Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

VOL. 40B


JUNE 2001


Advances in Contemporary Research





Natural camptothecins











Biswanath Das*, P Madhusudhan,
P Veena Reddy & Y Anitha

Camptothecins have been reported from different botanical species. The literature concerning the chemistry and bioactivity of these compounds have been briefly reviewed.









Reaction of indanocyclone with 3,4,3¢,4¢-tetradehydrobiphenyl (bisbenzyne)

















Shadpour E Mallakpour* &

Ramin G Gharehdaghi

The reaction of bisbenzyne 5 with indanocyclone 2 gives three structural isomers of novel polycyclic aromatic hydrocarbons (PAH,s) 6 in good yield. These compounds are very valuable, since their availability would facilitate anlytical studies of their possible presence in combustion pollutants.










anti-Markovnikov acetoxyphenylselenation of terminal alkenes











R D Vukićević* & M Randović

Acetoxyphenylselenation of some alkenes has been achieved by reaction of these substrates with diphenyl diselenide and lead tetraacetate in benzene, under thermal conditions. Unexpected anti-Markovnikov products, accompanied with some amount of their isomers, are obtained.














Synthesis of some new biologically active triazinothiadiazinones










B Shivarama Holla*, Richard Gonsalves,

B K Sarojini, Shalini Shenoy

A series of 4H, 8H-1,2,4-triazino[3,4-b]1,3,4-thiadiazin-4-ones 3a-i have been synthesized by the reaction of 4-amino-6-substituted-3-mercapto-1,2,4-triazin-5(4H)-ones with substituted phenacyl bromides. These compounds have been tested for antimicrobial activities.











Synthesis of 2,3-diphenyl-5-methyl-6-aroyl­benzo­[1,2-b : 5,4-b¢]difurans under PTC conditions and their antimicrobial activity













Y Thirupathi Reddy, P Narsimha Reddy,

M Kanakalingeswara Rao, B Rajitha*,

S M Reddy & Sridevi

Synthesis of 2,3-dipheny-5-methyl-6-aroylbenzo[1,2-b : 5,4-b’] difurans and their basic ethers has been reported under conventional and microwave irradiation.











Structure and synthesis of glycoborine, a new carbazole alkaloid from the roots of Glycosmis arborea : A note on the structure of glycozolicine





A K Chakravarty*, T Sarkar, K Masuda,

T Takeya, H Doi, E Kotani & K Shiojima

The structure of glycoborine has been elucidated as 5-methoxy-3-methylcarbazole by detailed analyses of 2D NMR spectra and confirmed by synthesis. The structure of glycozolicine has been proved to be erroneous.








Two new carbazole alkaloids from Murraya koenigii











B K Chowdhury*, S Jha, P Bhattacharyya &

J Mukherjee

Two new carbazole alkaloids, 1 and 2, have been isolated from Murraya Koenigii and their structures confirmed by spectral, chemical and synthetic evidences. The two com­pounds have been screened for antimicrobial acti­­-vity.













Synthesis of gingerenone – A and hirsutenone










S Venkateswarlu, M S Ramachandra,

M Rambabu &G V Subbaraju*

Total synthesis of gingerenone – A 5 has been accomplished from vanillin in 4 steps with an overall yield of 15%. Demethylation of 5 gives hirsutenone 6 in 36% yield.








Synthesis of substituted 2,2¢ and 4,4¢-bithia­zoles in various solvents




R Mostaghim* & Yousef A Beni








Synthesis of condensed heterocyclic systems : Some ring closure reaction involving phthalazine








Paresh Upadhyay, Hasmukh Joshi,

Jatin Upadhyay, A J Baxi & A R Parikh*

Some new condensed heterocycles have been synthesized via condensation of 1,4-dichlorophthalazine 1 with thiosemicarbazide followed by ring closure reactions. All the products 3-9 have been evaluated for their in vitro inhibitory activity.








A rapid and convenient synthesis of amides from aromatic acids and aliphatic amines in dry media under microwave irradiation







Abdol Reza Hajipour* & Majid Ghasemi

The synthesis of amides 2 from the corresponding aromatic acids 1 and aliphatic amines in the presence of catalytic amount of p-toluenesulfonic acid has been reported.








