Indian Journal of Chemistry |
||||
|
Sect. B: Organic Chemistry including Medicinal Chemistry |
||||
|
VOL. 45B |
NUMBER 1 |
JANUARY 2006 |
||
|
CONTENTS |
||||
Rapid Communications
|
||||
|
|
|
|
||
|
227 |
A new and simple synthetic
approach to functionalized sulphone derivatives by the Suzuki-Miyaura
cross-coupling reaction IPC: Int.Cl.7 C 07 D |
Synthesis
of various highly functionalized sulphone derivatives are reported via the
bis Suzuki-Miyaura (SM) cross-coupling reaction as a key step. In this
regard, the dibromo sulphone prepared by the thermal rearrangement of
corresponding sultine derivative has been used as a key building block to
prepare various functionalized aromatic sulphone derivatives. |
||
|
|
|
|||
|
|
Sambasivarao Kotha* & Arun
Kumar Ghosh |
|
||
|
|
|
|
||
|
|
Papers
|
|||
|
|
|
|
||
|
232 |
Synthesis of potent water soluble forskolin
analogues IPC:
Int.Cl.7 C 07 C |
Synthesis of
potent water soluble forskolin derivatives having specificity towards
positive inotropic activity is reported. The present study is based on our
report of novel development using 2-hydroxyacyl analogues of forskolin. |
||
|
|
|
|||
|
|
Bansi Lal*, Ashok Kumar Gangopadhyay, Ramesh
M Gidwani, Ramanujam Rajagopalan & Anil V Ghate |
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
247 |
A simple
synthesis of 5-spirobarbituric acids and transformations of
spirocyclopropanobarbiturates to 5-substituted barbiturates IPC: Int.Cl.7 C 07 D |
A simple
synthetic methodology for the synthesis of 5-spirobarbituric acids 2 and their transformations to
5-substituted barbituric acids 11 has
been developed. |
||
|
|
|
|||
|
|
Palwinder Singh*
& Kamaldeep Paul |
|
||
|
|
|
|
||
|
|
|
|
||
|
252 |
Antioxidant and
antimicrobial activity evaluation of polyhydroxycinnamic acid ester
derivatives IPC: Int.Cl.7 C 07 C // A 61 P 31/04, 31/10 |
Polyhydroxycinnamic acid esters 5a-p have been synthesized and their antioxidant, antimicrobial activity are studied. The SAR studies reveal that pyrogallol and catechol moieties are essential for good antioxidant activity. Butyl hydroxycinnamates exhibit higher antibacterial activity and none of them shows significant antifungal activity. |
||
|
|
|
|||
|
|
Somepalli Venkateswarlu, Marellapudi S
Ramachandra, Alluri V Krishnaraju, Golakoti Trimurtulu & Gottumukkala V Subbaraju* |
|||
|
|
|
|
||
|
|
|
|
||
|
258 |
Chemoselective
Knoevenagel reaction as a novel route for the synthesis of biscoumarinyl
methylsulphones and 4+1, 1+4 approach synthesis of aminooxadiazolyl and
N-(2,5-dimethyl)pyrrolylcoumarins IPC: Int.Cl.7 C 07 D |
|
||
|
|
|
|||
|
|
Ganesh N
Alawandi & Manohar V Kulkarni* |
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
267 |
Novel approach for
the rapid and efficient synthesis of heterocyclic Schiff bases and
azetidinones under microwave irradiation IPC: Int.Cl.7 C 07 D |
2-Azetidinones 4 have been prepared by the reaction
of Schiff bases 3 with
chloroacetyl chloride and triethylamine. The reaction is carried out by
conventional and microwave method. |
||
|
|
|
|||
|
|
Bhanvesh Naik & K R Desai* |
|
||
|
|
|
|
||
|
|
|
|
||
|
272 |
Vitamin B12
and BF3-etherate as catalysts in synthesis
of some C4-C12-alkyl b-D-xylopyranosides IPC: Int.Cl.7 C 07 C |
Synthesis of
alkyl b-d-xylopyranosides
6 has been performed by vitamin B12-catalyzed
reaction glycosylation of acetobromoxylose 1 with alkanols (ROH) 3 and
with glycosylation of alcohols 3
with tetra-O-acetyl b-d-xylopyranose 7
in the presence of BF3-etherate, as a Lewis acid catalyst. |
||
|
|
|
|||
|
|
Zorica D
Petrović*, Dejan Andjelković & Aleksandra Spasojević |
|
||
|
|
|
|
||
|
|
|
|
||
|
276 |
Hard-soft
acid-base (HSAB) principle and difference in d-orbital configurations of metals explain the regioselectivity
of nucleophilic attack to a carbinol in Friedel-Crafts reaction catalyzed by
Lewis and protonic acids IPC:
Int.Cl.7 C 07 C |
|
||
|
|
|
|||
|
|
Gautam Panda*,
Jitendra K Mishra, Shagufta, T C
Dinadayalane, G Narahari Sastry & Devendra S Negi |
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
288 |
Condensation
reactions of various nucleophiles with 3-formylchromone IPC: Int.Cl.7 C 07 D |
3-Formylchromones
1 have been condensed with
1-(2,4-difluorophenyl-2-[1,2,4]triazol-4-yl)ethanone in acetic anhydride to
afford 3-[3-(2,4-difluorophenyl)-3-oxo-2-[1,
2, 4]triazol-4-yl)-propenyl]chromon-4-ones 2. 3-Formylchromones
1 when heated with benzo[d]isoxazol-3-yl-acetic acid in dry
pyridine yield the compounds 3-(2-benzo[d]isoxazol-3-yl-vinyl)
chromon-4-ones 3.
