Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 40B

NUMBER 1

JANUARY 2001

CONTENTS

Rapid Communication

 

 

 

 
1

First synthesis of indane-based a-amino acid derivatives with a crown ether side chain

 

 

 

 

 

 

 

 

 

 

 

 

Sambasivarao Kotha* &

Enugurthi Brahmachary

First synthesis of indane-based unusual a-amino acid derivatives with a crown ether unit are reported using commercially available benzo-crown ethers and ethyl isocyanoacetate as a glycine equivalent.

 

 

 

 

Papers

 

 

 

5

Synthesis of macrocycles derived from vanillin and isovanillin

 

 

 

 

 

 

 

 

 

 

 

 

 

Sukeerthi Kumar & Sabir H Mashraqui*

Using vanillin and isovanillin, thia (6 and 11) and aza (7 and 12) bridged macrocycles have been synthesized via a common approach.

 

 

 

 

 

 

11

Reactivity of 3,5-diaryl cyclohexanone—Synthesis of spiro cyclohexanes

 

 

 

 

 

 

 

 

V Padmavathi, K Sharmila,

A Somasekhar Reddy & D Bhaskar Reddy*

Spiro cyclohexanooxirane 2, spiro cyclohexanocyclopropane 4, spiro cyclohexanothiirane 5 and spiro cyclohexanoaziridine 6 have been prepared from 3,5-diarylcyclohexanone 1.

 

 

 

 

 

 

15

Synthesis of 1,3,4-thiadiazole, 1,2,4-triazole and 1,3,4-oxadiazole derivatives containing 1-(p-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl moiety

 

 
 

 

 

 

 

 

 

 

 

 

 

 

 


Xiao-Wen Sun, Xin-Ping Hui,

Chang-Hu Chu & Zi-Yi Zhang*

A series of 1,3,4-thiadiazole, 1,2,4-triazole and 1,3,4-oxadiazole derivatives containing 1-(p-chlorophenyl)-5-methyl-1,2,3-triazol-4-yl moiety have been synthesized. All the compounds synthesized have been characterized by their elemental analyses and spectral data.

 

 

 

 

 

 

 

 
20

Preparation of isomeric hydrazones: Role of lone electron pair of nitrogen in controlling the stability

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Alaka Srivastava, Vandana Srivastava,

Shiva M Verma* & Anil K Saxena

 

 

 

 

 

 

 

25

Cyclic voltammetric investigation of the 6-keto 9-17 mono methyl substituted octadeconoic acids

 

 

 

 

 

 

 

 

 

S Erturan*, M Yalçin & S Tanyolaç

The oxidation potentials of the 6-keto 9-17 mono methyl substituted octadeconoic acids are determined. The effects of keto and methyl substitutes on oxidation potentials are investigated, and the kinetics and mechanism of reaction are established.

 

 

 

 

 

 

32

Kinetics and mechanism of the nucleophilic substitution reactions of 2-chloro-1-methylpyridinium iodide with primary and secondary amines

 

 

 

 

 

 

 

 

 

 

 

 

A Awwal, M Kabir*, M Enamullah,

D Hossain & M M Morshed

Rate constants for the title reactions have been determined. The overall reaction is found to be second order. A two-step reaction mechanism is consistent with the observed results in which the formation of an intermediate is believed to be rate determining.

 

 

 

 

 

 

 

37

Synthesis of some new thiouracil derivatives with expected biological activity

 

 

 

 

 

 

 

 

 

O A Fathalla

Several 5-substituted thiouracil derivatives have been prepared from 2-thiouracil-5-sulphonylchloride.

 

 

 

 

 

 

 

 
43

Synthesis and antibacterial activity of pyrazole and 1,3,4-oxadiazole derivatives of 2-phenyl-1,8-naphthyridine

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

K Mogilaiah*, D Srinivasa Chowdary &

R Babu Rao

Synthesis and characterization of some new 1,8-naphthyridinyl pyrazoles 3, 4, 6 and 1,3,4-oxadiazoles 8 starting from a useful synthon 2-phenyl-1,8-naphthyridine-3-carboxylic acid hydrazide 2 has been reported. Some of the compounds exhibit significant antibacterial activity.