Photochemistry of some 1,4-dihydropyridine derivatives : Part III—Photosensitized oxidation








H R Memarian*, M M Sadeghi &

A R Momeni

Indirect photooxidations of 1,4-dihydropyridine derivatives using triplet sensitizers have been investigated.
















Preparation and molecular rearrangement of 2a, 3a-epoxy lupan-1-one catalysed by boron trifluoride and by ultraviolet irradiation















S N Bose* & S K Chanda

2a, 3a-Epoxy lupan-1-one 11 has been synthesised from lupeol 2 by a sequence of reactions. Molecular rearrangement of 11 induced by boron trifluoride affords 2-formyl-A-nor-lupan-1-one 15 (enolized). Compound 15 is also formed on photolysis










Cu-exchanged Y-zeolite : A heterogeneous catalyst for the synthesis of a- aminoketones








Prodeep Phukan* & A Sudalai









Modelling chemical reactivity in Diels-Alder cycloaddition reactions of heteroacyl-1,4-benzoquinones—A semiempirical (AM1) com­pu­tational study












R T Pardasani*, P Pardasani, M M Agrawal & G Mathur

A semiempirical (AM1) computational study on the modelling of a number of heteroacyl-1,4-benzoquinones with electron-rich dienes like isoprene and 2,3-dimethyl-1,3-butadiene and electron deficient diene, like perchloro-1,3-butadiene is reported.











Synthesis of O-geranylconiferyl alcohol, a meta­­bolite of Fagara rhetza






Jakka Kavitha, Mulabagal Vanisree &

Gottumukkala V Subbaraju*

O-Geranylconiferyl alcohol 1 has been obtained starting from vanillin in four steps with an overall yield of 36%.









Synthesis of N-[2-and 3-(substituted aryloxy)] acetyl and propanoyl prrolidine/morpholine/ piperidine/piperazines and their bio-evaluation















Deepa Chauhan*, J S Chauhan*, J Singh*,

P P Gupta & M P Dubey















Synthesis of some new quinolinylimidazoles for their antiviral and antifungal activities
















V K Pandey* & Meenal Tandon

The reaction of 5-oxo-2-phenyl-3-styryl-1,3-oxazole with 7-hydroxy-4-methylquinolinyl[1,5-c]-2-mercapto­imida­zole in dioxan affords 2-[5¢-oxo-2¢-phenyl-sulpho­arylideno-1, 3-oxazolo]-7-hydroxy-4-methyl­qui­no­linyl­[1,5-c]­imidazdes 4a which are again treated with different aldehydes.











Prodrugs of nalidixic acid and norfloxacin





M S Y Khan* & Poonam Raghuvanshi

Prodrugs of nalidixic acid and norfloxacin using three different amino alcohols namely (i) monoethanolamine (ii) 1-amino-2-propanol and (iii) 3-amino-1-propanol have been prepared and tested against four different organisms.









A novel flavone from polygonum capitatum Ham ex D. Don









Liming Gao*, Xiaomei Wei &

Shangzhen Zheng

A new flavone has been isolated from polygonum capitatum Ham, and characterised as 3¢,4¢-methylenedioxy-3,5,6,7,8, 5¢-hexamethoxyflavone 2 on the basis of spectroscopy.











A new limonoid from Aphanamixis polystachya















Santosh K Agarwal*, Sushma Verma,

Sudhir S Singh & Sushil Kumar

A new compound isolated from the bark of the Aphanamixis polystachya has been characterised as dihydro amoorinin 2 by physico-chemical studies.










Screening of natural products for new leads as inhibitors of b-amyloid production : Latifolin from Dalbergia sissoo








N V S Ramakrishna*, E K S Vijaya Kumar,

A S Kulkarni, A K Jain, R G Bhat, S Parikh, A Quadros, N Deuskar & B S Kalakoti

Latifolia 1 has been isolated from the methylene chloride extract of the heartwood of Dalbergia sissoo and is found to exhibit the inhibition of b-amyloid synthesis with an IC30 of 180 mM.









Authors for correspondence are indicated by (*)