Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 2,876  since 20-11-07

VOL. 46B

NUMBER 11

NOVEmber 2007

CONTENTS

Papers

 

 

 

1815

Guanidino substituted isoindolones as novel glycoprotein IIb-IIIa receptor antagonists

Design and synthesis of potent new GP IIb-IIIa receptor antagonist. Compound with R1 = R2 = OCH2COOEt and X = O showed IC50 = 0.025 mM. Our study also indicated possibility of additional binding site near the central part of the molecule in the form of H-bond donor to ligand.

 

 

 

 

 

Bansi Lal*, Ashok K Gangopadhyay, P G Jagtap, Rajendra Tanpure, V S V V Rao, Ravindra D Gupte,
P Subbarayan & Gope Asudani

 

 

 

 

 

 

1833

Wavelength dependent regioselective E (trans)Z (cis) isomerization of 9-anthryldiene derivatives

 

 

 

 

 

Majjigapu Janaki Ram Reddy, Perepogu Arun Kumar, Uppalanchi Srinivas, Vummadi Venkat Reddy,
Maruthi Janaki Ram Reddy, G Venugopal Rao & Vaidya Jayathirtha Rao*

 

 

 

 

 

 

1848

Microwave assisted synthesis of indole and furan derivatives possessing good anti-inflammatory and analgesic activity

A number of indole 1 and furan 2-6 derivatives have been synthesized by condensation of indole-2- carboxylic acid with aryl sulfonyl hydrazide and furfuryl amine with various carboxylic acids and diacids using microwave irradiation. On anti-inflammatory and analgesic activity screening compound 5 exhibited good anti-inflammatory and analgesic activity.

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Sham M Sondhi*, Shubhi Jain, Reshma Rani & Ashok Kumar

 

 

 

 

 

 

1855

A comparative crystallographic analysis of the
X-ray structure of three cholest-based steroidal molecules

The molecular and crystal structures of (+)-4-cholesten-3-one 1 cholesteryl chloroformate 2 and cholesteryl-caprylate 3 have been determined by using X-ray crystallographic and computational techniques. All the three compounds crystallize in the monoclinic space group P21 with unit cell parameters: a=10.683(5), b=7.861(2), c=14.616(2), b=105.8(2)o for [1], a=12.294(2), b=9.399(8), c=12.787(2), b=113.3(1)o for [2] and a = 12.778(9), b = 9.201(4), c = 14.063(6) , b = 93.85(4)o for [3]. The number of molecules per unit cell in case of each structure is 2. The final R-factor for [1] is 0.054, [2] 0.077 and [3] 0.068. Besides some interesting geometrical and structural features, all the three molecules exhibit C-HO hydrogen bonding.

 

 

 

 

 

Rajnikant*, Dinesh, Kamni, Bandhan Sharma, Sonam Lotus & Kewal Gupta

 

 

 

 

 

 

 

1860

Photocyclisations of some 3-alkoxychromones: Substituent control on photoreactivity

Photoreorganisations of some phenyl substituted chromones, showing the effects of various substituents upon the 3-alkoxy moiety have been investigated.

 

 

 

 

Mohamad Yusuf*, Rupesh Kumar, W R Bansal & Ritu Bala

 

 

 

 

 

 

1868

Antifungal and Phytochemical studies of Eupatorium birmanicum DC

Antifungal activity of the chloroform and methanol extracts of the leaves of Eupatorium birmanicum DC. and isolation of
b-sitosterol, b-sitosterol-α-d-glucoside, o-coumaric acid, cerebroside 1, ceramide 2, and quercetin-3-O-rutinoside 3 from the leaves of the plant are reported.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

L Reena Devi, Th Shyamkeshor Singh &
Warjeet S Laitonjam*

 

 

 

 

 

Notes

 

 

 

1873

Synthesis and antimicrobial screening of 5-(4,7-dimethyl-2-oxo-2H-benzopyran-6-ylazo)-2-methyl-6-morpholin-4-yl-2,3-dihydro-3H-pyrimidin-4-one and 5-(4,7-dimethyl-2-oxo-2H-benzopyran-6-ylazo)-
2-methyl-6-piperidin-1-yl-2,3-dihydro-3H-pyrimidin-4-one
.

 

 

A facile synthesis of 5-(4,7-dimethyl-2-oxo-2H-benzopyran-6-ylazo)-2-methyl-6- morpholin -4-yl-2,3-dihydro -3H-pyrimidin-4-one and 5-(4,7-dimethyl-2-oxo-2H-benzopyran-6-ylazo)-2-methyl-6-piperidin-1-yl-2,3-dihydro-3H-pyrimidin-4-one.

 

 

 

 

 

 

 

 

 

Vinata V Mulwad* & Sagar A Mayekar

 

 

 

 

 

 

 

1879

Molecular and crystal structure of 6α-acetoxy azadirone

An approach towards the single crystal structure analysis of the biologically important limonoid, 6α-acetoxy azadirone is presented..

 

 

 

 

 

 

 

 

 

Jibon Kotoky*, Mahendra Kalita, Gautam Kumar Sarmah & Babulal Das

 

 

 

 

 

 

1883

Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and evaluation of bio-activity of thiazolo[3,2-b]-s-triazoles and isomeric thiazolo[2,3-c]-s-triazoles

 

 

 

 

 

Parvin Kumar, Jag Mohan & J K Makrandi*

 

 

 

 

 

 

 

1886

Gallium(III) halides catalyzed, microwave enhanced, synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent free condition

Gallium(III) halides catalyzed and microwave enhanced three component Biginelli reaction of aldehyde, 1,3-dicarbonyl compounds and urea or thiourea under solvent free conditions to afford 3,4-dihydropyrimidin-2-(1H)-ones in excellent yields is described. The present procedure for the production of dihydropyrimidinones describes the first ever catalytic activity of gallium(III) halides. This improved procedure is fairly simple, facile and environment friendly.

 

 

 

 

 

 

 

Anil Saini, Sanjay Kumar & Jagir S Sandhu*

 

 

 

 

 

 

1890

 

The electrosynthesis of pinacols

Electrosynthesis of pinacols by iron as electrode in acid condition is performed. The influence of electric potential and time on pinacol yield is explored. The optimal reaction conditions are: electric potential 4 V, time 60 min., methanol 6 mL, hydrochloric acid (2N) 2 mL, with the yield of pinacols up to 18-81%.

 

 

 

 

 

Yan-Jiang Bian* & Dong Sheng Bai

 

 

 

 

 

 

 

1893

KHSO4-SiO2-MeOH  An efficient selective solid-supported system for deprotection of alcohols from esters

 

 

KHSO4-SiO2 can efficiently deprotect alcohols from esters through transesterification in methanol.

 

 

 

 

Amrit Goswami*, Ram N Das & Naleen Borthakur

 

 

 

 

 

 

 

1896

Alkaloids of Sida cordifolia L

 

 

 

 

 

 

Ranajit K Sutradhar *, A K M Matior Rahman

Mesbah U Ahmad & Koushik Saha

 

 

 

 

Authors for correspondence are indicated by (*)