Indian Journal of Chemistry
Sect. B: Organic Chemistry including Medicinal Chemistry Total visitors: 1,820  since 14-07-08
VOL. 47B		NUMBER 5		MAY 2008
CONTENTS
Advances in Contemporary Research
721	Retrometabolism based drug targeting- soft drug approach		A soft drug is pharmacologically active as such and it undergoes a predictable and controllable metabolism to non-toxic and inactive metabolites.
	C S Ramaa*, Rhea Mohan, A S Mundada & V J Kadam
Papers
734	Double Michael addition reactions of methyl-3-aryl-2-(Z-styrylsulfonyl)-acrylate		The double Michael addition of active methylene compounds, viz., dimethyl malonate, ethyl cyanoacetate and malononitrile to methyl-3-aryl-2-(Z-styrylsulfonyl)acrylate is described.
	V Padmavathi*, K Sudheer & A Padmaja
740	Biologically active hydroximoyl chlorides as antifungal agents		An approach towards the synthesis ofchlorooximes as novel antifungal agents is reported.
	Tabasum Ismail, Syed Shafi, Parvinder Pal Singh, Naveed Ahmed Qazi, Sanghapal D Sawant, Intzar Ali, Inshad Ali Khan, H M S Kumar*, Ghulam Nabi Qazi & M Sarwar Alam
748	Synthesis of some new 10H-pyrido[3,2-b][1,4] benzothiazine and their ribofuranosides as possible chemotherapeutic agents		N-(2´, 3´, 5´-tri-O-benzoyl-b-d-ribofuranosyl)-8-chloro-7-methyl/7,9-dimethyl/ 8-chloro-9-methyl-3-nitro pyrido [3,2-b][1, 4]benzothiazine have been synthesized by the treatment of 10H-8-chloro-7-methyl/ 7,9-dimethyl/8-chloro-9-methyl-3-nitropyrido[3,2-b][1,4] benzothiazines. The antimicrobial activities of all these derivatives have been accomplished.
	Naresh Kumar & Ashok K Yadav*
753	Synthesis of novel naphtho[2,1-b]furo[3,2-b]pyridine derivatives as potential antimicrobial agents		The compounds 4a,b undergo Friedlander cyclization on treatment with active methylene compounds, and produce title compounds 5a,b, 6a,b and 7a,b. Some other routes for the synthesis of various derivatives of this new heterocycle have been investigated. All the newly synthesized compounds are characterized by elemental analysis, spectral studies, and have been evaluated for antimicrobial activity.
	D Ramesh, C Chandrashekhar & V P Vaidya*
759	Synthesis of some 7-methyl-3-(2-oxo-2H-chromen-3-yl)thiazolo[3,2-a]pyrimidin-5-ones		Reaction of 3-(2-amino-4-thiazolyl)-coumarins with ethyl acetoacetate in a mixture of PPA and POCl3 gave 7-methyl-3-(2-oxo-2H-chromen-3-yl)thiazolo[3,2-a]-pyrimidin-5-ones in a single step.
	P  Vijaya kumar, K Manoher Reddy & V  Rajeswar Rao*
Notes
764	Synthesis of some novel 1, 2, 4-triazolo [4, 3-a] 2H-pyrano [3, 2-e] pyridine derivatives		The compound 2 is prepared by reacting ethyl-5-methyl-6-cyano-7-chloro-2-oxo-2H-pyrano[2,3-b]pyridine-3-carboxylate 1 with hydrazine hydrate at room temperature furnishes 2 with good yield. Condensation of 2 with acids results in the formation of 1-substituted 2H-pyrano [3,2-e][1,2,4]triazolo[4,3-a]pyridine 3, further the hydrazine derivative 2 is transformed to 1-aryl- 2H-pyrano[3,2-e][1,2,4]triazolo[4,3-a]pyridine 4. These compounds are expected to have as better antihypertensive activity.
	N Vasanth Kumar & Uday C Mashelkar*
767	New tandem reactions for the construction of heterocycles via dianion strategy		The reaction of chiral and achiral salen ditopic ligands with sodium in dry isopropanol generates remote O,O-dianions. The dianions thus generated in situ are trapped by suitable phosphorus dielectrophiles to yield 2-oxo and 2-thioxo-1,3,7-dioxazaphospha-decines and 2-oxo and 2-thioxo-1,3,7,10-dioxadiazaphospha-tridecines in moderate to good overall yield. The products are characterized by elemental and spectral (IR, ^1H, ^13C, ^31P NMR and Mass) studies.
	M S Singh*, Pratibha Singh & Pallavi Singh
773	Two new neolignan glycosides from Pteris multifida poir		7S, 8S)-Δ^7^′-2,9′-dihydroxy-5′-methoxy-7,3′-dioxy-8, 4′-neolignan-4-O-β-d-apiofuranosyl-(1→6)-β-d glucopyranoside and (7S, 8S)-Δ^7^′-2,9,9′-trihydroxy- 7,3′-dioxy-8,4′-neolignan-4-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside, named as multifidoside A and B, have been isolated from the roots of Pteris multifida Poir.
	1  R1=H  R2=OMe                   2  R1=OH  R2=H
	Zheng Xu-Dong*, Hu Hao-Bin &Hu Huai-Sheng
778	Reaction of ethyl cyanoacetate with benzal-4-acetylanilines: An unexpected result
	Anjali Sidhu & Mangat Rai*
781	Synthesis, antimicrobial and mosquito larvicidal activity of N-protected amino acid/peptide isoxazoles		A series of N-protected amino acid/peptide isoxazoles 4-12 and 15-16 have been synthesized and the antimicrobial activity  evaluated against three gram positive, three gram negative bacteria and five plant pathogenic fungi. Mosquito larvicidal activity of the newly synthesized compounds is also studied against fourth instar larve Culex quinquefasciatus.
	E Rajanarendar*, G Mohan, E Kalyan Rao, A Siva Rami Reddy, B Praveen & M Srinivasa Rao
787	Synthesis and nematicidal activity of 2-(1H-benzo [d]imidazol-2-ylmethyl)-4-aryl-1-thia-4-azaspiro[4.5] decan-3-one		A series of N-cyclohexylidene-N-phenylamines 3 are prepared by the condensation of cyclohexanone 1 with aryl amine 2, subsequent treatment of 3 with thiomalic acid gave the corresponding 2-(3-oxo-4-aryl-1-thia-4-azaspiro[4.5]dec-2-yl)acetic acid 4, which on reaction with o-phenylenediamine gave 2-(1H-benzo[d]imidazol-2-ylmethyl)-4-aryl-1-thia-4-azaspiro[4.5]decan-3-one 5. The compounds are characterized by IR, ^1H NMR, MS and elemental analyses.  The antibacterial, antifungal and nematicidal activities of the compounds are also evaluated.
	A Srinivas, A Nagaraj & Ch Sanjeeva Reddy*
792	A novel and environmental friendly, one step synthesis of 2,6-diamino-4-phenyl pyrimidine-5-carbonitrile using potassium carbonate in water		A green, simple and environmentally friendly approach towards one-step synthesis of 2,6-diamino-4-phenyl pyrimidine-5-carbonitrile by three-component condensation of aromatic aldehydes, malononitrile and guanidine hydrochloride in aqueous medium using potassium carbonate and in presence of tetrabutyl ammonium bromide has been reported.
	M B Deshmukh*,P V Anbhule, S D Jadhav, S S Jagtap, D R  Patil, S M Salunkhe & S A Sankpal
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