Medicinal & Aromatic Plants Abstracts
Vol. 32, No. 2, April 2010


2010-02-0962 Abdel-Wahab, M.A.; Asolkar, R.N.; Inderbitzin, P.; Fenical, W. (Centre for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0204, USA) Secondary metabolite chemistry of the marine-derived fungus Massarina sp. strain CNT-016. Phytochemistry v. 68(8): p. 1212-1218, 2007 (Eng; 36 ref).

Chemical investigation of the culture broth extracts of the marine-derived fungus Massarina sp. (Lophiostomataceae) (strain CNT-016) has yielded two secondary metabolites, spiromassaritone (1) and massariphenone (2), as well as the previously reported fungal metabolites 6-epi-5'-hydroxy-mycosporulone (3) and enalin A (4). The structures of these compounds were established by a variety of one- and two-dimensional NMR experiments, while the relative configuration of spiromassaritone (1) was determined by X-ray crystallographic methods. The fungal strain was isolated as a sterile mycelium from an ocean mud sample and identified using ITS sequence analysis.

2010-02-0963 Abdel-Sattar, E.; Ahmed, A.A.; Hegazy, M.E.F.; Farag, M.A.; Al-Yahya, M.A.A. (Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Soudi Arabia) Acylated pregnane glycosides from Caralluma russeliana. Phytochemistry v. 68(10): p. 1459-1463, 2007 (Eng; 23 ref).

The chloroform extract of the aerial parts of Caralluma russeliana (Asclepiadaceae) yielded four acylated pregnane glycosides, namely russeliosides E-H, three were found now. The structures of the compounds were elucidated using MS, 1H NMR, I3C NMR, 1H-1H COSY, HMQC, NOESY and HMBC experiments.

2010-02-0964 Abdel-Massih, R.M.; Baydoun, E.A.H.; Waldron, K.W. ; Brett, C.T. (Department of Biology, American University of Beirut, Beirut, Lebanon) Effects of partial enzymic degradation of sugar beet pectin on oxidative coupling of pectin-linked ferulates in vitro. Phytochemistry v. 68(13): p. 1785-1790, 2007 (Eng; 15 ref).

Pectins were extracted from roots and petioles of sugar beet Beta vulgaris (Chenopodiaceae) and treated with alpha-arabinosidase, 1,4-beta-galactanase or polygalacturonase. They were then cross-linked using hydrogen peroxide and peroxidase. The effects on pectin molecular size were monitored by size-exclusion chromatography and viscometry. A decrease in apparent molecular size was observed after alpha-arabinosidase and polygalacturonase treatment, and all three enzymes caused a decrease in viscosity. The pectins were then cross-linked using hydrogen peroxide and peroxidase, and the effects on dehydrodiferulate formation were monitored by HPLC. Pretreatment with polygalacturonase caused no significant change in subsequent dehydrodiferulate cross-linking, while pretreatment with alpha-arabinosidase caused a slight change in the ratios of the different dehydrodiferulates formed. Pretreatment with 1,4-beta-D-galactanase caused a more significant change in the ratios of the different dehydrodiferulates formed, and also greatly increased the overall recovery of total ferulates (monomers plus dehydrodiferulales), both in root pectin and petiole pectin. The possible effects of polysaccharide microstructure on the dimerisation and further polymerisation of pectin-linked ferulates are discussed.

2010-02-0965 Altintas, A.; Kose, Y.B.; Kandemir, A.; Demircl, B.; Baser, K.H.C. (Faculty of Pharmacy, Department of Pharmacognosy, Anadolu University, 26470 Eskisehir, Turkey) Composition of the essential oil of Centaurea saligna. Chemistry of Natural Compounds v. 45(2): p. 276-277, 2009 ( Eng; 7 ref).

The essential oil composition of Centaurea saligna (Asteraceae) was studied. The aerial parts of the plant were hydrodistilled for 3 h using a Clevenger-type apparatus to produced a small amount of essential oil, which was trapped in n-hexane. The oil was analysed by GC and GC/MS. Forty compounds represnting 84.2 percent of the essential were characterized. Hexadecanoic acid, phytol, heptacosane and carvacrol were the main components detected.

2010-02-0966 Asian, S.; Evren, H.; Konuklugil, B.; Turkoglu, I. ; Kartal, M. (Faculty of Pharmacy, Department of Pharmacognosy, Ankara University, 06100 Tandogan-Ankara, Turkey) Essential oil composition of Achillea teretifolia from Turkey. Chemistry of Natural Compounds v. 45(2): p. 274-275, 2009 ( Eng; 7 ref).

Dried aerial parts of Achillea teretifolia (Asteraceae) were found to contain 0.4 percent (calculated per weight of dried plant material) of essential oil. The chemical composition of the essential oils was studied. Thirty seven compounds, represnting 83.53 percent of the essential oil were identified by GC-MS. The major compounds of the oil were piperitone (21.37 percent), linalool (18.99 percent), 1,8-cineole (6.795), alpha-terpineol (5.88 percent), and borneol (4.29 percent). The essential oil was found to be significantly rich with oxygenated monoterpenes with a percentage of 71.39 percent.

2010-02-0967 Baby, S.; Dan, M.; Thaha, A.R.M.; Johnson, A.J.; Kurup, R.; Balakrishnapillai, P.; Lim-Keat, C. (Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Pacha-Palode, Thiruvananthapuram 695 562, Kerala, India) High content of zerumbone in volatile oils of Zingiber zerumbet from southern India and Malaysia. Flavour and Fragrance Journal v. 24(6): p. 301-308, 2009 (Eng ; 53 ref).

The chemical profiles of volatile oils of Zingiber zerumbet (Zingiberaceae) rhizomes from six loacation in the southern Indian state of Kerala and also from Penang in Malaysia were determined. Chemical profiling of volatiles was carried out by extension GC-FID, GC-MS and associated techniques supported by H-NMR, "C-NMR, FABMS and HPTLC in rhizome oils of seven accession of Z. zerumbet. The south Indian accessions reported 76.3-84.8 percent zerumbone content in the rhizomes oils. The Malaysian accession recorded the lowest content of zerumbone (68.9 percent). The highest content of the zerumbone was recorded in accessions from Kerala.

2010-02-0968 Benavides, A.; Bassarello, C.; Montoro, P.; Vilegas, W.; Piacente, S.; Pizza, C. (Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciana (SA), Italy) Flavonoids and isoflavonoids from Gynerium sagittatum. Phytochemistry v. 68(9): p. 1277-1284, 2007 (Eng; 40 ref).

Four flavonoids namely (2R,3R)-2,3-trans-7,4'-dimethoxydihydroflavonol, (2R3S,4S)-2,3-trans-3,4-cis-7,4'-dimethoxy-3,4-flavandiol, 6-hydroxy-7,4' -dimethoxyflavone, 6,7,4'-trimethoxyflavone, along with the known isoflavonoids ferreirin, dihydrocajanin, dalbergioidin, dihydrobiochanin A and biochanin A and other 11 known compounds were isolated from the roots of Gynerium sagittatum (Poaceae). The structural characterization of these compounds was carried out via one- and two-dimensional NMR experiments in combination with ESI-MS. Finally a quantitative analysis of the isoflavones of the methanolic extract was performed by LC-ESI-MS. The high quantity of isoflavonoids found in G. sagittatum makes this plant a good natural source of isoflavonoids.

2010-02-0969 Berkov, S.; Codina, C.; Viladomat, F.; Bastida, J. (Departament de Products Naturals, Biologia Vegetal i Edofologia, Facultat de Farmacia, Universitat de Barcelona, Av. Joan XXIII sin, 08028 Barcelona, Spain) Alkaloids from Galanthus nivalis. Phytochemistry v. 68(13): p. 1791-1798, 2007 (Eng; 10 ref).

Phytochemical studies on Galanthus nivalis (Amaryllidaceae) of Bulgarian origin resulted in the isolation of five compounds: 11-O-(3'-hydroxybutanoyl)hamayne, 3,11-O-(3',3"-dihydroxybutanoyl)hamayne, 3-O-(2"-butenoyl)-11-O-(3'-hydroxybutanoyl)hamayne, 3,1 l,3"-O-(3',3",3'"- trihydroxybutanoyl)hamayne, and 2-O-(3'-acetoxybutanoyl)lycorine, together with five known alkaloids: ungeremine, lycorine, tazettine, hamayne, and ismine. Their structures were determined by 1H and 13C NMR spectroscopy and two-dimensional 1H-1H and 1H-13C chemical shift correlation experiments.

2010-02-0970 Bhandari, P.; Kumar, N.; Singh, B.; Kaul, V.K. ( Natural Plant Products Division, Institute of Himalayan Bioresource Technology, Palampur 176 061, Himachal Pradesh, India) Cucurbitacins from Bacopa monnieri. Phytochemistry v. 68(9): p. 1248-1254, 2007 (Eng; 24 ref).

Four cucurbitacins, bacobitacin A-D (1-4) as well as, a known cytotoxic, cucurbitacin E (5) together with three known phenylethanoid glycosides, monnieraside I, III and plantioside B were isolated form the aerial part of Bacopa monnieri (Scrophulariaceae). Their structures were elucidated on the basis of extensive spectroscopic investigations (1D, 2D NMR and ESI-QTOF-MS/MS). This is the first report on the characterization of cucurbitacins in B. monnier.

2010-02-0971 Bondarenke, S.P.; Frasinyuk, M.S.; Khilya, V.P. ( Taras Shevechenko Kiev National University, 01033, Ukraine, Kiev, ul. Vladimirakaya, 64) Aminomethylation of formononetin and cladrin by primary amines. Chemistry of Natural Compounds v. 45(4): p. 492-495, 2009 ( Eng; 21 ref).

The reaction of natural isoflavones formononetin and cladrin with primary amines and formalin in the presence of a base catalyst was studied. Several novel substituted 9,10-dihydro-4H,8H-chromeno {8,7-e} {91,3} oxazin-4-ones containing alkyl, benzyl, or heterylakyl substituents in the N-9 position were synthesized. Isoflavone formononetin (4'-methoxy-7-hydroxyisoflavone) was isolated from leaves of Genista (Leguminosae) and cladrin (3,4'-deimethoxy-7-hydroxyisoflavone) from Cladrastis lutea both belonging Leguminosae family.

2010-02-0972 Chang, X.L.; Jiang, Z.Y.; Ma, Y.B.; Zhang, X.M.; Tsim, K.W.K.; Chen, J.J. (State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Kinming 650204, Yunnan, China) Two new compounds from the roots of Ligusticum chuanxiong . Journal of Asian Natural Products Research v. 11(9-10): p. 805-810, 2009 (Eng; 11 ref).

Two new compounds, named ligusticoside A (1), a novel phthalide derivative with a lactonc ring, and 4-pentylcyclohex-3-ene-1alpha,2beta3-diol (2), were isolated from the rhizomes of Ligusticum chuanxiong (Umbelliferae). Their structures were determined by spectral methods (MS, IR, UV, 1D and 2D NMR). An X-ray diffraction experiment was performed to confirm the structure of compound 1.

2010-02-0973 Chen, R.J.; Cao, S.W.; Ruan, Z. (State Key Laboratory of Food Science and Technology, Department of Food Science and Technology, Nanchang University, Nanchang 330031, P.R. China) Isolation of chemical constiturnts from Daphne odora var. Margirmt by high-speed counter-current chromatography. Chemistry of Natural Compounds v. 45(4): p. 534-535, 2009 ( Eng; 10 ref).

Preparative high-speed counter-current chromatographic (HSCCC) separation and purification afforded the isolation of daphnetin, daphnodorin-B, p-hydroxybenzoic acid, and daphnodorin D1 from whole plant of Daphne odora var Margirmt (Thymelaeaceae). The purity of these constitutents was 99.6, 99.7, 99.5, and 99.2 percent, determined by HPLC, respectively. Their chemical structures were elucidated by UV, IR, ESIMS, PMR, and 13C NMR analyses.

2010-02-0974 Chen, Y.; Su, J.; Shen, Y.; Zhang, W.; Liang, S.; Zhang, W.; Kong, L. (Department of Natural Medicinal Chemistry, China Pharmaceutical University, No. 1, Shen Nong Road, Nanjing 210038, P.R. China) Flavonoids from Daphne holosericea. Chemistry of Natural Compounds v. 45(4): p. 542-544, 2009 ( Eng; 12 ref).

The constituents of the plant Daphne holosericea (Thymelaeaceae) were investigated and flavonoids were isolated from the EtOAc extract of stem bark. On the basis of 1H NMR (600 MHz), 13C NMR(150 MHz), HSQC, HMBC, and ESI-MS spectral analysis compounds were identified as stelleranol, isochamaejasmin, neochamaejasmin, tiliroside, daphnodorin B, 5-0-methylafzelechin, (-)-afzelechin, genkwanin, apiganin and kaempferol. All spectral data were found in agreement with the literatiure data.

2010-02-0975 Chen, R.N.; Yang, G.E.; Li, J.K.; Du, H.J.; Li, Q.S.; Zhang, Z.M. (School of Pharmaceutical Sciences, Shanxi Medical University, Taiyuan 03001, P.R. China) Cytotoxic constituents from Viscum coloratum. Chemistry of Natural Compounds v. 45(4): p. 547-549, 2009 ( Eng; 20 ref).

The air-dried stems and twigs of Viscum coloratum (Loranthaceae) on extraction with 75 percent ethanol offereded the isolation of nine compounds. The compounds were identified as loliolide, (plus)-epipinoresinol, (plus)-syringaresinol, 7,3',4'-trimethylquercetin, 3-epi-betulinic acid, betulonic acid, mixture of beta-amyrin and lupeol, pentacosanol and beta-sitosterol by NMR and MS spectra.

2010-02-0976 Coy, B.E.D.; Nieto, R.I.J. (Departamento de Quimica, Universidad Nacional de Colombia, Sede Bogota, Ciudad Universitaria, Carrera 30 No. 45-03, Edificio 451 Laboratorio 210. Bogota, Colombia) Sterol composition of the macromycete fungus Lactiporus sulphureus. Chemistry of Natural Compounds v. 45(2): p. 193-196, 2009 ( Eng; 14 ref).

The sterol composition of macromycete fungus Lactiporus sulphureus (Polyporaceae) commonly known as chicken of the woods was analyzed by GC-MS. The fungus contained mainly C16 to C20 fatty acids, C16 to C24 fatty acid esters, and C28, C29, and C30, delta5, delta7, and delta5.7 conventional sterols, and in minor amounts delta 0 analogues with saturated and unsaturated side chains. Moreover, erosterol peroxide and cerevisterol were identified.

2010-02-0977 Crouch, N.R.; Langlois, A.; Mulholland, D.A. ( National Products Research Group, School of Chemistry, University of KwaZulu-Natal, Durban 4041, South Africa) Bufadienolides from the southern African Drimia depressa (Hyacinthaceae : Urgineoideae). Phytochemistry v. 68(13): p. 1731-1734, 2007 (Eng; 8 ref).

Two bufadienolides, 3beta,16beta-dihydroxy-5beta-bufa-20,22-dienolide and . 16beta-hydroxy-5beta-bufa-20, 22-dienolide-3beta-O-beta-D-galactoside, have been isolated from bulbs of the poisonous South African geophyte, Drimia depressa (Hyacinthaceae).

2010-02-0978 Dai, H.F.; Gan, Y.J.; Que, D.M.; Wu, J.; Wen, Z.C. ; Mei, W.L. (Key Laboratory of Tropical Crop Biotechnology, Mnistry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Haikou 571101, China) Two new cytotoxic cardenolides from the latex of Antiaris toxicaria. Journal of Asian Natural Products Research v. 11(9-10): p. 832-837, 2009 (Eng; 8 ref).

Two new cardenolides, toxicarioside F (1) and toxicarioside G (2), were isolated from the latex of Antiaris toxicaria (Moraceae). Their structures were elucidated on the basis of spectral data and chemical evidence. Compounds 1 and 2 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by the MTT method.

