Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 3,503  since 20-10-08

VOL. 47B

NUMBER 10

October 2008

CONTENTS

Papers

1545

An efficient use of microwave-superoxide combination for the synthesis of organic carbamates and dithiocarbamates

The present report demonstrates an efficient use of microwave-tetraethylammonium superoxide combination under non-aqueous conditions to bring about a mild and safe carbamation/thiocarbamation of amines, using carbon dioxide/carbon disulfide and methyl iodide.

 

 

 

 

 

 

 

 

Satish Kumar Singh, Manjusha Verma &

Krishna Nand Singh*

 

 

 

 

 

 

1549

Heck reaction over palladium supported on nickel ferrite as an efficient and inexpensive catalyst

The palladium supported on nickel ferrite is found to be a highly active catalyst for the Heck olefination of aryl iodides and activated aryl bromides providing an excellent yield in an aerobic condition, in shorter reaction time.

 

 

 

 

 

 

 

 

 

Sanjay R Borhade & Suresh B Waghmode*

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1555

Synthesis and biological evaluation of some new aryl pyrazol-3-one derivatives as potential hypoglycemic agents

 

Condensation of various substituted phenylhydrazines 1 with  diethylethoxymethylene malonate (DEEM) 2 give new aryl pyrazol-3-one derivatives 3 in a single step. The pyrazol-3-one derivatives are screened for their hypoglycemic activity.

 

 

 

 

1

 

2

 

3

 

 

 

 

Nirupam Das, Abhilasha Verma, Prabhat K Shrivastava &

Sushant K Shrivastava*

 

 

 

 

 

 

 

1559

Design and syntheses of some new diphenyl­aminoisoxazolines as potent anti-inflam­matory agent

 

QSAR investigation on 3D molecular descriptors in diphenylaminoisoxazolines as anti-inflammatory agents has been reported. Based on this report expectedly potent derivatives are designed, synthesized and screened accordingly.

 

 

 

 

 

 

B R Dravyakar, D P Kawade, P B Khedekar &

K P Bhusari*

 

 

 

 

 

 

 

Notes

 

 

1568

Aromatization of 1,4-dihydropyridines using tetraethylammonium bromate as an oxidizing agent

 

Tetraethylammonium bromate has been prepared from the corresponding bromide and the  bromate  used for the oxidative aromatization of  the  1,4-dihydropyridines to the 4-substituted pyridines.  Reaction  conditions  are simple and the yield of the products are high.

 

 

 

 

Pranab J Das* & Akashi Baruah

 

 

 

 

 

 

 

1572

p-Toluenesulfonic acid catalyzed rapid and efficient protocol for one-pot synthesis of
α-amino nitriles

 

A simple, rapid and efficient practical method for one-pot synthesis of α-amino nitriles has been achieved by a three-component condensation of carbonyl compounds, amines and trimethylsilyl cyanide in the presence of p-toluene­sulfonic acid (p-TsOH) as a catalyst at ambient tempe­rature. Operational simplicity, economic consideration, high yield, short reaction time and low toxicity are the key features associated with this protocol.

 

 

 

Ch Sanjeeva Reddy* & M Raghu

 

 

 

 

 

 

1578

Facile ZrCl4 promoted four-component coupling one-pot synthesis of polyhydroquinoline derivatives through unsymmetric Hantzsch reaction

 

ZrCl4 catalyzed efficient unsymmetric Hantzsch reaction via four-component coupling reaction of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate at ambient temperature is described as the preparation of polyhydroquinoline derivatives. The process presented here is an operationally simple, economic, environmentally benign and provides excellent yield. Furthermore, the catalyst can be recovered conveniently and reused efficiently.

 

 

 

Ch Sanjeeva Reddy* & M Raghu

 

 

 

 

 

 

 

 

 

1583

Synthesis and biological evaluation of 2-amino­benzo­thiazole derivatives

 

As a part of systematic investigation of synthesis and biologically active compounds of 2-amino benzothiazoles, several new [(2"-substituted aryl)-4"-oxo-1", 3"-thia­zolidine-3"-iminoacetyl]-2-aminobenzothiazole 5 and [(5"-arylidene-2"-substituted aryl-4"-oxo-1", 3"-thia­zoli­dine)-3"-iminoacetyl]-2-aminobenzothiazole 6 from 2-amino­benzo­thiazole have been synthesized. All the synthesized products were evaluated for their antibacterial activity against Bacillus substilis, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus and antifungal activity against Aspergillus niger, Aspergillus flavus, Fusarium oxisporum and Trichoderma viride. The structures of all the synthesized compounds have been determined by spectral and chemical methods.

 

 

 

 

 

 

 

S D Srivastava* & J P Sen

 

 

 

 

 

 

 

1587

Synthesis and β-adrenergic blocking activity of naphthyloxypropylamines

 

A series of naphthyloxypropanolamines 4a-4l have been synthesized and tested for cardiac b-adrenergic blocking activity on the isolated perfused frog heart model. The compound 4e showed excellent blocking activity, i.e., 100% blockade of adrenaline response.

 

 

 

 

 

Ramya Vattipalli, Prabhakar Y Shirodkar,

Rakesh R Somani* & Vilasrao J Kadam

 

 

 

 

 

 

 

 

 

 

 

 

 

1591

A simplified Cadogan’s approach to synthesis of new isoxazolyl indazoles

 

 

 

 

 

 

 

 

 

 

E Rajanarendar*, A Siva Rami Reddy &

Firoz Pasha Shaik

 

 

 

 

 

 

 

 

1597

Facile syntheses of 4-hydroxy-7-methyl-1-inda­none, isolated from cyanobacterium Nostoc commune

 

Two different high yielding synthetic routes both starting with 6-methylcoumarin 2 have been described to prepare 4-hydroxy-7-methyl-1-indanone 1, a constituent of cyano­bacterium Nostoc commune having antibacterial activity.

 

 

 

 

 

 

 

 

 

 

 

Shrivallabh P Kamat*, Jose C Menezes,
Bhushan M Siddhaye & Shashikumar K Paknikar

 

 

 

 

 

 

 

 

 

 

 

 

 

1600

Studies on chemical constituents of Sanguisorba longifolia Bertol

 

Three new triterpenoids named as Changyediyuine I, Changyediyuine II, and Changyediyuine III have been isolated from the root of Sanguisorba longifolia Bertol (Chinese name Changyediyu berberidaceae), together with ten known compounds and their structures are deduced from spectroscopic methods and 2D NMR techniques.

 

 

 

 

Tong Shen*, Yilin He, Gaopan Sun, Wuxia Liu &

Shangzhen Zheng

 

 

 

 

 

 

 

1605

Ab initio molecular orbital and force field calculations on the interaction of daunomycin with GC base-pair and intercalation within DNA

 

 

 

 

 

 

 

Rajib L Sarma, Rituraj Kalita, Murshida Karim
Bipul Bezbaruah & C Medhi*

 

 

 

 

 

 

Authors for correspondence are indicated by (*)