Indian Journal of Chemistry
Sect. B: Organic Chemistry including Medicinal Chemistry Total visitors: 2,231  since 26-02-09
VOL. 48B		NUMBER 2		February 2009
CONTENTS
Rapid Communication
225	Synthesis of symmetrical and unsymmetrical trisubstituted benzene derivatives through ring-closing alkyne metathesis strategy and depropargylation with various catalysts
	Sambasivarao Kotha*, Deepti Bansal & Ramanatham Vinod Kumar Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai 400 076, India
	Papers
231	Facile, high regio- and chemoselective conversion of epoxides to β-chlorohydrins using chlorodiphenylphosphine under solvent-free conditions		A new method is described for the mild and high regioselective conversion of epoxides to β-chlorohydrins in high yields even in the presence of alcohols, carboxylic acids, oximes, amides, thiols and tetrahydropyranyl ethers using chlorodiphenylphosphine (ClPPh2) under solvent-free and neutral conditions at room temperature and in short reaction times. In addition, some other functional groups such as carbon-carbon double bonds, ester groups and also phenyl ring that are present in the epoxide molecules remain intact in this method.
	R= PhOCH2, CH2=C(CH3)CO2CH2, Ph, (CH3)2CHOCH2,CH2=CHCH2OCH2, ClCH2, C12H25, p-Cl-PhOCH2 or epoxide= cyclohexene oxide
	Ghasem Aghapour*, Asieh Afzali & Fahimeh Salek School of Chemistry, Damghan University of Basic Sciences, Damghan, 3671641167, Iran
237	Novel hybrid natural products derived from solanesol as wound healing agents		A series of hybrid compounds 2a-g, 3a,b, 4a-n have been synthesized from solanesol 1, an acyclic terpenoid alcohol, extracted from tobacco waste. These compounds have been evaluated for antioxidant, angiogenesis and wound healing activity.
	Shefali Srivastava^a, Kanwal Raj*^a, Pratibha Khare^a, Amiya P Bhaduri^a& Ramesh Chander^b, Ram Raghubir^c, K Mahendra^d, C V Narsimha Rao^d & S R Prabhu^d ^aMedicinal Chemistry Division, ^bBiochemistry Division & ^cPharmacology Division, Central Drug Research Institute, Lucknow 226 001, India and ^dCrop Chemistry and Soil Science Department, Central Tobacco Research Institute, Rajahmundry 533 105, India
248	ZrOCl2 catalyzed Baeyer condensation: A facile and efficient synthesis of triarylmethanes under solvent-free conditions		A facile and efficient synthesis of an array of triarylmethanes by the Baeyer condensation of different arylaldehydes carrying activated and deactivated groups and N,N-dimethylaniline using a catalytic amount of ZrOCl2 under solvent-free microwave irradiation conditions is described. Further, the catalytic activity of ZrOCl2 is compared with traditional Lewis acid catalysts and found that this synthetic method has the advantages of excellent yields (70-96%), shorter reaction time (few minutes) and solvent-free conditions.
	Ch Sanjeeva Reddy*, A Nagaraj, A Srinivas & G Purnachandra Reddy Department of Chemistry, Kakatiya University, Warangal 506 009, India
255	Synthesis of 4-hydroxy-3-formylideneamino-1H/methyl/phenylquinolin-2-ones
	B Bhudevi, P Venkata Ramana, Anwita Mudiraj & A Ram Reddy* Department of Chemistry, University College of Science, Osmania University, Hyderabad 500 007, India
261	A convenient one-pot synthesis of series of 3-(2,6-diphenyl-4-pyridyl)hydroquinolin-2-one under microwave irradiation and their antimicrobial activities		A series of 3-(2,6-diphenyl-4-pyridyl) hydroquinolin-2-ones 4a-x are synthesized in high yields by one pot cyclocondensation reactions under Krohnke’s reaction conditions using 2-chloro-3-formyl quinoline 1a-d various acetophenone 2a-f, N-phenacyl- pyridinium chloride 3 in the mixture of ammonium acetate and acetic acid by microwave irradiation.