2010-02-0979 Dayan, F.E.; Duke, S.O.; Sauldubois, A.; Singh, N. ; McCurdy, C.; Cantrell, C. (Agricultural Research Service, Natural Products Utilization Research Unit, P.O. Box 8048, University, MS 38677, USA) p-Hydroxyphenylpyruvate dioxygenase is a herbicidal target site for beta-triketones from Leptospermum scoparium. Phytochemistry v. 68(14): p. 2004-2014, 2007 (Eng; 38 ref).

p-Hydroxyphenylpyruvate dioxygenase (HPPD) is a key enzyme in tyrosine catabolism and is the molecular target site of beta-triketone pharmacophores used to treat hypertyrosinemia in humans. In plants. HPPD is involved in the biosynthesis of prenyl quinones and tocopherols, and is the target site of beta-triketone herbicides. The beta-triketone-rich essential oil of manuka Leptospermum scoparium (Myrtaceae), and its components leptospermone, grandiflorone and flavesone were tested for their activity in whole-plant bioassays and for their potency against HPPD. The achlorophyllous phenotype of developing plants exposed to manuka oil or its purified beta-triketone components was similar to that of plants exposed to the synthetic HPPD inhibitor sulcotrione. The triketone-rich fraction and leptospermone were approximatively 10 times more active than that of the crude manuka oil, with I50 values of 1.45, 0.96 and 11.5 microgmL-1, respectively. The effect of these samples on carotenoid levels was similar. Unlike their synthetic counterpart, steady-state O2 consumption experiments revealed that the natural triketones were competitive reversible inhibitors of HPPD. Dose-response curves against the enzyme activity of HPPD provided apparent I50 values 15.0, 4.02, 3.14, 0.22 microg mL-1 for manuka oil, triketone-rich fraction, leptospermone and gran-diflorone, respectively. Flavesone was not active. Structure activity relationships indicate that the size and lipophilicity of the side-chain affected the potency of the compounds. Computational analysis of the catalytic domain of HPPD indicates that a lipophilic domain proximate from the Fe2+ favors the binding of ligands with lipophilic moieties.

2010-02-0980 de C. Cursino, L.M.; Mesquita, A.S.S.; de O. Mesquita, D.W.; Fernandes, C.C.; Junior, O.L. Pereira; doAmaral, I.L. ; Nunez, C.V. (Instituto Nacional de Pesqulsas da Amazonia, Coordenacao de Pesquisas em Produtos Naturals-CPPN, Av. Andre Araujo, 2936, Alexio, Manaus, AM, Brasil. CEP 69060-001) Triterpenes from the leaves of Minquartia guianensis Aubl. (Olacaceae). Acta Amazonica v. 39(1): p. 181-186, 2009 (Fre; Eng; 13 ref).

The triterpenes, lupeol, taraxerol, lupen-3-one and squalene were isolated from the dichloromethane extract of the leaveas of Minquartia guianensis. These terpenoids were isolated through chromatographic techniques and identified using 1H and 13C Nuclear Magnetic Resonance (NMR).

2010-02-0981 De Marino, S.; Gala, F.; Borbone, N.; Zollo, F.; Vitalini, S.; Visioli, F.; Iorizzi, M. (Departimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli "Federico II", Via D Montesano 49, 1-80131 Napoli, Italy) Phenolic glycosides from Foeniculum vulgare fruit and evaluation of antioxidative activity. Phytochemistry v. 68(13): p. 1805-1812, 2007 (Eng; 29 ref).

Two diglucoside stilbene trimers and a benzoisofuranone derivative were isolated from Foeniculum vulgare (Apiaceae) fruit together with nine known compounds. Their structures were elucidated by spectral methods including 1D, 2D NMR and MS and chemical methods. Antioxidant activity was tested using three methods: DPPH, total antioxidant capacity and assay of lipid peroxidation.

2010-02-0982 Devkota, H.P.; Basnet, P.; Yahara, S. (Graduate School of Pharmaceutical Sciences, Kumamato University; 5-1 Oe-honmachi, Kumamoto 862-0973, Japan) Diterpene esters and phenolic compounds from Sapium insigne (Royle) Benth. ex Hook. fil.. Chemical & Pharmaceutical Bulletin v. 57(11): p. 1289-1291, 2009 (Eng; 21 ref).

From the leaves of Sapium insigne (Euphorbiaceae) two new phorol derivatives, such as 16-hydroxyphorbol-16-acetate and 4beta-deocy-16-hydroxyphorbol-16-acetate along with twelve known phenolic compounds such as 3-O-caffeoyl quinic acid, 1-O-galloyl-beta-D-glucose, 1,3-di-O-galloyl-beta-D-glucose, rutin, 1,3,4,6-tetra-O-galloyl-beta-D-glucose, quercetin, guaijaverin, nicotiflorin, scpolin, methyl gallate, corilagin, and 1,3,6-tri-0-galloyl-beta-D-glucose were isolated.

2010-02-0983 Dominguez, M.; Marin, J.C.; Esquivel, B.; Cespedes, C.L. (Phytochemistry Lab, UBIPRO, FES-Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios SIN, Los Reyes Iztacala, Tlalnepantla, Estado de Mexico, C.P. 54090, Mexico) Pensteminoside, and unusual catalpol-type iridoid from Penstemon gentianoides HBK (Plantaginaceae). Phytochemistry v. 68(13): p. 1762-1766, 2007 (Eng; 20 ref).

From the MeOH and ethyl acetate extracts of aerial parts of Penstemon gentianoides (Plantaginaceae) an unusual iridoid of the catalpol-type, was isolated and characterized as pensteminoside: (8-O-trans-cinnamoyl, 6-hydroxy, 1-beta-D-glucopyranoside-6'-O-((4"-hydroxy)-cinnamoyl)-catalpol) was isolated, along with the known iridoids: plantarelanoside and globularisicin, the flavone: luteol: and diosmetin, as well the phenylpropanoids, verbascoside and martynoside. Their structures were established by 1D and 2D NMR spectroscopic analyses.

2010-02-0984 Duan, C.L.; Kang, Z.Y.; Lin, C.R.; Jiang, Y.; Liu, J.X.; Tu, P.F. (School of Pharmaceutical Sciences, Peking University, Beijing 100191, China) Two new homoisoflavonoids from the fibrous roots of Ophiopogon japonicus (Thunb) Ker-Gawl. Journal of Asian Natural Products Research v. 11(9-10): p. 875-878, 2009 (Eng; 15 ref).

Two new homoisoflavonoids ophiopogonone D (1) and ophiopogonanone G (2) were isolated from the fibrous roots of Ophiopogon japonicus (Liliaceae). The structures of these two compounds were determined on the basis of spectroscopic means including HR-ESI-MS, 1D, and 2D NMR experiments. The cytotoxic activities of 1 and 2 against Hela and Hep2 cells are described.

2010-02-0985 Dzamic, A.; Sokovic, M.; Ristic, M.S.; Jovanovic, S. Grijic; Vukojevic, J.; Marin, P.D. (University of Belgrade-Faculty of Biology, Institute of Botany and Botanical Garden "Jevremovac", Studentski 16, 11000 Belgrade, Serbia) Chemical composition and antifungal activity of Illicium verum and Eugenia caryophyllata essential oils. Chemistry of Natural Compounds v. 45(2): p. 259-261, 2009 ( Eng; 14 ref).

The essential oil of star anise (Illicium verum and clove Eugenia caryophyllata syn Syzigium aromaticum Myrtaceae) were investigated as potential antifungal agent. In the essential oil of I. verum 16 compounds were identified (99.55 percent of total oil). trans-Anethole was dominant (90.82 percent), followed by eugenol (78.57 percent), beta-caryophyllene (15.56 percent), and alpha-humulene (1.88 percent) were the main components. Dominant compounds in the essential oil from star anise fruit were trans-anethole (94 percent), estragole, limonene, and cis-anethole. Dominant compounds in clove oils were eugenol, eugenylacetate, beta-caryophyllene and humulene.

2010-02-0986 Fan, Z.; Ruan, X.; Mu, R.; Wang, X.; Liu, S.; Wang, S. (Department of Environmental Sciences & Engineering, Fudan University, Shanghai 200433, China) Chemical composition of the volatile compounds of Cinnamomum septentrionale. Chemistry of Natural Compounds v. 45(2): p. 272-273, 2009 ( Eng; 3 ref).

Gas chromatography mass-spectrometry was used to study the volatile compounds of Cinnamomum septentrionale (Lauraceae). Total compound contents were 99.144 percent and the main constituents were 3-tert-pentylcyclopentanone (71.8995), 3,7-dimthyll-2,6-octadienal (4.412 percent), hexadecane (2.844 percent), camphor (2.734 percent), borneol (2.494), alpha-farnesene (1.801 percent), 3-carene (1.563 percent), beta-neoclovene (1.189 percent), and alpha-pinene (1.101 percent).

2010-02-0987 Fang, R.; Houghton, P.J.; Luo, C.; Hylands, P.J. ( Centre for Natural Medicine Research, King's College London, Franklin Wilkins Building, 150 Stamford Street, London SEI 9NH, United Kingdom) Isolation and structure determination of triterpenes from Iris tectorum. Phytochemistry v. 68(9): p. 1242-1247, 2007 (Eng; 21 ref).

Four iridal-type triterpenoids, two of which were new compounds, have been Isolated from rhizomes of Iris tectorum (Iridaceae). Their structures were determined by 1D and 2D NMR spectroscopy and ESI-MS spectrometry. The compounds were identified as the iritectols A and B, and the known iridobelamal A and isoiridogermanal. The presence of epoxide and tetrahydrofuran functions are not common in previously isolated iridal-type triterpenoids.

2010-02-0988 Feng, T.; Cal, X.H.; Zhao, P.J.; Du, Z.Z.; Li, W.Q.; Luo, X.D. (State Key of Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P.R. China) Monoterpenoid indole alkaloids from the bark of Alstonia scholaris. Planta Medica v. 75(14): p. 1537-1541, 2009 (Eng; 18 ref).

Six new monoterpenoid indole alkaloids, scholarisines B-G together with 15 known analogues were isolated from the bark of Alstonia scholaris (Apocynaceae). Their structures were determined by 1D and 2D NMR spectra and MS analyses. The structure of scholarisine B was further supported by the single-crystal X-ray.

2010-02-0989 Feng, F.; Chen, M.H.; Xing, C.X.; Liu, W.Y.; Xie, N. (Department of Natural Medicine Chemistry, China Pharmaceutical University, Nanjing 210009, China) Two novel sesquiterpenoids from Ainsliaea fragrans Champ.. Journal of Asian Natural Products Research v. 11(9-10): p. 855-859, 2009 (Eng; 10 ref).

A new sesquiterpene lactone, 3beta-O-beta-D-glucopyranosyl-8alpha-hydroxy-11alpha,13-dihydro-zaluza nin C (1), and a novel trinorguaiane-type sesquiterpene, 4beta, 10alpha-dimethyl-1beta,5alpha-bicycle3,5,0dec-6-en-4alpha, 10beta-diol (2), together with three known compounds, glucozaluzanin C (3), 11alpha, 13 -dihydrozaluzanin C (4), and 8alpha- hydroxy-11alpha, 13-dihydrozaluzanin C (5), were isolated from the whole plant of Ainsliaea fragrans (Compositae). The structures of 1 and 2 were elucidated on the basis of detailed spectral analysis. Structures of the known compounds were identified by comparison of its spectral data with those values in the literature.

2010-02-0990 Ganapaty, S.; Bharath, C.H.; Steve Thomas, P.; Fotso, S.; Laatsch, H. (Pharmacognosy and Phytochemistry Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India) Flavonoids of Derris heyneana Wight and Arm. Journal of Natural Remedies v. 8(1): p. 57-60, 2008 (Eng; 10 ref).

The genus Derris is a rich source of rotenoids and prenylated flavonoids. Chemical examination of Derris heyneana (Fabaceae) a rare species of Derris led to the isolation of stigmasterol, lupeol, three rotenoids, 6a, 12a-dehydrotoxicarol, dehydrodeguelin, 12-deoxo-12alpha-acetoxyelliptone and the isoflavone, 4-O-methylderrone. All compounds were isolated by sequential chromatography and characterized by NMR and MS spectral data. The flavonoids are reported for the first time from D. heyneana. The root of plant is used as insecticidal larvicidal, expectorant, antitussive, diuretic, antimicrobial, anti-fertility and for cancer chemopreventive remedy.

2010-02-0991 Gao, H.M.; Wang, Z.M.; Wang, W.H. (Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China) A new triterpenoid saponin from the stem of Akebia trifoliata var. australis. Journal of Asian Natural Products Research v. 11(11-12): p. 1012-1017, 2009 (Eng; 16 ref).

A new triterpene glycoside mutongsaponin F (1), together with five known saponins and two known lipids, was isolated from the 70 percent ethanol extract of the stems of Akebia trifoliata var. australis. Their structures were elucidated on the basis of the spectroscopic analysis and physicochemical properties as 3-beta-(beta-D-glucopyranosyl-(1-2)-O-beta-D-glucopyranosyl-(1-3)-O- -alpha-L-arabinopyranosyl )oxyl-30-norolean-12-en-28-oic acid alpha-L-rhamnopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D-g lucopyranosyl ester (1), 3-beta-(beta-D-glucopyranosyl-(1-2)-O-beta-D-glucopyranosyl-(1-3)-O- -alpha-L-arabinopyranosyl) oxy-30-norolean-12-en-28-oic acid (2), leonticin E (3), collinsonidin (4), arjunolic acid 28-O-glucopyranoside (5), asiatic acid 28-O-glucopyranoside (6), soya- cerebroside I (7), and 1-O-alpha-L-galactosyl-(1- 6)-O-beta-D- galactosyl-3-O- hexadecanoyl- glycerol (8), respectively.

2010-02-0992 Gapparov, A.M.; Aripova, S.F.; Vdovin, A.D.; Khuzhaev, V.U. (S. YU. Yunuso Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan) Phytochemical study of Convolvulus subhirsutus growing on Uzbekistan. Chemistry of Natural Compounds v. 45(4): p. 604-605, 2009 ( Eng; 9 ref).

From the chloroform part of the alcholic extract of the aerial part of Convolvulus subhirsutus (Convolvulaceae) a coumarin was isolated. The molecular weight of the coumarin was confirmed by a peak with mass 192 in the GC/MS. The spectral properties indicated that the isolated coumarin was scopoletin. The EtOAc fraction of extract on chromatography afforded the isolation of caffeic acid and its esters.

2010-02-0993 Garazd, M.M.; Garazd, Ya.L.; Ogorodniichuk, A.S.; Khilya, V.P. (Institute of Bioorganic and Petroleum Chemistry, National Academy of Science of Ukraine, 02094, Ukraine Kiev, ul. Murmanskaya, 1) Modified coumarins, 29. synthessis of structural analoges of natural 6-arylfuro3,2-gchromen-7-ones. Chemistry of Natural Compounds v. 45(2): p. 158-163, 2009 ( Eng; 28 ref).

3-Subsituted 6-arylfuro {3.2-g} chromen-7-ones, strictural analogs of natural furocoumarins, were synthesized by linear annelation of a furan fragment to a 3-arylcoumarin system. The 3-arylcoumarin core is pachyrrhizin isolated from the plant of Leguminosae family viz., Pachyrrhizus arosus P. tuberosus, Neorautassenia pseudopachyrriza and N. edulis.

2010-02-0994 Gbolade, A.A.; Tira-Picos, V.; Nogueira, J.M.F.; Oladele, A.T. (Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu Campus, Nigeria Sagamu, Nigeria) Comparative analysis of essential oils from the leaf, fruit and stem bark of Harungana madagascariensis. International Journal of Green Pharmacy v. 3(4): p. 290-292, 2009 (Eng; 16 ref).

A comparative analysis of hydrodistilled essential oils of the leaf, stem bark and fruit of Harungana madagascariensis (Hypericaceae) was carried out by gas chromatography-mass spectroscopy (GC-MS) for the first time. Both qualitative and quantitative differences existed in the composition of the three oils which comprised mainly sesquiterpene hydrocarbons (66.8-69.6 percent). Beta- caryophyllene (32.4 percent) and 18.4 percent respectively, for leaf and fruit oils only), alpha-humulene (10.4 percent, 9.8 percent and 7.3 percent respectively for leaf, stem bark and fruit oils), germacrene D (8.7 percent for leaf oil only), and alpha-farnesene (37.4 percent) and 10.4 percent respectively, for stem bark and fruit oils only) were the predominant constituents.

2010-02-0995 Ge, X.; Lin, D.C.; Zhang, W.D.; Zhang, X.R. ( Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China) Triterpenoid saponins and monoterpenoid glycosides from Incarvillea delavayi. Journal of Asian Natural Products Research v. 11(9-10): p. 838-844, 2009 (Eng; 19 ref).

Two new triterpenoid saponins, incarvillosides A (1) and B (2), and two new monoterpenoid glycosides, incarvillosides C (3) and D (4), were isolated from the high-polarity fraction of the whole plant of Incarvillea delavayi (Bignoniaceae). By means of spectroscopic data and chemical degradation, the structures were established as (3beta,21beta)-3,19,21,23-tetrahydroxyurs-12-en-28-oic acid 28-O-beta-D-glucopyranoside (1), (2beta,3beta,19alpha)-2,3,9,23-tetrahydroxyolean-12-en-28-oic acid 28-O-beta-D-glucopyranoside (2), (2S,6R-2,6-dimethyl-1,8- octanediol 1-O-beta-D-glucopyranoside (3), and (2S,6R)-2,6-dimethyl-1,8-octanediol 8-O-beta-D-glucopyranoside (4).

