Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

 

Total visitors: 1,541  since 18-07-06

VOL. 45B

NUMBER 7

JULY 2006

CONTENTS

Papers

 

 

 

1681

Phytochemical investigation of the flowers of Punica granatum

 

IPC: Int.Cl.8 C07D

Phytochemical investigation of the flowers of Punica granatum L. (Punicaceae) has been carried out which leads to the isolation of four new phytoconstituents identified as 4′-hydroxynon-6′-en-yl benzoate 1, 13-(15,19,19-trimethyl cyclohex-16-en)-yl-6,10-dimethyl-tridec-10-en-3b, 4b, 6a, 13b-tetraol 2, 3,7,8,4′-tetrahydroxy-3′-myrt-8-en-yl flavone 3 and a pentaglycoside named granatumoside 4. The structures of all these compounds have been established on the basis of spectral and chemical studies.

 

M Ali* & N Sharma

 

 

 

 

 

 

 

1686

Protonation effect on chemical shifts of some piperidones- unusual influence by anions

 

IPC: Int.Cl.8 C07D

1H and 13C NMR spectra are recorded for twelve picrate derivatives 4-15 derived from some 3-alkyl-2,6-diarylpiperidin-4-ones and 3,5-dimethyl-2,6-diaryl-piperidin-4-ones and analysed.

 

 

A Manimekalai* & J Jayabharathi

 

 

 

 

 

 

 

1692

2,3-Diphenyltetrahydrofurans (DPTF) − A new class of stereogenic diaryl heterocycles as potential COX-2 inhibitors−Computational evaluation of COX-2-DPTF binding behaviour

 

IPC: Int.Cl.8 C07D

Amongst the 12 DPTF derivatives which have been evaluated here, (2S, 3R, 5S)-2,3-diphenyltetrahydrofuran-5-carboxylic acid 2b shows highest COX-2 selectivity over COX-1.

 

 

Palwinder Singh*, Pervinder Kaur, Anu & Subodh Kumar

 

 

 

 

 

 

 

 

 

 

 

 

1699

Microwave assisted facile synthesis of amino pyrimidines bearing benzofuran and investigation of their antimicrobial activity

 

IPC: Int.Cl.8 C07D

2-Acetylbenzofuran on treatment with substituted aldehydes under solvent free microwave irradiation afford the corresponding chalcones 2a-e. The compounds 2a-e on reaction with guanidine hydrochloride under microwave irradiation produce 3a-e. The structures of the newly synthesized compounds have been established by elemental analysis and spectral data. The compounds 3a-e have been evaluated for their antimicrobial activity.

 

 

 

 

 

 

D B Aruna Kumar, G K Prakash, M N Kumaraswamy,

B P Nandeshwarappa, B S Sherigara & K M Mahadevan*

 

 

 

 

 

 

1704

Antibacterial and antifungal studies on some new acetylcinnolines and cinnolinyl thiazole derivatives

 

IPC: Int.Cl.8 C07D

Novel 3–acetylcinnolines have been prepared and converted to 4-(4,8-dimethylcinnolin-3-yl)-2-methyl-1,3-thiazole, 4-(4,8-dimethylcinnolin-3-yl)-2-amino-1,3-thiazole and N-(aryl)-4-(4,8-dimethylcinnolin-3-yl)-1,3-thiazol-2-amines. The newly synthesized acetylcinnolines and thiazolylcinnolines have been characterized by spectral analysis and screened for antibacterial and antifungal activities.

