Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 41B

NUMBER 12

DECEMBER 2002

CONTENTS

Rapid Communications

 

 

 

 

 

2602

Hydro-de-halogenation of a-haloketones by aluminium and ammonium oxalate in refluxing methanol

A simple and convenient method for the hydro-de-halogenation of a-haloketones by aluminium and ammonium oxalate in methanol is described.

 

 

 

 

 

D Nagaraja & M A Pasha*

 

 

 

 

 

 

 

 

 

 

2604

Effect of solvent and ultrasound on esterification of phenols

Phenols are coventiently acylated by acid chlorides in CH2Cl2 under the influence of ultrasound to give esters in satisfactory yields.

 

 

 

 

 

K Rama & M A Pasha*

 

 

 

 

Papers

 

 

 

 

2606

Hydrophobicity profile of amino acid residues: A differential scanning calorimetry and circular dichroism study of leucine and isoleucine co-polypeptides of the protein-based polymers of elastin

 

Relative hydrophobicity of Leu- and Ile-containing co-polypentapeptides of protein-based polymers has been discussed by their inverse temperature transition.

 

 

 

Poly[fV(VPGVG), fX(XPGVG)]

 

Poly[fV(VPGVG), fX(VPGXG)]

 

Where X is Ile & Leu

 

 

 

D Channe Gowda*, A Ramesha Baba &
Chi-Hao Luan

 

 

 

 

 

 

 

 

 

 

2614

Co-oxidation of malic acid and manganese(II) by chromium(VI) in the presence and absence of ionic surfactants

The redox reaction between malic acid, manganese(II) and chromium(VI) has been studied in aqueous as well as in the presence of CTAB, CPB and SDS micelles at 50°C.

 

HCrO4- +  HO -CH-COOH  + Mn(II)

 


        CH2-COOH

 

 

 


Cr(III)  +  CO2  + other products

 

 

 

Kabir-ud-Din*, Khaled Hartani & Zaheer Khan

 

 

 

 

 

 

2625

A quantum - chemical investigation on the addition of chlorine to homobenzobarrelene

In the electrophilic addition  of chlorine  to homobenzobarrelene(HBB), the HBB-Cl2 molecular complexes have been investigated by AM1 semiempirical method and HBB-Cl2 (endo) molecular complex has been found to be more stable than exo-complex. The cationic intermediates of the electrophilic addition have been searched by MNDO method. A benzylic type rearranged cation has been found as the most stable one among the cationic intermediates of the electrophilic addition have been searched by MNDO method.

 

 

R Abbasoğlu* & S Savaşkan Yılmaz         

 

 

 

 

2630

Structure-reactivity correlation of anilines in acid medium

Reaction rates of molecular anilines in acid medium are obtained and correlated in terms of structure-reactivity relationships.

 

 

 

C Karunakaran*, S Kandasamy &
P N Palanisamy

 

 

 

 

 

 

2635

Juvenile hormone like substances: Part XV- Synthesis and biological activities of some juvenile hormone analogues containing sulphonamide feature

A large number of juvenile hormone analogues (4-19; R=H, CH3; R2=R1C6H4NH-,  ), have been synthesized. Preliminary biological screening of one representative reveals a positive juvenile hormonal activity and chemosterilizing effect against potato tuber moth, Phthorimaea operculella.

 

 

 

 

R K Mahajan*, Ved Parkash Patial &
Pamita Sharma

 

 

 

 

 

 

 

2642

Synthesis and anti-inflammatory activity of some new 2,3-disubstituted-6-monosubstituted-quina­zolin-4(3H)-ones

Synthesis of some new 3-(substitutedphenyl)-2-(substitutedphenylchalconylaminoazetidinon - 2¢-yl)-6-monosubstituted-quinazolin-4(3H)-ones.

 

 

 

Preeti Rani, Archana, V K Srivastava &
Ashok Kumar*

 

 

 

 

 

 

 

2647

Synthesis of some newer indolyl-thiadiazolyl-pyrazolines and indolyl-oxadiazolyl-pyrazolines as potential anti-inflammatory agents

A series of 1-acetyl-5-substitutedaryl-3-[5¢-(3¢¢-indolylmethyl)-2¢-amino-1¢,3¢,4¢,-thiadiazol-2¢N-yl]-2-pyra­zo­lines (6a-6e) and 1-acetyl-5-substitutedaryl-3-[5¢-(3¢¢-in­doly­lmethyl)-2¢-amino-1¢,3¢,4¢-oxadiazol-2¢N-yl]-2- py­ra­zolines (6¢a-6¢e) have been synthesized from indole. Some of these compounds showed potent anti-inflammatory activity.

 

 

 

Shalabh Sharma, Virendra Kishor Srivastava & Ashok Kumar*

 

 

 

 

 

 

 

 

 

2655

Electrochemical synthesis of precursors of non-steroidal anti-inflammatory agents

Electochemical synthesis of 2-hydroxy-2-(p-iso-butylphenyl)propanoic acid and 2-hydroxy-2-(6-methoxynaphthyl)propanoic acid has been reported by electrocarboxylation of p-isobutylacetophenone and 2-acetyl-6-methoxynaphthalene respectively.