2010-02-0996 Geetha, B.S.; Rameshkumar, K.S. (Phytochemistry and Phytopharmacology Division, Tropical Botanical Garden Research Institute Palode, Thiruvanthapuram, Kerala-695562) Essential oil constitutents of Naringi crenulata leaves. Indian Perfumer v. 53(3): p. 29-30, 2009 (Eng; 21 ref).

The essential oil obtained by hydrodistillation of the leaves of Naringi crenulata was analyzed by GC-FID and GC-MS. Thirty three components comprising 87.9 percent of the oil were identified by GC-MS. Sesquiterpenoids (81.0 percent) predominated the oil components; beta- caryophyllene (17.9 percent), spathulenol (7.0 percent) and alpha-acorenol (6.2 percent) being the major constituents.

2010-02-0997 Goleblowski, M.; Paszkiewicz, M.; Halinski, L.; Malinski, E.; Stepnowski, P. (Faculty of Chemistry, University of Goansk, ul. Sobieskiego 18/19, 80-952 Gdansk, Poland) Chemical composition of commercially available esential oils from eucalyptus, pine, ylang, and juniper. Chemistry of Natural Compounds v. 45(2): p. 278-279, 2009 ( Eng; 8 ref ).

Chemical composition of the natural extracts and essential oils of commercial pine, eucqalyptus, Juniper and, Ylang-Yiang was studied. In total 23 terpenes and sesquiterpene alcohols were identified and quantified. Comparison with the composition of pure extracts obtained from different individual species revealed a similar qualitative profile of volatiles. However, there were quantitative differences between the dominant compounds found is pine oil and the species extract. The content of main components of the other commercial oils were quite similar to those of natural extract.

2010-02-0998 Gousiadou, C.; Karioti, A.; Heilmann, J.; Skaltsa, H. (School of Pharmacy, University of Athens, Panepistimiopolis, Zografou 15771 Athens, Greece) Iridoids from Scutellaria albida ssp. albida. Phytochemistry v. 68(13): p. 1799-1804, 2007 (Eng; 27 ref).

Three iridoid glycosides, 6'-O-E-p-coumaroylgardoside (1), 6'-O-p-E-coumaroyl-8-epi-loganic acid (2) and scutelloside (3) were isolated from the aerial parts of Scutellaria albida subsp. albida (Lamiaceae). In addition to an anomeric mixture in equilibrium of one iridoid aglycone (4, 4a), nine iridoid glycosides (5-13), four known phenylethanoid glycosides (14-17), and six known phenolic derivatives (18-23).

2010-02-0999 Gupta, D.; Singh, V.; Prakash, D. (Department of Pharmacy, Shri Ram Murti Smarak College of Engineering & Technology, Nainital Road, Bareilly-243202, Uttar Pradesh, India) Chemical constituents from Tinospora cordifolia stem. Journal of Medicinal and Aromatic Plant Sciences v. 31(3): p. 209-214, 2009 (Eng; 49 ref).

The ethanolic extract of stem of T. cordifolia (Menispermaceae) on column chromatography over silica gel afforded seven compounds. On the basis of spectral data and physico-chemical properties, heptacosanol-1, n-nonacosanol, n-tetracontanol, tinosporasteryl palmitate, n-triacontanyl palmitate, n-hexacosanyl stearate and n-octacosanol were identified.

2010-02-1000 Gvazava, L.N.; Kikoladze, V.S. (Kutateladze Institute of Pharmaceutical Chemistry, 0159, Tbilisi, ul. P. Saradzhishvili, 36, Georgia) Cycloartane glycosides from Euphorbia gloreosa. Chemistry of Natural Compounds v. 45(4): p. 595-596, 2009 ( Eng; 11 ref).

Eight compounds, two genins cyclosiversigenin and asgenin and their glycosides were isolated from the ground aircdried roots of Euphorbia glareasa (Euphorbiaceae). Study of the acid hydrolysis products of the glycosides showed that all contained cyclosiversigenin as the genin. A structures of the carbohydrate parts of the glycosides were established using chemical transformations (Hakomori methylation with subsequent methanolysis and GC of the sugars) and IR and PMR spectral data.

2010-02-1001 Haba, H.; Lavaud, C.; Harkat, H.; Magid, A.A.; Marcourt, L.; Benkhaled, M. (Department de Chimie, Faculte des Sciences, Universite de Batna, Batna 05000, Algeria) Diterpenoids and triterpenoids from Euphorbia guyoniana. Phytochemistry v. 68(9): p. 1255-1260, 2007 (Eng; 27 ref).

Two new compounds with tigliane and cycloartane skeletons: 4,12-dideoxy(4alpha)phorbol-13-hexadecanoate (1) and 24-methylene-cycloartane-3,28-diol (2), respectively, in addition of four known diterpenoids and 13 triterpenoids: 3-benzoyloxy-5,15- diacetoxy-9,14- dioxojatropha-6(17),11-diene (4), ent-abieta-8(14),13(15)-dien-16,12-olide (5), ent-8alpha,14alpha-epoxyabieta-ll,13(15)-dien-16,12-olide (6), ent-3-hydroxyatis -16(17)-ene-2,14-dione (7), 3beta-hydroxytaraxer-14-en-28-oic acid (8), beta-sitosteryl-3beta-glucopyranoside-6'-O-palmitate (9), multiflorenyl acetate (10), multiflorenyl palmitate (11), peplusol (12), 24-methylenecycloartanol (3), lanosterol (13), euferol (14), butyrospermol (15), cycloartenol (16), obtusifoliol (17), cycloeucalenol (18) and beta-sitosterol (19), were isolated from the roots of Euphorbia guyoniana (Euphorbiaceae). Their structures were established on the basis of physical and spectroscopic analysis, including 1D and 2D homo- and heteronuclear NMR experiments (COSY, HSQC, HMBC and NOESY) and by comparison with the literature data.

2010-02-1002 Hiramatsu, F.; Murayama, T.; Koseki, T.; Shiono, Y. (Department of Bioresource Engineering, Fcaulty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan) Strobilols A-D four cadinane-type sesquiterpenes from the edible mushrooms Strobilurus ohshimae. Phytochemistry v. 68(9): p. 1267-1271, 2007 (Eng; 7 ref).

Four sesquiterpenoids - strobilols A (1), B (2), C (3), and D (4) - were isolated from the organic extracts of fruiting bodies of the edible mushroom Strobilurus ohshimae (Tricholomataceae). Their structures were determined by spectroscopic methods. Compound 1 exhibited moderate activity against the brine shrimp Artemia salina. This paper is the first report on isolation of cadinane-type sesquiterpenoids from S. ohshimae.

2010-02-1003 Huan, Y.; Dong, W.; Li, T.; Baochang, C. (Jiangsu key Laboratory of Chinese medicinal Processing, Nanjing, China, 210029) Flavonoid aglycones of Oxytropis falcata. Chemistry of Natural Compounds v. 45(2): p. 239-241, 2009 ( Eng; 20 ref).

From the chloroform extract of Oxytropis falcata (Leguminosae) compounds, 2',4'-dihydroxydihydrochalcone, 2'-methoxy-4', hydroxychalone, 2'-hydroxy -4'-methoxychalcone, 2',4'-dihydroxychalcone, 'isoliquiriti- genin, pinostrobin, pinocembrin, 7-hydroxyflavonone, liquiritigenin, kaempferol, isorhamnetin, quercetin, myricetin, chrysin, apigenin, and luteolin were isolated and the their structure were determined by physical and chemical properties and NMR analysis.

2010-02-1004 Hussain, J.; Khan, F.U.; Rehman, N.U.; Ullah, R.; Mohmmad, Z.; Tasleem, S.; Naeem, A.; Shah, M.R. (Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, NWFP, Pakistan) One new triterpene ester from Nepeta suavis. Journal of Asian Natural Products Research v. 11(11-12): p. 996-999, 2009 (Eng; 18 ref).

One new tetracyclic triterpene ester (1) has been isolated from the chloroform-soluble portion of the whole plant of Nepeta suavis (Labiatae) along with two known compounds, namely artemetin (2) and jaceidin (3). The structures of the isolated compounds were assigned on basis of their 1H and 13C NMR spectra including two-dimensional NMR techniques such as COSY, HMQC, and HMBC experiments and comparison with the literature data.

2010-02-1005 II'Ina, T.V.; Kovaleva, A.M.; Goryachaya, O.V.; Aloksandrov, A.N. (National Pharmaceutical University, Ukraine, Kharkov, ul. Pushkinskaya, 53' Ukraine SRI for Ecological Problems, Kharkov) Essential oil from Galium verum flowers. Chemistry of Natural Compounds v. 45(4): p. 587-588, 2009 ( Eng; 3 ref).

The composition of essential oil obtained from Galium verum (Rubiaceae) was studied using GC/MS. The compounds isolated were nine terpenoids, five aromatics, four fatty acids and other organic compounds. Total amount of compounds in flowers was 2.74 percent, calculated as per absolute dry raw material.

2010-02-1006 Inada, A.; Morimoto, C.; Yoshikawa, T.; Inatomi, Y.; Murata, H. (Faculty of Pharmaceutical Sciences, Setsunan University; 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan) 24-Ethyl,24-methyl-29-nor-lanostanes from leaves of Freycinetia formosena. Chemical & Pharmaceutical Bulletin v. 57(11): p. 1303-1304, 2009 (Eng; 12 ref).

Two new 24-ethyl,24methyl-29-nor-lanostanes were isolated from the MeOH extract of leaves of Freycinetia formosana (Pandanaceae). Their structures were elucidated as 24-ethyl, 24methyl-29-nor-5alpha lanosta-4 (28), 7-dien-3beta-ol, respectively based on spectroscopic analysis.

2010-02-1007 Iskendeov, D.A.; Isaev, I.M.; Isaev, M.I. (S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent) Triterpene glycosides from Astragalus and their genins. LXXXIL, Cyclomacroside B, a new glycoside. Chemistry of Natural Compounds v. 45(4): p. 511-513, 2009 ( Eng; 7 ref).

The structure of the new cyloartane glycoside, cyclomacroside B, isolated from Astragalus macropus (Leguminosae) was shown to be 1,7-di-O-acetyl-24R-cycloartan- 1alpha,3beta,7beta,24,25-pentaol 3-O-alpha-L-rhamnopyranoside-24-O-beta-D-xylopyranoside based on PMR, 13C NMR, DEPT, COSY, HSQC, and HMBC spectral data.

2010-02-1008 Jijun, L.; Feng, H.; Zhongyan, W.; Yongbo, Y.; Fengkui, M. (Shenyang Pharmaceutical University, Shenyang Liaoning 110016, China) Chemical composition of the essential oil from leaves of Callicarpa nudiflora. Chemistry of Natural Compounds v. 45(2): p. 267-268, 2009 ( Eng; 6 ref).

The essential oil obtained in a yield of 0.1 percent dry weight from the leavs of Callicarpa nudiflora (Verbenaceae) was analyzed by GC-MS. Thirty-four constituents, accounting for more than 87 percent of the total oil composition, were identified. The main components of the essential oil were humulene epoxide (4.24 percent), o-cymene (3.93 percent), sabinene (3.625), beta-terpineol (2.955), and linalool (2.055).

2010-02-1009 Kang, W.Y.; Ji, Z.Q.; Wang, J.M. (Pharmaceutical College of Henan University, Kaifeng, Henan, 475004, P.R. China) Composition of the essential oil of Adiantum fiabellulatum. Chemistry of Natural Compounds v. 45(4): p. 575-577, 2009 ( Eng; 6 ref).

In order to identify the chemical constitutents of the essential oil in the roots and leaves of Adiantum flabellulatum (Adiantaceae) and to differentiate them, the essntial oil composition was examined using the HS-SPME techniques. Forty-two compounds in the roots which comprised 94.6 percent of the volatile fraction were identified. The main constituents of the oil in the roots were n-decanoic acid, 6,10,14-trimethyl1-2-pentacanone, diethyl phthalate, and nonanoic acid. Thirty-eight compounds were identified in the leaves which comparised 91.64 percent of the volatile fraction. The main constituents were n-decanoic acid, 2-isopropenyl-4a,8-dimethyl-1,2,3,4,4a,5,6,7,- octahydronaphthalene {1R-(1alpha,7beta,8aalpha)}- 1,2,3,5,6, 7,8,8a-octahydro-1,8a-dimethyl-7 -(methylethenyl)-naphthalene, alpha-panasinen, 4-tetradecyne, beta-pinene, and nonanoic acid. Ninteen compounds were common in both roots and leaves which shows that there are some similarities between the essential oil in roots and leaves.

2010-02-1010 Karioti, A.; Skopeliti, M.; Tsitsilonis, O.; Heilmann, J.; Skaltsa, H. (Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157-71, Athens, Greece) Cytotoxicity and immunomodulating chacteristics of labdane diterpens from Maruubium cylleneum and Marrubium velutinum. Phytochemistry v. 68(11): p. 1587-1594, 2007 (Eng; 15 ref).

From the aerial parts of Marrubium cylleneum (Lamiaceae), one labdane nor-diterpene has been isolated together with two labdane diterpenes, hitherto not known as natural products. The structures of the isolated compounds were established by means of NMR 1H-1H-COSY, 1H 13C-HSQC, HMQC-TOCSY, HMBC, NOESY and MS spectral analyses. Several diterpenoids from M. cylleneum and M. velutinum were tested for their cytotoxic effect against various cancer cell lines and their immunomodulating potential in human peripheral blood mononuclear cells in standard in vitro assays, The results show a differential cytotoxicity of some compounds as well as their ability to improve selected lymphocyte functions.

2010-02-1011 Kaya, A.; Baser, K.H.C.; Demirci, B. (Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Botany, 26470, Eskisehir, Turkey) Composition of essential oil of endemic Salvia wiedemannii in Turkey. Chemistry of Natural Compounds v. 45(4): p. 552-553, 2009 ( Eng; 10 ref).

In total 35 compounds were identified from the essential oil of Salvia wiedemannii (Lamiaceae), represnting 96 percent of the oil. Four main classes of compounds were: monoterpene hydrocarbons, oxgenated monoterpenes, sesquiterpene hydrocarbons and others. The main compounds were 1,8 cine ole, beta pinene and alphapinene.

2010-02-1012 Kimura, Y.; Kuroki, M.; Maeda, M.; Okano, M.; Yokoyama, M.; Kino, K. (Deaprtment of Biofunctional Chemistry, Graduate School of Natural Science and Technology, Okayama University, 1-1-1 Tsushima-Naka, Okayama 700-8530, Japan) Glycoform analysis of Japanese cypress pollen allergen, cha o 1: a comparison of the glycoforms of cedar and cypress pollen allergens. Bioscience, Biotechnology, and Biochemistry v. 72(2): p. 485-491, 2008 (Eng; 14 ref).

A Japanese cypress Chamaecyparis obtusa pollen allergen, Cha o l, is one of the major allergens that cause allergic pollinosis in Japan. Although it has been found that Cha o 1 is glycosylated and that the amino acid sequence is highly homologous with that of Japanese cedar pollen allergen (Cry j 1), the structure of N-glycans linked to Cha o 1 remains to be determined. In this study, analyzed the structures of the N-glycans of Cha o1. The N-glycans were liberated by hydrazinolysis from purified Cha o 1, and the resulting sugar chains were N-acetylated and pyridylaminated. The structures of pyridylaminated N-glycans were analyzed by a combination of exoglycosidase digestion, two dimensional (2D-) sugar chain mapping, and electrospray ionization mass spectrometry analysis. Structural analysis indicated that the major N-glycan structure of Cha o1 is GlcNAc2Man3Xyli-Fuc1GlcNAc2 (89 percent), and that high-mannose type structures (Man9GlcNAc2, Man7GlcNAc2) occur as minor components (11 percent).

2010-02-1013 Kingston, D.G.I. (Department of Chemistry, MIC 0212, Virginia Polytechnic Institute and State University Blacksburg, V A 24061, USA) Review: The shape of things to come: structural and synthetic studies of taxol and related compounds. Phytochemistry v. 68(14): p. 1844-1854, 2007 (Eng; 62 ref).

The history of the development of Taxol(Registered) (paclitaxel) as an anticancer drug is reviewed, and some aspects of the phytochemistry of Taxus species (Taxaceae) and of the medicinal chemistry of taxol are discussed. The nature of the taxol-tubulin interaction is then described, with an - emphasis on studies that led to the discovery and experimental proof of the T-taxol conformation as the tubulin-binding conformation of taxol. The implications of this conformation for future drug development are also briefly covered.

2010-02-1014 Kislichenko, V.S.; Omel'chenko, Z.I.; Vel'ma, V.V. (National Pharmaceutical University, 61002, Ukraine, Kharkov, ul. Pushkinskaya, 53) Sterols from Setaria italica grain. Chemistry of Natural Compounds v. 45(2): p. 286, 2009 (Eng; 3 ref).

