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Indian Journal of Chemistry |
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Sect. B: Organic Chemistry including Medicinal Chemistry |
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VOL. 46B |
NUMBER 2 |
FEBRUARY 2007 |
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CONTENTS |
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Papers |
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303 |
Isothiazolo-fused quinoline analogues:
Synthesis of isothiazolo [5, 4-b]
quinolines and their oxidation products, 3[2H]-one-1, 1-dioxideisothiazolo [5, 4-b] quinolines from 2-chloro-3-formylquinolines IPC: Int.Cl.8 C07D |
Synthesis of
isothiazolo[5, 4-b]quinolines 2 is
described in two steps from the reaction of
2-chloro- 3-formylquinolines 1 with
sodium sulfide and hydroxylamine
followed by cyclisation with acetic anhydride. |
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A Srivastava, Atish
Chandra & R M Singh* |
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308 |
The effect of Glu→Asp substitution on
a 310 type fold in IPC: Int.Cl.8 C07C |
The solution conformation
of the peptide Boc-(d)-Asp1-Ala2-Gly3-Lys4-NHMe
based on NMR studies is compared with its (d)-Glu1 analog
reported earlier. Results establish that (d)-Asp analog is devoid of
the salt bridge and is a complex ensemble of consecutive folds. |
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V D Bobade*, P C Mhaske & N D Gaikwad |
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314 |
Synthesis of n-alkyl glucosides by
amyloglucosidase IPC: Int.Cl.8 C07C |
Amyloglucosidase
from Rhizopus mold (3.2.1.3) have been employed for the synthesis of n-alkyl
glucosides from alcohols of carbon chain lengths C1 to C18 and n-octyl
glucoside, maltoside and sucroside by shake flask and reflux methods. |
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Giriyapura R Vijayakumar, Charles George
& Soundar Divakar* |
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320 |
Fate of Embelin in Pippalyadi Yoga, an
Ayurvedic oral contraceptive: Structure of Embelin-borax complex and
evaluation of anti-fertility activity IPC: Int.Cl.8
A61K |
The existence of
embelin 1 in the complex form with borax in Pippalyadi Yoga, an
Ayurvedic oral contraceptive have been reported. Its structure 3,
stoichiometry and pH stability have
been determined. Synthesis and isolation of 3 from Pippalyadi Yoga
have been reported for the first time. The individual constituents along with
embelin-borax complex and formulation have been evaluated for their
anti-fertility effects. |
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Inder Pal Singh, Sandip B Bharate, Anubha
Singh & Kamlesh K Bhutani* |
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326 |
Asymmetric synthesis of (R)-(–)-baclofen
via asymmetric dihydroxylation IPC: Int.Cl.8 C07C |
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V V Thakur, A S Paraskar & A Sudalai* |
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331 |
Cu(OTf)2 Catalyzed high yield
synthesis of Hantzsch 1,4-dihydropyridines IPC: Int.Cl.8 C07D |
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Abhimanyu S Paraskar & Arumugam Sudalai* |
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336 |
Synthesis and antimicrobial investigation of
some novel phenyl pyrazole, azetidinone and diazenyl ethanone derivatives of
benzofurans IPC: Int.Cl.8 C07D |
Salicylaldehyde and 2-hydroxy acetophenone on reaction with chloroacetone afford corresponding benzofurans 2a and 2b. The compounds 2a and 2b on treatment with phenylhydrazine in ethanol give 3a-d. The products 3a-d underwent cyclization to produce substituted pyrazoles 4a-d. The compounds 2a-b on treatment with aromatic amines afford 5a-h, these on treatment with chloroacetyl chloride produced azetidinones 6a-h. The compounds 2a and 2b with various diazotized aromatic amines produced phenyl diazenyl benzofurans 7a-h. Their antimicrobial activities have been evaluated. |
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D B Aruna Kumar, G K Prakash, M N
Kumaraswamy, B P Nandeshwarappa, B S Sherigara & K M Mahadevan* |
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344 |
Synthesis of novel triazole, quinoline,
oxazole and imidazole annulated carbostyrils by microwave irradiation IPC: Int.Cl.8 C07D |
A simple and
ecofriendly synthesis of 3,4,6-trisubstituted-9,10-dihydro-11-oxo-quinolino[2,3-b]-1,3,4-thiadiazino[2,3-d]-1,2,4-triazole 3, 2-guanidino / substituted guanidino-1,3-thiazolo[4,5-b]-1-H-6,8-disubstituted-4-oxo-quinoline 5, 2-guanidino/substituted guanidino-1,3-oxazolo[4,5-b]-1-H-6,8-disubstituted-4-oxo-quinoline 7 and 2-amino/substituted
amino-3,8-dihydro-9-oxo-4,6-disubstituted quinolino[2,3-d]-imidazole 9 by
