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Indian Journal of Chemistry |
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Sect. B: Organic Chemistry including Medicinal Chemistry Total visitors: 61 since 08-01-08 |
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VOL. 47B |
NUMBER 1 |
January
2008 |
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CONTENTS
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Papers
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90 |
Ab initio and DFT investigation of the mechanism and stereochemistry of electrophilic addition |
The mechanism and stereochemistry of the addition reaction to bicyclo [3.2.2]nona-6,8-diene of chlorine are investigated quantum chemically. |
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Rza Abbasoglu*, Yaprak Uygur & Abel Magerramov |
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97 |
Design and
synthesis of non-cytotoxic tetrahydrothieno[3,2-c]pyridine
derivatives exhibiting complement inhibition
activity |
A series of
non-cytotoxic 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine analogues
exhibiting improved complement inhibition
properties (IC50 78 mM) over existing
tetrahydrothieno[3,2-c]pyridine derivatives have been synthesized. |
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Hoshang E Master*, Shabana I Khan & Krishna A Poojari |
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106 |
Synthesis and antitubercular, antiviral and anticancer activity of
3-(3-mercaptoalkyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)chromen-2-one
and its derivatives |
Reaction of various
3-(2-bromoacetyl)coumarins 1 with 4-amino-5-mercapto alkyl-4H-[1,2,4]triazole-3-thiols
2 in anhydrous ethanol furnish corresponding 3-(3-mercaptoalkyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazin-6-yl)chromen-2-ones
3.The compounds 3a-f and 3s-t are further converted into
their thioethers by reaction with phenacyl chloride. |
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P Vijaya Kumar & V
Rajeswar Rao
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112 |
Synthesis and antimicrobial activity of new
isoxazolyl-1,3-benzoxazines |
New isoxazolyl-1,3-benzoxazines are
synthesized from 4-amino-3,5-dimethyl isoxazole by condensation with different
salicylaldehyde, followed by reduction and subsequent smooth ring closure in
presence of formaldehyde. |
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E Rajanarendar*, G Mohan
& A Siva Rami Reddy
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117 |
Synthesis and anti-tuberculosis activity of
2,4-disubstituted quinolines |
Anti-tuberculosis activities of 2,4-disubstituted quinolines
synthesized in six steps from isatin are reported. |
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A Nayyar & R Jain* |
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129 |
Conformational analysis of N1,N5‑diacyltetrahydro‑1,5‑benzodiazepin‑2‑ones
using NMR spectra and semiempirical MO calculations |
The N1,N5‑diacetyl- and N1,N5‑dibenzoyltetrahydro-4-methyl‑1,5‑benzodiazepin‑2‑ones
(4 and 5, respectively) prefer boat conformations BE with endo
orientations of the acyl groups at N1 and exo
orientations of the acyl groups at N5 positions. |
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M Venkatraj*, S Ponnuswamy & R Jeyaraman |
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136 |
Synthesis of condensed pyrimidines and their
evaluation for anti-inflammatory and analgesic activities |
A number of condensed pyrimidine derivatives
1
and
3-8 have
been synthesized by the condensation of
4-isothiocyanato-4-methylpentane-2-one with 1,2 diaminocyclohexane,
3-amino-2-naphthol, 1-amino-2-naphthol hydrochloride, 3-amino-2-naphthoic
acid, 1,3-diamino-2-hydroxypropane and 1,3 diaminoguanidinehydrochloride
respectively. Condensation of 3-isothiocyanatobutanal with 1,
2-diaminocyclohexane and 1,3-diaminoguanidine hydrochloride gives compounds 2 and 9. On anti-inflammatory and analgesic
activity evaluation compounds 1 and 8 exhibit good analgesic activity. |
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Sham M Sondhi*, Shubhi Jain, Amarendra Dhar Dwivedi, Rakesh Shukla &
Ram Raghubir |
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Notes
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144 |
Synthesis of some new
2-(4-alkylthiophenoxy)-4-substituted-1,3-thiazoles as possible anti-inflammatory
and antimicrobial agents |
Some novel 1,3-thiazoles 4a-q, 6a-j containing 4-alkylthio
phenoxy group at position 2 and aryl/substituted alkyl moiety at position 4
have been synthesized from ethyl [4-(alkylthio) phenoxy] acetates. The newly synthesized compounds have been
characterized by IR, 1H and 13C NMR and mass spectral studies. These compounds
have been screened for their anti-inflammatory, antibacterial and antifungal
activity. Preliminary results reveal that some of the tested compounds show
promising biological activity. |
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Karabasanagouda
T, Airody Vasudeva Adhikari*, Ramgopal Dhanwad &G Parameshwarappa |
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153 |
Friedel-Craft reaction in dry media under
microwave irradiation |
Friedel-Craft reaction on aromatic and hetero aromatic compounds
in dry media under microwave irradiation has been carried out successfully
using acid washed montmorillonite K10 clay as well as TLC grade silica gel as
heterogeneous catalyst. This method enhances the rate of the reaction, increases
yields and purity of products. |
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Nirada Devi* & Mausumi Ganguly |
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155 |
Microwave and ultrasound assisted synthesis
of 16-methyl-8(Z)-heptadecenoic and 16-methyl-6(Z)-heptadecenoic
acids |
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Jasamrit Kaur, Irvinder Kaur, Sonu, Goverdhan L Kad & Jasvinder Singh* |
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159 |
Formation and antimicrobial activity of 2-azetidinones from selective ester cleavage in 1,3,3-trisubstituted 4-[2’-(O-diarylacyl)-hydroxyphenyl]-2-azetidinones |
A selective
ester cleavage in the titled compounds using NaOH in EtOH afforded new
2-azetidinones with antibacterial and antifungal activity. |
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G S Singh* &
T Pheko |
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163 |
Nardal,
a new sesquiterpene aldehyde from the plant, Nardostachys jatamansi DC |
Nardal,
a new bicyclic sesquiterpene aldehyde has been reported from Nardostachys jatamansi DC and its
structure has been elucidated based on the spectral data of its 2,4-DNP
derivative and its comparison with known compound. |
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G Venkateswara Rao*, T Annamalai & |
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166 |
Two new clerodane diterpenoid glucosides
and other constituents from the roots of Elsholtzia bodinieri
Van′t |
Two new clerodane
diterpenoid glucosides have been isolated from the roots of Elsholtzia bodinieri Van′t. Their
structures have been elucidated as 6-hydroxy-(-)-hardwickiic acid 2′-β-D-glucopyranosylbenzyl
ester 1 and 6,7-dihydroxy-(-)-hardwickiic
acid 2′-β-D-glucopyranosylbenzyl ester 2 by spectroscopic and
chemical methods. |
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1 R= -H 2 R= -OH |
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Haobin
Hu*, Hong Cao, Yufeng Jian, Xudong Zheng & Jianxin Liu |
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171 |
The synthesis of
some new (1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)
diarylmethanol |
The synthesis of
some new (1-aryl-5-methyl-1H-1,2,3-triazol- 4-yl)diarylmethanol derivatives has
been reported. |
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Heng-Shan Dong*, Guo-Yong
Huo & Zhi-Tao Ma |
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Authors for correspondence are indicated by (*) |
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