Indian Journal of Chemistry

Sect. A: Inorganic, Bio-inorganic, Physical, Theoretical & Analytical

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CODEN: ICACEC; ISSN: 0376-4710 (Print), 0975-0975 (Online)

 

 

 

 

 

VOLUME 53A

NUMBER 6

JULY 2014

 

CONTENTS

 

 

781

 

In vitro antioxidant studies on diselenodinicotinamide: A potent GPx mimic

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Parashiva Prabhu C, B Adhikari, P P Phadnis,
S Chakraborty , V K Jain* & K I Priyadarsini
*

 

 

 

Water soluble, diselenodinicotinamide exhibits antioxidant activity and multifunctional biological activities similar to mimics of glutathione peroxides, evident from its ability to inhibit free radical induced damage to biomolecules like lipids and DNA. Also, since it is non-toxic to normal cells but slightly toxic to cancer cells, it is a potential candidate for future in vivo studies as an antioxidant.

 

 

 

 

787

 

Synthesis, antitumor activity and G-quadruplex
DNA/ct-DNA binding property of a cationic
platinum(II) complex of 2-(4-nitro)-imidazo-
[5,6-f][1,10]-phenanthroline

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Xu-Jian Luo, Qi-Pin Qin, Yu-Lan Li, Yan-Cheng Liu* & Hong Liang*

 

 

 

The cationic platinum(II) complex shows higher cytotoxicity on selected tumor cell lines than cisplatin, but no obvious cytotoxicity on HL-7702 normal liver cell line. This complex can induce the human telomeric DNA to transform into the antiparallel G-quadruplex structure.

 

 

 

 

793

 

A binuclear zinc(II) Schiff base complex: Crystal structure characterization, antitumor activity and cell apoptosis induction in BEL-7404 tumor cells

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Yao Huang*, Wen-Xiang Wang & Xiao-Jun Zhou

 

 

 

 

 

799

 

Catalytic activity of sulfated zirconia solid acid catalyst for esterification of myristic acid with methanol

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

K Saravanan, Beena Tyagi* & H C Bajaj

 

 

 

A very small amount of SZ catalyst (0.5 wt%) exhibits excellent activity for the selective formation of methyl myristate at 60 oC after 5 h. The re-used catalyst also shows good catalytic performance without significant difference in activity up to five reaction cycles.

 

 

 

 

 

 

 

806

 

Rheological properties of lamellar liquid crystals formed in Brij97/castor oil/water systems in the presence of soybean lecithin

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Ling Wei, Zhongni Wang*, Xin Liu, Fumin Guo, Jun Fan & Lei Fu

 

 

 

Dynamic moduli of the lamellar liquid crystals formed in Brij97-soybean lecithin/castor oil/water system are clearly dependent on the soybean lecithin concentration and structure of the oil component. This is consistent with the molecular area of the surfactants at the interface and reflects the strength of the liquid crystal network.

 

 

 

Notes

 

816

 

Synthesis of single crystal zeolite L rods with high aspect ratio using rice husk ash as silica source

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Rituparna Das, Sourav Ghosh & Milan Kanti Naskar*

 

 

Single crystal zeolite L rods with high aspect ratio have been synthesized using rice husk ash, an agrowaste material, as the silica source.

 

 

 

 

 

820

 

Highly active ZnS loaded TiO2 photocatalyst for
mineralization of phenol red sodium salt under
UV-A light

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

P Dhatshanamurthi, B Subash, B Krishnakumar &
M Shanthi
*

 

 

 

 

 

Authors for correspondence are indicated by (*)

 

 

 

Indian Journal of Chemistry

Vol. 53A, July 2014, pp. 781-786

 

 

In vitro antioxidant studies on diselenodinicotinamide: A potent GPx mimic

 

Parashiva Prabhu Ca, B Adhikarib, P P Phadnisa, S Chakrabortyc, V K Jaina, * & K I Priyadarsinib, *

aChemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

Email: jainvk@barc.gov.in

bRadiation and Photochemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

Email: kindira@barc.gov.in

cBio-organic Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India

Received 2 January 2014; revised and accepted 2 June 2014

                Multifunctional biological activities of a glutathione peroxidase mimic, diselenodinicotinamide (2, 2′-diseleno-bis-[3-amidopyridine]) (SNA), as an antioxidant are evaluated for its ability to inhibit free radical induced damage to biomolecules like lipids and DNA. Damage to lipids has been assayed by lipid peroxidation and DNA damage by gel-electrophoresis using AAPH or γ-radiation induced damage. The results indicate that SNA, at micro-molar concentration, protects both lipids and DNA from AAPH and γ-radiation induced damage. Also, SNA is non-toxic to normal cells but slightly toxic to cancer cells. These results coupled with its water solubility and GPx mimicking activity make SNA a potential candidate for future in vivo studies as an antioxidant.