microwave irradiation is found to be more efficient than the conventional
method. |
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Vijay V Dabholkar* & Sagar D Parab |
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Notes
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349 |
TiCl4 Promoted synthesis of
benzimidazole derivatives IPC Code: Int Cl.8 C 07 D |
A highly efficient method for the synthesis of benzimidazoles
from o-phenylenediamines and aldehydes using TiCl4 as a catalyst in solvent-free
conditions is reported. |
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Rahul R Nagawade & Devanand B Shinde* |
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352 |
Synthesis and pharmacological study of
thiazolidinones and mannich bases of 4-amino-3-mercapto-5-pyridin-3’-yl-[1,2,4]-triazole IPC: Int.Cl.8 C07D |
4-Amino-5-(3-pyridyl)-4H-1,2,4-triazole-3-thiol 1 is prepared from methyl nicotinate
through a multi-step reaction sequence1. Compound 1 react with various aromatic aldehydes
in the presence of gl. acetic acid to give
4-substituted-benzal-amino-3-mercapto-5-pyridin-3’yl-[1,2,4]-triazoles 2a-i, which on further
cyclocondensation with thioacetic acid afforded 3-(3’-mercapto-5’-pyridin-3’’-yl-[1, 2, 4]-triazole-4’-yl)-2-aryl-1,3-thiazolidin-4-ones
3a-i. Compounds 2a-i on reaction with formaldehyde
and with different aromatic amines in dioxane yielded
2-[bis-aryl-amino-methyl]-5-pyridin-3’-yl-4-substituted-banzal-amino-2,3-dihydro-[1,2,4]-triazlole-3-thiones
4a-i. The pharmacological evaluations have been performed for their
antimicrobial and antitubercular activities. |
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T K Dave, D H Purohit, J D Akbari & H S
Joshi* |
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357 |
Justicia lignans: Part 10 _ Synthesis of
tiruneesiin, the first neolignan from
Justicia species IPC: Int.Cl.8 C07D |
Total synthesis
of the benzofuranoid neolignan, (±)-tiruneesiin 1, has been
achieved through Ag2O induced dimerization of methyl ferulate
followed by functional group transformations. |
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Gottumukkala
V Subbaraju*, Jakka Kavitha, Dodda
Rajasekhar, Feng-Lin Hsu & Kur-Ta Cheng |
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360 |
Synthesis and characterization of some
2-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)-4H-chromon-4-ones, 4-(2-hydroxyphenyl)-6-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)pyrimidine-2-(1H)-thione,
2-(5-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)-1H-pyrazol-3-yl)phenol and
2-(2,3-dihydro-2-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)-benzo[b][1,4]thiazepin-4-yl)-phenol IPC: Int.Cl.8 C07C |
Different
thiophene containing chromones, thiopyrimdines, pyrazolyl pyrazoles and
dihydro benzothiazepines are synthesized and characterized with the help of
spectral studies. |
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M S More, M S Shingare, S B Kale, N R Dalvi
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366 |
A new prenylated isoflavone from Tephrosia tinctoria IPC: Int.Cl.8
C07D |
A new prenylated
isoflavone, 7-O-geranylbiochanin A 1 is isolated from the roots of Tephrosia
tinctoria Pers. together with three
known compounds, 7-O-methylglabranin
2, flemichapparin B 3 and dehydrodeguelin 4. |
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1 |
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B Anil Kumar Reddy, S Ibrahim Khalivulla
& D Gunasekar* |
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370 |
Stereoselectivity of the Wittig reaction in
two-phase system IPC Code: Int. Cl.8 C07C |
The Wittig
reaction of benzyltriphenylphosphonium chloride with aliphatic and aromatic
aldehydes has been investigated, respectively, in two-phase solvent system
(dichloromethane / water) in the presence of sodium hydroxide. |
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Saleh Al Busafi* & Waffa Al Rawahi |
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375 |
A novel synthesis of nitrofuran containing
1,3,4,5-tetra substituted pyrazoles via 1,3-dipolar addition reaction IPC: Int.Cl.8 C07D |
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3 |
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Satheesha Rai N & Balakrishna Kalluraya* |
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379 |
Two new eudesmanolides from Sphaeranthus indicus (Linn) IPC Code: Int Cl.8 A61K |
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Ravindra B Jadhav, Kiran B Sonawane, Nirmala
R Deshpande & Supada R Rojatkar* |
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Authors for correspondence are indicated by (*) IPC: International Patent
Classification Int.Cl8.: International
Classification, 8th Edition, 2006 |
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