Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 2,895  since 14-12-07

VOL. 46B

NUMBER 12

DECEMBER 2007

CONTENTS

Rapid Communication

 

 

 

1999

Enantiospecific synthesis of the complete carbon framework of the diterpenes komarovispiranes

Enantiospecific total synthesis of komarovispiradiene starting from campholenaldehyde is described.

 

 

 

 

 

A Srikrishna* & B Beeraiah

 

 

 

 

 

Papers

 

 

 

2004

Proline ureas: Synthesis and pharmacological evaluation as VLA-4 antagonists

A series of novel proline urea derivatives are synthesized and evaluated as potential VLA-4 antagonists and are found to possess moderate in vitro VLA-4 inhibitory potential.

 

 

 

 

 

 

 

Viswajanani J Sattigeri*, Ajay Soni,

Sunanda G Dastidar, Abhijit Ray,

Sharif Ahmad, Jung B Gupta & Mohammad Salman

 

 

 

 

 

 

 

 

 

 

 

 

2021

Synthesis, spectral studies and biological activity of novel 3H-1,5-benzodiazepine derivatives

A very convenient, efficient method has been developed for the synthesis of various 3H-1,5-benzodiazepines from β-diketones and β-ketoesters 4a-e and o-phenylenediamine (o-PDA) in the presence of SiO2-Cl / wet SiO2 under microwave irradiation. The compounds 5a-e have been screened for their antimicrobial, antifungal and anthelmintic activity. The compound 5c has exhibited considerable antimicrobial and antifungal activity and compounds 5d and 5e showed significant anthelmintic activity.

 

 

 

 

 

 

Rajesh Kumar & Y C Joshi*

 

 

 

 

 

 

 

2026

Enzymatic syntheses of l-valyl, l-leucyl and l-isoleucyl esters of carbohydrates using Candida rugosa lipase

l-Valyl 1, l-leucyl 2 and l-isoleucyl 3 esters of carbohydrates 4-14 have been prepared through lipase catalysis using Candida rugosa lipase in organic media.

 

 

 

 

 

 

Bhandya R Somashekar & Soundar Divakar*

 

 

 

 

 

 

 

 

 

Notes

 

 

 

2045

One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by acidic ionic liquid

3,4-Dihydropyrimidin-2(1H)-ones have been synthesized via one-pot reaction of aromatic aldehydes, ethyl acetoacetate and urea or thiourea catalyzed by room temperature ionic liquid [hmim]HSO4.

 

 

 

 

 

 

Jing-Jun Ma, Xiao-Huan Zang, Xin Zhou,

Chun Wang*, Jing-Ci Li & Qing Li

 

 

 

 

 

 

 

2049

A facile synthesis 2,3,4,9-tetrahydro-b-carbolin-1-ones

A short and efficient synthesis and characterization of various tetrahydro-b-carboline derivatives have been synthesized using Japp-Klingmann condensation followed by cyclization.

 

 

 

 

 

 

Y Lingam, D Muralimohan Rao,

Dipal R Bhowmik & Aminul Islam*

 

 

 

 

 

 

 

2053

Selective hydroboration / oxidation of double bond in the presence of triple bond by sodium acetoxy­borohydride leading to the synthesis of acetylenic alcohols

 

 

 

 

 

Jasvinder Singh*, Munisha Sharma,

Goverdhan L Kad & Jasamrit Kaur

 

 

 

 

 

 

 

 

 

 

 

 

 

2056

Facile formation of bis(3-indolyl)­methyl­arenes by iodine-catalyzed reaction of indole with a,a˘-bis­(arylmethylene)­ketones and a-substituted aryl­methyleneketones in dry ethanol

 

 

 

 

Asok K Mallik*, Rammohan Pal &

Tapas K Mandal

 

 

 

 

 

 

 

2060

Chemical composition and antimicrobial activity of the essential oil of Alpinia officinarum rhizome

Forty-nine compounds representing 99.21% of the oil have been identified. The major constituents are 1,8-cineole (55.39%), D3-carene (8.96%) and b-pinene (4.29%). The oil shows antimicrobial and antifungal activity.

 

 

 

 

A K Indrayan*, S N Garg, A K Rathi &

V Sharma

 

 

 

 

 

 

 

2064

Synthesis and anti-inflammatory activity of fluorinated chalcone derivatives

A series of twelve 2',4'-difluorinated chalcones have been synthesized by Claisen-Schmidt condensation and evaluated for anti-inflammatory activity.

 

 

 

 

 

Dhanaji H Jadhav & C S Ramaa*

 

 

 

 

 

 

 

 

 

 

 

 

 

2068

Synthesis of substituted steroidal thiadiazole, triazole and oxidotriazole

Cholest-5-en-3b-gloxy acetic acid thiosemicarbazide 3 is obtained from ethyl-5-cholesten-3b-O-acetate 2 by its reaction with thiosemicarbazide. The steroidal thiosemicarbazide 3 on further, chemoselective heterocyclization with conc. H2SO4, conc. NaOH and I2/NaOH yields 3b-[5′-amino-1′,2′,4′-thiadiazole-3′-methoxy]-cholest-5-ene 4, 3b-[5′-mercapto-1′,2′,4′,-triazole-3′-methoxy]-cholest-5-ene 5 and 3b-[5′-mercapto-3′,5′-oxido-1′,2′,4′-triazolo-3′-methoxy]-5a-cholestane 6, respectively.

 

 

 

 

 

 

Shamsuzzaman*, Tabassum Siddiqui &

Mohd Gulfam Alam

 

 

 

 

 

 

 

2071

Efficient synthesis of 6-aryl-12H-pyrido­[2',3':4,5]­pyrimido[1,2-a][1,8]naphthyridin-12-ones under microwave irradiation

A simple and highly efficient procedure has been described for the synthesis of 6-aryl-12H-pyrido[2',3':4,5]pyrimido[1,2-a][1,8]naphthyridin-12-ones 3 by the reaction of 3-aryl-2-chloro-1,8-naphthyridines 1 with 2-aminonicotinic acid 2 in glacial acetic acid under microwave irradiation.

 

 

 

 

 

 

 

K Mogilaiah*, E Anitha, K Vidya &

N Vasudeva Reddy

 

 

 

 

 

 

 

 

 

 

 

 

 

2074

A simple two-step synthesis of avenanthramides, constituents of oats (Avena sativa L)

A simple and efficient synthesis of avenanthramides 5a-m using anthranilic acid, Meldrum’s acid and aromatic aldehydes via the half amide of malonic acid 3 is described.

 

 

 

 

Shrivallabh P Kamat* & Sulaksha J Parab

 

 

 

 

 

 

 

2079

Annual Index

 

 

 

 

 

 

 

 

Authors for correspondence are indicated by (*)