Indian Journal of Chemistry

Sect. B. Organic Chemistry including Medicinal Chemistry

VOL. 41B

NUMBER 11

NOVEMBER 2002

CONTENTS

 

Rapid Communications

 

 

2330

Synthesis of highly constrained unusual
a-amino acid derivative by the Diels-Alder approach

 

 

 

 

 

Sambasivarao Kotha*, Arun Kumar Ghosh & Manoranjan Behera

 

 

 

 

 

 

Papers

 

 

 

2333

Synthessis of new tetracyclic aristotelia alkaloids

 

R(-) carvone 6 is converted to the nitromethylcarvone ketals 8a,b, which on condensation with grammine afford the isomers 9a and 9c. 9a on Zn-Hg/HCl reduction and cyclization yields 1a. On the other hand 9c on reduction and hydrolysis affords 2a.

 

 

 

 

 

Md Abul Hashem* & Zannatul Ferdoush

 

 

 

 

 

 

 

 

 

 

 

2342

C- vs O-Alkylation of 1,3-dicarbonyl compounds using microwave irradiation

 

Study of C and O alkylation of b- carbonyl compunds under MWI has been carried out.

 

 

 

Sandeep Nayyar, Inderraj Trehan & Jasamrit Kaur*

 

 

 

 

 

 

 

2346

Information-bearing base-pair sets involving hydrogen-bonded nitrogen heterocycles: A theoretical modelling study

 

 

Deborah L Buam & R H Duncan Lyngdoh*

 

 

 

 

 

 

 

2357

Synthesis of new 1,2,4-triazolo-thiadiazoles and 2-oxoazetidines as antimicrobial, anticonvulsant and antiinflammatory agents

Several 2-arylidenylamino-5-(N1-1,2,4-triazolo-methyl)-1, 3, 4-thiadiazoles 4 and 1-[5'-(N1-1, 2, 4-triazolo-methyl)-1',3',4'-thiadiazol-2'-yl]-4-(substituted phenyl)-3-chloro-2-oxo-azetidines 5 have been synthesized and evaluated for their antimicrobial, anticonvulsant and antiinflammatory activities.

 

 

 

S K  Srivastava*, Soumya Srivastava & S D Srivastava

 

 

 

 

 

 

 

 

 

2364

Condensed bridgehead nitrogen heterocyclic systems: Synthesis and bioactivity of 2,3-dihydrothiazolo[3',2':2,3]-as-triazino[5,6-b] indole, 2,3-dihydro-4H-[1,3]thiazino[3',2' : 2,3]-as-triazino[5, 6-b]indole and quinoxalino[2', 3 ': 4,5]thiazolo[3,2-b]indolo[2,3-e]-as-triazine and their isomeric systems

Synthesis and bioactivity of 7-isopropyl-2, 3-dihydro­thia­zolo[3', 2' : 2, 3]-as-triazino[5, 6-b]indole, 2, 3-di-hydro-8-isopropyl-4H-[1, 3]thiazino[3', 2':2, 3]-as-tria­zino[5, 6-b]indole, 9-isopropylquinoxa­lino[2',3':4, 5]-thia­zolo[3, 2-b]indolo[2, 3-e]-as-triazine, 7-isopropyl-2,3-dihydro-[2',3':3,4]-as-tria­zino[5,6-b]in­dole, 8-iso-propyl-1H-2,3-dihydro[1, 3]thiazino[2', 3' : 3, 4]-as-tri-azino[5,6-b]indole and 3-isopro­pyl­quino­­xalino [2',3': 4, 5]thiazolo[2,3-c]-indolo[2,3-e]-as-triazine are reported.

 

 

Jag Mohan* & Ashok Kumar

 

 

 

 

 

 

 

 

 

2367

Synthesis and blood pressure lowering activity of some newer quinazolinones

Some new quinazolinones have been synthesized and evaluated for their hypotensive activity.

 

Mirdula Tyagi, V K Srivastava,
Ramesh Chandra & Ashok Kumar*

 

 

 

 

 

2371

Synthesis of potential quinazolinyl pyrazolines and quinazolinyl isoxazolines as anticonvulsant agents

Quinazolinyl pyrazolines and quinazolinyl isoxazolines have been synthesized as anticonvulsant agents.

 

Archana, V K Srivastava, Ramesh Chandra & Ashok Kumar*

 

 

 

 

 

 

 

2376

QSAR by molecular topology of 2,4-dihydroxy-thiobenzanilides ¾ A virtual screening approach to optimize the antifungal activity

Molecular topology has been used with success to find QSAR models to predict the antifungal activity of 2,4-dihydroxythiobenzanilides.

 

R García-Domenech*, A I Catalá, A García-García,
A Soriano, V Pérez-Mondéjar & J Gálvez

 

 

 

 

 

 

 

2385

Trisulcusine: A novel spiro quinazoline alkaloid from Anisotes trisulcus

 

Anisotes trisulcus have afforded a new spiro quinazoline alkaloid trisulcusine 1, along with earlier reported alkaloids peganine 2, vasicinone 3 and 5-methoxypeganine 4.

