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Indian Journal of Chemistry |
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Sect. B: Organic Chemistry including Medicinal Chemistry |
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VOL. 46B |
NUMBER 4 |
APRIL 2007 |
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CONTENTS
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Papers
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643 |
One-pot Reformatsky-Imine addition reaction
leading to the synthesis of structurally diverse IPC: Int.Cl.8 C07D |
b-Lactams are well-known for
being the part of various antibiotics. The Reformatsky-imine addition
reaction of a-bromoethylacetate
with aldimines derived from 3,4-methylenedioxy benzaldehyde and a-methylcinnamaldehyde
provided an efficient and practical access to structurally diverse b-lactams. All the new b-lactams have been
identified as 1,4-diaryl-2-azetidinones through their detailed spectral
studies. Further, it also reveals that the styryl bond of a-methylcinnamylideneanilines
did not participate in the reaction and gives b-lactams contrary to their
analogues cinnamylideneanilines and o-nitrocinnamylidene
anilines which gave d-lactams. |
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Jaspreet Rajput*, Baldev Singh & Kewal
Krishan Singal |
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649 |
A facile and high efficient synthesis of
nitriles from aldoximes and primary amides with a mixture of
triphenylphosphine/2, 3-dichloro-5, 6-dicyanobenzoquinone (PPh3/DDQ)
under neutral conditions IPC: Int.Cl.8 C07C |
Aldoximes are
immediately converted to their corresponding nitriles with a mixture of
triphenylphosphine and 2,3-dichloro-5,6-dicyanobenzoquinone in dichloromethane
under neutral conditions at room temperature. Also, nitriles are formed from
the reaction of primary amides with this reagent in refluxing acetonitrile
under neutral conditions. |
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Ghasem Aghapour* & Marjan Amirabadi |
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653 |
Synthesis of some new 4-thiazolidinones and
thiazin-4-ones as biologically potent agents IPC: Int.Cl.8 C07D |
Some new
4-thiazolidinones 6-(2-aryl-4-thiazolidinones)-2,5-bis-(4-methoxy-phenyl)-3-pyridazinones
5a-e, 6-(2-aryl-5-methyl-4-thiazolidinones)-2,5-bis-(4-meth-oxyphenyl)-3-pyridazinones
6a-e and thazin-4-ones
6-(2-aryl-1,3-thiazin-4-ones)-2,5-bis-(4-methoxyphenyl)-3-pyridazinones
7a-e are synthesised and evaluated for antibacterial and antifungal
activity. |
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J N Gadre*, Smita Nair & Saurabh Chitre
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660 |
A new and
efficient method for the synthesis of 5-arylmethylene-pyrimidine-2,4,6-trione
under solvent and catalyst free conditions IPC: Int.Cl.8
C07D |
A new
and efficient method has been used for the synthesis of
5-arylmethylene-pyrimidine-2,4,6-trione without any catalyst and solvent
under microwave irradiation. A number of condensation products are prepared
in a very short reaction time with high yields. |
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Ch Sanjeeva Reddy*, A Nagaraj & P
Jalapathi |
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664 |
On the reaction of anthranilic acid with
thionyl chloride : Iminoketene intermediate formation IPC: Int.Cl.8 C07D |
2-(Sulfinylamino)
benzoyl chloride is formed on treating anthranilic acid with thionyl
chloride. The formation of iminoketene intermediate from 2-(sulfinylamino)
benzoyl chloride explains many of its reactions. |
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Dominic E Jacob* & Lopez Mathew |
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669 |
Efficient synthesis of bis(indolyl) methanes
in aqueous medium catalyzed by molybdenyl acetylacetonate IPC: Int.Cl.8 C07D |
A mild and efficient
electrophilic substitution reaction of
indoles with aldehydes and ketones has been carried out in water using
a catalytic amount of MoO2(acac)2 to afford the
corresponding bis(indolyl)methanes in excellent yields. Vibrindole A, a
bacterial metabolite and 3,3'-diindolyl methane, a potent anti-carcinogenic
agent has also been successfully synthesized in excellent yield using this
methodology. |
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B Banerjee, S K Mandal & S C Roy* |
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674 |
The novel N,S-substituted
nitro dienes from the reactions of some mono(alkylthio)-substituted IPC: Int.Cl.8 C07D |
Thiosubstituted
nitrodien compounds 1a-f are
obtained from 2-nitropentachlorobutadiene and some alifatic thiols.
