Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

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VOL. 48B

NUMBER 9

September 2009

CONTENTS

Papers

 

 

 

1261

Simple and convenient methods for synthesis, resolution and application of aminonaphthols

 

The racemic aminonaphthols are obtained in 70-95% yield by simple and straightforward condensation of benzaldehyde, 2-naphthol and 1° or 2° amines in ethanol solvent under refluxing conditions and resolved using l-(+)-tartaric acid or R-(+)-binol/boric acid or dibenzoyl-l-(-)-tartaric acid. The readily accessible chiral aminonaphthols are useful for resolution of important racemic moieties like binol, ibuprofen and mandelic acid.

 

 

 

 

 

 

 

Mariappan Periasamy*, Shaik Anwar & Meda Narsi Reddy

 

School of Chemistry, University of Hyderabad, Central University P. O., Hyderabad 500 046, India

 

 

 

 

 

 

1274

Synthesis and antimicrobial activity of novel ethyl-5-(ethoxycarbonyl)-4-methylthiazol-2-yl-carbamate compounds

 

Different 2 and 5-substituted-4-methylthiazolyl carbamate compounds have been synthesized and screened for their antimicrobial activities.

 

 

 

 

B H M Mruthyunjayaswamy* & S M Basavarajaiah

 

Department of Studies and Research in Chemistry, Gulbarga University, Gulbarga 585 106, India

 

 

 

 

 

 

 

 

 

 

 

 

1279

Design, synthesis and evaluation of diclofenac-antioxidant mutual prodrugs as safer NSAIDs

Diclofenac has been conjugated with different naturally occurring antioxidants having antiulcerogenic properties with the objective of obtaining diclofenac-antioxidant mutual prodrugs as safer NSAIDs, devoid of ulcerogenic side effects.

 

 

 

 

 

 

 

 

 

 

Benu Manon & Pritam D Sharma*

 

University Institute of Pharmaceutical Sciences, Panjab University Chandigarh 160 014, India

 

 

 

 

 

1288

Synthesis of pharmaceutically important 1,3,4-thiadiazole and imidazolinone derivatives as antimicrobials

 

2-Aryl-5-(6′-chloro-1′,3′-benzothiazole-2-yl-amino)-1,3,4-thia­diazoles 2a-j and 4-(4′-arylidene)-2-phenyl-1-(6′-chloro-1′,3′-benzothiazol-2-yl-thiourido)-4,5-dihydroimidazolin-5-ones 3a-e have been synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectral data. All the compounds have been evaluated in vitro for their antimicrobial activities against several microbes and show significant activity.

 

 

 

 

 

 

 

 

 

 

 

Mohd Amir*, Arun Kumar, Israr Ali & S A Khan

 

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, India

 

 

 

 

 

 

 

 

 

 

 

 

1294

Synthesis and conformation of a hexapeptide fragment (3-8) of SPF peptide by NMR and restrained molecular dynamics

 

 

 

 

P N Sunilkumar, C Sadasivan, K S Devaky & M Haridas*

 

Department of Biotechnology and Microbiology, School of Life Sciences, Kannur University,
Thalassery Campus 670 661, India

 

 

 

 

 

 

Notes

 

 

 

 

 

 

1299

Studies on synthesis and plant growth retardant activity of cyclic bis-quaternary salts of ammonia from phthalic acid using conventional and microwave methods

 

 

 

3a: n=1

4a: n=1

3b: n=2

4b: n=2

3c: n=4

4c: n=4

 

Jyoti Bangar* & M L Sharma

 

Department of Chemistry, Punjab Agricultural University, Ludhiana 141 004, India

 

 

 

 

 

 

 

 

 

 

 

 

 

1307

Enzyme catalyzed acylation of 7-hydroxy-4-methyl-2H-chromene-2-one using microwave

 

The reaction of 7-hydroxy-4-methyl-2H-chromene-2-one with different acids are studied under microwave assisted dry media and solution phase as well as conventional heating.