 

 

 

 

 

 

              

 

2a-d                                                                   5a-b                                                                      5c-f

 

 

 

 

 

B Narayana*, K K Vijaya Raj, B V Ashalatha &

N Suchetha Kumari

 

 

 

 

 

 

 

 

 

 

 

 

 

1710

Synthesis and antibacterial activity of new oxa­diazolo[1,3,5]-triazine,1,2,4 triazolo and thiadiazolo 1,3,4 oxadiazole derivatives

 

IPC: Int.Cl.8 C07D

 

 

 

V V Mulwad* & Atul C Chaskar

 

 

 

 

 

 

 

1716

Synthesis and studies of novel homoveratryl based thiohydantoins as antibacterial as well as anti-HIV agents

 

IPC: Int.Cl.8 C07D

Novel N,N′-bis(3,4-dimethoxyphenylethyl)-5-(arylidene)-2-thiohydantoins have been prepared and tested for their antibacterial and anti-HIV activities against different microorganisms.

 

 

R B Patel, K R Desai & K H Chikhalia*

 

 

 

 

 

 

 

 

 

 

1722

Theoretical study of facial selectivity and regioselectivity in electrophilic addition reaction of chlorine to exo-tricyclo[4.2.1.02,5]nona-3,7-diene

 

IPC: Int.Cl.8 C07D

For prediction and interpretation of facial selectivity and regioselectivity of the electrophilic addition reaction to exo-tricyclo[4.2.1.02,5]nona-3,7-diene(exoTND) of chlorine, various models (geometric distortions, electron density, orbital effects, electrostatic effects and intermediates stabilities have been used.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Rza Abbasoğlu* & Sevil Savaşkan Yılmaz

 

 

 

 

 

 

 

1729

Isomerization of the Baylis-Hillman adducts using amberlyst-15 as a heterogeneous reusable catalyst: a simple and efficient stereoselective synthesis of (E)-cinnamyl alcohol derivatives

 

IPC: Int.Cl.8 C07C

 

 

 

Biswanath Das*, Joydeep Banerjee, Anjoy Majhi,

Nikhil Chowdhury, Katta Venkateswarlu & Harish Holla

 

 

 

 

 

 

1734

Synthesis of novel substituted/unsubstituted- (2,8-bis-trifluoromethyl-quinolin-4-yloxy)-acetic acid: Deriva­tives of cephalosporin and their antibacterial activity

 

IPC:.Int.Cl.8 C07D

Substituted/unsubstituted-(2,8-bis-trifluoromethyl-quinolin-4-yloxy)-acetic acid derivatives of cephalosporin have been synthesized by condensation of acid chlorides of substituted/un substituted - (2,8-bis-trifluoromethyl-quinolin-4-yloxy)-acetic acid with various silylated (6R, 7R)-7-amino-3-substituted-cephalosporanic acids. The products have been tested for their antibacterial activity.

 

 

Santosh Kumar Singh, Ajay Nahta, R P Tiwari & Praveen Jain*

 

 

 

 

 

 

 

 

 

 

 

 

 

1740

Solid phase synthesis of nuclear localization signal on a new PS-TTEGDA polymer support

 

IPC: Int.Cl.8 C07C

Synthesis and characterisation of nuclear localization signal I using hydroxymethyl 2% PS-TTEGDA resin is carried out.

 

 

 

H-Ala-Ala-Ala-Lys-Lys-Asn-Ser-Leu-Ala-Leu-Ser-
 Leu-Thr-Ala-Asp-Gln-Met-Val-Ser-Ala-Leu-Leu-O- CH2-C6H4 -
®- 2% PS-TTEGDA resin

 

 

 

 

Daisy Samuel*, Renil M & V N Rajasekharan Pillai

 

 

 

 

Notes

 

 

 

1747

Synthesis of a modified peptide fragment analog Val-Tyr (P)-Val-Ala-Ala-OH of cAMP protein kinase regulatory sub unit type II employing Fmoc chemistry

 

IPC: Int.Cl.8 C07D

 Synthesis of new peptide fragment analog (Val-Tyr(P)-Val-Ala-Ala-OH) incorporating Tyr into the phosphorylation site of the cAMP protein kinase regulatory sub unit type II in place of Ser (Val-Ser(P)-Val-Ala- Ala-OH) has been described.

