Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 48B

NUMBER 8

August 2009

CONTENTS

Papers

 

 

 

1121

Design, synthesis and antitubercular activity of compounds containing aryl and heteroaryl groups with alkylaminoethyl chains

 

 

 

 

 

 

 

 

Gautam Panda*, Maloy Kumar Parai, Ajay Kumar Srivastava, Vinita Chaturvedi, Y K Manju &
Sudhir Sinha

 

Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India

 

 

 

 

 

 

1128

Synthesis of biologically active novel bis Schiff bases, bis hydrazone and bis guanidine derivatives

 

A number of bis Schiff bases, bis hydrazone derivatives and bis guanidine derivatives have been synthesized. On screening for anti-inflammatory and analgesic activities compounds 3b and 11e have showed anti-inflammatory activity comparable to phenylbutazone. Compound 11e has exhibited analgesic activity comparable to phenylbutazone and compound 3b showed analgesic activity better than phenylbutazone.

 

 

 

 

 

 

 

Sham M Sondhi*, Monica Dinodia, Shubhi Jain & Ashok Kumar

Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India

 

 

 

 

 

 

 

1137

An efficient synthesis of phthalic acid derivatives via three component coupling reaction of ethyl
β-arylcrotonate, DMF.DMA and DMAD

 

A facile synthesis of biaryl systems has been achieved involving three-component coupling reaction of ethyl
β-arylcrotonate, DMF.DMA and electron deficient alkyne. Antibacterial and antifungal activities of a representative biaryl compound are also reported.

 

 

 

 

 

Chandran Prakash, Radhakrishnan Suresh Babu, Arasambattu K Mohanakrishnan*,

Manavalan Arulmani & P Thangavelu Kalaichelvan

 

Department of Organic Chemistry and Centre for Advanced Studies in Botany,
University of Madras, Guindy Campus Chennai 600 025, India

 

 

 

 

 

 

 

1144

Synthesis and characterization of 5-(2-nitro-1-arylpropyl)-4-aryl-1,2,3-selenadiazoles

The synthesis and characterization of new 5-(2-nitro-1-arylpropyl)-4-aryl-1,2,3-selenadiazoles, obtained from the a-functionalised semicarbazones are described. The structures of these compounds have been established by 1H and 13C NMR spectral data.

 

 

 

S Saravanan, A Amuthavalli & S Muthusubramanian*

 

School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India

 

 

 

 

 

 

 

1148

Intramolecular cycloaddition in cyclohexa-2,4-dienone and photochemical reactions: Synthesis of 12-methyl-3-oxa-endo-tricyclo[6.2.2.01,6]dodec-11-en-10-one, and pyran annulated bicycle­[3.3.0]octane and bicyclo[4.2.0]octane frameworks

 

 

 

 

Vishwakarma Singh* & Bharat C Sahu

 

Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400 076, India

 

 

 

 

 

Notes

 

 

 

1156

Synthesis and antimicrobial activity of 3-propene 1,2-benzisoxazole derivatives

 

A convenient and eco-friendly synthesis of 3-propene 1,2-benzisoxazole derivatives has been achieved in high yields. All the compounds have been tested for antibacterial and antifungal activity.

 

 

 

R A Shastri* & J S Varudkar

 

P. G. Department of Chemistry, Milind College of Science, Aurangabad 431 002, India

 

 

 

 

1161

Tetraethylammonium superoxide induced Michael addition of active methylene compounds to chalcones

 

Michael addition of active methylene compounds to chalcones using in-situ generated tetraethylammonium superoxide results in the formation of Michael adducts in 69-84% yield under mild reaction conditions, at room temperature.

 

 

 

 

Raghvendra Singh Raghuvanshi & Krishna Nand Singh*

 

Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India

 

 

 

 

 

 

 

1164

A new aliphatic acid from Achyranthes aspera Linn. Roots

 

A total of six compounds isolated from the ethanol extract of the roots of Achyranthes aspera Linn. (Amaranthaceae) are characterised as strigmasta-5, 22-dien-3-β-ol, trans-13-docasenoic acid, n-hexacosanyl n-decaniate, n-hexacos-17- enoic acid and n-hexacos-11-enoic acid  on basis of spectral data and chemical means, including a new aliphatic acid,
n-hexacos-14-enoic acid which is being reported for the first time from natural and synthetic source.

 

 

 

 

Surendra Kr Sharma*,  Neeru Vasudeva & M Ali

 

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar 125 001, India

 

 

 

1170

Reaction of 3-aminocyclohex-2-en-1-ones with arylidenemalononitriles: Synthesis, characteriza­tion and antimicrobial activity of some new quinoline bearing pyrazole nucleus

 

A new series of quinoline bearing pyrazole nucleus D1-36 have been prepared in one pot by condensing various arylidenemalononitriles A1-3 and 3-aminocyclohex-2-en-1-ones B1-12 in alcohol and in the presence of catalytic amount of piperidine. All the compounds have been characterized by their percentage yield, melting point, elemental analysis, 1H and 13NMR spectra and IR spectra. These compounds have also been screened for their antimicrobial activities.

 

 

 

 

 

 

Nirav K Shah, Manish P Patel & Ranjan G Patel*

 

Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388 120, India

 

 

 

 

 

 

 

1174

Biocatalytic acylation of Efavirenz intermediate:  Unexpected novel product formation

 

An efficient lipase catalyzed biocatalytic method has been developed for the synthesis of Efavirenz analogues (benzoxazine derivative).

 

 

 

 

 

 

Mofazzal Husain*, Saswata Lahiri, Shilpi Tomar, Virinder S Parmar &  Debashish Datta

 

Chemical Research Division, Matrix Laboratories Limited, Plot No 34, A & B Anrich Industrial Estate,

Bollaram, Jinnaram (Mandal) Medak Dist 502 325, India

 

 

 

 

 

 

 

1178

VOSO4-catalyzed Biginelli condensation: An efficient synthesis of dihydro-1H-pyrimidine-2-thione/one and octahydro-2,5-quinazolinedione

 

The three component condensation of an aldehyde 1, urea/thiourea 2 and β-ketoester 3 / dimidone 7 in the presence of a catalytic amount of VOSO4 is disclosed for the synthesis of 3,4-dihydro-1H-pyrimidine-2-thione/one (DHPMs) 4 and octahydro-2,5-quinazolinedione 8 under solvent-free micro­wave irradiation conditions. High yields are achieved even on 1 g scale, while reaction times are considerably shortened compared to conventional heating conditions.

 

 

 

 

 

 

 

 

Ch Sanjeeva Reddy*, M Raghu & A Nagaraj

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

 

1183

Synthesis and characterization of steroidal 5′- formyl [6,7-c] pyrazoles using Vilsmeier-Haack reagent

 

The reaction of steroidal tosylhydrazones 1-3 in DMF-POCl3  under ice-cold conditions afforded steroidal 5′-formyl [6,7-c] pyrazoles 4-6 respectively.

 

 

4-6

 

 

 

 

Shamsuzzaman*, M Shaheen Khan, Zishan Tabassum & Mahboob Alam

 

Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India

 

 

 

 

 

 

1187

Synthesis of some novel barbituric acid and
1,3-cyclohexanedione based condensed hetero­cycles

 

 

 

 

Anand Sachar, Poonam Gupta, Shallu Gupta & R L Sharma*

 

Department of Chemistry, University of Jammu, Jammu 180 006, India

 

 

 

 

 

 

 

 

Authors for correspondence are indicated by (*)