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Indian Journal of Experimental Biology

 

ISSN : 0019-5189

CODEN : IJEB (A6) 42(9) 847-944 (2004)

VOLUME 42

NUMBER 9

SEPTEMBER 2004

 

 

CONTENTS

 

Mini Review

Monoamine oxidase inhibitors, their structural analogues, and neuroprotection

Bernard N Sowa, Andrew Holt, Kathryn G Todd & Glen B Baker

851
 
Papers

 

Development of preincubated chicken eggs following exposure to 50 Hz electromagnetic fields with 1.33-7.32 mT flux densities                     

Maryam Shams Lahijani & Kazem Sajadi


858

 

 

Effect of low-power helium-neon laser irradiation on 13-week immobilized articular cartilage of rabbits

Mohamad Bayat , Anayatallah Ansari & Hossien Hekmat


866

 

 

Vitamin E prevents deleterious effects of di (2-ethyl hexyl) phthalate, a plasticizer used in PVC blood storage bags

C R Dhanya, N S Gayathri, K Mithra, K V Neelakantan Nair & P A Kurup


871

 

 

Effectiveness of ethylene glycol bis (2-aminoethyl ether) tetraacetic acid (EGTA) against cerium toxicity

Sadhana Shrivastava & R Mathur

[IPC Code: Int. Cl.7 A61 P]


876

 

 

Oxyradicals under UV-B stress and their quenching by antioxidants

Karishma Jain, Sunita Kataria & K N Guruprasad

884

 

 

Evaluation of antimitotic activity of Rotula aquatica (Lour): A traditional herb used in treatment of cancer

S Patil, S Narayanan, G Eibl & C I Jolly

[IPC Code: Int. Cl.7 A61 P]


893

 

 

Dietary intervention with iron and black tea infusion in reducing cytotoxicity of arsenic

Sandeep Poddar

[IPC Code: Int. Cl.7 A61 K]

900

 

 

Hypocholesterolemic effect of protein prepared from Phaseolus aconitifolius (Jacq.)

M Mayilvaganan, S P Singh & R P Johari

[IPC Code: Int. Cl.7 A61 P]

904

 

 

Hypolipidemic effect of Coriandrum sativum L. in triton-induced hyperlipidemic rats

A Arun Sam Lal, T Kumar, P Balakrishna Murthy & K Sadasivan Pillai

 [IPC Code: Int. Cl.7 A61 P]

909

 

 

Evaluation of tocolytic efficacy of selective beta2 adrenoceptor agonists on buffalo uterus

Satish K Garg, K M Garg & M Sabir

913

 

 

Ondansetron amelioration of scopolamine induced cognitive deficits in three-panel runway apparatus in rats

Naveen Kumar & Anil Kumar Kela


919

 

 

In vitro and in vivo antimycobacterial activity of anti-inflammatory drug,
diclofenac sodium

N K Dutta, K Asok Kumar, Kaushiki Mazumdar, Sujata G Dastidar, R Ray & A N Chakrabarty

922

 

 

 

Isolation, characterization and optimization of antifungal activity of an actinomycete of soil origin

S K Augustine, S P Bhavsar, M Baserisalehi & B P Kapadnis

928

 

 

 

Isolation of Mycoplasma bovoculi from genitally diseased bovines and its experimental pathogenicity in pregnant guinea pigs

Y Singh, D N Garg , P K Kapoor & S K Mahajan


933

 

 

Notes

 

(CTG)n Expansion at DMPK locus seen only in muscle tissue: A novel case

Qurratulain Hasan, Vasavi Mohan & Y R Ahuja

937

 

 

Effect of chlorpromazine, imipramine and lithium on MAO-A and MAO-B activity in rat brain mitochondria

Maitreyi Nag


941

 

 

Author Index

 

   
Keyword Index
 
   
Announcement  

National Symposium on Good Laboratory Practice (GLP) and Regulatory Issues

850

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 851-857

 

Mini Review

 

Monoamine oxidase inhibitors, their structural analogues, and neuroprotection

Bernard N Sowa, Andrew Holt, Kathryn G Todd & Glen B Baker

 

Monoamine oxidase (MAO) inhibitors have been used for many years in the treatment of psychiatric and neurological disorders. More recently, some of these drugs and their analogues have been shown to have neuroprotective and neurorescue effects in several models of neurologic insult, including in vitro and in vivo models of cerebral ischemia. This review will discuss current evidence regarding these aspects of l-deprenyl, tranylcypromine, phenelzine, and some structurally related drugs.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 858-865

