Indian Journal of Chemistry
Sect. B: Organic Chemistry including Medicinal Chemistry Total visitors: 2,036  since 20-10-08
VOL. 47B		NUMBER 10		October 2008
CONTENTS
Papers
1545	An efficient use of microwave-superoxide combination for the synthesis of organic carbamates and dithiocarbamates		The present report demonstrates an efficient use of microwave-tetraethylammonium superoxide combination under non-aqueous conditions to bring about a mild and safe carbamation/thiocarbamation of amines, using carbon dioxide/carbon disulfide and methyl iodide.
	Satish Kumar Singh, Manjusha Verma & Krishna Nand Singh*
1549	Heck reaction over palladium supported on nickel ferrite as an efficient and inexpensive catalyst		The palladium supported on nickel ferrite is found to be a highly active catalyst for the Heck olefination of aryl iodides and activated aryl bromides providing an excellent yield in an aerobic condition, in shorter reaction time.
	Sanjay R Borhade & Suresh B Waghmode*
1555	Synthesis and biological evaluation of some new aryl pyrazol-3-one derivatives as potential hypoglycemic agents		Condensation of various substituted phenylhydrazines 1 with diethylethoxymethylene malonate (DEEM) 2 give new aryl pyrazol-3-one derivatives 3 in a single step. The pyrazol-3-one derivatives are screened for their hypoglycemic activity.
	1 2 3
	Nirupam Das, Abhilasha Verma, Prabhat K Shrivastava & Sushant K Shrivastava*
1559	Design and syntheses of some new diphenylaminoisoxazolines as potent anti-inflammatory agent		QSAR investigation on 3D molecular descriptors in diphenylaminoisoxazolines as anti-inflammatory agents has been reported. Based on this report expectedly potent derivatives are designed, synthesized and screened accordingly.
	B R Dravyakar, D P Kawade, P B Khedekar & K P Bhusari*
	Notes
1568	Aromatization of 1,4-dihydropyridines using tetraethylammonium bromate as an oxidizing agent		Tetraethylammonium bromate has been prepared from the corresponding bromide and the bromate used for the oxidative aromatization of the 1,4-dihydropyridines to the 4-substituted pyridines. Reaction conditions are simple and the yield of the products are high.
	Pranab J Das* & Akashi Baruah
1572	p-Toluenesulfonic acid catalyzed rapid and efficient protocol for one-pot synthesis of α-amino nitriles		A simple, rapid and efficient practical method for one-pot synthesis of α-amino nitriles has been achieved by a three-component condensation of carbonyl compounds, amines and trimethylsilyl cyanide in the presence of p-toluenesulfonic acid (p-TsOH) as a catalyst at ambient temperature. Operational simplicity, economic consideration, high yield, short reaction time and low toxicity are the key features associated with this protocol.
	Ch Sanjeeva Reddy* & M Raghu
1578	Facile ZrCl4 promoted four-component coupling one-pot synthesis of polyhydroquinoline derivatives through unsymmetric Hantzsch reaction		ZrCl4 catalyzed efficient unsymmetric Hantzsch reaction via four-component coupling reaction of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate at ambient temperature is described as the preparation of polyhydroquinoline derivatives. The process presented here is an operationally simple, economic, environmentally benign and provides excellent yield. Furthermore, the catalyst can be recovered conveniently and reused efficiently.
	Ch Sanjeeva Reddy* & M Raghu
1583	Synthesis and biological evaluation of 2-aminobenzothiazole derivatives		As a part of systematic investigation of synthesis and biologically active compounds of 2-amino benzothiazoles, several new [(2"-substituted aryl)-4"-oxo-1", 3"-thiazolidine-3"-iminoacetyl]-2-aminobenzothiazole 5 and [(5"-arylidene-2"-substituted aryl-4"-oxo-1", 3"-thiazolidine)-3"-iminoacetyl]-2-aminobenzothiazole 6 from 2-aminobenzothiazole have been synthesized. All the synthesized products were evaluated for their antibacterial activity against Bacillus substilis, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus and antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporum and Trichoderma viride. The structures of all the synthesized compounds have been determined by spectral and chemical methods.
	S D Srivastava* & J P Sen
1587	Synthesis and β-adrenergic blocking activity of naphthyloxypropylamines		A series of naphthyloxypropanolamines 4a-4l have been synthesized and tested for cardiac b-adrenergic blocking activity on the isolated perfused frog heart model. The compound 4e showed excellent blocking activity, i.e., 100% blockade of adrenaline response.
	Ramya Vattipalli, Prabhakar Y Shirodkar, Rakesh R Somani* & Vilasrao J Kadam
1591	A simplified Cadogan’s approach to synthesis of new isoxazolyl indazoles
	E Rajanarendar*, A Siva Rami Reddy & Firoz Pasha Shaik
1597	Facile syntheses of 4-hydroxy-7-methyl-1-indanone, isolated from cyanobacterium Nostoc commune		Two different high yielding synthetic routes both starting with 6-methylcoumarin 2 have been described to prepare 4-hydroxy-7-methyl-1-indanone 1, a constituent of cyanobacterium Nostoc commune having antibacterial activity.
	Shrivallabh P Kamat*, Jose C Menezes, Bhushan M Siddhaye & Shashikumar K Paknikar
1600	Studies on chemical constituents of Sanguisorba longifolia Bertol		Three new triterpenoids named as Changyediyuine I, Changyediyuine II, and Changyediyuine III have been isolated from the root of Sanguisorba longifolia Bertol (Chinese name Changyediyu berberidaceae), together with ten known compounds and their structures are deduced from spectroscopic methods and 2D NMR techniques.
	Tong Shen*, Yilin He, Gaopan Sun, Wuxia Liu & Shangzhen Zheng
1605	Ab initio molecular orbital and force field calculations on the interaction of daunomycin with GC base-pair and intercalation within DNA
	Rajib L Sarma, Rituraj Kalita, Murshida Karim Bipul Bezbaruah & C Medhi*
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