Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 4,926  since 16-04-08

VOL. 47B

NUMBER 4

APRIL 2008

CONTENTS

Papers

 

 

 

575

A convenient synthesis of tert-butyl ethers under microwave condition

 

Synthesis of tert-butyl ethers from various alcohols and substituted phenols can be achieved using tert-butyl bromide in the presence of basic lead carbonate as a catalyst under microwave irradiation in absence of solvent. The catalyst is easily recovered via filtration and reused up to three times without appreciable loss of activity.

 

 

 

 

 

K A Mahammed, P S Keshava Murthy &

K Mohana Raju*

 

 

 

 

 

 

 

 

579

Synthesis and QSAR studies of thiosemi­carbazides, 1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles derivatives as potential anti­bacterial agents

 

Several new 2-(2-(4-chlorophenyl)acetyl)-N-arylhydrazine­carbo­thioamides 1, 5-(4-chlorobenzyl)-4-aryl-4H-1,2,4-triazole-3-thiols 2, 5-(4-chlorobenzyl)-N-aryl-1,3,4-thiadiazol-2-amines 3 and 5-(4-chlorobenzyl)-N-aryl-1,3,4-oxadiazol-2-amines 4 have been synthesized and evaluated for their antibacterial activity. The QSAR studies of the new bio-active molecules have been carried out by Hansch’s LFER method.

 

 

 

 

 

N C Desai*, A M Bhavsar, M D Shah &

Anil K Saxena

 

 

 

 

 

 

 

 

 

 

 

 

 

 

586

QSAR studies on 4-thiazolidinones and 2-azetidin­ones bearing benzothiophene nucleus as potential anti-tubercular agents

 

QSAR investigation on 3D molecular descriptors in 4-thia­zoli­dino­­nes and 2-azetidinones as anti- tubercular agents have been reported.

 

 

 

 

 

 

 

 

A S Narute, P B Khedekar & K P Bhusari*

 

 

 

 

 

 

 

 

592

A study on types of hydrogen bonding in crystal structure of 1-acetyl-3-thiosemicarbazide

 

The unit cell structure of 1-acetyl-3-thiosemicarbazide (ATSC) and the types of hydrogen bonds present in crystalline form are envisaged from single crystal X-ray diffraction studies. The topological analysis of hydrogen bonds indicated both inter- and intramolecular hydrogen bonding. The single crystal X-ray diffraction data corresponding to hydrogen bonding reveals the hydrogen-bond strength sequence as: N─H· · ·N > O─H· · ·O > N─H· · ·O > N─H· · ·S.

 

 

B Sireesha, B Krishna Rao, Ch Sarala Devi* & Pallepogu Raghavaiah

 

 

 

 

Notes

 

 

 

597

TiO2: A simple and an efficient catalyst for esterification of phenols under solvent- free condition

 

In the presence of catalytic amount of titanium oxide (TiO2), without any additional solvent at 25 °C, phenols are conveniently acylated by acid chlorides to get phenolic esters in excellent yields. The TiO2 powder can be reused three times after simple washing with CH2Cl2. 

 

 

 

 

 

 

 

Mohamed Afzal Pasha* & Krishnappa Manjula

 

 

 

 

 

 

 

 

 

 

 

 

 

601

Solvent-free synthesis of 2-alkyl and 2-alkenyl­ben­zo­thiazoles from fatty acids under microwave ir­radiation

 

2-Alkyl and 2-alkenylbenzothiazoles have been synthesized from fatty acids under microwave-assisted solvent free conditions.

 

 

 

 

 

 

 

 

 

 

 

Abdul Rauf*, Saloni Gangal & Shweta Sharma

 

 

 

 

 

 

 

 

606

Conventional as well as microwave assisted synthesis of some new N9-[hydrazinoacetyl-(2-oxo-3-chloro-4-substituted aryl azetidine)]-carbazoles: Antifungal and antibacterial studies

Carbazole on reaction with chloroacetyl chloride afford N9-(chloroacetyl)-carbazole, 1 which on treatment with hydrazine hydrate has yielded N9-(hydrazinoacetyl)-carbazole, 2. Condensation of 2 with various aromatic aldehydes has afforded N9-(arylidene hydrazinoacetyl)-carbazoles, 3 which on cycloaddition with chloroacetyl chloride in the presence of triethylamine has yielded-N9-[hydrazineacetyl (2-oxo-3-chloro-4-substituted aryl azetidine)]-carbazoles 4. All the above reactions are also performed by microwave assisted synthetic method which gave better results as compared to conventional method. The structures of all the products are characterized by microanalytical data and spectroscopic techniques. All the synthesized products are screened for their antibacterial activity against Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and antifungal activity against Aspergillus nigar, Aspergillus flavus, Fusarium oxisporium and Trichoderma viride.