 

 Papers

 

Development of preincubated chicken eggs following exposure to 50 Hz electromagnetic fields with 1.33-7.32 mT flux densities

Maryam Shams Lahijani & Kazem Sajadi

 

The effects of applying extremely low-frequency (50 Hz) electromagnetic fields (ELF-EMF) for 24 hr and different densities (1.33-7.32 mT) were examined on healthy, freshly fertilized white leghorn chicken eggs (55-65 g). Results showed no increase in the rate of abnormalities in exposed groups, but were only significant in 4.19, 5.32 and 5. 86, 6.65 mT densities. Alizarin red S and alcian blue 8GX staining showed some embryos with extra ribs, defects in ribs and vertebrae, anuria and abnormal beaks. Study of egg weight, after 9 days of incubation, showed no significant differences between control, sham-exposed and experimental groups. Analysis of crown-rump, beak-occipital length and weight of embryo, showed significant decrease in weight at 4.39 and 5.52 mT intensities, comparing with control and sham-exposed groups. These results revealed that 50 Hz electromagnetic fields can even induce developmental alterations in preincubated chick embryos and confirm that its strength could be a determinant factor for the embryonic response to extremely low frequency EMFs (window effects) prior to incubation.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 866-870

 

 Effect of low-power helium-neon laser irradiation on 13-week immobilized
articular cartilage of rabbits

Mohammad Bayat, Anayatallah Ansari and Hossien Hekmat

 

Influence of low–power (632.8 nm, Helium–Neon, 13 J/cm2, three times a week) laser on 13–week immobilized articular cartilage was examined with rabbits knee model. Number of chondrocytes and depth of articular cartilage of experimental group were significantly higher than those of sham irradiated group. Surface morphology of sham-irradiated group had rough prominences, fibrillation and lacunae but surface morphology of experimental group had more similarities to control group than to sham irradiated group. There were marked differences between ultrastructure features of control group and experimental group in comparison with sham irradiated group. Low-power Helium-Neon laser irradiation on 13- week immobilized knee joints of rabbits neutrilized adverse effects of immobilization on articular cartilage.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 871-875

  

Vitamin E prevents deleterious effects of di (2-ethyl hexyl) phthalate,
a plasticizer used in PVC blood storage bags

C R Dhanya, N S Gayathri, K Mithra, K V Neelakantan Nair & P A Kurup

 

Vitamin E administration prevented DEHP induced deleterious effects like (i) degenerative changes in the brain and thyroid, (ii) decrease in the activity of neuronal membrane Na+ - K+ ATPase, (iii) decrease in the concentration of insulin, cortisol and TSH, and (iv) the increase in T3 and T4 in female Albino rats. The results suggest use of vitamin E to prevent harmful effects of repeated transfusion of DEHP containing blood as in thalassemia patient. The possibility of using vitamin E to prevent the harmful effects of repeated transfusion of DEHP containing blood, as in thalassemia patients, is discussed.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 876-883

 

 Effectiveness of ethylene glycol bis (2-aminoethyl ether) tetraacetic acid
(EGTA) against cerium toxicity

Sadhana Shrivastava & R Mathur

 

Therapeutic efficacy of EGTA (ethylene glycol bis (2-aminoethyl ether) tetraacetic acid) against cerium intoxicated mice was studied. Administration of cerium showed significant decrease in haemoglobin percentage, RBC counts and blood glucose level with an increase in the activity of serum transaminases and WBC counts. Decrease in the activity of alkaline phosphatase and glycogen content was noted in liver and kidney after cerium exposure. Light and electron microscopical investigations showed that these changes were recouped considerably with the administration of EGTA suggesting its therapeutic efficacy against cerium toxicity.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 884-892

 

 Oxyradicals under UV-B stress and their quenching by antioxidants

Karishma Jain, Sunita Kataria & K N Guruprasad

 

