Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 4,147  since 05-09-08

VOL. 47B

NUMBER 9

September 2008

CONTENTS

Papers

 

 

 

1397

Synthesis of biologically active 3-(2-oxo-2H-benzopyran-6-yl)-2-(-2-oxo-2H-benzopyran-6-ylimino)-thiazolidin-4-one and its derivatives

 

 

 

 

 

Vinata V Mulwad* & Sagar A Mayekar

 

 

 

 

 

 

 

 

1402

A mild and versatile synthesis of bis(indolyl)­methanes and tris(indolyl)alkanes catalyzed by antimony trichloride

 

Antimony trichloride is found to be a mild and efficient catalyst for electrophilic substitution reaction of indole derivatives with a variety of carbonyl compounds in acetonitrile to afford the corresponding bis(indolyl)-methane in excellent yield. a,b-Unsaturated aldehydes give tris(indolyl)alkane under the same reaction condition.

 

 

 

 

 

Pradip Kundu & Gourhari Maiti*

 

 

 

 

 

 

 

 

 

 

 

 

 

1407

The reactions of polyhalogenated-2-nitro-1,3-butadiene with alkylthio, thiomorpholine and piperazine derivatives

 

Mono(thio)substituted-1,3-nitrodiene compounds 3a-c give 5a, 5c, 7a, 7c, 9a, 9c, 11a, 11c, 13a, 13b with thiomorpholine 4 and piperazine derivatives 6, 8, 10, 12. The new compound 3a is synthesized from reaction of 1 with 2a. The compound 7b crystallizes in the monolinic crystal system (space group P21/n) with the n-butyl group attached to S1 and C2Cl3 group disordered. The butadiene unit is not completely planar as can be expected if the two double bonds are fully conjugated. The structure has been solved by direct methods by using SHELXS-97 program and refined by using SHELXL-97 to the residul index R1= 0.048.

 

 

 

 

 

 

 

 

Cemil Ibis* & N Gulsah Deniz

 

 

 

 

 

 

 

1414

Enantiospecific synthesis of (+)-trans-a-himachalene via an intramolecular type II carbonyl ene reaction

 

Enantiospecific synthesis of (+)-trans-a-himachalene, starting from (R)-carvone, has been accomplished.

 

 

 

 

 

 

 

 

 

A Srikrishna* & P Ravi Kumar

 

 

 

 

 

 

 

 

 

 

 

 

 

1423

Construction of spiro[4.5]decane via ring-closing metathesis reaction: Formal synthesis of acorone and isoacorones

 

Two approaches for formal synthesis of spirosesquiterpenes acorones have been described.

 

 

 

 

 

 

 

 

A Srikrishna* & M Srinivasa Rao

 

 

 

 

 

Notes

 

 

 

1430

Titanocene(III) chloride mediated radical-induced synthesis of 3,4-disubstituted tetra­hydrofurans: Formal synthesis of (±)-burseran and (±)-dehydrocubebin

 

Sinthesis of 3,4-disubstituted tetrahydrofurans has been achieved via radical  cyclization of epoxides using titanocene(III) chloride (Cp2TiCl) as a transition-metal radical source. The radical initiator (Cp2TiCl) is generated in situ from commercially available titanocene dichloride (Cp2TiCl2) and zinc dust in THF under argon. Formal synthesis of two bioactive lignans, burseran and dehydrocubebin has also been accomplished through the radical technology.

 

 

 

 

 

 

 

 

 

S Jana, M Paira & S C Roy*

 

 

 

 

 

 

 

 

 

 

 

 

 

1435

Synthesis of p-tert-butylcalix[8]arene ether deri­vatives

 

 

 

2a : R = -CH3

2b : R = -C2H5

2c : R = C3H7

2d : R = -C4H9

 

 

 

 

2e : R = -C5H11

2f : R = -C6H13

2g : R = -C8H17

 

 

 

 

Jianmin Yi, Kewen Tang*, Saijin Huang &
Kelong Huang

 

 

 

1438

Synthesis and antibacterial activity of 6-(5-phenyl-[1,3,4]thiadiazol-2-ylamino)-benzopyran-2-ones

 

 

 

 

Sagar A  Mayekar & Vinata V Mulwad*

 

 

 

 

 

 

 

1443

Studies on synthesis of unsymmetrical 2,2˘-bisbenzimidazole sulphides of pharmacological interest

 

The synthesis of 2-(a-thioethyl-2˘-benzimidazolyl)- benzimidazole 3 by alternative routes is described.

 

 

R=H, CH3, OCH3, NO2, Cl

 

 

P K Dubey*, A Naidu, P V V Prasada Reddy,
N D Mahesh Kumar & B George Vineel

 

 

 

 

 

 

 

 

 

 

1447

The structure of Hantzsch coumarin

 

The dimethyl dicoumarin prepared by Hantzsch and Zurcher has been characterized as 4,6-dimethyl-2H,8H-benzo[1,2-b:4,5-b’]dipyran-2,8-dione by unambiguous synthesis of both angular and linear pyranocoumarins by Wittig reaction promoted by clay and comparing them with authentic Hantzch coumarin prepared as described in literature. This is the first record of synthetic proof for the structure of Hantzch coumarin

 

 

 

 

P Ramesh*, Anoop T Das, P Mohandass &

R Nagasathya

 

 

 

 

 

 

 

 

1451

Synthesis and pharmacological activities of novel furobenzopyrone and benzofuran derivatives

 

The reactions of 2-cyanoacetohydrazide and 2'-acetyl -2-cyano-acetohydrazide with each of furobenzopyrone derivatives 1a-d and benzofuran derivatives 10a,b have been studied. The antimicrobial and antiinflammatory activity of the new compounds have also been evaluated.

 

 

 

 

E R El-Sawy*, Kamel H Shaker, A H Mandour,
A Shehab El-Din & M M Abdula

 

 

 

 

 

 

 

 

 

 

 

 

 

1463

An efficient synthesis of 1,5-benzodiazepines catalysed by GaCl3 under solvent free conditions

Various 1,5-benzodiazepine derivatives have been synthesized from o-phenylenediamines and ketones using catalytic amount of GaCl3 (5 mol%) under solvent free conditions. This method is facile, efficient, environmentally benign and affords 1,5-benzodiazepines in excellent yield.

 

 

 

 

Sanjay Kumar & Jagir S Sandhu*

 

 

 

 

 

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