Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 4,685  since 26-02-09

VOL. 48B

NUMBER 2

February 2009

CONTENTS

Rapid Communication

 

 

 

225

Synthesis of symmetrical and unsymmetrical trisubstituted benzene derivatives through ring-closing alkyne metathesis strategy and depro­pargyla­tion with various catalysts

 

 

 

Sambasivarao Kotha*, Deepti Bansal & Ramanatham Vinod Kumar

 

Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai 400 076, India

 

 

 

 

Papers

 

 

 

231

Facile, high regio- and chemoselective conversion of epoxides to β-chlorohydrins using chloro­diphenyl­phosphine under solvent-free conditions

 

A new method is described for the mild and high regioselective conversion of epoxides to β-chlorohydrins in high yields even in the presence of alcohols, carboxylic acids, oximes, amides, thiols and tetrahydropyranyl ethers using chloro­diphenyl­phosphine (ClPPh2) under solvent-free and neutral conditions at room temperature and in short reaction times. In addition, some other functional groups such as carbon-carbon double bonds, ester groups and also phenyl ring that are present in the epoxide molecules remain intact in this method.

 

 

R= PhOCH2, CH2=C(CH3)CO2CH2, Ph, (CH3)2CHOCH2,CH2=CHCH2OCH2, ClCH2,
 C12H25, p-Cl-PhOCH2 or epoxide= cyclohexene oxide

 

 

Ghasem Aghapour*, Asieh Afzali & Fahimeh Salek

 

School of Chemistry, Damghan University of Basic Sciences, Damghan, 3671641167, Iran

 

 

 

 

 

 

 

 

 

 

 

 

237

Novel hybrid natural products derived from solanesol as wound healing agents

 

A series of hybrid compounds 2a-g, 3a,b, 4a-n have been synthesized from solanesol 1, an acyclic terpenoid alcohol, extracted from tobacco waste. These compounds have been evaluated for antioxidant, angiogenesis and wound healing activity.

 

 

 

 

 

 

 

 

 

Shefali Srivastavaa, Kanwal Raj*a, Pratibha Kharea, Amiya P Bhaduria & Ramesh Chanderb,

Ram Raghubirc, K Mahendrad, C V Narsimha Raod & S R Prabhud

 

aMedicinal Chemistry Division, bBiochemistry Division & cPharmacology Division, Central Drug Research Institute, Lucknow  226 001, India

and

dCrop Chemistry and Soil Science Department, Central Tobacco Research Institute, Rajahmundry  533 105, India

 

 

 

 

 

 

248

ZrOCl2 catalyzed Baeyer condensation: A facile and efficient synthesis of triarylmethanes under solvent-free conditions

 

A facile and efficient synthesis of an array of triarylmethanes by the Baeyer condensation of different arylaldehydes carrying activated and deactivated groups and N,N-dimethylaniline using a catalytic amount of ZrOCl2 under solvent-free microwave irradiation conditions is described.  Further, the catalytic activity of ZrOCl2 is compared with traditional Lewis acid catalysts and found that this synthetic method has the advantages of excellent yields (70-96%), shorter reaction time (few minutes) and solvent-free conditions. 

 

 

 

 

 

 

 

Ch Sanjeeva Reddy*, A Nagaraj, A Srinivas & G Purnachandra Reddy

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

 

 

 

 

 

255

Synthesis of 4-hydroxy-3-formylideneamino-1H/methyl/phenylquinolin-2-ones

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

B Bhudevi, P Venkata Ramana, Anwita Mudiraj & A Ram Reddy*

 

Department of Chemistry, University College of Science, Osmania University, Hyderabad 500 007, India

 

 

 

 

 

261

A convenient one-pot synthesis of series of 3-(2,6-diphenyl-4-pyridyl)hydroquinolin-2-one under micro­wave irradiation and their antimicrobial activities

 

A series of 3-(2,6-diphenyl-4-pyridyl)  hydroquinolin-2-ones 4a-x are synthesized in high yields by one pot cyclo­condensation reactions under  Krohnke’s reaction conditions using  2-chloro-3-formyl quinoline 1a-d various acetophenone 2a-f, N-phenacyl- pyridinium chloride 3 in the mixture of  ammonium acetate and acetic acid by  microwave irradiation.