 

 

 

 

 

 

 

 

 

 

S K Srivastava*, A Nema & S D Srivastava

 

 

 

 

 

 

 

 

 

 

 

 

 

 

613

Synthesis of some novel per acetylated lactosyl N-carbamides, N-benzothiazolyl carbamides and N-carbamates

Per acetylated lactosyl N-carbamides, N-benzothiazolyl carbamides and  N-carbamates are prepared by the reaction of 1-hepta-O-acetyl-b-d-lactosyl isocyanate 1 with aryl amines, substituted benzothiazole and various alcohols respectively.

 

 

 

 

 

 

 

 

 

A S Dandale & S P Deshmukh*

 

 

 

 

 

 

 

 

 

 

 

 

 

619

Two new phytoconstituents from Rumex mari­timus

 

A new polyhydroxy ketone derivative and a terpene glycoside have been isolated from the seeds of Rumex maritimus. Their structures have been established as 3,7,11,15-tetramethyl-n-octadac-13-en-3,4,6,7,8,11-hexol-12-one 1 and 8b-hydroxy-14b-methyl-7-oxopodocarp-5-en-13-(19a-hydroxy-19,22,22-tri­me­thyl­­­heptyl)-22-O-(b-d-glucopyranosyl)-(4®1)b-d-glucopyranoside 2, respectively, on the basis of chemical and spectral data analysis.

 

 

 

 

1

 

 

2

 

 

 

S Tarique Abdullah, Hinna Hamid,

M Sarwar Alam*, S H Ansari & Mohammed Ali

 

 

 

 

 

 

 

 

623

p-TsOH catalyzed efficient synthesis of bis­(indolyl)methanes

 

 

 

 

 

 

 

 

B China Raju* & J Madhusudana Rao

 

 

 

 

 

 

 

 

 

 

 

 

 

 

626

Synthesis and pharmacological screening of some 1,4-dihydropyridine and their derivatives for anticonvulsant activity

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Shashikant R Pattan*, S S Purohit, V P Rasal,

S Mallya, S C Marihal, A B Khade &

M S Paschapur

 

 

 

 

 

 

 

 

630

An efficient synthesis of some 5-substituted-3-methyl-2-cyclohexen-1-ones using micro­waves

The simple synthesis of some 5-substituted-3-methyl-2-cyclo­hexe­nones using the microwave irradiation technique of con­densation of ethylacetoacetate with eight different aldehydes and piperazine is reported.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Divya Jyothi & S Hari Prasad*

 

 

 

 

 

 

 

 

 

 

 

 

 

633

Synthesis and antimicrobial activity of 2-(2′-arylidene-hydrazino-acetyl-amino)-4-phenyl-1,3-thiazoles and 2-[2′-{4′′-substituted-aryl-3′′-chloro-2′′-oxo-azetidine}-acetyl-amino]-4-phenyl-1,3-thiazoles

 

2-(2′-Substituted-arylidene-hydrazino-acetyl-amino)-4-phenyl-1, 3-thiazoles, 3 and 2-[2′-{4′′-substituted-aryl-3′′-chloro-2′′-oxo-azetidine}-acetyl-amino]-4-phenyl-1,3-thiazoles 4 have been synthesized from 2-(2′-hydrazino-acetyl)-amino-4-phenyl-1,3-thiazole, 2 using 2-amino-4-phenyl-1,3-thiazole as the starting material. All the synthesized products are evaluated for their antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporium and Trichoderma viride and antibacterial activity against Bacillus substilis, Eschericha coli. Klebsiella pneumoneae and Staphylococcus aureus respectively. The structures of all the synthesized compounds have been determined by their spectral and microanalytical data.

 

 

 

 

 

 

 

S K Sonwane, S D Srivastava* & S K Srivastava

 

 

 

Authors for correspondence are indicated by (*)