Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 40B






Chemical transformation of lapachol to dehydroiso-a-lapachone and related quinones


Pahup Singh*, Renuka Jain & Vivek Krishna

Chemical transformation of lapachol to dehydroiso-a-lapachone, dehydroiso-b-lapachone, a-lapachone, b-lapachone and dehydro-a-lapachone in a single step synthesis by the reaction with sodium nitrite and glacial acetic acid and to di- and tribromo derivatives by the reaction with bromine in chloroform has been achieved.





Synthesis of 3-methoxy-5-hydroxy-3¢, 4¢-methylenedioxy-6¢¢,6¢¢-dimethylpyrano[2¢¢, 3¢¢: 7, 8]flavone



3-Methoxy-5-hydroxy-3¢, 4¢-methylenedioxy-6¢¢,6¢¢-dimethyl­pyrano[2¢¢, 3¢¢:7, 8]flavone 7 has been synthesised from phloroacetophenone in several steps.



M Amzad Hossain






Synthesis and 1H and 13C NMR spectral analysis of some spirolactones of 2, 4-diaryl-3-azabicyclo[3.3.1]nonan-9-ones

Synthesis and spectral analysis of a few substituted spiro­lactones starting from 2,4-diaryl-3-azbi­cyclo[3.3.1]
nonan-9-ones 1 is described.



M Ganesan, N Chandrasekara &

K Ramarajan*



Reactivity of heterocyclic ketones towards chlorination by chloramine-T—A kinetic study

Based on the experimental observations, a suitable mechanism for the chlorination of 1-hetera-2, 6-diphenylcyclohexan-4-ones by chloramine-T (CAT) has been proposed and the reactivity of ketones explained.



K Selvaraj*, V Venkateswaran, K Ramarajan & T Mohamed Ikramudden









Anionic ring-opening polymerization of d,l-lactide



Poly-d,l-lactide (PLA) homopolymer has been prepared by anionic ring-opening polymerization of d,l-lactide by potassium poly(ethyleneglycol-200)ate.




Zhixue Zhu, Xianmo Deng* &

Chengdong Xiong







Synthesis of hemin and prophyrin derivatives and their evaluation for anticancer activity


Sham M Sondhi*, Nidhi Singhal,

Rajeshwar P Verma, Sudershan K Arora &

Sunanda G Dastidar

N-Ethylaminoadenosine, histamine, 2-amino-2-thia­zo­line, 4-aminoantipyrine, sulphathiazole and a number of 3, 4-diaryl-2-iminothiazolines are coupled with hemin using EDC as a coupling agent. The synthesized mono and bis coupled hemin derivaties have been evaluated for anticancer activity.





Synthesis and antimicrobial activity of 1-[3-methoxy-4-[4-chlorophenylthioethoxy]-5-iodophenyl]prop-2-ene-1-one and its intermediates


B Ram*, B Balram, D Subhadra &

P K Sai Prakash

The synthesis and antimicrobial activity of the title compound and its intermediates are reported.






Synthesis of new 4-thiazolidinones bearing potentially active heteryl moieties



Synthesis of new 4-thiazolidinones with 1, 4-benzo-thiazinyl moiety (4A) and imidazolyl moiety (4B) has been carried out for the first time. The newly synthesized compounds have been screened to evaluate their microbial activity.




V S Ingle, A R Sawale, R D Ingle &

R A Mane*






Comparative QSAR studies with molecular negentropy, molecular connectivity, STIMS and TAU indices: Part II—General anaesthetic activity of aliphatic hydrocarbons, halocarbons and ethers

The study reveals that increase in molecular bulk (Nv) and decrease in branchedness (B) are conducive to general anaesthetic activity. Moreover, important contributions of branchedness, shape factors (STIMS like NX, NY and NB) and functionality (F of TAU) towards the activity suggest that the nonspecific nature of general anaesthetic actions requires further evaluation.



Kunal Roy*, Dipak Kumar Pal, A U De &

Chandana Sengupta




Synthesis of an intermediate for A-ring of 19-nor-1a, 25-dihydroxyvitamin D3 analogues



An optically active intermediate 5b for the A-ring of 19-nor-1a, 25-dihydroxyvitamin D3 has been synthesized in 9 steps starting from D(+)-xylose 6.