 

Adnan J Al-Rehaily, Khalid A EL-Sayed,
Mansour S Al-Said & Bahar Ahmed*

 

 

 

 

[[[[[[

 

 

 

 

2390

Phytochemical investigation of Hemidesmus indicus R. Br. roots

Phytochemical investigation of the roots of Hemidesmu indicus furnish 2, 6, 10, 14, 18, 22-hexamethyl-tetracos-1-oic acid (hemidesmusoic acid), n-octyl-2, 6, 10, 14-tetramethyl hexadec-7-ol-10-en-13-on-1-octanoate (octyl hemidesditerpenoate) and n-non-2¢-en-1¢-yl-13-(15, 19, 19-trimethyl-cyclohex-14, 16-dienyl)-2, 6, 10-trimethyl-tetradec-6-ol-13-on-1-oate (hemidesmusesterterpenoic ester) as the new phytoconstituents along with b-sito-steryl glucuronate and b-sitosterol.

 

 

S K Roy, M Ali*, M P Sharma &
R Ramachandram

 

 

 

 

 

 

Notes

 

 

 

 

2395

A practical synthesis of trans-resveratrol

A practical preparation of biologically active substance trans-resveratrol 1 has been described starting from cheap and easily available materials such as 3,5-dihydroxybenzoic acid and 4-methoxylbenzyl alcohol.

 

 

 

Zhen Lu Shen, Guang Lan Zhuo &
Xuan Zhen Jiang*

 

 

 

 

 

 

 

 

 

2399

Synthesis of amoradicin

The synthesis of amoradicin 6 is described.

 

 

M Amzad Hossain* & S M Salehuddin

 

 

 

 

 

 

 

 

 

 

2402

Synthesis of some spiroheterocycles

5- Sprio-4-acetyl-2-(acetylamino)-D2-1, 3, 4-thiadiazo-line derivatives have been synthesised by cyclisation of thiosemicarbazones of 2,6-diphenylpiperidin-4-one derivatives using acetic anhydride and fully characterised by their analytical and spectral data.

 

 

 

S Balasubramanian, C Ramalingan &
S Kabilan*

 

 

 

 

 

 

 

 

 

 

2405

Synthesis of 6,6'-methylenebisquinazolinones and 7,7'-methylenebis-1,4-benzodiazepin-2,5-diones

 

 

 

L Manmohan Reddy, P Pratap Reddy &
P S N Reddy*

 

 

 

 

 

2410

N,N-Linked bisazaheterocycles: Part VI — Synthesis of tetraquinazolinones

 

 

 

L Manmohan Reddy, P Pratap Reddy &
P S N Reddy*

 

 

 

 

 

 

 

2414

Microwave assisted solid phase synthesis of pyrimidine derivatives

Microwave assisted solid phase synthesis of derivatives of thiobarbituric acids has been reported.

 

Mazaahir Kidwai*, Bhavesh Dave & R Venkataramanan

 

 

 

 

 

 

2419

Microwave assisted deoximation of carbonyl compounds using aqueous hydrochloric acid

An effective and mild hydrolytic cleavage of oximes to carbonyl compounds in the presence of aqueous hydrochloric acid under microwave irradiation is a mild technique.

 

Marimuthu Anniyappan, D Muralidharan & Paramasivan T Perumal*

 

 

 

 

 

 

 

 

2421

Friedel Crafts reaction on [2,3]oxopolymethelene indoles

  1,2  R=H, CH3, Cl

  R = H, CH3, Cl, COCH3

 

K J Rajendra Prasad*, R Balamurali &
C Kavitha

 

 

 

 

 

 

 

2425

Oxidation of urazoles to triazolinediones under solvent-free conditions using permanganate and alumina-supported permanganate

Treatment of urazoles with potassium permanganate leads to a simple and mild oxidation reaction, which produces triazoline­diones. The reaction is conducted under solvent-free conditions and triazolinediones can be isolated in good to high yields by a simple work-up procedure.

 

Abdol R Hajipour*, Shadpour E Mallakpour*, Mohammad A Zolfigol & H Adibi

 

 

 

 

 

 

 

2428

Crystal structure of N[(2¢-hydroxy)benzylidene]-3-chloro-4-fluroaniline

Crystal structure of the title compound has been determined by X-ray methods.

 

                

 

K V Arjuna Gowda, M M Kokila, Puttaraja,
M V Kulkarni & N C Shivaprakash*

 

 

 

 

 

 

 

2432

Do chromium(VI) complexes oxidize via a common mechanism?

The oxidation of 2-propanol by 12 chromium(VI) reagents exhibit identical kinetic behavior and the DG¹s do not differ significantly.

 

Cr(VI)  +  CH3CHOHCH3           ®   CH3COCH3  +  Cr(IV)  +  2H+    slow

 

 

C Karunakaran*, K Latha, R Venkataramanan & S Senthil Velan

 

 

 

 

 

 

 

 

 

2436

Synthesis and antifungal activities of w-(5-arylamino-1,3,4-thiadiazol-2-thio)- w-(1H-1,2,4-triazol-1-yl)acetophenones

Several w-(5-arylamino-1, 3, 4-thiadiazol- 2- thiol)-w-(1H-1,2,4-triazol-1-yl)acetophenones 4a-i have been synthesized. The representative compounds exhibit some antifungal and plant growth regulatory activities.

 

 

 

Chang-Hu Chu, Xin-Ping Hui, Peng-Fei Xu,
Zi-Yi Zhang* , Zhi-Chun Li & Ren-An Liao

 

 

 

 

 

 

 

Authors for correspondence are indicated by (*)