calculations

 

IPC Code: Int.Cl.8 C07D

Oxidation of N-hydroxy-r-2,c-6-diphenylpiperidines using DMD yields the corresponding N-hydroxy derivatives 8-13 which are found to prefer distorted chair conformations.

 

 

 

J C Thenmozhiyal, M Venkatraj, R Jeyaraman & S Ponnuswamy*

 

 

 

 

 

 

 

 

 

1894

Synthesis of model compounds for the investigation of biomarker’s thermal behaviour

 

IPC Code: Int.Cl.8 C07C

The model compounds 6a, which are used to investigate the organic structure and thermal behaviour of fossil fuels, have been synthesized starting from 4-hydroxybenzyl cholesteryl ether 5a and 4-hydroxybenzyl thiocholesterol 7a.

 

 

 

 

Okan Sirkecioğlu*, Bekir Karlığa, Naciye Talınlı  & Colin Snape

 

 

 

 

 

 

1900

Vilsmeier Haack reaction of substituted 2-acetamido-thiazole derivatives and their antimicrobial activity

 

IPC Code: Int.Cl.8 C07D

Vilsmeier Haack reaction of 2-acetamido thiazole having carbethoxy group at C-4 affords the unexpected N-formylated product, which is followed by deacetylation. The same reaction with substituents other than carbethoxy group at C-4 position (viz CH3, CH2COOC2H5, coumarinyl, phenyl, etc.) gives the expected C-5 formylated products which are tested for their antimicrobial activity.

 

 

 

 

R S Koti, G D Kolavi, V S Hegde & I M Khazi*

 

 

 

 

 

 

 

1905

Synthesis and antibacterial activity of 1,3,4-oxadiazolyl-1,8-naphthyridines

 

IPC Code: Int.Cl.8 C07D

 

 

 

A series of 1-(4-acetyl-5-aryl-5-methyl-[1,3,4]-oxadiazol-2-ylmethyl)-3-phenyl-1H-[1,8]-naphthyridin-2-ones 4 have been prepared and tested for their antibacterial activity.

 

 

 

 

 

 

 

K Mogilaiah* & K Vidya

 

 

 

 

 

 

 

1909

An enantiospecific synthesis of 2-pupukeanone

 

IPC Code: Int.Cl.8 C07C

 

 

 

Utilising intramolecular rhodium carbenoid CH insertion as key reaction, racemic as well as enantiospecific synthesis of 2-pupukeanone has been described.

 

 

 

 

 

 

 

 

 

 

 

A Srikrishna*, P Ravi Kumar & S J Gharpure

 

 

 

 

 

 

 

1920

Synthesis of 2-(5-azido-5-deoxy-b-d-ribofuranosyl)-4-methyl-5-nitro-1,2,3-triazole

 

IPC Code: Int.Cl.8 C07D

The synthesis of 2-(5-azido-5-deoxy-b-d-ribofuranosyl)-4-methyl-5-nitro-1,2,3-triazole  has been accomplished in 5 steps starting from d-ribose.

 

 

 

 

 

 

Geetha Banda, D Srinivasulu, V Ugandhar & I E Chakravarthy*

 

 

 

 

 

 

 

1924

A new route to the synthesis of long-chain

methyl a-chlorooxoalkanoates

 

IPC Code: Int.Cl.8 C07C

Long-chain methyl a-chlorooxoalkanoates are prepared from long-chain epoxyalkanoates using CTMS and Jones reagent.

 

 

 

 

 

 

Abdul Rauf* & Shabana Ahmad

 

 

 

 

 

Notes

 

 

 

 

1929

Synthesis and microbiological evaluation of 2-acetanilido-
4-arylthiazole derivatives

IPC Code: Int.Cl.8 C07D

Ten different substituted compounds synthesized from 2- acetanilido 4-arylthiazole derivatives and 2-pyrazine 4-arylthiazole have been evaluated for their antifungal and antibacterial activities.

 

 

 

S R Pattan *, M Shamrez Ali, J S Pattan, S S Purohit,
V V K Reddy & B R Nataraj

 

 

 

 

 

 

 

1933

A new biflavonoid from Cycas beddomei

 

IPC Code: Int.Cl.8 A61K

 

 

 

 

Biswanath Das*, Gurram Mahender, Yerra Koteswara Rao & Ponnaboina Thirupathi

 

 

 

 

 

 

 

1936

Stereoselective crossed-aldol condensation of 3-acetyl-2,5-dimethylthiophene / furan with aromatic aldehydes in water: Synthesis of (2E)-3-aryl-1-(thien-3-yl/fur-3-yl)prop-2-en-1-ones

 

IPC Code: Int.Cl.8 C07D

 Synthesis of new peptide fragment analog (Val-Tyr(P)-Val-Ala-Ala-OH) incorporating Tyr into the phosphorylation site of the cAMP protein kinase regulatory sub unit type II in place of Ser (Val-Ser(P)-Val-Ala-Ala-OH) has been described.