Yong Wu*, Mei Guan, Tao Ji & Li Cheng



Synthesis of novel oxeteno[2,3-a]carbazole derivatives


R Balamurali & K J Rajendra Prasad*

A convenient synthesis of 3, 4-dihydro-2-phenyl­oxeteno[2,3-a]carbazoles 3 from 1-oxo-1, 2, 3, 4-tetra­hydrocarbazoles 1 through 2-benzylidine-1-oxo-1,2,3,4-
tetrahydrocarbazoles 2 is described.







A simple synthesis of hydroxyisoflavones

Simple synthesis of hydroxyisoflavanones by employing (HCHO)n and (C2H5)2 NH as a base is reported.




Panchanan Gouda* & S K Grover






Trimethylchlorosilane/acetyl chloride induced metal mediated chemoselective chlorination of 16-dehydro-20-oxopregnanes

Chemoselective chlorination of 16-dehydropregnenolone
acetate through in situ generation of MnCl4 species has been described.




Saroj Hazarikaa & P K Chowdhury*






NaBrO3-FeCl3 as a new reagent for oxidation of benzylic and secondary alcohols to carbonyl compounds

NaBrO3 combined with FeCl3 is found to be an efficient reagent for the conversion of benzylic and secondary alcohols into aldehydes and ketones, respectively.




Ahmad Shaabani* & Shahram Ajabi



Butyltriphenylphosphonium tetraborate (BTPPTB) as a selective reducing agent for the reduction of imines, enamines and oximes and reductive alkylation of aldehydes or ketones with primary amines in methanol or under solid-phase conditions

The reagent 1 in methanol or under solvent-free conditions is very useful for the reduction of imines, enamines and oximes or reductive amination of aldehydes or ketones and reductive methylation of amines.




Abdol Reza Hajipour*,

Iraj Mohammadpoor-Baltork &

Mohammadreza Noroallhi






Deoximation of oximes to carbonyl compounds through  in situ  generation of nitrosyl chloride

Oximes are effectively deoximated to regenerate the carbonyl compounds by a system comprising NaNO2 and acetyl chloride at room temperature.



Papori Goswami & P K Chowdhury*






Synthesis and fungitoxicity of fluorinated 1,2,4-trazolo- and thiadiazolo[3, 2-b]oxadia-zoles



Harendra Singh*, Manoj Kumar Srivastava, Brij Kishore Singh, Sanjay Kumar Singh & Garima Dubey

2-Amino-5-aryl-1, 3, 4-oxadiazole 1, undergoes regioselective condenssation with KSCN to give 2a-e and with aryl isothiocyanates to give 2d-i in methanol. Thioureas 2 on reaction with ethanol and iodine, till the decolourisation of iodine yield 4. These compounds have been tested in vitro for their fungicidal activity against Cephalosporium saccharii, Aspergillus niger and Fusarium oxysporum.






Synthesis and biological activity of new benzimidazoles



N P Shetgiri* & S V Kokitkar

A series of 1-[(4-(4¢-substituted)-phenyl-3-alkyl/
aralkylthio-4H-1, 2, 4-triazol-5-yl)ethyl]-2-methyl-1H-benzimidazoles (6aa-6ag, 6ba-6bg, 6ca-6cg) has been synthesized, characterized and screened for their antimicrobial activity.



Two new flavone glycosides from Polygonum vivparum L.

Two new flavone glycosides, 5, 4¢-dimethoxyl 6, 7-methylenedioxyflavone-3-O-b-d-xylopyranoside (vivpa-rum A) and 3¢-hydroxy-5, 4¢-dimethoxy-6, 7-methyl-
b-d-xylopyranoside (vivparum B), have been isolated and their structures elucidated by chemical and spectral analysis.



Shangzhen Zheng*, Kanglan Li, Jinxin Wang, Tong Shen & Xuwei Shen






A flavonoid diglycoside from Punica granatam







Rashmi Srivastava, Deepa Chauhan* &

J S Chauhan






Volatile components of Arbutus unedo fruits by GC-MS

Ethyl acetate extracts of Arbutus unedo fruits are concentrated to a small volume and subjected to analyze the chemical constituents by gas chromatography-mass spectrometry (GC-MS).



Nurettin Yayli*, F Ahmet Ayaz,

Mustafa Küçükislamolu & Arzu Aytekin






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