 

 

 

J Damodar, R Ramesh Raju &

S Jayarama Reddy*

 

 

 

 

 

 

 

 

 

 

2659

Synthesis of sulpha drug acridine derivatives and their evaluation for anti-inflam­matory, analgesic and anticancer activity.

A number of sulpha drug acridine derivatives have been synthesized and evaluated for anti-inflammatory, analgesic and anti-ancer activity.

 

 

 

S M Sondhi*, Monika Johar, Nirupama Singh, Rakesh Shukla, Ram Raghubir & S G Dastidar

 

 

 

 

 

 

 

 

 

 

2667

Synthesis of new substituted 6-ureidopurines and 6-ureido-9-(2,3,5-triacetylribo­furano­syl)pur­i­nes having cytokinin (plant growth promoting) activity

Substituted 6-ureidopurines 6a-j and 6-ureido-9-(2,3,5-triacetylribofuranosyl) purines 7a-j have been synthesized by condensing substituted phenyl isocyanates
2a-j with adenine 3 and 2,3,5-triacetyladenosine 5 respectively in pyridine. Compounds 6a, 7a, 7b and 7i having substitutents at position-3 of phenyl ring are found to show higher cytokinin (plant growth promoting) activity than benzyladenine at all concentrations.

 

 

 

Vandana Mhatre & Vidya Joshi*

 

 

 

 

 

 

Notes

 

 

 

 

2676

Stereoselective synthesis of substituted steroidal 1,3-oxathiolanes

Reactions of steroidal oxirames 1-3 with thioacetamide in the presence of LiBr in THF afford substituted steroidal 1,3-oxathiolanes 4-6.

 

 

 

 

Kamlesh Sharma, Kishwar Saleem* &

Anwar Salim

 

 

 

 

 

 

 

 

 

 

2679

Synthesis of 4-(1-phenylmethyl-5-imidazolyl)-1,4-dihydropyridines as calcium channel antagonists

Various dihydropyridines in which o-nitrophenyl group of nifedipine has been replaced with 2-alkylthio-1-phenylmethyl-5-imidazolyl substituent have been synthesized as calcium channel blockes.

 

 

 

 

 

F Hadizadeh*, A Shafiee, R Kazemi &

M Mohammadi

 

 

 

 

 

 

 

 

2683

Electron ionisation induced rearrangements in some 1-(o-toluyl)-3,4-dihydroisoquinolines and related isoquinolines

 

 

 

 

 

Keshav Rai Agnihotri & Tejvir Singh*

 

 

 

 

 

 

 

 

 

 

2687

Aerobic oxidation of olefins catalyzed by the glutamic acid Schiff base cobalt complex

The glutamic acid salicylaldehyde schiff base cobalt complex catalyzes the aerobic oxidation of linear aliphatic olefins and cyclohexene. The mechanism of the oxidation is discussed.

 

Rong-Min Wang*, Cheng- Jun Hao,

Yu-Feng He, Yun- Pu Wang, Chun-Gu Xia

 

 

 

 

 

 

 

2690

One pot synthesis of some new biologically active arylfuryl thiadiazolotriazinones

 

 

 

 

 

B Shivarama Holla*, M K Shivananda &

B Veerendra

Synthesis of a series of 1,3,4- thiadiazolo[2,3-c]-1,2,4-triazin-4-ones carrying arylfuryl moieties 3 has been carried out starting from 1,2,4-triazin-5(4H)-ones 1.

 

 

 

 

 

 

2694

Synthesis and biological evaluation of some new azetidinones and thiazolidinones

The compounds 5a-1 and 6a-1 have been synthesised by the condensation of 4 with chloroacetyl chloride and thiolactic acid respectively. The compounds have been evaluated for their antimicrobial and anti-tubercular activity.

 

J J Modha, J M Parmar, N J Datta & H H Parekh*

 

 

 

 

 

 

2698

19-Epialstonine from Amphicome emodi roots

The structure of  19-epialstonine 1 has been established on the basis  of spectroscopic (2D NMR) and chemical studies.

 

Biswanath Dinda* & Utpal  Chandra De

 

 

 

 

 

 

 

 

 

2701

Components from seeds of Cichorium intybus Linn.

A new seco-sterol named as cichosterol, characterized as 13,14-seco-stigma 5(6), 14(15)-diene-3-b-ol 1 and a rare sterol glycoside stigma 5(6)-ene-3-a-O-(b-d-glucopyranoside) 2 have been obtained from the seeds of Cichorium intybus Linn.

 

 

 

 

Bahar Ahmad*, Sandhya Bawa,
Abu B Siddiqui, Tanveer Alam & Shah A Khan

 

 

 

 

 

 

 

 

 

 

2706

Esculentins A & B, two new diterpenes from Casearia esculenta

The structures of two new diterpenes 1 and 2, isolated from the twigs of Casearia esculenta, have been  elucidated by spectral analysis. 1 and 2 show weak cytokine inhibition activity.

 

 

 

E K S Vijayakumar*, Swati Bal-Tembe,
Kalpana S Joshi & V B Deore

 

 

 

 

 

 

 

 

 

 

2709

Additions and Corrections

 

 

 

 

 

 

 

 

 

 

2710-2745    Annual Index

 

 

 

 

 

 

Authors for correspondence are indicated by (*)