Further, 3-formylchromones 1 on heating with N-methylpiperizine in ethanol give 1-(2-hydroxyphenyl)-3-(4-methylpiperazin-1-yl)
propenones 4. |
||
|
|
|
|||
|
|
V B Halnor, N R
Dalvi, N S Joshi, C H Gill & B K Karale* |
|
||
|
|
|
|
||
|
|
|
|
||
|
292 |
Pyrazolo-fused quinoline analogues: Synthesis of 1H-pyrazolo
[3, 4-b] quinolines and 3-amino-1H-pyrazolo [3, 4-b]
quinolines from 3-formyl and 3-cyano-2-chloroquinolines IPC: Int.Cl.7 C 07 D 215/00 |
Synthesis of 1H-pyrazolo [3,4-b] quinolines 6 is described in two steps from substituted
2-chloro-3-formyl quinolines 1. |
||
|
|
|
|||
|
|
Ambika Srivastava, Mrityunjay K Singh & R M Singh* |
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
297 |
Polymer-supported
formate and zinc: A novel system for the transfer hydrogenation of aromatic
nitro compounds IPC: Int.Cl.7 C 07 D |
A mild and
efficient catalytic transfer hydrogenation (CTH) system has been developed
for the facile reduction of aromatic nitro compounds using recyclable
polymer-supported formate and commercial zinc dust. |
||
|
|
|
|||
|
|
G R Srinivasa, K
Abiraj & D Channe Gowda* |
|
||
|
|
|
|
||
|
|
Notes
|
|||
|
|
|
|
||
|
302 |
Lithium chloride
as an efficient catalyst for Friedlander synthesis of 1,8-naphthyridines via
the use of microwave irradiation and pestle/mortar IPC: Int.Cl.7 C 07 D |
Microwave irradiation and pestle / mortar techniques have been employed
successfully in the presence of lithium chloride for the synthesis of
1,8-naphthyridines 3 from 2-aminonicotinaldehyde 1 and active methylene compounds 2. |
||
|
|
|
|||
|
|
K Mogilaiah*, M
Prashanthi & S Kavitha |
|
||
|
|
|
|
||
|
|
|
|
||
|
305 |
Efficient
deprotection of tetrahydropyranyl ethers by silica sulfuric acid IPC: Int.Cl.7 C 07 D |
|
||
|
|
|
|||
|
|
Abdol R Hajipour*, Amin Zarei, Leila Khazdooz, Seied A Pourmousavi, Saeed
Zahmatkesh & Arnold E Ruoho |
|||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
309 |
Synthesis and
antimicrobial screening of 3H,11H-9-methyl-3-oxopyrano[2,3-f]cinnolino[3,4-c]pyrrazole
and its derivatives IPC: Int.Cl.7 C 07 D // A 61 P 31/04, 31/10 |
Various 3H,11H-9-methyl-3-oxopyrano[2,3-f]cinnolino[3,4-c]pyrrazole 4, 3H-9-methyl-3-oxo-11-(N-methylenemorpholino)pyrano[2,3-f]cinnolino[3,4-c]pyrrazole 5, 3H-9-methyl-3-oxo-11-phenyl
pyrano[2,3-f]cinnolino[3,4-c]pyrrazole 6 and 3H-9-methyl-3-oxo-11-(4-methyl-7-methoxy-2-oxo-2H-[1]-benzopyran-6-yl)pyrano[2,3-f]cinnolino[3,4-c]pyrrazole 7 have been synthesized from 6-aminocoumarins
and screened for their antimicrobial activities and are found to possess
significant antibacterial and antifungal activities. |
||
|
|
|
|||
|
|
Bharati P Choudhari & Vinata V Mulwad* |
|
||
|
|
|
|
||
|
|
|
|
||
|
314 |
Synthesis and
antimicrobial screening of 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-4,5,6,7-tetrahydrobenzimidazo[5,6-c]furan
and 5H,7H-N-(coumarin-6-yl)-2, 8-diphenyl-5,
7-dioxo-6-(7-methoxy-4-methylcoumarin-6-yl)-4, 5, 6,7-tetrahydro
benzimidazo[5,6-c]pyrrole IPC: Int.Cl.7 C 07 D |
Synthesis and
antimicrobial screening of 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-4,5,6,7-tetrahydrobenzimidazo[5,6-c]furan 5 and 5H,7H-N-(coumarin-6-yl)-2,8-diphenyl-5,7-dioxo-6-(7-methoxy-4-methylcoumarin-6-yl)-4,5,6,7-tetrahydro benzimidazo[5,6-c]pyrrole 6 via Schiff base formation of 6-aminocoumarin has been
