Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 48B

NUMBER 11

November 2009

CONTENTS

Rapid Communication

 

 

 

1543

Novel fluorescence emissions from 3-styrylindoles

Fluorescence emission features of 1-5 in solution and solid-state are described.

 

 

 

 

Anil K Singh* & Abera Asefa

 

Department of Chemistry, Indian Institute of Technology Bombay Powai, Mumbai 400 076, India

 

 

 

 

 

 

Papers

 

 

 

 

 

 

1548

Synthesis and biological activities of new 7-o-b-d-glucopyranosyloxy-3-(3-oxo-3-arylprop-1-enyl)-chromones

A convenient route to synthesize some new medicinally important 7-hydroxy-3-(3-oxo-3-arylprop-1-enyl)-chromones and their o-b-d-glucosides is described.

 

 

 

K M Hatzade, V S Taile, P K Gaidhane, V D Umare, A G M Haldar & V N Ingle*

 

Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, India

 

 

 

 

 

 

 

 

 

 

 

 

1558

Synthesis and antimicrobial screening of 4H-2-acetyl-3-acetyamido furo[3,2-c] benzopyran 4-one, 11H-2,4-dimethyl-3,4-dihydro-3-amino-4-hy­dro­xy-pyrimido [3,2-d]furo [3,2-c] benzopyran-11-one and 4H-2-acetyl-3-(3-methyl-1,2,4-tria­zol-4-yl) furo[3,2-c] benzopyran 4-one

 

 

 

 

 

V V Mulwad* & A S Hegde

Department of Chemistry, The Institute of Science, 15, Madam Cama Road, Mumbai 400 032, India

 

 

 

 

 

 

 

1565

Spectral and single crystal X-ray structure of 4-(4′-methyl) benzylidene amino-5-phenyl-3-merca­pto-1,2,4-triazole and its antimicrobial activity

 

4-(4-Methyl) benzylidene amino-5-phenyl-3-mercapto-1,2,4-triazole (MBPMT) has been synthesized and characterized by spectroscopic analysis and single crystal X-ray diffraction pattern. The antimicrobial activity of MBPMT in DMSO medium is also assessed.

 

 

 

 

Aliya Begum, A V Aparna, B Sireesha, Ch Sarala Devi* & Pallepogu Raghavaiah

 

Department of Chemistry, Nizam College, Osmania University, Basheerbagh, Hyderabad 500 001, India

 

 

 

 

 

 

1571

Evaluation of lipophilicity, antimicrobial activity and mutagenicity of some novel ester prodrugs of metronidazole

 

Various novel aliphatic and aromatic prodrug derivatives of MTZ have been synthesized and reported for their lipophilicity, anaerobic antimicrobial activity and mutagenicity using Ames mutagenicity assay.

 

 

 

Sonal Dubey*, Vinod Jain & G B  Preethi

K.L.E.S’s College of Pharmacy, Rajajinagar, Bangalore  560 010, India

 

 

 

 

 

 

 

 

 

 

 

 

1577

Synthesis of biologically active benzothiazole substi­tuted thiazolidinone derivatives via cycliza­tion of unsymmetrical imines

 

 

 

Arasampattu S Nagarajan, S Kamalraj*, J Muthumary & Boreddy S R Reddy

Industrial Chemistry Laboratory, Central Leather Research Institute, Chennai 600 020, India

 

 

 

 

 

 

 

1583

Synthesis of phthalimido or succinimido-[2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl)ethyl}­ami­no]-1,3-thiazolidin-5-yl]ethanoate and their anti­microbial activities

 

Some phthalimido or succinimido-[2-aryl-4-oxo-3-[{2-oxo-2-(phenothiazin-10-yl) ethyl}amino]-1,3-thiazolidin-5-yl]ethano­ates 6a-h have been synthesized by (chloroacetyl)­phenol­thia­zine 1 through multiple step approach. Synthesized compounds are characterized by analytical and spectral studies and evaluated for antimicrobial activities.