 

 

 

 

 

 

 

Kuramkote Shivanna Devaraju, Basanagoud S Patil, Subramanyam J Tantry, S V Suresh Babu, Taranath Shetty K  &Vommina V Suresh Babu*

 

 

 

 

 

 

 

1753

Synthesis and characterization of new isoxazoles derived from benzosuberones

 

IPC: Int.Cl.8C07D

Synthesis of new isoxazoles have been reported.

 

 

 

 

 

 

 

 

Venkateswarlu Peesapati* & Srinivas Bathini

 

 

 

 

 

 

 

 

 

 

 

 

 

1756

Studies in the synthesis of 2-mercapto-5-methoxy­benzimidazole

 

IPC: Int.Cl.8 C07D

Synthesis of 2-mercapto-5-methoxybenzimidazole by using cheaper and easily available raw materials is discussed.

 

 

 

 

 

 

S S Mahajan* & R G Nandre

 

 

 

 

 

 

 

1759

Three-component Mannich-type reaction catalyzed by iodine

 

IPC: Int.Cl.8 C07D

 

 

 

 

 

 

Dolly Kataki & Prodeep Phukan*

 

 

 

 

 

 

 

 

 

 

 

 

 

1762

Microwave assisted rapid and efficient synthesis of nitrogen and sulphur containing heterocyclic compounds and their pharmacological evaluation

 

IPC: Int.Cl.8 C07D

2-Azetidinones 4 and 4-thiazolidinones 5 have been prepared by the reaction of Schiff bases 3 with chloroacetyl chloride and triethylamine and thiolactic acid, respectively. The reaction is carried out by conventional and microwave methods.

 

 

 

 

 

 

 

 

 

 

 

Ketan Mistry & K R Desai*

 

 

 

 

 

 

 

1767

An efficient and regiospecific biocatalytic esterification of some organic acids using beef pancreas lipase (Bpl)

 

IPC: Int.Cl.8 C07D

 

 

 

 

 

 

 

 

 

 

H N Roy*, M S Sarkar & A M Paul

 

 

 

 

 

 

 

1770

Synthesis of some novel ethyl 5-methyl-6-cyano-7-substituted-2-oxo-2H-pyrano[2,3-b]pyridine-3-carboxy­late derivatives

 

IPC: Int.Cl.8 C07D

The compound 1 reacts with N, N-dimethylamino­ethylene­malonate in acetic acid under reflux conditions to give 5-methyl-6-cyano-7-hydroxy -2H-pyrano [2,3-b] pyridine-2-one 2, which is further treated with phosphorous oxychloride to obtain ethyl 5-methyl-6-cyano-7-chloro-2-oxo-2H-pyrano [2,3-b] pyridine-3-carboxylate 3. This chloride derivative 3 is finally converted to various amino derivatives 4a-j by condensa­tion with corresponding amines. These compounds are expected to have antihypertensive activity

 

 

 

N Vasanth Kumar & Uday C Mashelker*

 

 

 

 

 

 

 

 

 

 

 

 

 

1774

Diterpenes from the seeds of locally grown Zea mays

 

IPC: Int.Cl.8 C07D

Orthosiphol F 1 and Ceriopsin C 2, the two new diterpenes have been isolated from the hexane extract of the title organism.

 

 

M Amzad Hossain*, A Islam, Y N Jolly & M Aminul Ahsan

 

 

 

 

 

 

1778

Synthesis of N-3(4-(4-chlorophenyl thiazole-2-yl)-(2-(amino)­methyl)-quinazoline-4(3H)-one and their deri­va­ti­ves for antitubercular activity

 

IPC: Int.Cl.8 C07D

 

 

 

Shashikant R Pattan*, V V Krishna Reddy,

F V Manvi, B G Desai & A R Bhat

 

 

 

 

Authors for correspondence are indicated by (*)

IPC: International Patent Classification

Int.Cl8.: International Classification, 8th Edition, 2006