Foxtail millet (Setaria italica Gramineae) was studied to identify and determine quantitatively sterols in grain by GC-MS. A total of 12 sterols were identified by analyzing the grain. The major sterols were; gama-sitosterol (2.781 mg/kg); stigmastanol (1.006 mg/kg); 5-cholesten-3-ol, 24-methyl (0.913 mg/kg); and campesterol (0.867 mg/kg).

2010-02-1015 Kitic, D.; Zlatkovic, B.; Palic, R.; Jovanovic, T. ; Ristic, M. (Faculty of Medicine, Department of Pharmacy, Bulevar Zorana Djindjica 81, Nis, University of Nis, Serbia) Fatty acids of some plants of the genus Calamintha. Chemistry of Natural Compounds v. 45(2): p. 231-233, 2009 ( Eng; 8 ref).

The composition of fatty acids and their contents were determined in four species of the genus Calamintha viz. C. sylvatica C. grandiflora C. glandulosa and C. vardarensis (Lamiaceae) by GC and GC/MS analysis. In the species investigated main fatty acids were olic acid, palmitic acid and linolic acid.

2010-02-1016 Koshevol, O.N.; Komisarenko, A.N.; Kovaleva, A.M.; D'yakonova, Y.V. (National Pharmaceutical University, 61002, Ukraine, Kharkov, ul. Pushkinskaya, 53) Coumarins from Eucalyptus viminalis leaves. Chemistry of Natural Compounds v. 45(4): p. 532-533, 2009 ( Eng; 4 ref).

Six compounds were isolated from the air dried leaves of Eucalyptus viminalis (Myrtaceae). Physicochemical and chemical methods (PC, TLC, UV and IR spectroscopy, specific rotation, melting point, acid and enzymatic hydrolysis) were used to identify the isolated compounds. The compounds were identified as: umbelliferone, scopoletin, daphnoretin, coumarin, scopolin and skimmin.

2010-02-1017 Kostadinova, E.P.; Alipieva, K.I.; Kokubun, T.; Taskova, R.M.; Handjieva, N.V. (Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria) Phenylethanoids, iridoids and a spirostanol saponin from Veronica turrilliana. Phytochemistry v. 68(9): p. 1321-1326, 2007 (Eng; 15 ref).

From the aerial parts of Veronica turrilliana (Plantaginaceae) two phenylethanoid glycosides, turrilliosides A and B and a steroidal saponin, turrilli- anoside were isolated and their structures elucidated as beta-(3,4-dihydroxyphenyl)ethyl-4-O-E-caffeoyl-O-beta-glucopyranosyl- (1-4)-alpha-rhamnopyranosyl-(1-6)-beta-glucopyranoside, beta-(3,4-dihydroxyphenyl)ethyl-4-O-E-caffeoyl-6-O-E-feruloyl-beta-glucopyranosyl-(1-4)-alpha-rhamnopyranosyl-(1-6)-beta-glucopyranoside and (23S,25S)-12beta,23-dihydroxyspirost-5-en-3beta-yl O-alpha-rhamnopyranosyl-(1-4)-beta-glucopyranoside, respectively. Furthermore, eight known glucosides are reported namely, catalpol, catalposide, verproside, amphicoside, isovanilloylcatalpol, aucubin, arbutin, and 6-O-E-caffeoylarbutin, the latter two for the first time in the genus Veronica. The two phenylethanoid glycosides were found to be potent DPPH radical scavengers. All of the tested compounds were inactive against the representative species of fungi and bacteria.

2010-02-1018 Kovalev, S.V. (National Pharmaceutical University, Ukraine, Kharkov, 61146, ul. Blyukhera, 4) Flavonoids from Lotus ucrainicus and L. arvensis. Chemistry of Natural Compounds v. 45(4): p. 550-551, 2009 ( Eng; 7 ref).

The flavonoid composition of Lotus ucrainicus (Leguminosae) herbs was studied during flowering. The isolated compounds were identified using physicochemical (UV, IR, PMR spectroscopy), chemical, and biochemical analytical methods. Comparison of the results with literature data and authetic samples identified compounds as kaempferol, quercetin, astragalin, hyperoside and isorhamnetin.

2010-02-1019 Kovaleva, A.M.; Grud,ko, I.V.; Aleksandrov, A.N.; Komissarenko, A.N. (National Pharmaceutical University, Ukraine, Kharkov, ul. Puskinskaya, 53, Ukraine SRI for Ecological Problems, Kharkov) GC/MS study of the chloroform fraction of Melilotus officinalis. Chemistry of Natural Compounds v. 45(4): p. 585-586, 2009 ( Eng; 3 ref).

The components of the lipophilic fraction from Melilotus officinalis (Fabaceae), that was obtained by CHCl3 was studied. Compounds were identified by comparison of mass spectra with those in the Wiley 275 and NIST98 libraries and mass spectra of standards. The dominant components in total lipophilic CHCl3, extract were 1,3-di-O-methyl-myo-inositol (75.503 percent), acetal (5.874), palmitic acid (2.252) and linolic acid (1.958 percent).

2010-02-1020 Kovaleva, A.M.; Gencharov, N.F.; Komissarenko, A.N.; Sidora, N.V.; Kovalev, S..V. (National Pharmaceutical University, Ukraine, Kharkov, ul. Pushkinskaya, 53) GC/MS study of essential oil components from flowers of Crataegus jackii, C. Robesoniana, C. Flabellata. Chemistry of Natural Compounds v. 45(4): p. 582-583, 2009 ( Eng; 7 ref).

The study of essential oils from flowers of three Crataegus species viz. C. robesoniana; C. flabellita and C. jackii (Rosaceae) revealed the presence of 46 compounds. The important compounds were acyclic, monocyclic and bicyclic mono and sesquiterpenoids, norterpenoids and triterpenoids). m010-02-1021 Kurnia, D.; Akiyama, K.; Hayashi, H. (Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, Japan)

29-Norcucurbitacin derivatives isolated from the Indonesian medicinal plant, Phaleria macrocarpa (Scheff.) Boerl.. Bioscience, Biotechnology, and Biochemistry v. 72(2): p. 618-620, 2008 (Eng; 6 ref).

The new 29-norcucurbitacin, desacetylfevicordin A (1), together with three known 29-norcucurbitacin derivatives (2-4) were isolated from seeds of the Indonesian medicinal plant, Phaleria macrocarpa (Thymelaeaceae). The structures of 1-4 were elucidated on the basis of spectroscopic analyses and chemical transformation. These compounds exhibited toxicity against the brine shrimp (Artemia salina).

2010-02-1022 Li, J.T.; Yin, B.L.; Liu, Y.; Wang, L.Q.; Chen, Y.G. (Department of Chemistry, Yunnan Normal University, Kunming 650092, China) Mono-aromatic constituents of Dendrobium longicornu. Chemistry of Natural Compounds v. 45(2): p. 234-236, 2009 ( Eng; 13 ref).

The air-dried whole plants of Dendrobium longicornus (Orchidaceae) on extraction with 9.5 percent EtOH affordeed the isolation of eight compounds. The isolates were identified as bis(2-ehtyl) (hexyl) phthalate, dibutyl phthalate, ethyl haematommate, methyl beta-orcinol carboxylate, n-docosyl trans - ferulate, gallic acid, ferulaldehyde and beta-sitosterol based on NMR and MS data, and comparison of data with those reperted in the literature.

2010-02-1023 Li, Y.; Wang, Y.L.; Li, L.; Liu, L.; Lu, Y.X.; Cheng, X.C.; Zhang, Q.L. (Beijing Institute of Radiation Medicine, Beijing 100850, China) Structural characterization of polysaccharides from the roots of Urtica fissa. Journal of Asian Natural Products Research v. 11(11-12): p. 951-957, 2009 (Eng; 20 ref).

Three polysaccharides were isolated from the roots of Urtica fissa (Urticaceae) by extraction, ultrafiltration, anion-exchange, and gel-filtration chromatography. The structures were characterized using acetylation, methylation, and spectral methods (GCMS, NMR). All three polysaccharides are mainly composed of D-arabinofuranosyl, D-galactopyranosyl, D-glucopyranosyl residues with different structural characteristics. Polysaccharide A of MW 5.2 X 10 to the power 3 contained a linear chain of 1-linked beta-D-glucopyranosyl, 1,6-linked beta-D-glucopyranosyl, 1,6-linked alpha-galactopyranosyl, and 1,5-linked beta-arabinofuranosyl moieties. Polysaccharide B of MW 7.7 X 10 to the power 4 possessed a chain consisting of 1,5-linked alpha-D-arabinofuranosyl, 1,3-linked beta-D-mannopyranosyl, 1,6-linked beta-D-glucopyranosyl, and 1,6-linked alpha-D-galactopyranosyl residues, but 4-O of alpha-D-galactopyranosyl residues were branched by terminal beta-D-glucopyranosyl residues. Polysaccharide C of MW 5.3 X 10 to the power 4 composed of a chain of 1,5-linked alpha-D-arabinofuranosyl, 1,4-linked beta-D-galactopyranosyl, 1,5-linked beta-D-xylopyranosyl, 1,4-linked beta-D-mannopyranosyl, 1-linked beta-D-glucopyranosyl residues, and the terminal beta-D-glucopyranosyl residues are attached to 3-O positions of 1,6-linked alpha-D-glucopyranosyl residues.

2010-02-1024 Lin, Y.P.; Hsu, F.L.; Chen, C.S.; Chern, J.W.; Lee, M.H. (Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan) Constituents from the Formosan apple reduce lyrosinase activity in human epidermal melanocytes. Phytochemistry v. 68(8): p. 1189-1199, 2007 (Eng; 50 ref).

Tyrosinase is a copper-containing monooxygenase that catalyzes melanin synthesis in skin melanocytes. Herein, 13 compounds from the Formosan apple Malus doumeri var. formosana (Rosaceae), an indigenous Taiwanese plant, were isolated and identified. The active constituents were identified as 3-hydroxyphloretin (7) and catechol (9); they exhibited potent hydroxyl radical-scavenging (IC50 values, 0.6 and 1.1 microM) and cellular tyrosinase-reducing activities (IC50 values, 32 and 22 microM) in human epidermal melanocytes. In addition, evaluated the level of several tyrosinase-related proteins by Western blot analysis. In contrast to 3-hydroxyphloretin (7), which showed no effect on the level of these proteins, catechol (9) reduced their activity and the expression of the respective genes, as determined by quantitative real-time PCR. In a kinetic analysis of mushroom tyrosinase, 3-hydroxyphloretin (7) was a competitive inhibitor. These two constituents exhibited metal-coordinating interactions with copper ions in a virtual model of molecular docking with human tyrosinase. Thus, 3-hydroxyphloretin (7) and catechol (9) were the most active constituents from the Formosan apple; they exhibited antioxidant and tyrosinase reducing activities, suggesting their possible use as cosmetic agents.

2010-02-1025 Liu, Y.; Jiang, J.H.; Yin, B.L.; Chen, Y.G. ( Department of Chemistry, Yunnan Normal University, Kunming 650092, China) Chemical constituents of Dendrobium cariniferum. Chemistry of Natural Compounds v. 45(2): p. 237-238, 2009 ( Eng; 11 ref).

Five compounds were isolated from the ethanol extract of whole plant of Dendrobium cariniferum (Orchidaceae). Compounds were identified as gigantol batatasin, stigmasterol, daucosterol and 3,3,5-tetra hydroxybibenzyl based on co-TLC and comparison of 1H-NMR, 13C-NMR and EI-MS with those of authentic samples.

2010-02-1026 Liu, Y.; Jiang, J.H.; Zhang, Y.; Chen, Y.G. ( Department of Chemistry, Yunnan Normal University, Kunming 650092, China) Chemical constituents of Dendrobium aurantiacum var. denneanum. Chemistry of Natural Compounds v. 45(4): p. 525-527, 2009 ( Eng; 14 ref).

Eight compounds were isolated from the various fraction of ethanol extract of whole plants of Dendrobium aurantiacum var denneanum (Orchidaceae). The isolated compounds were identified as gigantol, moscatin, stigmasterol, moscatilin, crepidatin, p-hydroxybenzaldehyde, coumarin and luteolin.

2010-02-1027 Liu, C.; Zhong, S.M.; Chen, R.Y.; Wu, Y.; Zhu, X.J. (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Beijing 100050, China) Two new compounds from the dried tender stems of Cinnamomum cassia. Journal of Asian Natural Products Research v. 11(9-10): p. 845-849, 2009 (Eng; 9 ref).

Two new compounds, cinnamic aldehyde cyclic D-galactitol 3'R,4'S-acetal (1) and cinnamomumolide (2), along with six known compounds, syringaresinol (3), lyoniresinol (4), 5,7,3'-trimethoxyl-(-)-epicatechin (5), 5,7-dimethoxyl-3',4'-di-O-methylene-(plus or minus )-epicatechin (6), 2-methoxyl-4-hydroxy cinnamyl aldehyde (7), and glucosyringic acid (8), have been isolated from the dried tender stems of Cinnamomum cassia. Their structures were elucidated based on spectroscopic data. Compound 2 was elucidated as 8-methoxyl-9-hydroxy-3',4'-methylenedioxy-3S,4R-diphenyl butyrolactone, named cinnamomumolide, which exhibited antioxidant activity in protecting against the injury caused by hydrogen peroxide oxidation on human umbilical vein endothelial cells, with an EC50 value of 10.7 microM. Compounds 3-8 were isolated from the title plant for the first time.

2010-02-1028 Liu, J.; Feng, Z.; Xu, J.; Wang, Y.; Zhang, P. ( Key Laboratory of Bioactive and Resources Utilization of Chinese Herbal Medicine, Chinese Academy of Medical Sciences, Beijing 100050 , PR China) Rare biscoumarins and a chlorogenic acid derivative from Erycibe obtusifolia. Phytochemistry v. 68(13): p. 1775-1780, 2007 (Eng; 25 ref).

Three coumarins, 7,7'-dihydroxy-6,6'-dimethoxy-3,3'-biscoumarin (1), 7,7'-dihydroxy-6,6'-dimethoxy-8,8'-biscoumarin (2) and 7-O-4'-O-(3",4"-dihydroxycinnamyl)-beta-D-glucopyranosyl-6-methoxyco umarin (3), and a chlorogenic acid derivative, methyl-3-O-(4"-hydroxy-3",5"-dimethoxybenzoyl)-chlorogenate (4) were isolated from the roots of Erycibe obtusifolia (Convolvulaceae) along with four known coumarins, scopoletin (5), scopolin (6), cleomiscosin A (7) and cleomiscosin B (8). Their structures were elucidated by spectroscopic methods. Among them, compounds (1) and (2) are rare carbon-carbon linked symmetrical biscoumarins.

2010-02-1029 Ma, J.; Dey, M.; Yang, H.; Poulev, A.; Pouleva, R. ; Dorn, R.; Lipsky, P.E.; Kennelly, E.J.; Raskin, I. (Biotech Centre, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, USA) Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii. Phytochemistry v. 68(8): p. 1172-1178, 2007 (Eng; 30 ref).

The extract of Tripterygium wilfordii (Celastraceae), which showed anti-inflammatory and immunosuppressivc activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide.

2010-02-1030 Maoka, T.; Akimoto, N.; Ishiguro, K.; Yoshinaga, M.; Yoshimoto, M. (Research Institute for Production Development, 15 Shimogamo-morimoto-cho, Sakyo-ku, Kyoto 606-0805, Japan) Carotenoids with a 5,6-dihydro-5,6-dihydroxy-beta-end group, from yellow sweet potato "Benimasari", Ipomoea batatas Lam. Phytochemistry v. 68(13): p. 1740-1745, 2007 (Eng; 12 ref).

A series of carotenoids with a 5,6-dihydro-5,6-dihydroxy-beta-end group, named ipomoeaxanthins A (1), B (2), Cl (3) and C2 (4) were isolated from the flesh of yellow sweet potato "Benimasari", Ipomoea batatas (Convolvulaceae). Their structures were determined to be {5R,6S,3'R)-5,6-dihydro-beta,beta-carotene-5,6,3'-triol (1), (5R,6S,5'R,6'S)-5,6,5',6'-tetrahydro-beta, beta-carotene-5,6,5'6'-tetrol (2), (5R,6S.5'R.S'R}-5',8'-epoxy-5,6,5',8'-tetrahydro-beta,beta-carotene-5, 6-diol (3), and (5R,6S,5'R,8'S)-5',8'-epoxy-5,6,5',8'-tetrahydro-beta, beta-carotene-5,6-diol (4) by UV-Vis, NMR, MS and CD data.

2010-02-1031 Martin, F.; Hay, A.E.; Corno, L.; Gupta, M.P.; Hostettmann, K. (Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland) Iridoid glycosides from the stems of Pithecoctenium crucigerum (Bignoniaceae). Phytochemistry v. 68(9): p. 1307-1311, 2007 (Eng; 19 ref).

