Indian Journal of Chemistry

Sect. B: Organic Chemistry including Medicinal Chemistry

Total visitors: 4,340  since 13-03-09

VOL. 48B

NUMBER 3

March 2009

CONTENTS

Rapid Communication

 

 

 

383

Synthesis of dimethyl ether of marsupsin

Synthesis of dimethyl ether of marsupsin is reported.

 

 

 

 

 

 

 

 

 

 

 

 

A Srikrishna* & M Mathews

 

Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India

 

 

 

 

Papers

 

 

 

386

N and N+1 cap effects of Gly, Ala, Leu, Val, Pro and Aib in Boc-(d)Glu1-Xxx2-Yyy3-Lys4-NHMe, a 310 type protohelix endlocked by Boc-( d)Glu

The N cap (Xxx2) and N+1 cap (Yyy3) position in the 310 helical model peptide Boc-(d)Glu1-Ala2-Gly3-Lys4-NHMe 1a is substituted with Gly, Ala, Leu, Val, Pro and Aib. An NMR enquiry confirms that all variants are distorted 310 type protohelices, differing appreciably in degree of ordering and overall stability in a manner that is strongly reminiscent of the presumed effects in helix nucleation.

 

 

 

 

V D Bobade*, N D Gaikwad & P C Mhaske

Department of Chemistry, HPT Arts & RYK Science College, Nashik 422 005, India

 

 

 

397

Synthesis of urea tethered glycosylated amino acids and glycopeptides mediated by DPPA employing Nα-Fmoc-Asp/Glu-5-oxazolidinones

The synthesis of urea linked glycosylated amino acids and glycopeptides has been described by reacting Nα-Fmoc-Asp/Glu-5-oxazolidinone and sugar amine in presence of DPPA.

 

n=1 or 2

 

 

G Nagendra , H P Hemantha & Vommina V Sureshbabu*

 

Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, 
Dr B. R. Ambedkar Veedhi, Bangalore 560 001, India

 

 

 

408

Environmentally benign aqueous zinc tetra­fluoroborate-catalyzed one-pot Biginelli conden­sa­tion at room temperature

Three component condensation to afford 3,4-dihydro­pyrimidin-2 (1H)-ones (DHPMs) and thiones has been reported using  an aqueous solution of zinc tetrafluoroborate.

 

 

 

 

 

S K Kundu, A Majee* & A Hajra

 

Department of Chemistry, Visva Bharati University, Santiniketan 731 235, India

 

 

 

413

Enantiospecific total synthesis of ent-10,11-thapsan-10-ol

 

Enantiospecific synthesis of the optical antipode of the natural sesquiterpene 10,11-epoxythapsan-10-ol has been reported.

 

 

 

 

 

 

 

A Srikrishna* & K Anebouselvy

 

Department of Organic Chemistry,  Indian Institute of Science, Bangalore 560 012, India

 

 

 

 

Notes

 

 

423

Cyanogenic and non-cyanogenic glycosides from Manihot esculenta (Euphorbiaceae)

 

 

 

 

 

 

Edet M Anam

 

Department of Chemical Sciences, Cross River University of Technology, CRUTECH, PMB 1123, Calabar, CRS, Nigeria

 

 

 

 

 

430

Synthesis of some new pyrazolines and isoxazoles carrying 4-methylthiophenyl moiety as potential analgesic and anti-inflammatory agents

Condensation of 4-acetylthioanisole with different aryl aldehydes under aldol conditions affords a,b-unsaturated ketones (propenones) which undergo facile and clean cyclization with hydrazine hydrate to yield pyrazolines 3a-m and cyclization with hydroxylamine hydrochloride affords isoxazoles 4a-k in quantitative yields. The structures of the newly synthesized compounds have been confirmed on the basis of spectral studies. Some of the selected compounds have been tested for their analgesic and anti-inflammatory activity.