Compounds 1a-f have reacted with thiomorpholine 2 and yielded 3a-f in
CH2Cl2. The compounds 5a-f have been obtained by the reactions of 1a-f with N-(diphenylmethyl)piperazine
4 in CH2Cl2.
2-Nitro-3,4,4-trichloro-1-(ethylthio)-1-[4-(1-diphenylmethyl)-piperazin-1-yl]-1,3-butadiene
5a is synthesized and its crystal structure is
determined. The compound 5a
crystallizes in the Orthorhombic crystal system (space
group P212121)
with the unit cell parameters a = 9.4240(2) Ĺ, b = 14.4007(2) Ĺ, c = 18.1891(2) Ĺ, a, b, g = 90°, V =
2468.48(7) Ĺ3, Z
= 4. The structure has been solved by direct methods (SIR92) and refined to
the residual index R1 =
0.078. |
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Cemil Ibis* & N Gulsah Deniz |
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681 |
Synthesis and spectral studies of some
heteroarylpiperidin-4-ones and their derivatives IPC: Int.Cl.8 C07D |
The 1H and 13C NMR spectra have
been recorded for t(3)-methyl-r(2), c(6)-di-2˘-furylpiperidin-4-one 1, t(3)-ethyl-r(2), c(6)-di-2˘-furylpiperidin-4-one 2, t(3)-isopropyl-r(2), c(6)-di-2˘-furylpiperidin-4-one 3, t(3), t(5)-dimethyl-r(2),
c(6)-di-2˘-furylpiperidin-4-one 4 and their derivatives |
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A Manimekalai*, J Jayabharathi, V M Porselvi
& N Prabha |
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Notes
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690 |
Synthesis and antimicrobial activity of
novel linearly fused 5-substituted- 7-acetyl-2,6-dimethyloxazolo[4,5-f]indoles IPC: Int.Cl.8 C07D |
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Dundappa S Donawade, A V Raghu & Guru S Gadaginamath* |
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694 |
Remote dianions and their application in the
synthesis of macroheterocycles IPC: Int.Cl.8 C07D |
A useful
sequence of reactions in one-pot. for the syntheses of nitrogen, oxygen and
phosphorus macroheterocycles is described. The key step involves the generation
of dianion that attacks to a variety of dielectrophiles leading to compounds 3-9
in good yields. |
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M S Singh*, Pratibha Singh, M David Raju
& A K Singh |
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698 |
Synthesis and evaluation of some 1,4-dihydropyridine
and their derivatives as antihypertensive agents IPC: Int.Cl.8 C07D |
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Shashikant
R Pattan*, V P Rasal,
N
V Venkatramana, A B Khade, S R Butle,
S
G Jadhav, B G Desai, F V Manvi
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702 |
Pyrido[2,3-d]pyrimidines and their ribofuranosides: Synthesis and
antimicrobial investigations IPC: Int.Cl.8 C07D |
4-Amino-5,7-disubstituted pyrido[2,3-d]pyrimidines 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones and 4-amino-3,5,7-trisubstituted pyrido
[2,3-d] pyrimidines-2,4-(1H,3H)-dione
and their ribofuranosides have been
synthesized. The antimicrobial activities of all these derivatives
have been studied. |
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Naresh Kumar,
Sangeeta Tiwari & Ashok K Yadav* |
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707 |
Ce(IV)
ammonium nitrate catalyzed chemoselective deprotection of acetonides IPC: Int.Cl.8 C07C |
Highly chemoselective deprotection of
diacetone sugars have been achieved at room temperature in excellent yields
using commercially available ceric ammonium nitrate (20 mole%) in moist CH3CN. |
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S Jana &
S C Roy* |
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710 |
Cascade
synthesis of racemic 3-arylphthalides IPC: Int.Cl.8
C07C |
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S T Patil &
A V Karnik* |
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713 |
Ecofriendly solvent free microwave enhanced
alkyl migration in N-alkyl anilines in dry media conditions IPC: Int.Cl.8 C07 C |
A rapid and efficient microwave enhanced
synthesis of para alkyl anilines on
dry media is reported. |
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R1- Alkyl R2- Alkyl / Br R3- Alkyl / NH2 /
Cl |
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S Selvakumar, M
Easwaramurthy & G J Raju* |
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Authors for correspondence are indicated by (*) IPC: International Patent
Classification Int.Cl8.: International
Classification, 8th Edition, 2006 |
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