Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 3,193  since 16-08-07

VOL. 46B

NUMBER 7

JULY 2007

CONTENTS

Rapid Communications

 

 

 

1133

Photochemical studies on b-ionyl hydrazone

Irradiation of degassed n-heptane solution of (E,E)-β-ionone hydrazone results in geometric isomerisation of its >C=N–linkage whereas in non-degassed condition (E)-5,6-epoxy-b-ionone is formed.

 

 

Solomon Libsu & Anil K Singh*

 

 

 

 

 

Papers

 

 

 

1137

Towards the total synthesis of halolitoralin-c

 

 

 

 

Ch Maheedhara Reddy, V N S Murthy

P K Mukkanti & Palle V R Acharyulu*

 

 

 

 

 

1143

 

Simple, economical and flexible apparatus for solid phase peptide synthesis

 

Simple, economical, flexible convenient apparatus to carry out manual solid phase peptide/solid phase synthesis using two vessels has been designed.

 

 

 

 

 

 

Kota Satyanarayana*, K V R C Rajesh Kumar & Ch Venkanna

 

 

 

 

 

 

 

 

 

 

 

 

 

1148

Structural feature indenture for estrogen analogs as anticancer agents: De novo and Hansch Approach

The quantitative models derived for the study illustrates the significance of the b -hydroxy group of 17th position for the drug–enzyme interaction and allowed hydrogen-bonding interaction to estrogenic receptor in optimal manner (free rotation) as compared to oxo group (restricted orientation). The results of the study also reveal the necessity of sulfonamide moiety at 3rd position of estrogen. Additionally, presence of smaller substituents at 2nd position will be conducive for the activity.

 

 

Arun Kumar Gupta*, Anurekha Jain, Avijeet Jain,
Anirudh Joshi & S Revathi

 

 

 

 

 

 

1154

Steroidal saponins from the rhizomes of Agapanthus africanus (Linn)

Two new spirostan saponins have been isolated from the rhizomes of Agapanthus africanus (Linn) and identified as (25R)-5α-spirost-7-ene-2-α,3β,5α-triol-3-O[-α-l-rhamnopyranosyl(1→2]-β-d-glucopyranosi­de 1 and (25R)-5α-spirost-7-ene-2α,3β,5α,9α -tetrol-3-O-β-d-glucopyranoside 2.

 

 

 

 

D N Singh*, N Verma & D K Kulshreshtha

 

 

 

 

 

 

 

1159

A selective synthesis for novel pyranodi­pyrimidines

Pyrano[2, 3-d]pyrimidines have been cyclised using various aromatic acids on different solid supports to yield pyranodipyrimidines selectively.

 

 

 

Mazaahir Kidwai*, Ritu Goyal & Kavita Singhal

 

 

 

 

 

 

 

 

 

 

 

 

 

1164

Ester prodrugs of flurbiprofen: Synthesis, plasma hydrolysis and gastrointestinal toxicity

Nine alkyl ester prodrugs of flurbiprofen have been synthesized with an aim to reduce it’s gastrointestinal side-effects.

 

 

 

 

 

 

 

 

Rhea Mohan & C S Ramaa*

 

 

 

 

 

 

1169

Synthesis of novel aliphatic thiourea derivatives containing s-triazine moiety as potential antimicrobial agents

A new series of aliphatic thiourea incorporating 1,3,5-s-triazine moiety containing morpholine and various substituted aryl urea is reported along with their in vitro antimicrobial studies.

 

 

 

 

 

 

 

 

Akshay D Desai, Dharmesh H Mahajan &
Kishor H Chikhalia*

 

 

 

 

 

 

 

 

 

 

 

 

 

1174

Environmentally benign synthesis of fluorinated pyrazolone derivatives and their antimicrobial activity

Synthesis of fluorinated pyrazolone derivatives from 3-formyl chromone and 4-formyl pyrazoleby conventional, ultrasonication and microwave irradiation has been carried out and their antimicrobial activity has been studied.