Sixteen crude extracts from six Panamanian plants of the family Bignoniaceae were submitted to rapid TLC tests against DPPH and acetylcholinesterase. Pithecoctenium crucigerum which showed interesting activity against DPPH, has been studied. The chemical investigation of the methanol extract from the stems afforded the iridoid glycoside theviridoside and three derivatives (6'-O-cyclopropanoylth eviridoside, 10-O-hydroxybenzo- yltheviridoside and 10-O-vanilloyltheviridoside), along with five known phenylethanoid glycosides (verbascoside, isoverbascoside, forsythoside B, jionoside D and leucosceptoside B). These last compounds were all active against DPPH. The structures were determined by means of spectrometric and chemical methods, including 1D and 2D NMR experiments and MS analysis.

2010-02-1032 Martinez-Luis, S.; Perez-Vasquez, A.; Mata, R. ( Departamento de Farmacia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, DF 04510, Mexico) Review: Natural produts with calmodulin inhibitor properties. Phytochemistry v. 68(14): p. 1882-1903, 2007 (Eng; 92 ref).

This review summarizes properties of various naturally occurring compounds with reported calmodulin (CaM)-inhibitory properties, which include about 159 natural products belonging to different structural classes. Most inhibitors are alkaloid and peptide type of compounds and have been isolated from a wide variety of natural sources, including many plant species. Among the most potent natural anti-CaM substances, however, are several animal venoms and the antibiotic polymixin. The largest number of compounds described were discovered by means of enzymatic functional assays.

2010-02-1033 Marzouk, M.M.; Kawashty, S.A.; Saleh, N.A.M.; Al-Nowaihi, A.S.M. (National Research Center, Phytochemistry and Plant Systematics Department, Dokki, 12622, Giza, Egypt) A new kaempferol trioside from Farsetia Negyptia. Chemistry of Natural Compounds v. 45(4): p. 483-486, 2009 ( Eng; 13 ref).

A new kaempferol trioside, kaempferol-3-O-(2"alpha-L-arabinopyranosyl)-alpha-L-rhamnophyranoside- 7-O-alpha-L-rhamnophyranoside, along with eight known flavonoid compounds were isolated from the methanolic extract of Farsetia aegyptia (Brassicaceae) growing in Egypt. The structures were established on the basis of detailed spectral analysis (UV, 1H NMR, 13C NMR, APT, HMBC, FABMS, and EIMS).

2010-02-1034 Mathouet, H.; Elomri, A.; Lameiras, P.; Daich, A.; Verite, P. (Laboratoire de Pharmacognosie, UMR 6014-CNRS, Universite de Rouen, Faculte de Pharmacie, 22 Boudevard Gambetta, F-76183 Rouen Cedex 1, France) An alkaloid, two conjugate sesquiterpenes and a phenylpropanoid from Pachypodanthium confine Engl. and Diels. Phytochemistry v. 68(13): p. 1813-1818, 2007 (Eng; 18 ref).

Two sesquiterpene-trimethoxystyrene conjugates (E)-1-3'-(4'',8"-dimethylnona-3'', 7"-dienyl)cyclohex-3'-enyl-2,4,5-t rimethoxybenzene (1) and (Z)-1-3'-(4",8''-dimethylnona-3",7''- dienyl)cyclohex-3'-enyl-2,4,5-t rimethoxybenzene (2), a phenylpropanoid 1,2,4-trimethoxy-5-(1-methoxy-ethyl)-benzene (3), and an aporphine alkaloid N-acetylpachypodanthine (4), were isolated in addition to several known compounds from cyclohexane, dichloromethane and alkaloid extracts from bark of Pachypodanthium confine (Annonaceae). The structures of these compounds were established based on the interpretation of their high resolution NMR (HSQC, HMBC, COSY and NOESY) spectral data.

2010-02-1035 Matich, A.J.; Bunn, B.J.; Comeskey, D.J.; Hunt, M.B.; Rowan, D.D. (The Horticultural and Food Research Institute of New Zeland Ltd., Private Bag 11030, Palmerston North 4442, New Zealand) Chirality and biosynthesis of lilac compounds in Actinidia arguta flowers. Phytochemistry v. 68(13): p. 1746-1751, 2007 (Eng; 17 ref).

Biosynthesis of lilac compounds in 'Hortgem Tahi' kiwifruit Actinidia arguta flowers was investigated by treating inflorescences with ds-linalool. The incorporation of the deuterium label into 8-hydroxylinalool, 8-oxolinalool, the lilac aldehydes, alcohols, and alcohol epoxides was followed by GC-MS and enantioselective GC-MS. Both (R)- and (S)-linalool were produced naturally by the flowers, but 8-hydroxylinalool, 8-oxolinalool, and the lilac aldehydes and alcohols occurred predominantly as the (S) and 5'(S)-diastereoisomers, respectively. The enantioselective step in the biosynthesis of the lilac aldehydes and alcohols was concluded to be the oxidation of linalool to (S)-8-hydroxylinalool. In contrast, the lilac alcohol epoxides had a 5'(R):(S) ratio, the same as for linalool, which suggests that either these compounds are not synthesised from the 5'(S)-configured lilac aldehydes and alcohols, or that if indeed they are, then it is by an enantioselective step that favours utilisation of the 5'(R)--configured compounds.

2010-02-1036 McChesney, J.D.; Venkataraman, S.K.; Henri, J.T. ( Tapestry Pharmaceutical, Inc., 4840 Pearl East Cir, #300W, Boulder, CO 80301, United States) Plant natural products: back to the future or into extinction?. Phytochemistry v. 68(14): p. 2015-2022, 2007 (Eng; 48 ref).

Natural product substances have historically served as the most significant source of new leads for pharmaceutical development. However, with the advent of robotics, bioinformatics, high throughput screening (HTS), molecular biology-biotechnology, combinatorial chemistry, in silico (molecular modeling) and other methodologies, the pharmaceutical industry has largely moved away from plant derived natural products as a source for leads and prospective drug candidates. Can, or will, natural products ever recapture the preeminent position they once held as a foundation for drug discovery and development? The challenges associated with development of natural products as pharmaceuticals are illustrated by the Taxol story. Several misconceptions, which constrain utilization of plant natural products, for discovery and development of pharmaceuticals. are addressed to return natural products to the forefront.

2010-02-1037 Meera, ; Kalidar, S.B. (Department of Chemistry, Haryana Agricultural University, Hisar-125004, Haryana, India) Naringenin diglucoside and other constituents from Citrus paradisi Macf.. Journal of Medicinal and Aromatic Plant Sciences v. 31(2): p. 116-117, 2009 (Eng; 6 ref).

Column chromatography of the juice of grapefruit (Citrus paradisi Rutaceae) resulted in the isolation of three compounds namely dryobalanone, beta-sitosterol and naringenin 7-O-beta-glucopyranosyl (1-4) glucopyranoside. These compounds have been characterized on the basis of spectral data. Naringenin 7-O-beta-glucopyranosyl (1-4) glucopyranoside is a new compound.

2010-02-1038 Melek, F.R.; Miyase, T.; Ghaly, N.S.; Nabil, M. ( Chemistry of Natural Compounds Department, National Research Center, Dokki 12622, Giza, Egypt) Triterpenoid saponins with N-acetyl sugar from the bark of Albizia procera. Phytochemistry v. 68(9): p. 1261-1266, 2007 (Eng; 16 ref).

Three (1,2,4) and one known (3) triterpenoid saponins were isolated from the bark of Albizia procera (Leguminosae). The saponins were characterized as 3-0-beta-D-xylopyranosyl-(1 - 2)-alpha-L-arabinopyranosyl-(1 - 6)-2-acetamido-2-deoxy-beta-D- glucopyranosyl echinocystic acid (1), 3-O-alpha-L-arabinopyranosyl-(1 - 2)-beta-D-fucopyranosyl-{1-6}-2-acetamido-2-deoxy-beta-D-glucopyranosyl echinocystic acid (2) and 3-O-beta-D-xylopyranosyl-(1 - 2)-alpha-L-arabinopyranosyl-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyra nosyl acacic acid lactone (4). Their structures were elucidated by 1D and 2D NMR experiments, FABMS as well as chemical means. Saponins 1 and 3 exhibited cytotoxicity against HEPG2 cell line with IC50 9.13 microg/ml and 10 microg/m, respectively.

2010-02-1039 Mertens, M.; Buettner, A.; Kirchhoff, E. (Fraunhofeer-Institute for Process Engineering and Packaging (IVV), Giggenhauser Strasse 35, 85354, Freising, Germany) The volatile constituents of frankincense - a review. Flavour and Fragrance Journal v. 24(6): p. 279-300, 2009 (Eng ; 24 ref).

Frankincense (olibanum), a white gum resin of Boswellia tree, cultivated mainly in eastern Africa (B. sacra and in India (B. serrata Burseraceae). The review on frankincense provide an overview of current knowledge of the volatile constituents of frankincense, with explicit consideration concerning the diverse Boswallia varieties. Altogether, more than 300 volatiles in frankincense have been repoted in the literature. In particular, a broad diversity has been found in the qualitative and quantitative composition of the volatiles with respect to different varieties of Boswellia. A detailed discussion of the various analytical approaches applied to isolate and analyse the volatile fractions of frankincense is also presented.

2010-02-1040 Morikawa, T.; Yamaguchi, I.; Matsuda, H.; Yoshikawa, M. (Kyoto Pharmaceutical University; Misasagi, Yamashina-ku, Kyoto 607-8412, japan) A new amide, piperchabamide F, and two new phenylpropanoid glycosides, piperchabaosides A and B, from the fruit of Piper chaba. Chemical & Pharmaceutical Bulletin v. 57(11): p. 1292-1295, 2009 (Eng; 27 ref).

A new amide, piperchabamide F, and two new phenylpropanoid glycosides, piperchabaosides A and B, were isolated from 80 percent aqueous acetone extract from fruit of Piper chaba (Piperaceae). Their stereostructures were elucidated on the basis of chemical and physicochemical evidence.

2010-02-1041 Noor, A.T.; Perveen, S.; Begum, A.; Fatima, I.; Malik, A.; Tareen, R.B. (International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan) Aitchisonides A and B, new iridoid glucosides from Aitchisonia rosea. Journal of Asian Natural Products Research v. 11(11-12): p. 985-989, 2009 (Eng; 6 ref).

Aitchisonides A (1) and B (2), new iridoid glucosides, were isolated from the n-butanolic fraction of Aitchisonia rosea (Rubiaceae) along with deacetylasperulosidic acid (3) and nepetanudoside B (4) which were reported for the first time from the genus Aitchisonia. Their structures have been assigned on the basis of spectral analysis including 1H and 13C NMR spectra and by DEPT, 2D COSY, NOESY, and HMBC experiments.

2010-02-1042 Novruzov, E.N.; Abdullaeva, G.A.; Shamsizade, L.A. ; Mustafaev, N.S. (Institute of Botany, National Academy of Sciences of Azerbaidzhan, Baku, AZ1073, Patamdarskoe Shosse, 40) Flavonoids and anthocyans from Alhagi pseudoalhagi. Chemistry of Natural Compounds v. 45(2): p. 249-250, 2009 ( Eng; 12 ref).

Four flavonoid were isolated from the aerial part and the qualitative composition and quantitaive contents of three anthocyans from flowers of Alhagi pseudoalhagi (Fabaceae) were determined. Flavonoids were identified by preparative paper chromatography (Whatman-3) of the ether extract isolated two compounds from MeOH with mp 312 degree C, (as quercetin), isorhamnetin, isorhamnetin 3-rutinoside, and 5,7,4-tetrachydroxy flavon (rutin). Anthocyans were identified to be delphinidin-3-monoglucoside, cyanidin-3, 5 diglucoside and delphinidin-3, 5-digalucoside.

2010-02-1043 Odoemelam, S.A.; Onwubuazu, G.C. (Department of Chemistry, Michael Okpara University of Agriculture, Umudike, P.M.B. 7267, Umuahia, Abia State, Nigeria) Evaluation of the chemical composition of parts of Alstonia boonei used in folk medicine. Journal of Medicinal and Aromatic Plant Sciences v. 31(1): p. 17-20, 2009 (Eng; 26 ref).

Alstonia boonei (Apocynaceae) were evaluated for their proximate chemical composition, mineral constituents, vitamins and phytochemical composition. The results revealed the presence of bioactive constituents consisting of alkaloids (1.80-2.17 percent), flavonoids (0.28-0.91 percent), saponins (0.40-3.44 percent) and tannins (0.16-0.36 percent) in different parts of the plant. It also contained ascorbic acid (108.8-492.8 mg/100g), thiamin (0.21-0.44 mg/100g), riboflavin (0.22-0.31 mg/100g) and niacin (0.02-0.06 mg/100g). Potassium was the most abundant mineral observed in all plant parts while iron and zinc had their highest concentrations in the leaves. The plant was found to be a good source of both macro and micro minerals with the highest concentrations of the elements stored in the bark and leaves. Crude protein was significantly higher in the leaves while there was no significant difference (P less than 0.05) in the ash value in the bark, leaves and roots.

2010-02-1044 Olennikov, D.N.; Tankhaeve, L.M.; Rokhin, A.V. ( Institute of General and Experimental Biology, Siberian Division, Russian Academy of Sciences, 670047, Ulan Ude, ul. Sakh' yanovoi, 6) Glucofructans from Taraxacum officinale roots . Chemistry of Natural Compounds v. 45(2): p. 141-144, 2009 ( Eng; 7 reff).

The structure of glucofructans from Taraxacum officinale (Asteraceae) roots growing in Buryatia was studied by chemical, chromatographic, and spectral methods. It was found that fructose, glucose, saccharose, l-kestose, and nystose were presents in the free state. The structures of the two dominant polymeric compounds, TGf-1 (5.7 kDa) and TGf-2 (2.6 kDa), which were linear inulin-type macromolecules consisting of fructofuranose units bonded through beta-(2 to 1)-bonds, were studied.

2010-02-1045 Olennikov, D.N.; Tankhaeva, L.M.; Sandanov, D.V. ( Institute of General and Experimental Biology, Siberian Branch Academy of Sciences, 670047, Ulan-Ude, ul. Sakh'yanovoi, 6) Fatty acids from seeds of Sophora flavescens and Styphnolobium japonicum. Chemistry of Natural Compounds v. 45(2): p. 225-226, 2009 ( Eng; 6 ref).

The total lipid content determined in seeds of Saphora flavescens and Styphnolobium japonicum (Fabaceae) was 3.37 and 5.31 percent, respectively. Fatty acids of total lipids from S. flavescens seeds contained 16 compounds and from S. japonicum 15. The staurated:unsaturted acids ratios were 1:1:14 and 1:4.63. Palmitic, linoleic, oleic and stearic acids dominated for each species. The total content of them was 86.47 and 90.49 percent of the total acids, respectively. The significant content of palmitic acid was found in lipids of S. flavescens (34.38 percent), in contrast with S. japonicum for which linoleic acid was the dominant (54.95 percent).

2010-02-1046 Panthama, N.; Kanokmedhakul, S.; Kanokmedhakul, K. (Natural Products Research Unit, Department of Chemistry, Faculty of Science, Khan Kaen University, Khan Kaen 40002, Thailand) Galloyl and hexahydroxydiphenoyl esters of phenylpropanoid glucosides, phenylproponoid and phenylpropanoid glucosides from rhizome of Balanophora fungosa. Chemical & Pharmaceutical Bulletin v. 57(12): p. 1352-1355, 2009 (Eng; 12 ref).

From the Balanophora fungosa (Balanophoraceae) five new galloyl and (S)-hexahydroxydiphenyl esters of phenypropanoid glucosides; 1-0-(E)-coumaroyl-3-galloyl-4,6-(S)-HHDP-beta-D-glucopyranose, 1-0-(E)-coumaroyl-3,4,6-trigalloly-beta-D-glucopyranose, 1-0-(E)-caffenoyl-1,3,4,6-trigalloyl-beta-D glucopyranose, 1-0-(E)-cinnamoyl1-3-galloyl1- 4,6-(S)-HHDP-beta-D-glucopyranose, and 1-0-(E)-cinnamoyl-4-galloyl-beta-D-glucopyranose, together with twenty known compounds were identified as four triterpenes, one steroid, one lignan, three phenylpropanoids five phenylpropanaoid glucosides, five galloyl and HHDP esters of phenylpropanoid glucosides, and one bischroman. Their structures were determined on the basis of 1D and 2D spectroscopic data.

2010-02-1047 Perry, P.L.; Wang, Y.; Lin, J. (Firemenich inc, North America R&D, PO Box 5880, Princeton, NJ 08543, USA) Analysis of honeydew melon (Cucumis melo var. inodorus) flavour and GC-MS/MS identification of (E,Z)-2,6-nonadienyl acetate. Flavour and Fragrance Journal v. 24(6): p. 341-347, 2009 (Eng ; 39 ref).