Formation of oxyradicals under UV-B stress was investigated using cucumber cotyledons. UV-B radiation induced production of free radicals which were analyzed by ESR spectroscopy. Evidence was obtained for the formation of superoxide and hydroxyl radicals in the tissues by comparing PBN-adducts formed with radicals obtained by chemical auto-oxidation of KO2 and Fenton’s reaction. Addition of superoxide dismutase (SOD) to the reaction mixture partially reduced the intensity of signals confirming the production of superoxide radical as well as hydroxyl radicals. These radicals were quenched in vitro by the natural antioxidants a-tocopherol, ascorbic acid and benzoquinone. Changes in the level of antioxidants were also monitored under UV-B stress. The endogenous level of ascorbic acid was enhanced and a-tocopherol level was reduced in the tissue after exposure to UV-B radiation. The present report happens to be the first direct evidence obtained for the formation of superoxide and hydroxyl radicals in plant tissues exposed to UV-B radiation.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 893-899

 

 Evaluation of antimitotic activity of Rotula aquatica (Lour):A traditional herb used in treatment of cancer

S Patil, S Narayanan , G Eibl & C I Jolly

 

Rotula aquatica was extensively used by vaidyas  (Ayurvedic practioners) in holistic treatment of cancer. In the present study, an attempt has been made to evaluate the antimitotic activity of R. aquatica. Preliminary antimitotic screening was done using Allium cepa root tip assay. The mitotic index of the root tips markedly decreased with increasing concentration of the aqueous extract. The different fractions obtained by successive extraction of R. aquatica using solvents of increasing polarity were also evaluated for their antimitotic activity. Tannins were isolated which showed a better activity than the non-tannin fraction. Experiments were also carried out with incorporation of folic acid in the aqueous extract. Folic acid inhibited the antimitotic activity of aqueous extract of R. aquatica in a dose dependent manner. The results obtained were compared with methotrexate¾ a known drug available in market as anti-cancer agent. The studies were extended to human cells using 3 pancreatic cancer cell lines, viz: HPAF-II, BxPC-3, and CAPAN-2. Extract of R. aquatica was found to be extremely effective in the prevention of cell proliferation of the pancreatic cancer cell lines. The phytochemical evaluation revealed presence of polyphenols (tannins) and steroids. A HPTLC fingerprinting was developed and studied. Two compounds were isolated and subjected to spectral studies like UV, IR and mass spectrums. The empirical formula was derived by considering this data with elemental analysis of the compounds.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 900-903

 

Dietary intervention with iron and black tea infusion in reducing cytotoxicity of arsenic

Sandeep Poddar

 

The relative efficacy of infusion of black tea leaf, Camellia sinensis (Linn.) O. Kuntze, (Theaceae), and iron as freshly prepared aqueous solution of ferrous sulphate in reducing the cytotoxic effects of arsenic, was tested in bone marrow cells of laboratory bred Swiss albino mice. Ferrous sulphate and tea given alone did not induce chromosomal breakage to any appreciable extent. Tea decreased chromosome damage induced by arsenic to a significant extent, while the addition of ferrous sulphate did not alter the protective action of tea against arsenic. Such protection against arsenic cytotoxicity by prolonged dietary administration of black tea infusion¾a common routine beverage¾is of importance in view of widespread exposure of human populations to arsenic damage through drinking water from tubewells in Eastern India and Bangladesh.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 904-908

 

 Hypocholesterolemic effect of protein prepared from Phaseolusaconitifolius (Jacq.)

M Mayilvaganan, S P Singh & R P Johari

 

Hypocholesterolemic effect of protein concentrate (PC) prepared from moth bean (Phaseolus aconitifolius Jacq.) seeds relative to that of pigeon pea PC and casein were investigated in rats fed on hypercholesterolemic diet containing two per cent cholesterol. The test diets containing casein and legume PCs at 10% protein level were fed to albino rats (Wistar strain) for 45 days. Compared to casein, the two legume PCs produced significantly lower levels of liver total lipid and cholesterol levels except that pigeon pea PC produced only non-significant decrease of total cholesterols in the heart. In addition, the legume PCs produced significantly lower levels of serum triglycerides and total lipids as well as lower levels of total and low-density lipoprotein cholesterol. Moreover, only moth bean PC produced a significantly higher level of serum high-density lipoprotein cholesterol. Generally, PC of moth bean seemed to be more potent at lowering the elevated hepatic and serum lipids and cholesterol levels, which were attributed to the amino acid profile of this lesser-known legume as these indices well correlated with serum cholesterol levels.

