Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 48B

NUMBER 5

May 2009

CONTENTS

Papers

 

 

 

685

Photo-reorganization of some 3-alkoxy-2-(alkoxy­phenyl)chromones

 

A photo-reorganization of 3-alkoxy-2-(alkoxyphenyl)­chro­mones to isomeric angular tetracyclic compounds is described. Substituent effect of 3-alkoxy group and the effect of position of alkoxy group in phenyl ring are explained.

 

 

 

 

 

Ramesh C Kamboj*, Urmila Berar, Surinder Berar,

Mandeep Thakur & Satish C Gupta

 

Department of Chemistry, Kurukshetra University, Kurukshetra 136 119, India

 

 

 

 

 

 

692

Photo induced synthesis of methyl derivative of cryptosanguinolentine

 

A simpler method to synthesize the methyl derivative of an alkaloid cryprosanguinolentine is described. 4-Hydroxy-2-methylquinoline is iodized using iodine, potassium iodide and aqueous sodium hydroxide and dehydroxyhalogenated with phosphorous oxychloride. The respective anilinoquinoline is prepared and cyclized by UV irradiation. Upon selective methylation 5,6-dimethyl-5H-indolo[3,2-c]quinoline is produced which is utilized as a DNA intercalating agent.

 

 

 

 

 

P Pitchai, P S Mohan* & R M Gengan

 

Department of Chemistry, Bharathiar University, Coimbatore 641 046, India

 

 

 

 

 

 

 

 

 

 

 

 

 

697

Synthesis and antimicrobial evaluation of some alkoxyphthalimide derivatives of naphthyridine

 

Some 2-{[5-(4-substitutedphenyl)-8,8-dimethyl-6-oxo-6,7,8,9-tetrahydrobenzo­[b][1,8]naphthyridin-10-5H-yl]methoxy}ph­th­ali­mide 4a-e 2-{2-[5-(4-substitutedphenyl)-8,8-dimethyl-6-oxo-6, 7, 8, 9-tetrahydrobenzo[b][1,8]naphthyridin-10-5H-yl]­ethoxy}­phthalimide derivatives 5a-e have been synthesized and screened for antimicrobial activities.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Dinesh Bhambi, Vijay Kumar Salvi, Archita Bapna,

Gangotri Pemawat & G L Talesara*

 

Synthetic Organic Chemistry Laboratory, Department of Chemistry,

M. L. Sukhadia University, Udaipur 313 001, India

 

 

 

 

 

 

 

 

 

 

 

 

 

705

New 2-aminopyridine containing acid anthraquinone dyes, their application and micro­bial studies

 

New 2-aminopyiridine based anthraquinone acid dyes have been synthesized by condensation of bromamine acid with 2-aminopyirdine to produced 1-amino-4-(2-aminopyirdinyl) anthraquinone-2-sulfonic acid which is diazotized and coupled with various naphthalene based acid coupling components to get new series of acid anthraquinone dyes. The dyed fibres showed moderate to very good fastness to light, washing and rubbing. All the dyes have been screened for their antimicrobial activity.

 

 

 

 

                R=Naphthalene base coupling component

 

 

 

Navin B Patel* & Ashok L Patel

 

Department of Chemistry, Veer Narmad South Gujarat University, Surat 395 007, India

 

 

 

 

 

 

712

Microwave-assisted synthesis of some new biquinoline compounds catalyzed by DMAP and their biological activities

 

A series of new biquinoline derivatives 4a-t have been synthesized by reaction of [(2-chloro-3-quinolyl) methylene]methane-1,1-dicarbonitrile 2a-d and 3-arylamino-5,5-dimethyl-cyclohex-2-en-1-one 3a-e under microwave irradiation catalyzed by 4-(N,N-dimethylamino) pyridine (DMAP). The synthesized compounds 4a-t have been screened for their antifungal and antibacterial activity.

 

 

 

Jay P Nirmal, Manish P Patel & Ranjan G Patel*

 

Department of Chemistry, S.P.University, Vallabh Vidyanagar 388 120, India

 

 

 

 

 

 

 

Notes

 

 

718

Synthesis and antimicrobial activity of 4-[5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl]-di­hy­dro­pyridines and 4-[5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl]-3,4-dihydropyrimidin-2-ones

New derivatives of dihydropyridine and  dihydropyrimidone are synthesized by Hantzsch cyclization and modified Bignelli’s cyclization, respectively. The antimicrobial activity of these compounds is also described. The compounds 2a, 3d, 3e and 3f show good activity.