	Niraj K Ladani, Manish P Patel & Ranjan G Patel* Department of Chemistry, S P University, Vallabh Vidyanagar 388 120, India
267	Synthesis, analgesic and anti-inflammatory activities of bis(indolyl)methanes		A series of bis(indolyl)methanes have been synthesized by stirring a mixture of indole and aldehydes in methanol:water (1:1 v/v) containing catalytic amount of sodium bisulphite at RT. Acute toxicity, analgesic, anti-inflammatory and ulcerogenic activities of the prepared bis(indolyl)methanes are evaluated in vivo in comparison to standard drugs (ibuprofen and indomethacin). In acute toxicity study, no mortality is observed in the tested compounds and compound 3c is found to be safe. All the tested compounds show significant analgesic and anti-inflammatory activity without an ulcerogenic activity. The most active compounds of this series are 3c and 3d.
	Kuppusamy Sujatha^a, Paramasivan T Perumal,^b,*Doraisamy Muralidharan^b & Melani Rajendran^c ^aSri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai 600 116, India ^bOrganic Chemistry Division, Central Leather Research Institute, Adyar, Chennai 600 020, India. ^cDepartment of Anatomy, Sri Ramachandra University, Porur, Chennai 600 116, India
273	Synthesis, anti-inflammatory and analgesic activity evaluation of some pyrimidine derivatives		A number of pyrimidine derivatives are synthesized. These compounds are screened for anti-inflammatory and analgesic activities. Compounds 10 and 14 exhibited good anti- inflammatory activity and compound 11 showed analgesic activity comparable to standard drug ibuprofen.
	Sham M Sondhi^a,*, Monica Dinodia^a, Reshma Rani^a, Rakesh Shukla^b & Ram Raghubir^b ^aDepartment of Chemistry, Indian institute of Technology Roorkee, Roorkee 247 667, India ^bDepartment of Pharmacology, Central Drug Research Institute, Lucknow 226 001, India
	Notes
282	Synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles		Synthesis of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles 4 have been achieved by the reaction of acetophenone 3-(3-chlorophenyl)-1,8-naphthyridin-2-ylhydrazones 3 with Vilsmeier-Haack reagent (POCl3-DMF). The compounds 4 have been screened for their antibacterial activity.
	K Mogilaiah*, K Vidya, S Kavitha & K Shiva Kumar Department of Chemistry, Kakatiya University, Warangal 506 009, India
286	Synthesis of biologically active 4-coumarin-6-yl(amino)-5-coumarin-3-yl-3-phenyl-1,2, 4-oxadiazolines
	Sanket P Chaudhari & Nandini R Pai* Department of Chemistry, D. G. Ruparel College, Senapati Bapat Marg, Mahim, Mumbai 400 016, India
291	Flavones and acridones from Atalantia wightii ^a		Two flavones racemoflavone 1 and atalantoflavone 2 and four acridones atalaphylline 3, 5-hydroxynoracronycin 4, citrusinine-I 5 and citrusinine-II 6 are isolated and identified from Atalantia wightii (leaves) along with a triterpene epi-friedlinol 7.
	Satish Kumar, Kanwal Raj^∗ & Pratibha Khare Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226 001, India
295	ZrCl4 promoted efficient one-pot synthesis of α-amino nitriles		A convenient and efficient one-pot method for the synthesis of a variety of α-amino nitriles from aldehydes, amines and trimethylsilyl cyanide in the presence of a catalytic amount of ZrCl4 at room temperature is described using non-toxic catalyst.
	M Raghu & Ch Sanjeeva Reddy* Department of Chemistry, Kakatiya University, Warangal 506 009, India
301	Microwave assisted facile and efficient synthesis of benzopyran
	A K Tripathi*, S Koul & S C Taneja Bio-Organic Chemistry Section, Indian Institute of Integrative Medicines, (formerly Regional Research Laboratory, CSIR), Jammu 180 001, India
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