 

 

 

Indian Journal of Experimental Biology

Vol. 42, September 2004, pp. 909-912

  

Hypolipidemic effect of Coriandrum sativum L. in triton-induced hyperlipidemic rats

A Arun Sam Lal, T Kumar, P Balakrishna Murthy & K Sadasivan Pillai

 

In the biphasic model of triton-induced hyperlipidemia, C. sativum at a dose of 1g/kg body weight reduced cholesterol and triglycerides levels in both synthesis and excretory phases in rats, and the results were comparable with that of Liponil, a commercially available herbal hypolipidemic drug. The results suggest that coriander decreases the uptake and enhances the breakdown of lipids. From the study it can be assumed that coriander has the potential to be popularized as a household herbal remedy with preventive and curative effect against hyperlipidemia.

 

 

 

Indian Journal of Experimental Biology

Vol. 42, September 2004, pp. 913-918

  

Evaluation of tocolytic efficacy of selective beta2 adrenoceptor agonists on buffalo uterus

Satish K Garg, K M Garg & M Sabir

 

Present study was conducted on prostaglandin F2alpha (PGF), oxytocin, (OT), potassium chloride (KCl) and barium chloride (BaCl2) pre-contracted perimetrial uterine strips of dioestrus and pregnant buffaloes to evaluate the tocolytic efficacy of selective b2 adrenoceptor agonists-albuterol (salbutamol) and terbutaline. Cumulative concentration-response curves of both the b2 adrenoceptor agonists were constructed and the mean effective concentration (EC50) values determined and compared statistically. Based on the comparative EC50 values in relaxing the pre-contracted uterine strips with different spasmogens, the rank order potency of albuterol was found to be¾ PGF > BaCl2 > OT > KCl on uterine strips from dioestrus animals, while OT> BaCl2> PGF >KCl on the uterine strips of pregnant buffaloes. The rank order potency of terbutaline on uterine strips from dioestrus stage animals was- BaCl2 > OT > KCl > PGF, while BaCl2 > PGF> KCl > OT on uterine tissues of pregnant animals. Thus, irrespective of the state of uterus, whether gravid or non-gravid, KCl-depolarized uterine tissues required comparatively higher concentrations of albuterol or terbutaline to produce tocolytic effect. High concentrations of K+ in biophase may have interfered with the b2 adrenoceptor agonists-induced outward K+ current and hyperpolarization. From the results of present study, it was evident that selective b2 adrenergic agonists had good tocolytic efficacy on the uterus of buffaloes. Further, indirectly the possibility of existence and activation of KCa channels by selective b2 adrenoceptor agonists in mediating tocolysis of buffalo myometrium can not be ruled out, however, detailed studies using specific KCa channel blockers are required for characterizing the nature of such channels in buffalo uterus.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 919-921

 

 Ondansetron amelioration of scopolamine induced cognitive deficits
in three-panel runway apparatus in rats

Naveen Kumar & Anil Kumar Kela

 

Effect of ondansetron (5-HT3-receptor antagonist) was studied on the working memory deficits induced by scopolamine, a muscarinic receptor antagonist in rats using a three-panel runway apparatus. Varying doses of scopolamine (0.1-0.56-mg/kg, ip) were administered alone or in combination with ondansetron (0.01-1.0 mg/kg, ip) and memory errors and latency period of the session were recorded on a three-panel runway apparatus. Treatment with scopolamine (0.56 mg/kg) produced working memory deficits in rats. Treatment with ondansetron (1.0 mg/kg) significantly reduced the scopolamine-induced working memory deficits.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 922-927

 

In vitro and in vivo antimycobacterial activity of antiinflammatory drug, diclofenac sodium

N K Dutta, K Asok Kumar, Kaushiki Mazumdar & Sujata G Dastidar and R Ray & A N Chakrabarty

 

The non-steroidal antiinflammatory drug diclofenac sodium exhibited remarkable inhibitory action against both drug sensitive and drug resistant clinical isolates of Mycobacterium tuberculosis, as well as other mycobacteria. This agent was tested in vitro against 45 different strains of mycobacteria, most of which were inhibited by the drug at 10-25 mg/ml concentration. When tested in vivo, diclofenac, injected at 10 mg/kg body weight of a Swiss strain of white mice, could significantly protect them when challenged with a 50 median lethal dose of M. tuberculosis H37 Rv102. According to Chi-square test, the in vivo data were highly significant (P<0.01).

