Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 5,781  since 23-01-09

VOL. 48B

NUMBER 1

January 2009

CONTENTS

Papers

 

 

 

83

New antifungal triterpenoid saponin from Launaea pinnatifida Cass.

 

A new antifungal triterpenoid saponin (compound 1) 3β-O-[α-L-rhamnopyranosyl-(1→3)-O-α-L-arabinopyranosyl-(1→3)-O-β-D-galactopyranosyl]-spergulatriol along with known compounds glutenol and hopenol-b has been isolated from the methanol soluble fraction of the defatted seeds of the plant.

 

 

 

 

 

R N Yadava* & N Chakravarti

 

 

 

 

 

 

88

Synthesis and in vitro study of biological activity of heterocyclic N-Mannich bases

Three series of N-Mannich bases of 3,4-dihydropyrimidine-2(1H)-ones (DHPMs) 7a-g, 8a-g and 9a-g have been prepared by Mannich reaction of three DHPMs derivatives 4a, 4b and 4c respectively with seven different heterocyclic secondary amino compounds 6a-g and formaldehyde 5. All the three series of N-Mannich bases have been analyzed with a view to elucidate their elemental analysis and spectral studies (FTIR, 1H NMR). They have been assayed in vitro for their antimicrobial activity.

 

 

 

 

 

T B Shah*, A Gupte, M R Patel, V S Chaudhari, H Patel & V C Patel

 

 

 

 

 

 

97

Substituted 1,2,4-triazoles and thiazolidinones from fatty acids: Spectral characterization and antimicrobial activity

Fatty hydrazides are reacted with phenyl isothiocynate to give thiosemicarbazides followed by cyclization to furnish 1,2,4-triazoles and thiazolidinones in moderate yield.

 

 

 

 

 

 

Mudasir Rashid Banday & Abdul Rauf *

 

 

 

 

 

 

103

Conformational studies of nonapeptide using NMR

The study of conformation of nonapeptide Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val (YMDGTMSQV), capable of being recognized by melanoma specific T-cells, corresponds to residue 369 to 377 of tyrosenase gene has been carried out. Secondary structures have been obtained by 1H NMR and molecular dynamic simulation using CSI values, 2D COSY, NOESY and ROESY.  

 

 

 

 

 

Jalaj Tripathi*, Prashant Desai, Sudha Srivastava & Evans Cuthino

 

 

 

 

110

Conformational study of N‑acyl‑r-2‑c-4‑diphenyl‑3‑ azabicyclo[3.3.1]nonanes and N3,N7‑diformyl‑r-2,c-4,t-6,t-8‑tetraphenyl‑3,7-diazabicyclo[3.3.1]nonane by NMR spectroscopy and semi-empirical molecular orbital calculations   

The stereochemistry and stereodynamics of N‑chloroacetyl‑ and N‑benzoyl-r‑2,c‑4‑ diphenyl‑3‑azabicyclo[3.3.1]nonanes and N3,N7‑diformyl‑r‑2,c‑4,t‑6,t‑8-tetraphenyl‑ 3,7‑diazabicyclo-[3.3.1]nonane  have been studied using NMR spectral techniques and semi-empirical calculations.

 

 

 

 

 

 

 

M Venkatraj*, S Ponnuswamy  & R Jeyaraman

 

 

 

 

Notes

 

 

120

H3PW12O40 catalyzed efficient synthesis of

4-substituted coumarins

 

 

 

 

 

B China Raju*,T Hari Babu & J Madhusudana Rao

 

 

 

 

 

 

124

Synthesis and plant growth regulatory activity of o-nitrobenzoylthiourea derivatives

A series of o-nitrobenzoylthiourea derivatives have been synthesized in high yields. Some of the compounds have considerable wheat growth promoting activities.

 

 

 

 

 

 

Qi Lin, Hong Yao, Tai-Bao Wei & You-Ming Zhang* 

 

 

 

 

 

 

128

Synthesis and antimicrobial screening of 4H-2-benzoyl-3-hydroxy-3-methyl-2-phenyl 2,3-dihydro-furo[3,2-c]benzopyran-4-one and  4H-3-methyl-2-phenyl furo[3,2-c]benzopyran-4-one

A facile synthesis of biologically active 4H- 2-benzoyl-3-hydroxy-3-methyl-2-phenyl 2,3-dihydro-furo[3,2-c]benzo-pyran-4-one and  4H-3-methyl-2-phenylfuro[3,2-c]benzo-pyran-4-one from 3-acetyl-4-hydroxy 2H[1]benzopyran 2-one through acid catalysed 1,2-elimination is presented.

 

 

 

 

 

V V Mulwad* & A S Hegde

 

 

 

134

Tungstate-catalysed oxidation of triptans with  hydrogen peroxide: A novel method for the synthesis of N,N-dimethyltryptamine N-oxides

 

Synthetic method of important metabolites N,N-dimethyl-2-[5-[substituted-1H-indole-3-yl]ethanamine-N-oxides 8a-d of triptans 1-4 and their spectral data is reported.

 

 

 

 

 

 

 

Purna Chandra Ray*, Vasantha Mittapelli,
Yogendra Kumar Chauhan, Babu Rao Konudula & Om Dutt Tyagi

 

 

 

 

 

 

137

Synthesis and antimicrobial screening of 5-benzylidine-2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one and its derivatives

 

 

 

 

 

 

 

 

 

Vinata V Mulwad* , Abid Ali Mir & Hitesh T Parmar

 

 

 

 

 

 

142

Synthesis of Schiff’s bases of 8-methyltetra-zolo[1,5-a]quinoline as potential anti-inflam-matory and antimicrobial agents

 

 

 

 

 

 

 

 

 

Sandhya Bawa* & Suresh Kumar

 

 

 

 

 

 

 

146

Synthesis of functionalized diaryl alkanes from azines

 

Substituted diaryl alkanes are synthesized from benzalazines and acetophenone/propiophenone azines via Friedel Craft`s reaction with substituted mono- and poly-nuclear aromatic hydrocarbons. Diaryl methanes/ethanes and propanes are obtained by reaction with benzalazine, N,N'-bis(1-phenyl) azine and N,N'-bis(1-propyl)azine, respectively.

 

 

 

 

 

 

 

Rudolf M Manih & Bekington Myrboh*

 

 

 

 

 

 

152

A one pot method of conversion of aldehydes into nitriles using iodine in ammonia water: Synthesis of 2-chloro-3-cyanoquinolines

One pot rapid transformations of heteroaromatic carbaldehyde to cyano group by using cheap and easily available iodine and ammonia water has been described.

 

 

 

 

 

 

Shraddha Upadhyay, Atish Chandra & R M Singh*

 

 

 

 

Authors for correspondence are indicated by (*)