Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 47B

NUMBER 8

August 2008

CONTENTS

Papers

 

 

 

1243

Synthesis of mandelic acid derived phthalimides as a new class of anti-inflammatory and antimicrobial agents

In the present study, a new series of 2-(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl) ethyl 2-hydroxy-2-(substituted phenyl) acetates 6a-e have been synthesized from the combination of N-(2-hydroxy ethyl) phthalimide 5 and substituted mandelic acids 2a-e, possessing potent antimicrobial and anti-inflammatory activity.

 

 

 

 

Ravi Varala, Vijay Kotra, M Mujahid Alam,

N Ramesh Kumar, S Ganapaty &

Srinivas R Adapa*

 

 

 

 

 

 

 

1249

Chemical composition of Inula cuspidata C.B. Clarke

Five compounds viz. thymyl isobutyrate 1, thymol 2, 8α-hydroxy presilpheperfolene 3, intermedeol 4 and thymyl isovalerate 5 have been isolated and identified from steam volatile extracts of Inula cuspidata C.B. Clarke.

 

 

 

 

 

C S Mathela*, A Tiwari, R C Padalia &

C S Chanotiya

 

 

 

 

 

 

 

 

 

 

 

 

 

1254

Synthesis of various heterocycles using coumarinyl isothiocyanates

 

 

 

 

 

 

 

 

 

 

 

 

Sagar A Mayekar & Vinata V Mulwad*

 

 

 

 

 

 

1260

Synthesis and biological activities of new hydroxy-3-pyrazolyl-4H-chromen-4-ones and their
o-glucosides

 

A simple method for the synthesis of hydroxy pyrazolyl chromones and conversion to their corresponding o-b-d-glucopyranosyloxy pyrazolyl chromones is described.

 

 

 

 

 

 

 

 

K M Hatzade, V S Taile, P K Gaidhane, A G M Haldar &

V N Ingle*

 

 

 

 

 

 

 

 

Notes

 

 

1271

Synthesis, characterization and pharmacological studies on some triazolothiadiazines and triazolothiadiazoles containing naphtho[2,1-b]furan

Reaction of naphtho[2,1-b]furan-2-carboxyhydrazide 1 with carbon disulphide and ethanolic potassium hydroxide followed by treating with hydrazine hydrate/phenyl hydrazine yields 4-amino/anilino-5-naphtho[2,1-b] furan - 2 –yl - 4H -1,2,4-triazole-3-thiols 2a,b. These compounds on reaction with chloroacetic acid, carbon disulphide, aromatic aldehydes and carboxylic acids, separately, undergo cycloaddition to produce corresponding triazolothiadi azines/tri azolothiadiazoles. Some of the selected compounds are evaluated for pharmacological activity.

 

 

 

 

K C Ravindra, H M Vagdevi* & V P Vaidya

 

 

 

 

 

 

 

1277

Electrochemical nuclear acetamidation of aromatic compounds at the platinum anode

The nuclear acetamidation of aromatic compounds have been carried out at platinum anode under the process of nuclear oxidation. The removal of electrons from the aromatic π-electron system is achieved by the electrochemical oxidation.

 

 

 

 

Laxmi Kant Sharma, Sanjeev Kumar, Pragati Yadav & R K P Singh*

 

 

 

 

 

 

1281

Synthesis and antiallergy activity of 2-aryl-5-aroylmethylimidazo [1,2-a]quinoxalin-4-one

Quinoxaline-2,3-diones have been alkylated with phenacyl bromides using K2CO3, acetone and PTC to give 1,4-bis(aroylmethyl)quinoxaline-2,3-diones which when refluxed in acetic acid containing ammonium acetate yield the imidazo 1,2-aquinoxalines. Antiallergy activity of these compounds is discussed.

 

 

 

V S Hariharakrishnan*, Kodali Hariprasad, B V Rao & A N Singh

 

 

 

 

 

 

 

 

 

 

1284

Synthesis and in vitro study of novel isoxazolyl benzoimidazolyl benzamides, acrylamides and propionamides as antimicrobial agents

A series of novel 2/3 (1H-benzoimidazol-2-yl)-N-(5-methyl-3-isoxazolyl)benzamides, acrylamides and propion­amides have been synthesized and the antimicrobial activities are evaluated against two Gram-positive and two Gram-negative bacteria and two plant-pathogenic fungi.

 

 

 

 

 

E Rajanarendar*, K Ramu, A Siva Rami Reddy &
Firoz Pasha Shaik

 

 

 

 

 

 

1291

Synthesis of some sulphonamide insect juvenile hormone- Part I

Juvenile hormone analogues containing sulphonamide features has been synthesized and one out of them bearing heterocyclic ring at side chain was further evaluated for its biological activities against potato tuber moth.

 

 

 

 

Pamita Awasthi* & R K Mahajan

 

 

 

 

 

 

 

 

 

 

 

 

 

1298

Alstonoside, a secoiridoid glucoside from Alstonia scholaris

A new secoiridoid glucoside, alstonoside, together with two isoflavone apioglucosides, formononetin 7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside and biochanin A 7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside are isolated form the stems of Alstonia scholaris and their structures elucidated on the basis of detailed 1-dmensional, 2D-NMR and mass spectral data.

 

 

 

 

P Steve Thomas, Anil Kanaujia*,

Dipankar Ghosh, Rajeev Duggar&

Chandra Kant Katiyar

 

 

 

 

 

 

 

1303

Synthesis and biological evaluation of some new 4,5-dihydro-3-(2-aryl-indol-3-yl)-5-(4-chlorophenyl)-N1-phenylpyrazoles

 

 

 

 

Vijai Nath Pathak* , Ragini Gupta &

Neetu Gupta

 

 

 

 

 

 

 

1308

Lipase catalyzed asymmetric synthesis of (R)-melonol

Among three different lipases tested, pig pancreatic lipase (PPL) has been found to be suitable for transesterification of (±)-melonol to afford (R)-melonol with an enatiomeric excess of 94%. Moreover, lipase-catalyzed hydrolysis of (±)-melonol acetate yields (S)-melonol.

 

 

 

 

Sujata Syam, Monica D Rane & Sujata V Bhat*

 

 

 

 

Authors for correspondence are indicated by (*)