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 928-932

 

 Isolation, characterization and optimization of antifungal activity
of an actinomycete of soil origin

S K Augustine, S P Bhavsar, M Baserisalehi & B P Kapadnis

 

About 312 actinomycetes were isolated from soil samples on chitin agar. All these isolates were purified and screened for their antifungal activity against pathogenic fungi. Out of these, 22% of the isolates exhibited activity against fungi. One promising isolate with strong antifungal activity against pathogenic fungi was selected for further studies. This isolate was from Pune, and was active against both yeasts and molds. Various fermentation parameters were optimized. Based on morphological and biochemical parameters, the isolate was identified as Streptomyces. The correlation of antifungal activity with growth indicated growth dependent production of antimetabolite. Maximum antifungal metabolite production (600 units/ml) was achieved in the late log phase, which remained constant during stationery phase, and it was extracellular in nature.

 

 

 

Indian Journal of Experimental Biology

 Vol. 42, September 2004, pp. 933-936

 

Isolation of Mycoplasma bovoculi from genitally diseased bovines and its experimental
pathogenicity in pregnant guinea pigs

Y Singh, D N Garg & P K Kapoor and S K Mahajan

 

Thirteen strains of M. bovoculi, 6 from frozen bull-semen (3.5% of 168), 3 from neat bull-semen (3.0% of 100), one each from heart blood and stomach contents of aborted foetus of 85 (1.18%) bovine-abortions, one each from stomach contents and pooled internal organs of 9 (11.1%) stillborn calves, were isolated. All the isolates were resistant to ampicillin and sensitive to spiramycin, vibramycin, demeclocyclin, oxytetracycline, lincomycin and tylosin. However, variation in resistance to tetracycline, erythromycin, neomycin, kanamycin and streptomycin was observed. The gross lesions like congestion of lungs, liver, kidney and spleen were noted only in stillborn calf. However, significant microscopic lesions were encountered in internal tissues of both the aborted bovine fetuses and stillborn calf. Thickened alveolar wall, congestion of blood vessels, mesenchymal cell proliferation along with infiltration of lymphocytes and macrophages were observed in lungs. The liver showed mild infiltration of lymphocytes, macrophages in hepatic triad and necrosis of hepatic cells. The kidney tissues had focal lymphocytic infiltration in the interstitium. One strain of M.bovoculi (isolate # SBC-7/84,IO) isolated from a stillborn calf was found abortigenic upon experimental inoculation in pregnant guinea pigs.

 

 

 

Indian Journal of Experimental Biology

Vol. 42, September 2004, pp. 937-940

 

 

Notes

 

(CTG)n Expansion at DMPK locus seen only in muscle tissue: A novel case

Qurratulain Hasan, Vasavi Mohan & Y R Ahuja

 

Triplet repeat expansion in 3 untranslated region of myotonic dystrophy protein kinase (DMPK) gene has been implicated as causative in myotonic dystrophy (DM). In cases of DM, high levels of somatic instability have been reported, in which inter-tissue repeat length differences as large as 3000 repeats have been observed. This study highlights the inter-tissue (CTG)n expansion variability at the DMPK locus. Molecular analysis of DMPK gene, encompassing the triplet repeat expansion, was carried out in 31 individuals (11 clinically identified DM patients, 20 controls). All controls showed a 2.1kb band (upto 35 CTG repeats), while four cases exhibited an expansion (>50 repeats). A novel observation was made in one case, wherein the DNA from lymphocytes showed a normal 2.1kb band while the muscle tissue DNA from the same patient was heterozygous for normal and 4.3 kb band (>700 repeats). Our results suggested that because inter-tissue variability existed in the (CTG)n repeat number at DMPK locus, an attempt should be made to evaluate affected tissue along with blood wherever possible prior to making a final diagnosis. This is important not only for diagnosis and prenatal analysis, but also while providing genetic counseling to families.

 

 

 

Indian Journal of Experimental Biology

Vol. 42, September 2004, pp. 941-944

  

Effect of chlorpromazine, imipramine and lithium on MAO-A and MAO-B
activity in rat brain mitochondria

Maitreyi Nag

 

Drugs with efficacy in psychiatric disorders affect the function of central neurotransmitter amines, which are inactivated primarily by monoamine oxidase (MAO). Effect of these drugs on the two types of MAO (MAO-A and MAO-B) has been studied in rat brain. The result showed that chlorpromazine (CPZ) and imipramine (IMI) at concentrations of 1´10-2, 5´10-3 and 2.5´10-3 M inhibited rat brain mitochondrial MAO-A activity in vitro by 82, 50, 39 and 86, 74, 38 %, respectively. CPZ at concentrations of 5´10-3, 2.5´10-3, 1´10-3 M inhibited rat brain mitochondrial MAO-B activity in vitro by 83, 55, 39 %, respectively, while IMI at concentrations of 5´10-4, 2.5´10-4, 1´10-4 M inhibited the in vitro enzyme activity by 43, 35, 21 %, respectively. Lithium at concentration of 5´10-3 M could not either inhibit MAO-A or MAO-B in the mitochondrial fraction of rat brain.