 

 

 

 

 

Karabasanagouda Ta, Airody Vasudeva Adhikari*b & Girisha Mc

aSeQuent Scientific Ltd., New Mangalore 575 011, India

bDepartment of Chemistry, National Institute of Technology Karnataka, Surathkal 575 025, India

cDepartment of Pharmaceutical Chemistry, Gulbarga University, Gulbarga 585 106, India

 

 

 

 

438

A cleaner approach for reduction of some symmetric diimines using NaBH4

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

V K Aghera & P H Parsania*

 

Department of Chemistry, Saurashtra University, Rajkot 360 005, India

 

 

 

 

443

Phytochemical investigation of Calotropis procera Ait roots

 

Phytochemical investigation of the roots of Calotropis procera Ait. (Asclepiadaceae) yields two new phytoconstituents procerursenyl acetate and proceranol together with the known compounds N-dotriacont-6-ene, glyceryl mono-oleolyl –2-phosphate, methyl myrisate, methyl behenate and  glyceryl – 1, 2 –dicapriate –3- phosphate. The structures of the new compounds have been identified as urs - 18α-H- 12, 20 (30) - diene - 3b-yl acetate and n-triacontan -10b-ol on the basis of spectral data analysis and chemical reactions.

 

 

Structure 1

Structure 2

Structure 1: Procerursenyl acetate 2 (urs - 18α-H- 12, 20 (30) - diene - 3b-yl acetate)

Structure-2: Proceranol 6 (n-triacontan -10b-ol)

 

 

Perwez Alam & Mohd Ali*

 

Department of Pharmacognosy and Phytochemistry,
Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi 110 062, India

 

 

447

One pot stereoselective synthesis of isoxazolines from N-phenyl-α-chloro nitrone

 

Isoxazolines have been synthesized from N-phenyl-α-chloro nitrone using 1,3 dipolar cycloaddition reaction with alkynes and the reactions are found to be highly stereoselective in nature.

 

 

 

Bhaskar Chakraborty*, Saurav Kafley & Manjit Singh Chhetri

 

Organic Chemistry Laboratory, Sikkim Govt. College, Gangtok, Sikkim 737 102, India

 

 

 

 

452

Synthesis of (±)- (E)-2,6-dimethyl-6-hydroxy-2,7-Octadienoic acid, its methyl ester and (±)- (E)-2,6-dimethyl-octa-2,7-diene-1,6-diol over solid support using microwave

 

A simple, exceedingly mild, ecofriendly and an efficient methodology for the synthesis of (±)-(E)-2,6-dimethyl-6-hydroxy-2,7-octadienoic acid, its methyl ester and (±)-(E)-2,6-dimethyl-octa-2,7-diene-1,6-diol by utilization of microwave energy has been achieved.

 

 

 

Ashima Singh, M L Sharma & Jasvinder Singh*

 

Department of Chemistry and Centre for Advanced studies in Chemistry, Panjab University, Chandigarh, 160 014, India

 

 

 

 

455

A facile indium-mediated synthesis of protected and unprotected [1-(hydroxymethyl)­vinyl]­alkanols

 

Protected and unprotected [1-(hydroxymethyl)vinyl]alkanols have been synthesized from  the homologated γ-hydroxy esters which have been prepared by indium-mediated allylation of the rearranged bromides derived from hydroxyl esters in water medium.

 

 

 

Nimalini D Moirangthem, Bhavna Thingom & Warjeet S Laitonjam*

 

Department of Chemistry, Manipur University, Canchipur 795 003, India

 

 

 

 

460

Microwave-assisted one-pot synthesis of anti­fungal  active  1-substituted-3,7-dialkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[3,4-b][1,3,4]thia­dia­ze­pines using solid support

 

A simple, efficient and environment-friendly procedure is developed for the synthesis of 1-substitued-3,7-dialkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines in the presence of N,N-dimethylformamide as an energy transfer medium, p-TsOH as catalyst and basic alumina as solid support under microwave irradiation.

 

 

 

Monika Gupta*, Satya Paul & Rajive Gupta

 

Department of Chemistry, University of Jammu, Jammu 180 006, India

 

 

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