Keywords: Bioinorganic chemistry, Diselenodinicotinamide, Selenium, Antioxidant activity, Glutathione peroxidase

 

Indian Journal of Chemistry

Vol. 53A, July 2014, pp. 787-792

 

 

Synthesis, antitumor activity and G-quadruplex DNA/ct-DNA binding property of a cationic platinum(II) complex of 2-(4-nitro)-imidazo-
[5,6-f][1,10]-phenanthroline

Xu-Jian Luoa, b, Qi-Pin Qina, Yu-Lan Lia, Yan-Cheng Liua, * & Hong Lianga, b, *

aGuangxi Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources,
School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, Guangxi 541004, PR China

bCollege of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China

Email: ycliugxnu@yahoo.cn (YCL)/ hliang@gxnu.edu.cn (HL)

Received 21 January 2014; revised and accepted 23 June 2014

A cationic platinum(II) complex (1), [Pt(4-NOIP)(en)]∙Cl2 (4-NOIP = 2-(4-nitro)-imidazo-[5,6-f][1,10]-phenanthroline, en = 1,2-ethylenediamine), has been synthesized and characterized by IR, UV-vis, ESI-MS and element analysis. The interaction of complex (1) with ct-DNA and human telomeric G-quadruplex DNA [Htel-21] has been investigated by circular dichroism absorption and UV–vis absorption titration as well as fluorescent intercalator displacement assay. The circular dichroism absorption data shows that complex (1) can induce linear human telomeric DNA to transform into antiparallel G-quadruplex structure. The binding contants for complex (1) bound to Htel-21 and ct-DNA are 6.89×105 and 7.53×104 M-1, respectively, indicating that complex (1) interacts with Htel-21 more intensively than ct-DNA. The FID assay suggests that complex (1) intercalates into ct-DNA and Htel-21 quite strongly. CD and UV–vis data together with FID experiments have shown that the complex can intercalate more intensely into Htel-21 and ct-DNA and induce formation and stabilization of antiparallel
G-quadruplex. The anticancer activity of the complex have been tested against four different cancer cell lines and normal cell line HL-7702; the complex shows a higher activity than cisplatin and only weak cytotoxicity to HL-7702.

Keywords: Bioinorganic chemistry, Platinum, G-quadruplex DNA, Telomeric DNA, Antitumor activity,
DNA binding

 

Indian Journal of Chemistry

Vol. 53A, July 2014, pp. 793-798

 

 

A binuclear zinc(II) Schiff base complex: Crystal structure characterization, antitumor activity and cell apoptosis induction in BEL-7404 tumor cells

Yao Huang*, Wen-Xiang Wang & Xiao-Jun Zhou

School of Chemical Engineering, Yunnan Open University, Kunming, Yunnan, 650500, P R China

Email: ynou_hy@163.com

Received 22 January 2014; revised and accepted 03 June 2014

The Schiff base ligand, 4-chloro-2-(quinolin-8-yliminomethyl)-phenol (HClQP), reacts with ZnCl2.4H2O to afford a binuclear zinc(II) complex (1), which has been synthesized and characterized by IR, ESI-MS, elemental analysis and single crystal X-ray diffraction analysis. In complex (1), the two zinc atoms are in a five-coordinated tetragonal pyramidal geometry and a four-coordinated tetrahedral geometry, respectively. The in vitro cytotoxicities of complex (1) against four human tumor cell lines and the HL-7702 normal liver cell line have been screened and evaluated by MTT assay, in comparison with HClQP and cisplatin. The IC50 values of complex (1) is in the range of 7.51–15.66 µM against these tumor cell lines, in which the MCF-7 and BEL-7404 cells showed the highest sensitivity to complex (1). The HL-7702 cell line was neither sensitive to complex (1) nor to HClQP and cisplatin. This suggests the potent cytotoxic selectivity of complex (1) on the tumor cell lines. The cell apoptosis induction of complex (1) visualized by fluorescence microscopy shows evident apoptosis in BEL-7404 tumor cells induced by complex (1). In view of these results, the central zinc(II) of complex (1) is expected to play a key role to exert the cell apoptosis induction in BEL-7404 cells, which may explain the significant antitumor activity of complex (1).

Keywords: Bioinorganic chemistry, Crystal structure, Antitumor activity, Apoptosis, Schiff bases, Zinc

 

Indian Journal of Chemistry

Vol. 53A, July 2014, pp. 799-805

 

 

Catalytic activity of sulfated zirconia solid acid catalyst for esterification of myristic acid with methanol

K Saravanana, b , Beena Tyagia, b, * & H C Bajaja, b

aDiscipline of Inorganic Materials and Catalysis, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI),
GB Marg, Bhavnagar,
Gujarat 364 002, India

bAcademy of Scientific and Innovative Research, CSIR-Central Salt and Marine Chemicals Research Institute,
  GB Marg, Bhavnagar 364 002, India

Email: btyagi@csmcri.org

Received 3 June 2014; revised and accepted 24 June 2014

                The catalytic activity and reusability of sulfated zirconia solid acid catalyst is evaluated for esterification of myristic acid with methanol. The catalyst exhibits excellent activity with 98% conversion of myristic acid and selective formation of methyl myristate in presence of a very small amount of catalyst, i.e., 0.5 wt% (to acid) at 60 oC after 5 h. The re-used catalyst also shows good catalytic performance without significant difference in activity up till five reaction cycles. Characterization of the used catalyst revealed no significant change in structural and textural properties, however a slight decrease in surface acidity was observed due to deposition of carbonaceous matter on the surface acid sites.