 

 

 

 

 

 

 

 

 

 

Niraj K Ladani, Manish P Patel & Ranjan G Patel*

 

Department of Chemistry, S P University, Vallabh Vidyanagar 388 120, India

 

 

 

 

 

 

 

 

 

 

 

 

 

267

Synthesis, analgesic and anti-inflammatory acti­vities of bis(indolyl)methanes

A series of bis(indolyl)methanes have been synthesized by stirring a mixture of indole and aldehydes in methanol:water (1:1 v/v) containing catalytic amount of sodium bisulphite at RT. Acute toxicity, analgesic, anti-inflammatory and ulcerogenic activities of the prepared bis(indolyl)methanes are evaluated in vivo in comparison to standard drugs (ibuprofen and indomethacin). In acute toxicity study, no mortality is observed in the tested compounds and compound 3c is found to be safe. All the tested compounds show significant analgesic and anti-inflammatory activity without an ulcerogenic activity. The most active compounds of this series are 3c and 3d.

 

 

 

 

 

 

 

 

Kuppusamy Sujathaa, Paramasivan T Perumal,b,*Doraisamy Muralidharanb & Melani Rajendranc

 

aSri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai 600 116, India

bOrganic Chemistry Division, Central Leather Research Institute, Adyar, Chennai 600 020, India.

cDepartment of Anatomy, Sri Ramachandra University, Porur, Chennai 600 116, India

 

 

 

 

 

 

273

Synthesis, anti-inflammatory and analgesic activity evaluation of some pyrimidine derivatives

A number of pyrimidine derivatives are synthesized. These compounds are screened for anti-inflammatory and analgesic activities. Compounds 10 and 14 exhibited good anti- inflammatory activity and compound 11 showed analgesic activity comparable to standard drug ibuprofen.

 

 

 

 

 

 

 

 

 

 

 

Sham M Sondhia,*, Monica Dinodiaa, Reshma Rania, Rakesh Shuklab & Ram Raghubirb

 

aDepartment of Chemistry, Indian institute of Technology Roorkee, Roorkee 247 667, India

bDepartment of Pharmacology, Central Drug Research Institute, Lucknow 226 001, India

 

 

 

 

 

 

Notes

 

 

 

282

Synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles

 

Synthesis of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naph­thy­ridin-2-yl]pyrazoles 4 have been achieved by the reaction of acetophenone 3-(3-chlorophenyl)-1,8-naphthyridin-2-ylhydra­zones 3 with Vilsmeier-Haack reagent (POCl3-DMF).  The compounds 4 have been screened for their antibacterial activity.

 

 

 

 

 

K Mogilaiah*, K Vidya, S Kavitha & K Shiva Kumar

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

286

Synthesis of biologically active 4-coumarin-6-yl(amino)-5-coumarin-3-yl-3-phenyl-1,2, 4-oxa­dia­zolines

 

 

 

 

 

 

 

 

 

Sanket P Chaudhari & Nandini R Pai*

 

Department of Chemistry, D. G. Ruparel College, Senapati Bapat Marg, Mahim, Mumbai 400 016, India

 

 

 

 

 

 

 

 

 

 

 

 

291

Flavones and acridones from Atalan­tia wightii a

 

Two flavones racemoflavone 1 and atalantoflavone 2 and four acridones atalaphylline 3, 5-hydroxynoracronycin 4, citrusi­nine-I 5 and citrusinine-II 6 are isolated and identified from Atalantia wightii (leaves) along with a triterpene epi-friedlinol 7.

 

 

Satish Kumar, Kanwal Raj & Pratibha Khare

 

Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226 001, India

 

 

 

 

 

 

295

ZrCl4 promoted efficient one-pot synthesis of α-amino nitriles

 

A convenient and efficient one-pot method for the synthesis of a variety of α-amino nitriles from aldehydes, amines and trimethylsilyl cyanide in the presence of a catalytic amount of ZrCl4 at room temperature is described using non-toxic catalyst.

 

 

M Raghu & Ch Sanjeeva Reddy*

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

301

Microwave assisted facile and efficient synthesis of benzopyran

 

 

 

A K Tripathi*, S Koul & S C Taneja

Bio-Organic Chemistry Section, Indian Institute of Integrative Medicines,
(formerly Regional Research Laboratory, CSIR), Jammu 180 001, India

 

 

 

Authors for correspondence are indicated by (*)