An aroma extract of honeydew melon, Cucumis melo var. inodorus (Cucurbitaceae) was obtained by hydrodistillation under vaccum followed by solid phase extraction, and analysed by GC-MS, Forty-two volatiles were identified. The major volatiles were mostly saturated and unsaturated C9 alcohol and aldehydes. The levels of the corresponding acetates were too low to be detected by classical GC-MS analysis. However , using a sensitive and selective GC-MS/MS method, (E,Z)-2,6-nonadienal was the most impactful compound. AEDA results also showed that (Z, Z)-3,6-nonadien-1-ol and phenylethyl alcohol imparted fresh and sweet-floral characters, respctively, to honeydew aroma.

2010-02-1048 Pi, H.F.; Zhang, P.; Ruan, H.L.; Zhang, Y.H.; Sun, H.D.; Wu, J.Z. (Faculty of Pharmaceutical Sciences, Tongji Medical College of Huazhong University of Science and Tehnology, Wuhan 430030, China) Two new triterpenoids from the leaves and stems of Fritillaria hupehensis. Journal of Asian Natural Products Research v. 11(9-10): p. 779-782, 2009 (Eng; 10 ref).

Two new cycloartane-type triterpenoids 25-hydroxyl-9,l9-cycloart-22-ene-3-one (1) and (23Z)-9,l9-cycloart-23-ene-3alpha,25-diol (2) along with 9,19-cycloart-25-ene- 3beta, 24xi-diol (3) and cycloeucalenol (4) have been isolated from the leaves and stems of Fritillaria hupehensis. Their structures were elucidated on the basis of spectroscopic analysis.

2010-02-1049 Pizzolatti, M.G.; Brighente, I.M.C.; Bortoluzzi, A.J.; Schripsema, J.; Verdi, L.G. (Departamento de Quimica, Universidade Federal de Santa Catarina, 88040-900 Florianopolis, Brazil) Cyathenosin A, a spiropyranosyl derivative of protocatechuic acid from Cyathea phalerata. Phytochemistry v. 68(9): p. 1327-1330, 2007 (Eng; 8 ref).

Cyathenosin A, a spiropyranosyl derivative of protocatechuic acid was isolated from the stem pith of Cyathea phalerata (Cyatheaceae). Its structure was determined by MS, 1D and 2D NMR spectroscopic analyses and confirmed by single crystal X-ray analysis. Cyathenosin A is the first example of a naturally occurring compound containing a spirocyclic orthoester pyranosidic structure.

2010-02-1050 Rakhmanberdyeva, R.K. (S. Yu. Yunsov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent) Arabinogalactomannan from Gleditsia macracantha seeds. Chemistry of Natural Compounds v. 45(2): p. 145-148, 2009 ( Eng; 7 ref).

A polysaccharide with MW 25,000 consists of arabinose, galactose, and mannose units in a 1:28:3,2 ratio was isolated from Gleditsia macracantha (Leguminosae) seeds. Chemical and spectral methods established that the polysaccharide was a branched galactomannan with side branches consisting of arabinose units.

2010-02-1051 Rameshkumar, K.B.; Sudheesh, N.; George, V. ( Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Thiruvanathapuram-695562, Kerala, India) Essential oil composition of (Scleria lithosperma) (L.) Sw.. Indian Perfumer v. 53(3): p. 46-47, 2009 (Eng; 11 ref).

Essential oil from the rhizomes of Scleria lithosperma (Cyperaceae) obtained by hydrodistillation was analyzed by gas chromatographic techniques. Twenty two compounds comprising 96.5 percent of the oil were identified by GC-MS. The major constituents were the fatty acids, palmitic acid (43.3 percent), linoleic acid (14.0 percent) and oleic acid (7.8 percent).

2010-02-1052 Rana, V.S.; Verdeguer, M.; Blazquez, M.A. (Natural Product Chemistry Lab, Medicinal Plants and Horticultural Resources Division, Institute of Bioresources of Sustainable Development, Takyelpat Institutional Area, Imphal-795 001, Manipur, India) Chemical composition of Acorus calamus L. leaves and rhizomes from Manipur. Indian Perfumer v. 52(4): p. 39-41, 2008 (Eng; 33 ref).

The essential oil compositions of Acorus calamus (Araceae) rhizomes and leaves were determined by GC/MS. The yields of the oil in rhizomes and leaves were found to be 0.87 and 0.27 percent on fresh weight basis. A total of fifty seven compounds were identified. The main compounds identified in the rhizome oil were beta-asarone (76.46 percent), shyobunone (4.40) cis-ethylisoeugenol (4.20) and isoelimicin (1.73) while leaf oil contained beta-asarone (84.68 percent), shyobunone (2.19) and linalool (2.3) as major compounds. Beta-asarone was found in greater amount in leaf oil as compared to rhizome.

2010-02-1053 Rezanka, T.; Sigler, K. (Institute of Microbiology, Videnska 1083, 14220 Prague, Czech Republic) Sinaicinone, a complex adamantanyl derivative from Hypericum sinaicum. Phytochemistry v. 68(9): p. 1272-1276, 2007 (Eng; 23 ref).

The structure of sinaicinone, isolated from the aerial parts of the Egyptian medicinal plant Hypericum sinaicum (Guttiferae) has been elucidated by means of spectroscopic data such as UV, 1R, MS, 1D and 2D NMR spectra, and chemical degradation. It is a complex adamantanyl derivative with a unique skeleton and oxygenated side chains.

2010-02-1054 Rivero-Cruz, B.; Rivero-Cruz, I.; Rodriguez-Sotres, R.; Mata, R. (Departamentos de Farmacia y Bioquimica, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico) Effect of natural and synthetic benzyl benzoates on calmodulin. Phytochemistry v. 68(8): p. 1147-1155, 2007 (Eng; 11 ref).

The present investigation describes the effect of the spasmolytic benzylbenzoates 1-9 from Brickellia veronicifolia (Asteraceae) on CaM-using a functional in vitro enzymatic assay. Bovine brain PDE1 was used as a monitoring enzyme. The most active natural inhibitors of the system CaM-PDE1 were benzyl benzoates 3-5, which inhibited the activity of PDE1 in a concentration-dependent manner. In addition, these series of analogs of compound 4, compounds 10a--32a, were prepared and assayed. The benzyl benzoates from the first series, namely 10a-24a, possess no substituents on ring B but different number and position of hydroxyl or methoxy groups in ring A. The second group (25-32a), on the other hand, possesses an A ring identical to that on compound 4, but different substituents in Ring B. The most active compounds were 14a, 15a and 30a. These compounds were two to six times more potent than chlorpromazine, a well known CaM inhibitor. Benzyl benzoates 14a and 15a have methoxyi groups at C-2/C-4 and C-3/C-4 in ring A, respectively; while 30a, in addition to the methoxyi groups at C-2/C-6 of ring A, hold a benzoyloxy moiety at C-3' of ring B. Kinetic studies revealed that compounds 3, 4, 14a, 15a and 30a behave as competitive CaM antagonists.

2010-02-1055 Rodrigues, J.; Rinaldo, D.; dos Santos, L.C.; Vilegas, W. (Instituto de Quimica, Universidade Estadual Paulista, UNESP, C.P. 355, 14801-97, Araraquara, Sao Paulo, Brazil) An unusual C6-C6" linked flavonoid from Miconia cabucu (Melastomataceae). Phytochemistry v. 68(13): p. 1781-1784, 2007 (Eng; 28 ref).

Chromatographic fractionation of the methanolic extract from the leaves of Miconia cabucu (Melastomataceae) afforded the first example of a C6-C6'' linked flavone dimer, 5-hydroxy-4',7-dimethoxyflavone-(6-C-6")-5"-hydroxy-3'",4''',7"-trimet hoxyflavone as well as the known compounds, quercetin-3-O-alpha-L-rhamnopyranosyl-(2--l)-O-beta-D-xylopyranoside, quercetin-3-O-alpha-L-rhamnopyranoside, myricetin-3-O-alpha-L-rhamnopyranoside, quercetin-3-O-beta-D-glucopyranoside, kaempferol-3-O-beta-D-(6"-coumaroyl)-glucopyranoside and gallic acid. Their chemical identities were established by application of NMR spectroscopic methods including 2D-NMR, as well as UV and ESI-MS analyses.

2010-02-1056 Sadhu, S.K.; Khan, M.S.; Ohtsuki, T.; Ishibashi, M. (Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan) Secoiridoid components from Jasminum grandiflorum. Phytochemistry v. 68(13): p. 1718-1721, 2007 (Eng; 9 ref).

Secoiridoid glucosides, 2"-epifraxamoside and demethyl-2"-epifraxamoside, and the secoiridoid, jasminanhydride were isolated from Jasminum grandiflorum (Oleaceae) together with four previously known phenolics and a triterpene. Structures were elucidated by detailed spectroscopic analysis. Stereochemistry of the compounds was determined by differential NOE experiment.

2010-02-1057 SafaelGhomi, J.; Akhoondi, S.; Batooli, H.; Dackhill, M. (The Essential Oil Research Center, University of Kashan, 51167 Kashan, Iran) Chemical variability of essential oil components of two Rosa x damascena genotypes growing in Iran. Chemistry of Natural Compounds v. 45(2): p. 262-264, 2009 ( Eng; 15 ref).

The study was conducted determine the essential oil composition of a white sample of Rosa damascena (Rosaceae) growing in Central Iran (Kashan area) and carry out a comparative evaluation between this oil and the oil of the other species, pink. The flowering aerial parts of two rose species yielded essential oils which were subjected to a GC-MS analysis in order to determine possible similarities or differences among them. The oil obtained from the aerial parts of the white sample yielded 0.035 percent v/w with 21 components. The major constituents of the total amount of 99.50 percent were: citronellol (53.615), nonadecane (17.575), geraniol (12.59 percent), heneicosane (5.46 percent), and phenyl ethylacetate (2.95 percent). The pink species yield was 0.025 percent v/w 40 components, representing 99.64 percent of the total composition. The major components were: citronellol (34.7 percent), nonadecane (14.5 percent), heneicosane (10.3 percent), beta-caryophyllene (7.8 percent), and nerol (5 percent). The compounds with the characteristic rose scent of the essential oil of R. damascena such as citronellol, geraniol, nerol, and phenyl alcohol, are found in both the samples. The white flower showed a total result of 66.2 percent for citronellol and geraniol as the monoterpene alcohol contents while the second specimen showed 39.7 percent for citronellol and nerol. The major amount of the white flower oil belonged to monoterpene alcohols (67.8 percent), while the pink sample represented 41.9 percent for these compounds.

2010-02-1058 Safder, M.; Imran, M.; Mehmood, R.; Malik, A.; Afza, N.; Iqbal, L.; Latif, M. (International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan) Asphorodin, a potent lipoxygenase inhibitory triterpene diglycoside from Asphodelus tenuifolius. Journal of Asian Natural Products Research v. 11(11-12): p. 945-950, 2009 (Eng; 11 ref).

Asphorodin (1), a new diglycoside, has been isolated from the ethyl acetate-soluble fraction of Asphodelus tenuifolius (Liliaceae). It showed significant inhibitory activity against the enzyme lipoxygenase in a concentration-dependent manner. The Lineweaver-Burk and Dixon plots indicated that the nature of inhibition was non-competitive.

2010-02-1059 Sah, P.; Rustagi, V.; Garg, S.P. (Desert Plant Analysis Laboratory, Department of Chemistry, J.N.V. University, Jodhpur-342005, Rajasthan, India) Two new phytoconstituents from the seeds of Psoralea corylifolia Linn.. Journal of Medicinal and Aromatic Plant Sciences v. 31(4): p. 330-335, 2009 (Eng; 37 ref).

Isolation of a coumarin and a chalcone from the seeds of Psoralea corylifolia Leguminosae) is being reported for the first time from the variety found in western Rajasthan. On the basis of physical and spectral techniques of UV, IR, 1H NMR, mass and chemical reactions, they have been identified as 6,7-(2'-3'-dihydrofurano)-benzopyran-2-one and 2'-hydroxy-3'-4'-(2'', 3''-dihydrofurano)-chalcone.

2010-02-1060 Sajjadi, S.E.; Jafari, A.; Naderian, M. (Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan-8174673461, Iran) Chemical composition of the essntial oil of Helichrysum oilgocephalum. Chemistry of Natural Compounds v. 45(2): p. 269-271, 2009 ( Eng; 16 ref).

The aerial parts of Helichrysum oligocephalum (Asteraceae) yielded 0.2 percent (v/w) of a yellowish oil with an aromatic odour. Eighty-two components were detected in the essential oil. Thymol (14.4 percent), beta-caryophyllene (4.9 percent), beta-thujone (4.8 percent), spathulenol (4.3 percent), n-ethyl dodecanote (3.4 percent), hexadecanoic acid (3.4 percent), viridiflorol (3.0 percent), and humulene epoxide II (2.6 percent) were the major constituents of the oil.

2010-02-1061 Saleem, M.; Nazir, M.; Akhtar, N.; Onocha, P.A.; Riaz, N.; Jabbar, A.; Ali, M.S.; Sultana, N. (Department of Chemistry, The Islamia University of Bahawalpur, Baghdad Campus-ul-Jadid, Bahawalpur 63000, Pakistan) New phthalates from Phyllanthus muellerianus (Euphorbiaceae). Journal of Asian Natural Products Research v. 11(11-12): p. 974-977, 2009 (Eng; 17 ref).

Species of the genus Phyllanthus are known for their medicinal values and many are explored phytochemically. Some of them produce phthalates which usually have antimicrobial properties. This paper deals with the phytochemical investigation on Phyllanthus muellerianus. As a result, five compounds, bis(2-ethyloctyl)phthalate (1), bis(2-ethylicosyl)phthalate (2), 3-friedelanone (3), beta-sitosterol (4), and methyl gallate (5), have been isolated and characterized. Metabolites 1 and 2 are new compounds, while 3-5 have been isolated for the first time from this source. Structures of all the isolates were established on the basis of MS, 1D and 2D NMR spectral data and in comparison with the reported data.

2010-02-1062 Senthilkumar, M.; Gurumoorthi, P.; Janardhanan, K. (Ethnopharmacology Unit, Department of Botany, Bharthiar University, Coimbatore-641046, Tamil Nadu, India) Preliminary phytochemical analysis of some plants used by local people in Marudhamalai hills, Coimbatore district, Tamil Nadu. Indian Journal of Applied & Pure Biology v. 24(2): p. 473-478, 2009 (Eng; 10 ref).

Preliminary phytochemical analysis of various plant parts of three plant species, Strychnos nux-vomica (Loganiaceae), Pergularia daemia and Toddalia asiatica var, floribunda (Rutaceae) collected from Marudhamalai hills, in Western Ghats was evaluated in increasing order of polarity solvents such as petroleum ether, benzene, chloroform, acetone, ethyl acetate, ethanol and hot water. The significance of plants and the importance of chemical constituents are discussed with respect to the role of these plants in traditional use.

2010-02-1063 Shawl, A.S.; Rather, M.A.; Kumar, T. (Indian Institute of Integrative Medicine, Srinagar, Kashmir-190005-India) Essential oil composition of Artemisia pallens (Davana) cultivated in Kashmir valley-India. Indian Perfumer v. 53(3): p. 32-33, 2009 (Eng; 20 ref).

Artemisia pallens (Asteraceae), Davana is an annual aromatic herb native to South India. It is prized for its essential oil known as Davana oil of commerce. Artemisia pallens was successfully introduced in Kashmir for its essential oil. The oil on GC and GC-Mass examination led to the identification of 26 compounds. Major constituents were davanone (72.59), (E)-ethyl cinnamate (8.40), beta-eudesmol (3.20), davanol isomer- 2 (2.86), (E) methyl cinnamate (2.41), davanol isomer 1 (2.05), bicyclogermacrene (1.66), geranyl acetate (1.38) and linalool (1.08). The higher content of davanone in the oil suggests that the oil produced from Kashmir is quite competitive and acceptable to the industry.

2010-02-1064 Silva, J.R.M.; Cardoso, C.A.L.; Re-Poppi, N. ( Universidade Federal de Mato Grosso do Sul, Departamento de Quimica, Caixa Postal 649, 79070-900, Campo Grande/MS, Brazil) Essential oil composition of the leaves of Campomanesia pubescens. Chemistry of Natural Compounds v. 45(4): p. 565-567, 2009 ( Eng; 13 ref).

Sixty-one components were identified in the leaf essential oil of Campomanesia pubescens (Myrtaceae) represnting 94.8 percent of the total oil. The monoterpenes constitute the dominant fraction in the oil (60.3 percent), and it was particularly rich in monoterpene hydrocarbons (87.3 percent of this fraction). The sesquiterpenes fraction showed 34.5 percent of the total oil. The major constituents identified (representing 53.5 percent of the oil) were limonene (22.4 percent), alpha-pinene (13.3 percent), sabiknene (19.5 percent), bicyclogermacrene (4.4 percent), and linalool (3.9 percent).