Keywords: Catalysts, Sulfated zirconia, Zirconia, Solid catalysts, Esterification, Myristic acid

 

Indian Journal of Chemistry

Vol. 53A, July 2014, pp. 806-815

 

 

Rheological properties of lamellar liquid crystals formed in
Brij97/castor oil/water systems in the presence of soybean lecithin

Ling Wei, Zhongni Wang*, Xin Liu, Fumin Guo & Jun Fan

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes,
Ministry of Education, Shandong Normal University, Jinan 250 014, PR China

Email: zhongniw@hotmail.com

Received 19 December 2013; revised and accepted 26 June 2014

Phase diagrams of Brij97/castor oil (COil)/water in the presence of soybean lecithin (SL) have been determined at 37 oC. The lamellar phases have been investigated by polarizing optical microscopy, rheological technique and small angle X-ray scattering. With increasing SL content, the domain of the lamellar phase extends to higher COil concentration. At constant surfactant concentration, the shear viscosity increases for samples containing more SL. The storage modulus G' increases on addition of SL and reaches a maximum in the SL/COil/water system, with the smallest area of surfactant molecules at the interface. For the Brij97/SL (1:3) system, at a fixed ratio of COil/water, the dynamic moduli increases with increasing surfactant concentration. At 37 oC, the Brij97/SL (1:1)/water/oil systems with ethyl oleate and COil have a higher moduli and smaller aS than with isopropyl myristate. The values of activation energy of ethyl oleate and COil systems are larger than that of isopropyl myristate system, indicating that the network in lamellar phases in ethyl oleate and COil systems are stronger than in the isopropyl myristate system.

Keywords: Liquid crystals, Lamellar liquid crystals, Surfactants, Phase behavior, Rheological properties

 

Indian Journal of Chemistry

Vol. 53A, July 2014, pp. 816-819

 

Synthesis of single crystal zeolite L rods with high aspect ratio using rice
husk ash as silica source

Rituparna Das, Sourav Ghosh & Milan Kanti Naskar*

Sol-Gel Division, CSIR-Central Glass & Ceramic Research Institute, Kolkata 700 032, India

Email: milan@cgcri.res.in

Received 21 April 2014; revised and accepted 20 June 2014

Single crystal zeolite L rods with high aspect ratio have been prepared using rice husk ash as silica source in the presence of other aqueous-based precursors via a single-step hydrothermal process at 170 oC for 72 h. Crystallization behavior of the particles is studied by X-ray diffraction, and the characteristic vibration bands of zeolite L are confirmed by FTIR spectroscopy. BET surface area and total pore volume of the particles are found to be 142 m2 g-1 and 0.19 cm3 g-1, respectively. Rod-shaped morphology of zeolite L with an aspect ratio of 10-50 is observed by FESEM and TEM. Selected area electron diffraction pattern of TEM confirms the single crystal nature of the particles.

Keywords:   Aluminosilicates, Zeolite L, Rice husk ash, Hydrothermal synthesis, Crystallization, Microstructure

 

Indian Journal of Chemistry

Vol. 53A, July 2014, pp. 820-823

 

 

Highly active ZnS loaded TiO2 photocatalyst for mineralization of phenol
red sodium salt under UV-A light

P Dhatshanamurthi, B Subash, B Krishnakumar & M Shanthi*

Photocatalysis Laboratory, Department of Chemistry, Annamalai University, Annamalainagar 608 002,
Tamil Nadu, India

Email: shanthimsm@gmail.com

Received 6 February 2014, revised and accepted 17 June 2014

ZnS loaded TiO2 (ZnS-TiO2) has been successfully synthesized by precipitation-cum-sol gel method. The photocatalytic activity of (ZnS-TiO2) has been investigated for the degradation of phenol red sodium salt in aqueous solution using UV-A light. In presence of ZnS, there is a shift in the absorbance of TiO2 in both UV and visible region. ZnS-TiO2 is found to be more efficient than bare TiO2, TiO2-P25 and ZnS at pH 6.5 for mineralization of the dye under UV-A light. The effects of operational parameters such as the amount of photocatalyst and dye concentration on photomineralization of the dye have been analyzed. The mineralization has been confirmed by COD measurements. Mechanism of degradation by ZnS-TiO2 is proposed. The catalyst is found to be reusable.

Keywords: Photocatalysis, Dye degradation, Zinc sulphide, Phenol red sodium salt, Titania