 

 

 

 

 

 

Mohamed A Hassan*, Suzan Batterjee & Layla A Taib

 

 

 

 

 

 

 

1942

Ultrasound accelerated synthesis of proteinogenic and α,α-dialkylamino acid ester salts

 

IPC Code: Int.Cl.8C07C

 

A simple and efficient sonochemical esterification of proteinogenic as well as cyclic α,α-dialkyl amino acid methyl and ethyl ester hydrochloride salts employing  thionyl chloride and alcohol has been reported.

 

 

 

 

 

 

Kantharaju & Vommina V Suresh Babu*

 

 

 

 

 

 

 

1945

New anthraquinones from Rubia cordifolia roots

 

IPC Code: Int.Cl.8 A61K

 

 

 

 

Three new anthraquinones namely 1-hydroxy-2,7-dimethylanthraquinone, 2-hydroxy-6-methylanthraquinone and   2,6-dihydroxyanthraquinone along with n-nonadecane, n-heptadecane, 8˘-hydroxy-n-pentadecanyl decan-4-en-1-oate, n-octacosanyl octa-1-oate and 3,5-di-(p-hydroxybenzyl) phenol have been isolated from Rubia cordifolia roots and characterized on the basis of spectral data.

 

                                                               R1            R2            R6            R7

                                  4                           OH           CH3               H             CH3

                                  5                           H             OH           CH3          H

                                                     6                         H             OH           OH           H

 

 

Md. Sohail Akhtar, Mohd Ali*, Madhurima,

Showkat R Mir & Onkar Singh

 

 

 

 

 

 

 

1951

Syntheses of novel derivatives of  2-acetylfuro[2,3-a]-carbazoles, benzo[1, 2-b]-1,4-thiazepino[2,3-a]carbazoles and 1-acetyloxycarbazole-2-carbaldehydes

 

IPC Code: Int.Cl.8 C07D

 

 

 

 

 

V Sangeetha & K J Rajendra Prasad*

 

 

 

 

 

 

 

1955

Efficient synthesis of 3-(4-methyl-3-phenyl- furo [3,2-c] quinoline-2-carbonyl)- chromen-2-ones under microwave irradiation

 

IPC Code: Int.Cl.8 C07D

A rapid and efficient method for the preparation of 3-(4-methyl-3-phenyl-furo[3,2-c]quinoline-2- carbonyl)- chromen-2-ones by the reaction between 3-(2-bromo-acetyl)-chromen-2-ones and (4-hydroxy-2-methyl-quinolin-3-yl)-phenyl- methanones using dimethyl formamide and anhydrous potassium carbonate under microwave irradiation is reported.

 

 

 

 

V Naveen Kumar & B Rajitha*

 

 

 

 

 

 

 

1958

An efficient synthesis of 9(10H)-acridinones under microwaves

 

IPC Code: Int.Cl.8 C07D

 

 

9(10H)-Acridinones have been prepared from N-phenylanthranilic acids with high yields using PPA as catalyst under microwave irradiation.

 

 

 

 

 

 

V Nadaraj, S Kalaivani & S Thamarai Selvi*

 

 

 

 

 

 

1961

Synthesis, characterization and in vitro anti-JEV activity of N-[p-{3'-(2'-aryl-4'-oxo-1',3'-thiazolyl)} diphenyl]-7-hydroxy-4-methyl-2-oxoquinolines

 

IPC Code: Int.Cl.8 C07D

 

 

 

 

Synthesis, characterization and in vitro anti-JEV activity of N-[p-{3'-(2'-aryl-4'-oxo-1',3'-thiazolyl)} diphenyl]-7-hydroxy-4-methyl-2-oxoquinolines have been described.

 

 

 

 

 

 

 

 

 

Abha Bishnoi*, Krishna Srivastava & M N Joshi

 

 

 

 

 

 

 

1965

An efficient and practical procedure for synthesis of a,a′-bis(substituted benzylidene)cycloalkanones catalyzed by solid base SiO2-OK

 

IPC Code: Int.Cl.8 C07C

 

 

 

A series of aromatic aldehydes react with cycloalkanones catalyzed by solid base SiO2-OK to give the corresponding a,a′-unsaturated carbonyl compounds in good to excellent yields.

 

 

 

 

 

Tong-Shou Jin*, Ying Zhao, Li-Bin Liu & Tong-Shuang Li

 

 

 

 

 

 

1968

Flavonoid glycoside from Leucas lavandulaefolia (Rees) aerial parts

 

IPC Code: Int.Cl.8 A61K

 

 

 

 

A new  flavonoid glycoside 1 has been isolated from the aerial parts of Leucas lavandulaefolia Rees. The structure of 1 has been established as chrysoeriol-4˘-O-a-l-rhamnopyranosyl (1®2) b-d-galactopyranosyl (1®6) b-d-glucopyranoside on the basis of spectral data and chemical reactions.

 

 

 

 

 

 

K S Chandrashekar*, B J Arun, D Satyanarayana &
E V S Subramanyam

 

 

 

 

Authors for correspondence are indicated by (*)

 

IPC Code: International Patent Classification

Int.Cl8.: International Classification, 8th Edition, 2006