Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 48B

NUMBER 6

June  2009

CONTENTS

Papers

 

 

 

825

1H, 13C, 2D NMR and GCMS characterization of diol derivatives

Isocoumarnarins react with sodium borohydride to afford structurally diverse diols in two steps. Structure is confirmed by two dimensional NMR and GCMS analysis.

 

 

 

 

 

P Manivel & F Nawaz Khan*

 

Chemistry Division, School of Science and Humanities, VIT- University, Vellore 632 014, India

 

 

 

 

 

 

833

Synthesis and antimicrobial activity of some new cyanopyridine and cyanopyrans towards Myco­bacterium tuberculosis and other micro­organisms

 

2-Amino-3-cyano-6-(3,5-dibromo-4-methoxyphenyl)-4-aryl-pyridines 2a-i are synthesized by the reaction of compounds (2E)-3-(3,5-dibromo-4-methoxyphenyl)-1-arylprop-2-en-1-one 1a-i with malononitrile in the presence of ammonium acetate. Condensation of compounds 1a-i with malononitrile in pyridine has yielded 2-amino-3-cyano-6-(3,5-dibromo-4-methoxyphenyl)-4-arylpyrans 3a-i. The constitution of all the synthesized compounds have been established by elemental analyses, IR, 1H NMR, and mass spectral data. All the compounds are screened for their antitubercular and antimicrobial activities.

 

 

 

D H Vyas, S D Tala, J D Akbari, M F Dhaduk,

K A Joshi & H S Joshi*

 

Department of Chemistry, Saurashtra University, Rajkot 360 005, India

 

 

 

 

 

 

 

840

Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines

 

 

 

 

 

 

 

 

 

 

P Mani Chandrika, T Yakaiah, B Narsaiah*, V Sridhar,

G Venugopal, J Venkateshwara Rao, K Pranay Kumar,

U S N Murthy & A Raghu Ram Rao

 

Medicinal Chemistry Research Division, University College of Pharmaceutical

Sciences, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

 

848

Synthesis of blocked trisaccharide analogue related to the repeating unit of the O-antigen from E. coli : 025

 

 

 

 

 

 

 

 

Jayant Srivastava, Anakshi Khare & Naveen K Khare*

 

Department of Chemistry, University of Lucknow, Lucknow 226 007, India

 

 

 

 

 

 

853

Novel synthesis and biological activity study of pyrimido[2,1-b] benzothiazoles

 

A convenient and apparently simple procedure has been developed to prepare a series of substituted pyrimido [2,1-b] benzothiazoles by the conjugate addition of the imino nitrogen of 2-aminobenzothiazoles to alkyne b-carbon atom of acetylenic acid followed by ring closure. Owing to the biological importance of synthesized compounds, they are screened for antimicrobial activity and found to exhibit significant activities.

 

 

 

 

 

 

 

 

 

 

 

Shikha Gupta*, Neha Ajmera, Naveen Gautam,

Rajni Sharma* & D C Gautam

 

 

aDepartment of Chemistry, University of Rajasthan, Jaipur, 302 004, India

 

 

 

 

 

 

858

A facile preparation of methyl indolylacetates via Stille carbonylation of N-protected bromomethylindoles

 

A systematic study on carbonylation of N-protected bromomethylindoles using different types of Pd catalysts and bases under Stille condition has been explored.

 

 

 

 

 

 

 

 

 

 

Neelamegam Ramesh, Vasudevan Dhayalan,
Radhakrishnan Sureshbabu & Arasambattu K Mohanakrishnan*

 

 

Department of Organic Chemistry, University of Madras, Guindy Campus

Chennai 600 025, India

 

 

 

 

 

 

 

865

Study of catalytic activity of ammonium di­hydrogen orthophosphate in the synthesis of 3,4-dihydropyrimidin-2-(1H)-one

 

Application of ammonium dihydrogen orthophosphate as a catalyst in the one pot synthesis of 5-ethoxycarbonyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2-(1H)-one by Biginelli condensation is reported for the first time.

 

 

 

 

 

N Ramatchandiran, S Sumathi & G Buvaneswari*

 

Materials Division - Chemistry, School of Science and Humanities, VIT University, Vellore 632 014, India

 

 

 

 

 

 

 

868

Facile and efficient synthesis of 1,3,4-oxadiazolyl 1,8-naphthyridines under microwave irradiation

 

An efficient and convenient method is described for the synthesis of 1-(5-aryl-[1,3,4]oxadiazol-2-yl-methyl)-3-(3-trifloromethylphenyl)-1H-[1,8]-naphthyridin-2-ones 5, by the oxidation of [2-oxo-3-(3-trifluoromethylphenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid arylidenehydrazides 4 with PhI(OAc)2 under microwave irradiation in solvent-free conditions.

 

 

 

 

 

K Mogilaiah*, H Sharath Babu & R Shiva Prasad

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

Notes

873

One pot synthesis of some novel 2,4-diaryl-6-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)pyridine deri­vatives

 

New 2,4-diaryl-6-(5-methyl-1-p-tolyl-1H-1,2,3-triazol-4-yl)­pyridine deri­vatives have been prepared and characterized.

 

 

 

Zi-Ping Cao, Wang-Jun Dong & Heng-Shan Dong*

 

State Key Laboratory of Applied Organic Chemistry,

Institute of Organic Chemistry, College of Chemistry and Chemical Engineering,

Lanzhou University, Lanzhou, Gansu 730 000, People’s Republic of China

 

 

 

 

 

 

 

877

2-(2-Alkylamino-4-aminothiazol-5-oyl)-N-methyl­benzimidazoles: Synthesis and the effect of intra molecular H-bonding in 1H NMR

Synthesis and characterization of 2-(2-alkylamino-4-aminothiazol-5-oyl)-N-methylbenzimidazoles, as the analogs of dendrodoine are described. The two signals in the 1H NMR spectrum arising from the NH2 hydrogens due to intramolecular H-bonding is also explained.

 

 

 

 

 

 

T F Abbs Fen Reji* & K N Rajasekharan

 

Department of Chemistry, Nesamony Memorial Christian College, Marthandam 629 165, India

 

 

 

 

 

 

 

882

Solvent free Stobbe condensation: A green approach

 

Solvent-free Stobbe condensation of the esters, methyl β benzoyl propionate methyl β naphthoyl propionate and dimethyl succinate with different aldehydes and ketones have been studied under green context.

 

 

 

 

Shubhra Banerjee*, Ravibabu A Tayde & Bhagyashree D Sharma

 

Department of Chemistry, Institute of Science, Nagpur 440 001, India

 

 

 

 

 

 

 

886

Indium trichloride: A versatile catalyst for the synthesis of fully saturated imidazoles

Ketimines are readily reduced to corresponding vicinal diamines using InCl3 and zinc followed by simple cyclization to fully saturated imidazoles

 

 

 

 

Mazaahir Kidwai*, Priya, Roona Poddar & Kavita Singhal

 

Green Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India

 

 

 

 

893

Effect of structure of diamide-diimide-diamines based on L-methionine on curing behaviour and thermal stability of DGEBA

 

New l-methionine-based diacids containing imide units are synthesized via reaction of dianhydride with l-methionine. A series of diamide-diimide-diamines has been synthesized by activation of obtained diacids with thionyl chloride and then condensation with excess of different aromatic diamines containing ether, methylene and sulfone units via high temperature condensation method.

 

 

 

 

Darshan, Priti Malhotra & A K Narula*

 

School of Basic and Applied Sciences, GGS Indraprastha University, Kashmere Gate, Delhi 110 006, India

 

 

 

 

 

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