 

 

Vijay Kumar Salvi, Shweta Sharma, Chirag Sharma, Dinesh Bhambi & G L Talesara*

 

Synthetic Organic Chemistry Laboratory, Department of Chemistry, M L Sukhadia University, Udaipur 313 001, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1590

Synthesis of quinoxaline quinones and regio­selectivity in their Diels-Alder cycloadditions

 

 

 

 

 

 

 

 

 

 

 

Gitanjali Sharma, Pankaj Raisinghani, Ignatious Abraham, R T Pardasani* & Tulsi Mukherjee

Department of Chemistry, University of Rajasthan, Jaipur 302 055, India

 

 

 

 

 

 

 

Notes

 

 

 

 

 

 

1597

Study on characterization and degree of esterification of styrene maleic anhydride by some medicines

 

Poly(styrene-co-maleic anhydride) conjugates with phenol based medicinal natural products like 2-methoxy-4-(2-propenyl)-phenol etc. in acetone and dioxane. The hydrolytic and binding behavior of the phenol based medicine was compared with the degree of esterification.

 

 

 

 

 

 

 

 

 

 

Ravish Singh Rajput*, D C Rupainwar, Rama Kant Singh & Amarika Singh

 

Applied Chemistry Division, Institute of Engineering and Technology, Sitapur Road, Lucknow 226 021, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1601

Microwave and conventional techniques for the synthesis of a series of pyrazolo [5,4-d]­pyri­midine derivatives and their antimicrobial screening

 

1-{4′-[(4′′-6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl)) amino]phenyl}-3-methyl-4-(substituted phenyl)-4,5-dihydcrobialropyrazolo[5,4-d]pyrimidin-6-ol 4I-XXX and 1-{4′-[(4′′-6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl)) amino] phenyl}-3-methyl-4-(substitutedphenyl)-4,5-dihydro pyrazolo[5,4-d]pyrimidin-6-thiol 5I-XXX have been synthesized from 1-{4′-[(4′′,6′′-diaryl-(1′′,3′′,5′′-triazin-2′′-yl))amino]phenyl}-3-methyl-2-pyrazolin-5-one 3. Both the reactions have been carried out by conventional and microwave methods. All the synthesized compounds 4I-XXX and 5I-XXX have been tested for their antimicrobial activity and the structures of the synthesized compounds have been established on the basis of elemental analysis and spectral data.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

P B Rana, J A Patel, B D Mistry* & K R Desai

 

Department of Chemistry, B.K.M Science College, Valsad 396 001, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1609

Novel pyrazolopyrones from enol lactones

 

Isomeric pyrazolopyrones 6-9 have been synthesized from one pot and facile condensation of chloroformylpyrazole 1, azidoformylpyrazole 2 with enol lactones 3 and 4 in good yield. The newly synthesized compounds have been characterized by IR, 1H NMR and mass spectral data.

 

 

 

 

Zeba N Siddiqui* & Mohammad Asad

 

Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India

 

 

 

 

 

 

 

1614

Microwave assisted synthesis and antimicrobial activity of some 2-(benzofuran-2-yl)-7-(substi­tu­ted)imidazo[2,1-b]benzothiazoles

 

2-(Benzofuran-2-yl)-7-(substituted) imidazo[2,1-b]benzothia­zo­les have been prepared by condensation of 2-(2-bromo­acetyl)benzofurans and various 2-amino-7-(substituted) benzo­thiazoles under normal thermal condition as well as microwave irradiation. The latter condition for the reaction has been found to be much more efficient in terms of the time and yield. The structures of the compounds 1a-l have been established on the basis of their elemental analysis, IR and 1H NMR spectral data. The antibacterial and antifungal properties of these compounds are described.

 

 

 

 

Rekha Rani & J K Makrandi*

 

Department of Chemistry, Maharshi Dayanand University, Rohtak 124 001, India

 

 

 

 

 

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