 

 

 

 

Rakesh Kumar*, Sakshi Malik & Ramesh Chandra

 

Department of Chemistry, Kirori Mal College, University of Delhi, Delhi 110 007, India

 

 

 

 

 

 

 

725

Synthesis and antiulcer activity study of 1,4-dihydropyridines and their Mannich bases with sulphanilamide

Synthesis of 1,4-dihydropyridines 1a-e has been performed following Hantzsch pyridine synthesis. Reaction with paraformaldehyde and sulfanilamide yielded 3,5-diethoxycarbonyl-1-[(4′-sulfamoyl-1′-amino methyl) phenyl]-1,4-dihydro-2,6-dimethyl-4-(substituted)-pyridines 2a-e. The antiulcer activity of 1,4-dihydropyridines is enhanced significantly on conjunction with sulfanilamide. Substitution of methoxy group increased the antiulcer potential of the compounds.

 

 

 

B B Subudhi*, P K Panda & D Bhatta

 

School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University,

 Khandagiri, Bhubaneshwar 751 030, India

 

 

 

 

 

 

 

 

 

 

 

 

729

Structural characterization of the O-antigenic polysaccharide from the lipopolysaccharide of Vibrio cholerae O37

 

 

 

 

 

 

Jhuma Ganguly*, Biswa P Choudhury,
G Balakrish Nair & Asish K Sen*

 

Department of Organic Chemistry (Carbohydrate), Indian Institute of Chemical Biology,

4, Raja S. C. Mullick Road, Jadavpur, Kolkata 700 032, India

 

 

 

 

735

Condensation of dimethyl malonate with benzal-4-acetylanilines: A chemoselective reaction

 

 

 

 

Anjali Sidhu & Mangat Rai*

 

Department of Chemistry, Punjab Agricultural University, Ludhiana 141 004 , India

 

 

 

 

 

 

 

737

Synthesis, X-ray diffraction and optical spectral study of benzo-18-crown-6 containing monoazo dyes

 

The 4′-nitrobenzo-18-crown-6 have been reduced by Fe/HCl to give 4′-aminobenzo-18-crown-6. This is diazotized and coupled with different phenols to give the corresponding azo-dyes. X-ray diffraction as well as UV-Vis study of 4′ (β naphthol azo benzo)18-crown-6, dye have been reported.

 

 

 

 

 

M B Deshmukh*, K N Alasundkar, S M Salunkhe, D K Salunkhe,

S A Sankpal, D R Patil & P V Anbhule

 

Department of Chemistry, Shivaji University, Kolhapur 416 004, India

 

 

 

 

 

 

 

 

 

 

 

 

 

741

Synthesis of impurity A in Carvedilol: a
 
b-adrenergic receptor

 

Carvedilol is prepared by different synthetic approaches. Almost in all the approaches the major impurities that are known in the literature A, B, C, D and E which are listed in European pharmacopoeia. In this publication, a description of these impurities and their origins in Carvedilol process are presented along with the preparation of impurity A.

 

 

 

 

G Madhusudhan*, K Chinnam Naidu,

B Anand Kumar, R Satyanarayana & V Balraju

 

Inogent Laboratories Private Limited, A GVK BIO Company, 28A, IDA,

Nacharam, Hyderabad 500 076, India

 

 

 

 

 

 

746

An environmentally benign indium (III) chloride catalysed one-pot synthesis of quinolines

 

A convenient eco-friendly procedure has been developed for the synthesis of quinoline derivatives by a simple one-pot reaction of substituted anilines with b-ketoesters using recyclable indium chloride as catalyst in ethanol.

 

 

 

 

 

Mazaahir Kidwai*, Vikas Bansal, Neeraj Kumar Mishra & Divya Bhatnagar

 

Green Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi 110007, India

 

 

 

 

 

 

749

Microwave assisted rapid and efficient synthesis of new 3-ethoxy-4,6-diaryl-4,5-dihydro-2,1-benzi­so­xazoles

 

A simple, extremely fast and efficient synthesis of new 3-ethoxy-4,6-diaryl-4,5-dihydro-2,1-benzisoxazoles has been achieved under microwave irradiation.

 

 

 

E Rajanarendar*, E Kalyan Rao & S Raju

 

Department of Chemistry, Kakatiya University,
Warangal 506 009, India

 

 

 

 

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