 

 

 

 

 

 

 

 

 
49

Synthesis and fungicidal activity of 3,6,9-triaryl-2-thioxothiazolo[4, 5-d][1, 3, 4]oxadia­zolo[2,3-b]pyrimidine and 3,10-diaryl-2-thioxothiazolo[4, 5-d]pyrimido[2, 1-b]pyrimi­dines

 

 

 

 

 

 

 

 

 

 

 

 

Nizamuddin*, Madhulika Mishra,

Manoj Kumar Srivastava &

Mukhtar Hussain Khan

3,6,9-Triaryl-2-thioxothiazolo[4, 5-d][1, 3, 4]oxadiazolo- [2,3-b]pyrimidines 4 and 3,10-diaryl-2-thioxo­diazolo[4,5-d]pyrimido[2,1-b]pyrimidines 6 have been synthesised from the Michael adducts 3-aryl-5-[{(5¢-phenyl-1¢, 3¢, 4¢-oxadiazol-2¢-yl)amino}-(aryl)]-methyl-2-thioxo-4-thiazolidinone 3 and 3-aryl-5-[(2-pyrimidyl­amino)aryl]methyl-2-thioxo-4-thiazolidinone 5, respectively.

 

 

 

 

 

 

 

 

 

 

54

Heterocyclic systems containing bridgehead nitrogen atom : Synthesis and bioactivity of thiazolo[3,2-b]-s-triazoles and isomeric thiazolo[2,3-c]-s-triazoles

 

 

 

 

 

 

 

 

 

 

 

 

 

Jag Mohan* & Anupama

The synthesis of 4 and 6 have been accomplished by treating 5-mercapto-3-p-(t-butylphenyl)-s-triazole 2 and 2-p-(t-butylphenyl)-3-thiosemicarbazide 1 independently with a-haloketones to produce uncyclized ketones which undergo cyclization with PPA and POCl3 respectively to furnish 4 and 6.

 

 

 

 

 

 

 
57

Synthesis of pyrazolines and cyanopyridines as potential antimicrobial agents

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Akhil H Bhatt, H H Parekh,

Khyati A Parikh & A R Parikh*

Reaction of chalcones with hydrazine hydrate under different conditions and malononitrile leads to the formation of pyrazolines 3a-p, 3¢a-p and cyanopyridines 4a-p respectively. The compounds have been evaluated in vitro for antimicrobial activity and antimycobacterial activity.

 

 

 

62

New 2-(2-arylvinyl)-7-substituted-quinaxolin-4(3H)-ones. Synthesis, reactions and antimicrobial activity

 
 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


S El-Meligie*, A K El-Ansary, M M Said &

M M M Hussein

Syntheses of quinazolinones 4, 5 and 6 starting from 3 have been reported.

 

 

 

 

Notes

 

 

 

 
70

Zinc promoted rapid and efficient synthesis of Fmoc- and Z-a,a-dialkylamino acids under neutral conditions

 

 

 

 

 

 

 

 

 

 

 

 

Vommina V Suresh Babu* &

Kuppanna Ananda

The introduction of Na-9-fluorenylmethyloxycarbonyl (Fmoc) and benzyloxycarbonyl (Z) groups into a,a-dialkylamino acids is described at neutral pH sing Fmoc-Cl or Z-Cl as an acylating agent respectively in the presence of activated zinc powder. The reaction is simple, fast and clean. It also permits the scale up with high yields.

 

 

 

 

 

 

 

 

 
75

Zinc-catalyzed ammonium formate reductions: Rapid and selective reduction of aliphatic and aromatic nitro compounds

 

 

 

 

 

 

 

 

 

 

D Channe Gowda*, B Mahesh &

Shankare Gowda

Aliphatic and aromatic nitro compounds are rapidly and selectively reduced to corresponding amino derivatives in high yields by using ammonium formate or formic acid with commercial zinc dust.

 

 

 

 

 

 

 
78

Synthesis of 9,9¢-bisacridinediones

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

P Murugan & V T Ramakrishnan*

Reaction of octaketone 3 with ammonium acetate/amine furnishes the 9,9¢-bisacridinediones 4a-c. The bisxanthene 5, prepared from octaketone 3, on treatment with ammonium acetate/methylamine gives 4a/4b.

 

 

 

 

 

 

 

82

Synthesis and pharmacological studies of new derivatives of dimethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

 

 

 

 

 

 

 

 

 

 

 

B M Khadilkar*, H G Jaisinghani,

M N Saraf & S K Desai

A new series of 1,4-dihydropyridine derivatives has been prepared by the incorporation of an amino unit. Aminomethylene group is attached to the aryl ring at C4 of the 1,4-dihydropyridine ring. The hydrochlorides of the compounds are tested for their biological activity.

 

 

 

 

 

 

87

Zederone: A sesquiterpenic keto-dioxide from Curcuma aromatica

 

 

 

 

 

 

 

 

Neerja Pant, D C Jain *, R S Bhakuni,

Veena Prajapati, A K Tripathi & S Kumar

Phytochemical analysis of the rhizomes of Curcuma aromatica Salisb. (Zingiberaceae) leads to the isolation and structural elucidation of a sesquiterpenoid named zederone, which shows moderate antifeedant activity against 4th instar larva Spilartica obliqua.

 

 

 

 

 

 

Authors for correspondence are indicated by (*)

 

 

 

 

 

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