described. |
||
|
|
|
|||
|
|
B P Choudhari
& V V Mulwad* |
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
318 |
Synthesis of
novel bone-targeted agents for treatment of osteoporosis IPC: Int.Cl.7 C 07 D |
Design,
synthesis and biological activities of novel bone-targeted
raloxifene-bisphosphonate conjugates are reported. |
||
|
|
|
|||
|
|
Junbo Wang,
Chunhao Yang, Huasheng Ding, |
|
||
|
|
|
|
||
|
|
|
|
||
|
322 |
A simple method
for deprotection of tert-butyldimethylsilyl
ethers by using stannous chloride under microwave irradiation IPC: Int.Cl.7 C 07 C |
A
facile regeneration of hydroxy compounds from their tert-butyldimethylsilyl
ethers in presence of stannous chloride under solvent free conditions using
domestic microwave oven has been performed efficiently. |
||
|
|
|
|||
|
|
Vinod H Jadhav,
Hanumant B Borate & Radhika D Wakharkar * |
|
||
|
|
|
|
||
|
|
|
|
||
|
325 |
Electrophilic
substitution reactions on 3-bromoacetylcoumarins IPC: Int.Cl.7 C 07 D |
Attempted
nitration and bromination of 3-bromoacetylcoumarins result in the formation
of racemic 3-w-bromonitroacetylcoumarins
and 3-w-dibromoacetylcoumarins. |
||
|
|
|
|||
|
|
K Y Anklekar, R
A Kusanur & M V Kulkarni* |
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
|
|
|
||
|
328 |
Convenient
synthesis of (E)-methyl O-alkylferulates: Formal synthesis of
O-geranylconiferyl alcohol, a
metabolite of Fagara rhetza IPC: Int.Cl.7 C 07 C |
A convenient two step synthesis of (E)-methyl O-alkylferulate described from vanillin. Reaction of vanillin with allyl-, prenyl- or geranyl- bromide has afforded respective alkyl ethers which on reaction with phosphorane, under microwave irradiation, gives (E)-methyl O-alkylferulates in high yield. In an alternative approach vanillin on reaction with phosphorane provides (E)-methyl ferulate which on reaction with the corresponding bromides gives (E)-methyl O-alkylferulates. |
||
|
|
Rajesh P
Mahajan, Shamkant L Patil* & Raghao S Mali * |
|
||
|
|
|
|
||
|
|
|
|
||
|
332 |
Pinacol coupling
of carbonyl compounds by using Al-NaOH/MeOH under microwave irradiation IPC: Int.Cl.7 C 07 C |
Microwave
irradiation accelerates the Pinacol coupling reaction of aromatic
aldehydes and ketones with Al
in aqueous NaOH-MeOH in high yield
within 5- 15 min. |
||
|
|
|
|||
|
|
Mohsen Mazaheri
Tehrani* & Jila Asghari |
|
||
|
|
|
|
||
|
|
|
|
||
|
335 |
Synthesis of 4-aryl-5-oxo-1H,4H-5,6,7,8-tetrahydroquinoline
and 4-aryl-5-oxo-1H-4,5,6,7-tetrahydrocyclopenteno[b]pyridine
derivatives by ultrasound irradiation and by conventional methods IPC: Int.Cl.7 C 07 D |
Arylhexahydro-quinoline-3-carboxylates
4a-d and arylcyclopenteno[b]pyridine-3-carboxylates 6a-e have been synthesized by the
condensation of cyclic 1,3-diones with aromatic aldehydes and b-aminocrotonate using
thermal and ultrasound irradiation methods. |
||
|
|
|
|||
|
|
D Thirumalai, P
Murugan & V T Ramakrishnan* |
|
||
|
|
|
|
||
|
Authors for correspondence are indicated by (*) IPC: International Patent
Classification Int. Cl7.: International
Classification, 7th Edition, 1999 |
||||