2010-02-1065 Singh, R.B. (School of Life Sciences, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002, U.P., India) Structural elucidation oligosaccharides from Strychnos nux-vomica Linn. (Kuchla) seeds polysaccharide by partial acid hydrolytic technique. Indian Journal of Applied & Pure Biology v. 24(2): p. 357-363, 2009 (Eng; 26 ref).

Polysaccharide was extracted with water from (Kuchla) Strychnos nux-vomica (Loganiaceae) seeds as D-galactose and D-mannose in the molar ratio of 1:4 moles. Upon partial acid hydrolysis of purified polysaccharide afforded three disaccharides and two trisaccharides as: (I) O-alpha-D-galactopyranosyl-( 1 to 6)-O-alpha-D-mannopyranose, (II) O-alpha-D-mannboyranosyl-(1 to 6)-O-alpha-D-mannopyranose, (III) O-beta-D-galactpyranosyl-(1 to 4)-O-beta-D-mannopyranose, (IV) O-beta-D-mannospyranosyl-(1 to 4)-O-beta-D-mannopyranosyl- (1 to 4)- O-beta-D-mannopyranose and (V) O-alpha-D -galactopyranosyl-( 1 to 6)-O-alpha-D-mannopyranosyl-(1 to 4)-O-beta-D-mannopyranose. Characterisation of oligosaccharides were carried out by degree of polymerization, optical rotation, derivatives (disaccharides) and periodate oxidation studies for the confirmation of earlier proposed structure to this polysaccharide.

2010-02-1066 Sokovic, M.D.; Dokovic, D.; Tesevic, V.; Vajs, V.; Marin, P.D. (Institute of Biological Research "Sinisa Stankovic", Bulevar Despota Stefana 142, 11000 Belgrade, Serbia) Fatty acid composition of seed oil of Phlomis fruticosa growing in Montenegro . Chemistry of Natural Compounds v. 45(4): p. 530-531, 2009 ( Eng; 10 ref).

The fatty acid composition of seed (nutlets) of Phlomis fruticosa (Lamiaceae) was analyzed using GC and GC/MS. The fatty acids identified were myristic, palmitic, stearic, oleic, and linoleic acids, and two unusual fatty aicds, laballenic and phlomic acids.

2010-02-1067 Struijs, K.; Vincken, J.P.; Verhoef, R.; van Oostveen-van Casteren, W.H.M.; Voragen, A.G.J.; Gruppen, H. ( Laboratory of Food Chemistry, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The Netherlands) The flavonoid herbacetin diglucoside as a constituent of the lignan macromolecule from flaxseed hulls. Phytochemistry v. 68(8): p. 1227-1235, 2007 (Eng; 31 ref).

Lignans in flaxseed are known to be part of a macromolecule in which they are connected through the linker-molecule hydroxy-methyl-glutaric acid (HMGA). In this study, the lignan macromolecule was extracted from flaxseed hulls and degraded to its monomeric constituents by complete saponification. Besides secoisolariciresinol diglucoside (SDG), the phenolic compounds p-coumaric acid glucoside (CouAG) and ferulic acid glucoside (FeAG) were isolated, which was expected based on indications from the literature. Also the flavonoid herbacetin diglucoside (HDG) was found. The presence of HDG was confirmed by NMR following preparative RP-HPLC purification. Also the presence of the three other constituents (CouAG, FeAG and SDG) was confirmed by NMR. To prove that HDG is a substructure of the lignan macromolecule, the macromolecule was fragmented by partial saponification. A fragment consisting of HDG and HMGA was indicated. This fragment was isolated by preparative RP-HPLC and its identity was confirmed by NMR. It is concluded that the flavonoid HDG is a substructure of the lignan macromolecule from flaxseed hulls and that it is incorporated in the macromolecule via the same linker-molecule as SDG.

2010-02-1068 Suman, A.; Ali, M.; Alam, P. (Phytochemistry Research Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India) New prenylated isoflavanones from the roots of Glycyrrhiza glabra. Chemistry of Natural Compounds v. 45(4): p. 487-491, 2009 ( Eng; 16 ref).

Two new prenylated isoflavanones were isolated from the roots of Glycyrrhiza glabra (Leguminosae) along with known compounds viz. cetoleic acid. beta-sitosterol, stigmasterol, lanast-5,24-dien-3beta-D-glucuronopyranoside, and glucuronic acid. The structures of the prenylated isoflavanones have been established as 8-isoprenyl-7,4'dihydroxylicoisofalvanone (glabraisflavanone A) and 7.3'-dihydroxy-8-isoprenyl-4' cyclogeraniloxyisoflavanone (glabraisoflavanone B) on the basis of spectral data analyses and chemical reactions.

2010-02-1069 Sun, S.; Tian, L.; Wu, Z.H.; Chen, G.; Wu, H.H.; Wang, Y.N.; Pei, Y.H. (School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China) Two new compounds from fermentation liquid of the marine fungus Trichoderma atroviride G20-12. Journal of Asian Natural Products Research v. 11(9-10): p. 897-902, 2009 (Eng; 2 ref).

The chemical constituent research on the ethyl acetate extracts of fermentation liquid of the marine fungus Trichoderma atroviride G20-12 led to the isolation of two new compounds, 2-hydroxybutan-3-yl 5'-(2"-hydroxy-N-(2'"-oxobutan-3'''-yl)propanamido)butanoate (1) and 3-hydroxy-5-(4-hydroxybenzyl)dihydrofuran-2(3H)-one (2). The structures of the new compounds were determined by spectroscopic and chemical analysis. The mangrove marine fungus G20-12 separated from the sediment on the root of Ceriops tagal which is arbor collected at the South Sea intertidal zone and identified as Trichoderma atroviride.

2010-02-1070 Suzgee, S.; Bitis, L.; Sozer, U.; Ozeelik, H.; Zap, J.; Kiemer, A.K.; Mericli, F.; Mericli, A.H. (Instanbul University, Faculty of Pharmacy, Department of Pharmacognosy, 34116 Beyazyl-Islanbul-Turkey) Alkaloids from the aerial parts of Consolida anthoridea and Delphinium linearilobum. Chemistry of Natural Compounds v. 45(2): p. 287-289, 2009 ( Eng; 21 ref).

Alkaloid content in the aerial parts of Consolida anthoroidea and Delphinium linearilobum (Ranunculaceae) were determined. Six diterpenoid alkaloids, ajaconine, hetisine, 13-0-acetylhetisine, alpha-atisine, spiratine A, and septentriosine, and two norditerpenoid alkaloids, 1-demethylwinkleridine, and senbusine B, were isolated and identified. All the alkaloids were identified by comparison of their H and C, DEPTNMR data and by Co-TLC.

2010-02-1071 Tamaki, Y.; Konishi, T.; Tako, M. (The United Graduate School of Agricultural Science, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan) Isolation and characterization of pectin from peel of Citrus tankan. Bioscience, Biotechnology, and Biochemistry v. 72(3): p. 896-899, 2008 (Eng; 13 ref).

Pectin is one of the most complex plant polysaccharides. It mainly constructs the primary cell wall and middle lamella in plant tissues and is covalently linked to other polymers. It is utilized in the food industry as a gelling agent and stabilizer of jam, jelly and acid milk product. A pectin was extracted from the peel of Citrus tankan with a yield of 2.75 percent. The uronic acid content was 80.0 percent, and the degree of methoxylation was 63.2 percent. The pectin was composed of D-GaIA, D-Gal, L-Ara and L-Rha in the molar ratio of 100: 11.3:3.6:2.6. The molecular weight was estimated to be approximately 9.2 x 10 4 to power. The pectin formed a gel by conventional procedures.

2010-02-1072 Tan, G.S.; Xu, K.P.; Li, F.S.; Wang, C.J.; Li, T.Y.; Hu, C.P.; Shen, J.; Zhou, Y.J.; Li, Y.J. (School of Pharmaceutical Sciences, Central South University, Changsha 410013, Hunan, China) Selaginellin C, a new natural pigment from Selaginella pulvinata Maxim (Hook et Grev.). Journal of Asian Natural Products Research v. 11(11-12): p. 1000-1003, 2009 (Eng; 9 ref).

A novel compound, selaginellin C (1), was isolated from Selaginella pulvinata as (R,S)-4-((1,2-dihydroxyethyl)-2',4-dihydroxy-3-((4-hydroxy-phenyl)ethy nyl)biphenyl-2-yl)((4-hydroxypheny)methylene)cyclohexa-2,5-dienone, along with two known compounds, selaginellin (2) and selaginellin A (3). The structure of the new compound was elucidated on the basis of 1D and 2D NMR as well as HR-ESI-MS spectroscopic analysis.

2010-02-1073 Tanjung, M.; Hakim, E.H.; Mujahidin, D.; Hanafi, M.; Syah, Y. M. (Natural Products Chemistry Research Group, Organic Chemistry Division, Institut Tecknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia) Macagigantin, a farnesylated flavonol from Macaranga gigantea. Journal of Asian Natural Products Research v. 11(11-12): p. 929-932, 2009 (Eng; 15 ref).

A new farnesylated flavonol derivative, macagigantin (1), together with two known flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Mucaranga gigantea (Euphorbiaceae). The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectroscopic data, including UV, IR, 1D and 2D NMR, and HR-EI-MS spectra. Compounds 1-3 were evaluated for their cytotoxic properties against P-388 cells, their IC50 values being 11.3, 6.0, and 5.1 microM, respectively.

2010-02-1074 Thomas, E.; Kizhakkayil, J.; Zachariah, T.J.; Syamkumar, S.; Sasikumar, B. (Indian Institute of Spices Research, Marikunnu P O, Calicut, Kerala, India) GS MS analysis of essential oil of export grade Indian, Guatemalan and Sri Lankan cardamoms. Journal of Medicinal and Aromatic Plant Sciences v. 31(3): p. 206-208, 2009 (Eng; 13 ref).

The essential oil of export grade Indian, Guatemalan and Sri Lankan cardamoms (Elettaria cardamomum Zingiberaceae) has been extracted by steam distillation and analyzed by GC MS. A total of 25 compounds have been identified, 22 compounds in Indian, 23 in Guatemalan and 24 in Sri Lankan cardamoms, and 22 of them were common to the three produces. the quantitative result of Indian cardamom indicates the high yield of 1,8-cineole (27.59 percent) and a-terpinyl acetate (41.65 percent) compared to (25.75 & 39.68 percent) in Guatemalan and (25.16 & 37.64) in Sri Lankan cardamoms.

2010-02-1075 Tkachenko, K.G. (V.L. Komarov Botanical Institute, Russian Academy of Science, 197376, St. Peterburg, Russia) Essential oils from roots of certain Heracleum species. Chemistry of Natural Compounds v. 45(4): p. 578-580, 2009 ( Eng; 10 ref).

The composition and dynamics of the principal components of essential oils from roots of 19 introduced species of Heracleum (Apiaceae) were found in order to determine if the data could be used to resolve issues with the species systematics of this genus. The results showed that the essential oil content in roots of various species varied form 0.1 to 1.0 percent. Species of the Pubescentia section had the greatest accumulations. Some species from various sections of the genus have rather similar component compoisitions for essential oils from roots. Esters, terpenes, and sesquiterpenes dominate the essential oil compositions. Species within a single section have similar compositions. Difference between species and sections are quantitative at both the principal level (alpha-pinene, beta-pinene, myrcene, ocimene, octylacetate, trans-alloocimene) and at the level of minor components (octanol, gamma-terpinene, terpinen-4-ol, etc.). The results showed that essential oil from roots of a single species obtained at different vegetation phased also differed in the ratio of components. Certain components such as alpha-and beta-pinene, camphene, myrcene, limonene, ocimene and octylactate were found in all species.

2010-02-1076 Tung, N.H.; Song, G.Y.; Park, Y.J.; Kim, Y.H. ( College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea) Two new dammarane-type saponins from the leaves of Panax ginseng. Chemical & Pharmaceutical Bulletin v. 57(12): p. 1412-1414, 2009 (Eng; 13 ref).

Two new dammarane-type saponins, named ginesenoside Ki (1a) and ginsenoside Km (1b), along with 15 known ones, were isolated from the leaves of Panax ginseng (Araliaceae). The structures of new saponins were elucidated on the basis of chemical and spectroscople methods.

2010-02-1077 Turmukhabetov, A.Z.; Agedilova, M.T.; Nurmaganbetov, Zh. S.; Kazantsev, A.V.; Shul'ts, E.E.; Shakirov, M.M. ; Bagrayanskaya, I.Y.; Adeknov, S.M. (Institute of Phytochemistry, Minnistry of Education and Science, Republic of Kazakhstan, 100009, Karaganda, ul. Gazalieva, 4, Kazakhstan) Synthesis of quaternary salts of Peganum harmala alkaloids. Chemistry of Natural Compounds v. 45(4): p. 601-603, 2009 ( Eng; 13 ref).

N-alkylation of (plus minus)-peganine (1), (plus minus)-vasicinone (2), and harmine (3), respectively, with methyliodide, boric acid chelated to ethyleneglycol, and protonation by dilute H2SO4. These alkaloids were isolated from Pegahum harmala. It was found that 1 reacted with methyliodide and boric acid to form iminium salts 4 and 5, respectively. Reaction of 2 with methyloidide afforded the isolation of iminium salt 6. Harmine reacted with methyliodide to give beta-carbolinium salt. Treatment of 3 with dilute H2SO4 in MeOH gave the bis-hydrate of bis-{N(2)-harminium}sulfate, the structure of which was elucidated by an X-ray structure analysis.

2010-02-1078 Uriburu, M.L.; Gil, R.R.; Sosa, V.E.; de la Fuente, J.R. (Consejo de Investigacion, Universidad Nacional de Salta, Avda Bolivia 5150, 4400 Salta, Argentina) Prenylflavonoids from Flourensia fiebrigii. Phytochemistry v. 68(9): p. 1295-1299, 2007 (Eng; 21 ref).

Three compounds: (2S)-8-(3''-methylbut-2"-enyl)-7,3',4'-trihydroxyflavanone, (2S)-8-(3"-methyl-4"-hydroxy-but-2"-enyl)-7,3'4'-trihydroxyflavanone and (2S)-8-(3"-methyl-4"-hydroxy but-2"-enyl)-5,3',4'-trihydroxy-7-methoxyflavanone, along with five previously known compounds, were isolated from the aerial parts of Flourensia fiebrigii (Asteraceae). Their structures were elucidated by application of various spectroscopic methods, including 1D and 2D NMR techniques.

2010-02-1079 Verma, R.S.; Rahman, L.; Verma, R.K.; Chanotiya, C.S.; Chauhan, A.; Yadav, A.; Yadav, A.K.; Singh, A. (Central Institute of Medicinal and Aromatic Plants, Resources Centre, Purara, P.O.- Gagrigole, Bageshwar, Uttarakhand-263688, India) Essential oil composition of Artemisia capillaris Thunb. flowers from Uttarakhand. Indian Perfumer v. 53(3): p. 32-33, 2009 (Eng; 21 ref).

The hydrodistilled essential oil of flowers of Artemisia capillaris (Asteraceae) grown in Kumaon region of western Himalaya was analyzed by GC and GC-MS. Twenty one compounds constituting 93.1 percent of the oil were identified. The major components were capillene (52.3 percent), gamma-terpinene (15.2 percent), eugenol (8.5 percent), beta-caryophyllene (6.6 percent) and p-cymene (3.3 percent).

2010-02-1080 Wang, Y.; Mu, R.; Wang, X.; Liu, S.; Fan, Z. ( Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China) Chemical composition of volatile constituents of Magnolia grandiflora. Chemistry of Natural Compounds v. 45(2): p. 257-258, 2009 ( Eng; 4 ref).

The volatile constituents of fresh leaves Magnolia grandiflora (Magnoliaceae) were extracted by headspace solid-phase microextraction (HS-SPME) combined with microwave-assisted extraction (MAE) and then analyzed by gas chromatography-mass spectrometery. In total 40 constituents were identified the main constituents were gamma elemene, 2,6-dimethyl-6-bicyclo {3.1.1}hept-2-ene, and caryophyllene.

2010-02-1081 Wang, L.; Zhang, C.F.; Wang, Z.T.; Zhang, M.; Xu, L.S. (Key Laboratory of Modern Chinese Medicines, Ministry of Education, China Pharmaceutical University, Nanjing 210038, China) Five new compounds from Dendrobium crystallinum. Journal of Asian Natural Products Research v. 11(11-12): p. 903-911, 2009 (Eng; 17 ref).

