Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 48B

NUMBER 10

October 2009

CONTENTS

Papers

 

 

 

1405

Synthesis, antimicrobial and antitubercular activity of some cyclohexenone and indazole derivatives

 

Various cyclohexenone 2a-j and indazole 3a-j derivatives have been synthesized and tested for antitubercular and antimicrobial activity. The structures of the compounds have been assigned by IR, 1H NMR and mass spectroscopy.

 

 

 

 

D H Vyas, S D Tala, J D Akbari M F Dhaduk & H S Joshi*

 

Department of Chemistry, Saurashtra University, Rajkot 360 005, India

 

 

 

 

 

 

 

1411

Study of [1,3] sigmatropic hydrogen migration in thymine, thymidine and thymidylic acid by AM1 method

 

The geometry and electronic structures of thymine, thymidine and thymidylic acid involving [1,3] sigmatropic hydrogen migration in the formation of tautomers have been fully optimized and evaluated by semi-empirical molecular orbital AM1 method. Thermodynamic parameters and mechanistic aspects have been investigated and are discussed.

 

 

Bojja Rajeshwar Rao

 

Environment Cell, E & P Kothagudem Thermal Power Station (O&M), Paloncha 507 115, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1419

A convenient synthesis of 2(2-benzo[b]furo)­indoles and benzofuropyrazoles

 

A short synthesis of benzo[b]furo indolyls 3a-g from 2-acetylbenzofuran 1 in two steps and corresponding pyrazoles 4a-g is described. An interesting scale up procedure for the synthesis of 2-acetylbenzofuran is also reported. This is the first report for the synthesis of benzofuroindolyl biheterocycle via Fischer indole cyclisation in ZnCl2/ CH3CN.

 

 

 

 

 

 

 

B C Goudarshivannanavar, H Jayadevappa & K M Mahadevan*

 

Department of P.G. Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta, 577 451, India

 

 

 

 

 

 

1424

Cu(OTf)2-catalyzed α-halogenation of ketones with 1,3-dichloro-5,5′-dimethylhydantoin and N-bromosuccinimide

 

 

 

 

Arun R Jagdale, Pandurang V Chouthaiwale & Arumugam Sudalai*

 

Chemical Engineering and Process Development Division, National Chemical Laboratory, Pashan Road,
Pune 411 008, India

 

 

 

 

 

 

 

 

 

 

 

 

Notes

 

 

 

 

 

 

1431

Microwave assisted synthesis of some novel pyrimidinones/thiones

 

A facile one pot microwave assisted synthesis and biological activity of a series of 1-substituted-4-aryl-5-ethoxycarbonyl-6-methylpyrimidine-2-one/thione are described.

 

 

 

 

 

 

 

 

 

Satheesha Rai N, Balakrishna Kalluraya*, Lingappa B & Shalini Shenoy

 

Department of Studies in Chemistry, Mangalore University, Mangalagangothri 574 199, India

 

 

 

 

 

 

 

1435

A facile synthesis of new 6-acetamido-3-aroyl-2-styryl chromones

 

New 6-acetamido-3-aroyl-2-styryl chromones have been synthesized for the first time from 6-acetamido-3-aroyl-2-methyl chromones.

 

 

 

 

 

 

 

 

 

 

 

S P Bondge, S R Mahalle, A S Burungale, L R Patil  & R A Mane*

 

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad  431 004, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1438

Synthesis of some new Dab butenolides

Some new Dab butenolides have been synthesized by the  condensation of two g-keto acids, b-(4-acetamido­benzoyl)­acrylic acid and b-(acetamido-3-nitrobenzoyl)acrylic acid with phenols.