 

 

S N Shelke, N R Dalvi, S B Kale, M S More,

C H Gill & B K Karale*

 

 

 

 

 

 

 

1179

Microwave enhanced heterocyclization: A convenient procedure for antimicrobial 1,5-benzothiazepine compounds

A series of 2,5-di hydro- 4- [1΄-(o-chloro phenyl)-3΄-methyl-5΄-pyrazolidene azomethine]-2-(substituted phenyl)-1,5 benzothiazepines 7a-j have been synthesized using environmentally benign procedure and evaluated for their antimicrobial activity. Neat reactants are subjected to microwave irradiation (MWI) under solvent-free-condition. The observed yields and enhancement in reaction rates are due to the solvent free conditions coupled with microwave usage. Structures of the synthesized compounds have been elucidated on the basis of their elemental analyses and spectral data.

 

 

 

 

Krunal G Desai* & Kishor R Desai

 

 

 

 

 

 

 

Notes

 

 

 

1187

Rhodium chloride catalyzed facile synthesis of α-aminonitriles

The facile synthesis of a series of α-aminonitriles by a one-pot three-component condensation of carbonyl compounds, amines and TMSCN in MeCN in presence of a catalytic amount of rhodium chloride at ambient temperature in high yields is described.

 

 

 

 

 

 

M A Pasha*, H M Nanjundaswamy  &
V P Jayashankara

 

 

 

 

 

 

1191

Synthesis, spectral studies and antimicrobial activity of 7-chloro-2-alkyl/aryl-4-alkyl/aryl-3-arylidene-3H-1,5- benzodiazepines

Ten new 7-chloro-2-alkyl/aryl-4-alkyl/aryl-3-arylidene-3H-1,5-benzodiazepines have been synthesized and characterized as antibacterial and antifungal agents.

 

 

 

 

 

 

Vijai N Pathak*, Rahul Joshi & Neetu Gupta

 

 

 

 

 

 

1198

Study of the thermo-oxidative degradation behavior of isotactic polypropylene with the varying ethylene content

The thermo-oxidative degradation behaviour of isota- ctic polypropylene is studied as a function of varying ethylene and oxygen concentration effects by means of gel permeation chromatography measurements.

 

 

 

 

M S Alam*, S M Abdur Razzaque,

G M Arifuzzaman Khan, A K Chakraborty &

M Moniruzzaman

 

 

 

 

 

 

 

 

 

 

1203

Microwave-assisted solvent-free synthesis of 4-methyl-2-hydroxy- and 2-methyl-4-hydroxy­quino­lines

Rapid and efficient microwave-assisted synthesis of 4-methyl-2-hydroxy- and 2-methyl-4-hydroxy­quino­lines from anilines and ethyl acetoacetate under different conditions is described.

 

 

V Nadaraj & S Thamarai Selvi*

 

 

 

 

 

 

 

1208

Solid phase deoximation of oximes to the corres­ponding carbonyl compounds using bromate exchange resin

Bromate Exchange resin (BRER) prepared by simple elution technique has been used for deoximation of oximes to the corresponding carbonyl compounds in biphasic condition. Reaction conditions are simple and yields of the carbonyl compounds are high.

 

 

Atul P Sikdar & Pranab J Das*

 

 

 

 

 

 

 

1211

Synthesis of some 4-substituted hydrazinotetra­zolo[1,5-a]quinoxalines

The reaction of 4-hydrazinotetrazolo[1,5-a]quin­oxaline with various aldehydes in DMF gives 4-substituted hydrazinotetrazolo[1,5-a]quinoxalines. The structures of compounds have been confirmed by IR and 1H NMR.

 

 

 

M B Deshmukh*, A R Mali, S D Jadhav &

A W Suryawanshi

 

 

 

 

 

Authors for correspondence are indicated by (*)