 

 

 

Author Index

 

Ahuja Y R

937

Jain Karishma

884

Nag Maitreyi

941

Ansari Anayatallah

866

Johari R P

904

Nair K V Neelakantan

871

Augustine S K

928

Jolly C I

893

Narayanan S

893

 

 

 

 

 

 

Baker Glen B

851

Kapadnis B P

928

Patil S

893

Baserisalehi M

928

Kapoor P K

933

Pillai K Sadasivan

909

Bhavsar S P

928

Kataria Sunita

884

Poddar Sandeep

900

 

 

Kela Anil Kumar

919

 

 

Chakrabarty A N

922

Kumar K Asok

922

Ray R

922

 

 

Kumar Naveen

919

 

 

Dastidar Sujata  G

922

Kumar T

909

Sabir M

913

Dhanya C R

871

Kurup P A

871

Sajadi Kazem

858

Dutta N K

922

 

 

Sam Lal A Arun

909

 

 

Lahijani Maryam Shams

858

Shrivastava Sadhna

876

Eibl G

893

 

 

Singh S P

904

 

 

Mahajan S K

933

Singh Y

933

Garg D N

933

Mathur R

876

Sowa Bernard N

851

Garg K M

913

Mayilvaganan M

904

 

 

Garg Satish K

913

Mazumdar Kaushiki

922

Todd Kathryn G

851

Gayathri N S

871

Mithra K

871

 

 

Guruprasad K N

884

Mohammad Bayat

866

Vasavi Mohan

937

 

 

Murthy P Balakrishna

909

 

 

Hasan Qurratulain

937

 

 

 

 

Hekmat Hossien

866

 

 

 

 

Holt Andrew

851

 

 

 

 

 
 

 

Keyword Index

 

b-Adrenoceptor agonists

913

Glucose

871

Ondansetron

919

Albuterol

913

 

 

 

 

Allium cepa

893

Heart

904

Phenelzine

851

Antifungal activity

928

Helium-neon laser

866

Phenylethylidenehydrazine

851

Antimitotic herb

893

Hydro-oxyradical

884

Pigeon pea

904

Arsenic

900

Hyperlipidaemia

909

Preincubated chick embryo

858

Ascorbic acid

884

Hypolipidemia

909

 

 

 

 

 

 

Rat

904, 941

Benzoquinone

884

Imipramine

941

Rotula aquatica

893

Bovine reproductive disorders

933

Immobilized articular cartilage

866

 

 

Brain mitochondria

941

Insulin

871

Scopolamine

919

Buffaloes

913

Iron

900

Serum

904

 

 

 

 

Streptomyces sp. PU 23

928

Casein

904

Laser irradiation

866

Superoxide radical

884

Cerium

876

Lipid

904

 

 

Chlorpromazine

941

Liponil

909

T3

871

Cholesterol

904

Lipoprotein

904

T4

871

Coriander

909

Lithium

941

Tea

900

Coriandrum sativum

909

Liver

904

Terbutaline

913

Cortisol

871

Low-power laser

866

Three-panel runway apparatus

919

Cucumber cotyledons

884

 

 

Tocolytics

913

 

 

MAO

941

a-Tocopherol

884

DEHP

871

Monoamine oxidase

851

Toxicity

876

l-Deprenyl

851

Moth bean

904

Tranylcypromine

851

Dietary protection

900

Mouse

876

Triton

909

DMPK locus

937

MTT assay

893

TSH

871

 

 

Muscle tissue

937

 

 

EGTA

876

Mycoplasma bovoculi

933

UV-B stress

884

(5Hz) Electromagnetic field

858

 

 

 

 

ELF-EMF

858

Na+ -K+ATPase

871

Vitamin E

871

(CTG)n Expansion

937

Neuroprotection

851

 

 

Experimental pathogenicity

933

Neurorescue

851

Working memory

919