 

 

 

 

 

Shailendra Prakash, Veena Joshi & R P Chamoli*

Department of Chemistry, Govt. Post-graduate College, Kotdwara 246 149, India

 

 

 

 

 

 

 

1442

Chalcones, pyrazolines and aminopyrimidines as antibacterial agents

 

2,4–Bis-ethylamino-6-[4'-{3"-(substitutedphenyl/2'"-furanyl)-2"-propenon -1"-yl} phenyl amino]-s-triazine 5a-d have been prepared by treating ketone 4 with different substituted aromatic and heterocyclic aldehydes in the presence of alkali. These chalcones 5a-d on cyclisation with hydrazine hydrate and guanidine nitrate to form pyrazolines 6a-d and aminopyrimidines 7a-d respectively. The structures of the synthesized compounds have  been established on the bases of IR, 1H NMR and elemental analysis. The compounds have been evaluated for antibacterial activity against E. coli,
S. paratyphi-A, S. aureus and B. subtilis .

 

 

 

 

 

Anjani Solankee*, Smruti Lad, Sejal Solankee & Ghanshyam Patel

 

Department of Chemistry, B.K.M.Science College, Valsad 396 001, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1447

Reaction of amines with nitrones derived from chromone-3-carbaldehyde

 

 

 

 

 

 

 

 

 

 

Sourav Maiti, Suman Kalyan Panja & Chandrakanta Bandyopadhyay*

 

Department of Chemistry, R. K. Mission Vivekananda Centenary College, Rahara, Kolkata 700 118, India

 

 

 

 

 

 

 

1453

Synthesis and evaluation of some novel substi­tuted 1,3,4-oxadiazole and pyrazole deriva­tives for antitubercular activity

 

A series of 1,3,4-oxadiazole and pyrazole derivatives have been synthesized and evaluated for antitubercular activity.

 

 

 

 

 

 

 

 

 

Shashikant R Pattan*, P A Rabara, Jayashri S Pattan, A A Bukitagar, V S Wakale & D S Musmade

Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar 413 736, India

 

 

 

 

 

 

 

 

 

 

 

 

1457

Synthesis of 6,7-dihydroxy-3-aryl-5-undecyl-4,1,2-benzoxadiazines

 

Condensation of Embelin 1 with different aromatic acid hydra­zides 2 in glacial acetic acid to give N1-5-hydroxy-6-undecyl-p-benzoaquinon-2-yl)-benzohydrides 3. Reductive cyclization of the product 3 with simultaneous acetylation in situ resulted in the formation of the compound 4 1-N-acetyl-6,7-diacetyl-3-aryl-5-undecyl-4,1,2-benzoxadiazine.

 

 

 

 

 

 

 

 

 

 

 

G Brahmeshwari

 

Department of Chemistry, University Arts and Science College, Subedari, Kakatiya University, |
Warangal 506 001, India

 

 

 

 

 

 

 

1462

Microwave assisted synthesis of 1,3,4-oxadiazolyl 1, 8-naphthyridines under solvent-free conditions using solid support

 

A convient synthesis of 1-(4-acetyl-5-aryl-5-methyl-[1,3, 4]oxadiazol-2-ylmethyl)-3-(4-chloro-phenyl)-1H-[1,8]naph­thy­ridin-2-ones 4, by cyclization of acetophenone [2-oxo-3-(4-chloro-phenyl)-2H-[1, 8]-naphthyridin-1-yl]methylcarbonyl-hydrazones 3 with acetic anhydride using silica gel as solid support under microwave irradition is described.

 

 

 

 

 

 

 

 

 

K Mogilaiah*, T Kumara Swamy, A Vinay Chandra & N Srivani

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1466

Green synthesis of 3-(2-oxo-2H-chromenyl)-1-[3-(4-methoxyphenyl)[1,8]naphthyridin-2-yl]-1H-4-pyra­zolecarbaldehydes under microwave irra­diation

 

POCl3-DMF over silica-gel has been used for the synthesis of 3-(2-oxo-2H-chromenyl)-1-[3-(4-methoxyphenyl][1,8]­naph­th­y­­­r­idin-2-yl)-1H-4-pyrazolecarbaldehydes 4 under microwave irradiation.

 

 

 

K Mogilaiah*, K Jagadeeshwar & R Shiva Prasad

 

Department of Chemistry, Kakatiya University, Warangal 506 009, India

 

 

 

 

 

 

 

1470

Retraction Notice

 

 

 

 

 

Authors for correspondence are indicated by (*)