 

 

 

 

Mazaahir Kidwai*, Poonam Mothsra & Roona Poddar

 

Green Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India

 

 

 

 

 

 

 

1311

A facile microwave assisted synthesis of flavones

 

Chalcones on irradiation under microwave in DMSO in presence of catalytic amount of I2 provides flavones in high yield. The corresponding chalcones are obtained by Claisen-Schimdt condensation of aromatic aldehydes with o-hydroxyacetophenone.

 

 

 

 

M J Menezes, S Manjrekar, V Pai, R E Patre & S G Tilve*

 

Department of Chemistry, Goa University, Taliegao Pleateau, Goa 403 206, India.

 

 

 

 

 

 

 

1315

A new reagent for selective reduction of nitro group

 

The nitro group in aromatic nitro and dinitro compounds containing reducible substituents have been selectively and rapidly reduced to corresponding amino or diamino compounds employing hydrazine glyoxylate in the presence of zinc or magnesium powder.

 

 

 

 

B Raju, R Ragul & B N Sivasankar*

 

Department of Chemistry, Government Arts College, Udhagamandalam, The Nilgiris 643 002, India

 

 

 

 

 

 

 

 

 

1319

Synthesis and antioxidant activity of indolyl chromenes

 

A simple and efficient method for the synthesis of indolyl chromenes 4a-h has been accomplished by the one-pot three-component reaction of salicylaldehyde and malononitrile with indole catalyzed by L-proline in water. All the synthesized compounds are evaluated for antioxidant activity. All of the compounds 4a-h have exhibited excellent free radical scavenging activity and found to be more potent than the standard. Compounds 4b-c and 4h have showed very high reducing power.

 

 

 

 

 

 

 

 

 

 

Gnanamani Shanthi, Paramasivan T Perumal*, Urmila Rao & Praveen Kumar Sehgal

 

Organic Chemistry Division, Central Leather Research Institute, Chennai 600 020, India

 

 

 

 

 

 

1324

Molecular and crystal structure of an isoflavonoid, 5,7,4′-trihydroxy-6,3′-diprenylisofla­vone from Cudrania javanensis

 

An approach towards the single crystal structure analysis of the biologically important isoflavonoid, 5,7,4′-trihydroxy-6,3′-diprenylisoflavone is presented.

 

 

 

 

 

 

 

 

 

 

 

 

 

Mahendra Kalita, Gautam Kumar Sarmah, Mohendra Nath Bora, Babulal Das & Jibon Kotoky*

 

Department of Life Sciences, Institute of Advanced Study in Science and Technology, Guwahati 781 035, India

 

 

 

 

 

 

 

 

 

 

1329

Phytochemical investigation of the whole plant of Astragalus leucocephalus

 

Three new lanostene type triterpenoids; astragalone 1, astragalene 2, sieversigenin 3 and a known triterpenoid, cyclosieversigenin 4 and  kaempferol 5 a flavone, have been isolated from the methanol extract of whole plant. Their structures have been elucidated mainly by spectroscopic methods.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Y Jayaprakash Rao, Ch Ramakrishna Reddy, N Gangadhar & G L David Krupadanam*

 

Department of Chemistry, Osmania University, Hyderabad 500007, India

 

 

 

 

 

 

 

1333

An efficient synthesis of α-(alkylidene)-5,5-di­methyl-δ-lactones

 

2-(-Alkylidene substituted)-5,5-dimethyl-δ-lactones 4a-f  have been synthesized in two steps. The stable phosphorane carbo­ethoxymethyledene (α-prenyl)-triphenylphosphorane 1 is con­densed with different carbonyl compounds to afford α, β-un­satu­rated esters 3a-f which are cyclised using PPA to  give title compounds.

 

 

 

 

Sonia B Parsekar, Chandan P Amonkar, Vishnu S Nadkarni & Santosh G Tilve*

 

Department of Chemistry, Goa University, Goa 403 206, India

 

 

 

 

 

 

 

1337

Additions and Corrections

 

 

 

 

 

Authors for correspondence are indicated by (*)