Five new compounds, dencryol A (1), dencryol B (2), crystalltone (3), crystallinin (4), and 3-hydroxy-2-methoxy-5,6-dimethylbenzoic acid (5), together with six known compounds, dendronobilin B (6), syringic acid (7), apigenin (8), isoviolanthin (9), 6'"-glucosyl-vitexin (10), and palmarumycin JC2 (11), have been isolated from the stems of Dendrobium crystallinum (Orchidaceae) of which compounds 9-11 were isolated from the genus Dendrobium for the first time, and all the other compounds were first obtained from this plant. Their structures were established on the basis of spectroscopic analysis and literature data.

2010-02-1082 Wang, Y.N.; Tain, L.; Hua, H.M.; Lu, X.; Sun, S.; Wu, H.H.; Pei, Y.H. (School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China) Two new compounds from the broth of the marine fungus Penicillium griseofulvum Y19-07. Journal of Asian Natural Products Research v. 11(11-12): p. 912-917, 2009 (Eng; 9 ref).

Two new compounds, 4-hydroxy-phenethyl succinate (1) and 4-hydroxy-phenethyl 2-(4-hydroxyphenyl)acetate (2), were isolated from the EtOAc extract of the broth of the marine fungus Penicillium griseofulvum Y 19-07 isolated from the mangrove Lumnitzera racemosa collected from South China sea. Five known compounds were also obtained in this study. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for their scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl free radical by spectroscopic assays. Also, in the cytotoxicity assay of the two new compounds against HL-60 and PC-3 prostate cancer cell lines, compound 2 showed potential activity with an IC50 value of 64.5 microM against human HL-60 cancer cells.

2010-02-1083 Wang, X.F.; Li, C.; Shi, Y.P.; Di, D.L. (Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China) Two new secoiridoid glycosides from the leaves of Olea europaea L.. Journal of Asian Natural Products Research v. 11(11-12): p. 940-944, 2009 (Eng; 7 ref).

Two new secoiridoid glycosides, oleuricines A (1) and B (2), together with five known triterpenoids. beta-amyrin, oleanolic acid, erythrodiol, urs-2beta,3beta-dihydroxy-12-en-28-oic acid, and beta-maslinic acid, were isolated from the EtOAc-soluble part of EtOH extract of the leaves of Olea europaea. The structures of these compounds were elucidated by various spectroscopic methods, including intensive 1D, 2D NMR, and HR-ESI-MS techniques.

2010-02-1084 Wang, L.; Zhao, J.F.; Zeng, X.H.; Xie, M.J.; Yang, X.D.; Zhang, H.B.; Li, L. (Key Laboratory of Medicinal Chemistry for Natural Reseaorces, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China) A novel aryltetralone lignan from Litsea pedunculata. Journal of Asian Natural Products Research v. 11(11-12): p. 1027-1030, 2009 (Eng; 17 ref).

A novel aryltetralone lignan, pedunculine A {1), together with a known lignan cagayanone A (2), was isolated from the leaves and twigs of Litsea pedunculata (Lauraceae). The structure of the new lignan was elucidated on the basis of spectroscopic methods and single-crystal X-ray diffraction.

2010-02-1085 Wang, Y.; Xu, K.; Lin, L.; Pan, Y.; Zheng, X. ( Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hongzhou 310027, PR China) Geranyl flavonoids from the leaves of Artocarpus altilis. Phytochemistry v. 68(9): p. 1300-1306, 2007 (Eng; 26 ref).

Five geranyl dihydrochalcones, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxy-6,6,9-trimethyl-6a,7,8,10a-tetrah ydro-6H-dibenzob,dpyran-5-yl)-1-propanone (2), 1-(2,4-dihydroxyphenyl)-3-3,4-dihydro-3,8-dihydroxy-2-methyl-2-(4-met hy-3-pentenyl)-2H-1-benzopyran-5-yl-1-propanone (4), 1 -(2,4-dihydroxyphenyl)-3-8-hydroxy-2-methyl-2-(3,4-epoxy-4-methyl-1 -pentenyl)-2H-1 -benzopyran-5-yl-1 -propanone (5), 1-(2,4-dihydroxyphenyl)-3-8-hydroxy-2-methyl-2-(4-hydroxy-4-methyl-2- penteny)-2H-l-benzopyran-5-yl-1-propanone (8), and 2-6-hydroxy-3,7-dimethylocta-2(E),7-dienyl-2',3,4,4'-tetrahydroxydih ydrochalcone (9), along with four known geranyl flavonoids (1, 3, 6, 7}, were isolated from the leaves of Artocarpus altilis (Moraceae). Their structures were established by spectroscopic means and by comparison with the literature values. Compounds 2, 4, and 9 exhibited moderate cytotoxicity against SPC-A-1, SW-480, and SMMC-7721 human cancer cells.

2010-02-1086 Wu, S.H.; Chen, Y.W.; Li, Z.Y.; Yang, L.Y.; Li, S.L. (Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P.R. China) Chemical constituents from the root bark of Paeonia delavayi. Chemistry of Natural Compounds v. 45(4): p. 597-598, 2009 ( Eng; 18 ref).

Nine compounds were isolated from the ethanol extract of root bark of Paeonia delavaji (Paeoniaceae). All the compounds were identified as olernolic acid, 23-dihydroxy-30-norolean-12, 20(29)-dien-28-oic- acid, akebonic acid, arjunglucoside II, 3-O-beta-D-glucopyranoside beta-sytosterine, syringic acid, p-hydroxybenzoic acid, gallic acid, and benzolic acid. Their structures were confirmed using a combination of spectral analyses, including NMR and mass spectrometry and by comparison with reported spectroscopic data in the literature.

2010-02-1087 Wu, S.H.; Shen, Y.M.; Chen, Y.W.; Li, Z.Y.; Yang, L.Y.; Li, S.L. (Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, P.R. China) Chemical constituents from the stem bark of Trewia nudiflora. Chemistry of Natural Compounds v. 45(4): p. 536-538, 2009 ( Eng; 11 ref).

The air-dried powdered stem bark of Trewia mudiflora (Euphorbiaceae) was extracted with 95 percent EiOH three times to isolate constituents from various factions. In total eight were compounds were isolated. The structures of these compounds were confirmmed using a combination of spectral analyses, including NMR and mass spectrometry, and by comparison with raported spectroscopic data in the literature. Compounds were identified as trewiasine, balanophonin, ficusal, erythro-guaiacylglycerol-beta-coniferayl aldehyde ether, three-quaiacylglycerol-beta-coniferyl aldehyde ether, 3,3-di-O-methyl ellagic acid, 3-O-methylellagic acid-4O-alpha-L, rhamnopyranoside and 3,3,-di-O-methylellagic acid-u'-O-alpha-L-rhamnopyranoside.

2010-02-1088 Wu, X.F.; Li, Y.; Lu, H.N.; Yu, S.S.; Ma, S.G.; Liu, J. (Key Laboratory of Bioactive Substances, Peking Union Medical College, Beijing 100050, China) Prenylated C6-C3 compounds from the fruits of Illicium simonsii. Journal of Asian Natural Products Research v. 11(11-12): p. 1055-1060, 2009 (Eng; 16 ref).

Two new prenylated C6-C3 compounds, 4-epi-illicinone E-12-shikimate (1) and 3-hydroxyillifunone B (2), together with five known prenylated C6-C3 compounds (3-7), were isolaled from the fruits of Illicium simonsii. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D and 2D NMR, CD spectra, and ESI-MS analysis.

2010-02-1089 Yagi, K.; Goto, K.; Nanjo, F. (Food Research Laboratories, Mitsul Norin Co., Ltd; 223-1 Miyabara, Fujieda, Shizuoka 426-0133, Japan) Identification of a major polyphenol and polyphenolic composition in leaves of Camellia irrawadiensis. Chemical & Pharmaceutical Bulletin v. 57(11): p. 1284-1288, 2009 (Eng; 21 ref).

The polyphenolic composition of Camellia irrawadiensis (Theaceae) a closely related species of C.sinensis (cultivated) tea, was investigated. The most predominant polyphenol, a kind of ellagitannin, was isolated from leaves of C. irrawadiensis. Its structure was established as 1,2-di-0-galloyl1-4,6-0-(S)-hexahydroxydiphenoyl-beta-D-glucose (2) on the basis of spectral and chemical evidence. Moreover, the polyphenols (catechins, strictinin, theogallin, and gallic acid) and two methylxanthines (theobraomine and caffeine) in leaves of C. irrawadiensis were determined by HPLC-Photodiode array detector analysis, and were compared to those in C. sinesis and C. taliensis. Total catechin content in C. irrawadiensis was lower than that in C. sinensis and C. taliensis. The content of 2 in C. irrawadiensis was 8.4 percent of dry leaf weight and comprised approximately 60 percent of the total polyphenols detected, while the compound 2 was not detected in C. sinensis and was reported to be 2.4 percent in C. taliensis.

2010-02-1090 Yan, J.; Sun, L.; Zhang, X.; Li, Z.; Zhou, L.; Qiu, M. (State key Laboratory of Phytochemitry and Plant Ressources in West China, Kimming Institute of Botany, the Chinese Academy of Sciences: Kunming 650204, P.R. China) Serratene triterpenoid from Palhinhaea cernua var. sikkimensis. Chemical & Pharmaceutical Bulletin v. 57(12): p. 1381-1384, 2009 (Eng; 12 ref).

Seven new serratene triterpenoids, 3alpha, 21 beta, 29-trihydroxy-16-oxoserrat-14-en-24-oic acid, 3beta,21beta,29-trihydroxy-16-oxoserrat-14-en-14-oic acid, 3beta,21beta,29=trihydroxyserrat-14-en-24-oic acid 3beta-(4-hydroxybenzoate), 3beta,21beta,29=trihydroxyserrat-14-en-24-oic acid 3beta-(4-hydroxy-3-methoxybenoate), 3beta,14alpha,15alpha,- 21beta,29- pentahydroxyserrat-14-en-oic acid 3beta-(4-hydroxybenzoate), 3alpha, 21beta,24,29-tetrahydroxyserrat-14-en-16-one, 3alpha,21beta,30b -trihydroxyserrat- 14-en-16-one were isolated from Palhinhaea cernua var sikkimensis (Lycopodiaceae) together with twelve known compounds. Their chemical structures were elucidated on the basis of spectroscopic evidence and comparison with literature values.

2010-02-1091 Yang, Z.; Chen, Q.; Hu, L. (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 199 Guoshoujing Road, Shanghai 201203, PR China) Dammarane-type glycosides from Gynostemma pubescens. Phytochemistry v. 68(13): p. 1752-1761, 2007 (Eng; 24 ref).

Triterpene sagonins 1-8 were isolated from the aerial parts of Gynostemma pubescens (Cucurbitaceae). Among them, compounds 1-4, 8 possess carboxylic groups at both C-21 and C-29, 5 contains a carboxylic group at C-21 and an aldehyde function at C-29, whereas 6 and 7 contain carboxylic groups at C-21 and hydroxymethylene groups at C-29. Their structural elucidation was accomplished by extensive spectroscopic methods including application of 1D (1H, 13C, I3C DEPT) and 2D NMR experiments (HMQC, HMBC, HSQC), HRESIMS analysis, as well as by chemical degradation.

2010-02-1092 Ye, G.; Ma, C.H.; Huang, X.Y.; Li, Z.X.; Huang, C.G. (Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, 555 Zuchongzi Road, Zhangjiang Hi-tech Park, Shanghai, PRC, 201203) Components of Sophora alopecuroides seeds. Chemistry of Natural Compounds v. 45(4): p. 545-546, 2009 ( Eng; 11 ref).

The isolation of alkaloids, flavonoids, steroids, and organic acids was carried out from the seed of Sophora alopecuroides (Fabaceae), a traditional Chinese medicine called locally "koudouzi"' which is used as an antibacterial and antiinflammatory agent and is widely distributed in northwest China. Their structures were determined using spectroscopic experiments and data available in the literature.

2010-02-1093 Yill, A.; utalipu, ; Aisa, H.A.; Isaev, M.I. (Key Laboratory of Plants Reseources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemsitry, Chinese Academy of Sciences (2008DP173081) Urumchi, Xinjiang, P.R. China) Betulinic acid and sterols from Astragalus altaicus. Chemistry of Natural Compounds v. 45(4): p. 592-593, 2009 ( Eng; 5 ref).

Air-dried roots of Astragalus altaicus (Leguminosae) were extracted exhaustively with MeOH and eveported to dryness to afford total extrcated compounds (10 percent of air-dried raw material). The whole extract was placed on a column of silica gel and eluted successively. Fractions eluted by CHCl3 offerded the isolation of beta sitosteral and fractions eluted by CHCl3:CH3OH (20:1) afferded a triterpenoid. PMR, 13C NMR, DEPT, COSY, HSQC, and HMBC spectra were used to determine that the triterpenoid was betulinic acid.

2010-02-1094 Zandleven, J.; Sorensen, S.O.; Harholt, J.; Beldman, G.; Schols, H.A.; Scheller, H.V.; Voragen, A.J. (Laboratory of Food Chemistry, Department of Agrotechnology and Food Sciences, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The Netherlands) Xylogalacturonan exists in cells walls from various tissues of Arabidopsis thaliana. Phytochemistry v. 68(8): p. 1219-1226, 2007 (Eng; 30 ref).

Evidence is presented for the presence of xylogalacturonan (XGA) Arabidopsis thaliana. This evidence was obtained by extraction of pectin from the seeds, root, stem, young leaves and mature leaves of A. thaliana followed by treatment of these pectin extracts with xylogalacturonan hydrolase (XGH). Upon enzymatic treatment, XGA oligosaccharides were primarily produced from pectin extracts obtained from the young and mature leaves and to a lesser extent from those originating from the stem of A. thaliana. The oligosaccharide GalA3Xyl was predominantly formed from these pectin extracts. No XGA oligosaccharides were detected in digests of pectin extracts from the seeds and roots. A low number of XGA oligosaccharides was obtained from pectins of A. thaliana. This indicates a uniform distribution of xylose in XGA from A. thaliana. The predominant production of GalA3Xyl, as well as the release of linear GalA oligosaccharides pointed to a lower degree of xylose substitution in XGA from A. thaliana than in XGA from apple and potato. The estimated amount of XGA accounted for approximately 2.5 percent, 7 percent and 6 percent (w/w) of the total carbohydrate in the pectin fraction of the stem, young leaves and mature leaves, respectively.

2010-02-1095 Zhang, Z.X.; Fei, D.Q. (School of Pharmacy, Lanzhou University, Lanzhou 730000, China) The sesquiterpenes from the roots of Cacalia roborowskii. Journal of Asian Natural Products Research v. 11(11-12): p. 958-961, 2009 (Eng; 10 ref).

A new sesquiterpene cacaroborin (1) was isolated from the roots of Cacalia roborowskii (Compositae) together with three known ones, cinalbicol (2), isopetasin (3), and 3alpha-angeloyloxylactone (4). The structure of compound 1 was elucidated as 1beta,10alpha-dihydroxy-8alpha-methoxyeremophil-7(11)-en-8beta,12-olid e on the basis of spectral evidence (1D, 2D NMR, IR, EI-MS, and HR-ESI-MS) and X-ray diffraction analysis. @BODYMORE =

2010-02-1096 Zhang, Q.H.; Tian, L.; Zhou, L.D.; Zhang, Y.; Li, Z.F.; Hua, H.M.; Pei, Y.H. (School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China) Two new compounds from the marine Nigrospora sphaerica. Journal of Asian Natural Products Research v. 11(11-12): p. 962-966, 2009 (Eng; 13 ref).

Two new compounds, 1-(5-oxotetrahydrofuran-2-yl)ethyl 2-phenylacetate (1) and 3-hydroxybutan-2-yl 2-bydroxy-3-phenylpropanoate (2), along with three known compounds, harzialactone A (3), benzeneethanol 4-hydroxy-1-acetate (4), and 1,4-dioxane-2,5-dione-3,6-bis(penylmethyl)-homopolymer (5), have been isolated from the fungus Nigrospora sphaerica. Their structures were determined on the basis of chemical and spectroscopic methods.

2010-02-1097 Zhang, Y.T.; Wang, Y.; Zhang, X.T.; Wu, D.L.; Zhang, X.Q.; Ye, W.C. (Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China) A new decalin derivative from red yeast rice. Journal of Asian Natural Products Research v. 11(9-10): p. 792-795, 2009 (Eng; 10 ref).

Red yeast rice, also called as 'red mold rice' or 'Hongqu', has been used as food and traditional medicine for a long time in China. Red yeast rice could be obtained by the fermentation of rice Oryza sativa with fungi of the genus Monascus purpureus (Monascaceae). A new decalin derivative, monascusic acid A (1), together with a new natural product (2), was isolated from the ethanol extract of red yeast rice. Their structures were elucidated by spectroscopic methods.

2010-02-1098 Zhang, T.; Zou, P.; Kang, L.P.; Yu, H.S.; Liu, Y.X.; Song, X.B.; Ma, B.P. (Beijing Institute of Radiation Meicine, Beijing 100850, China) Two novel furostanol saponins from Ophiopogon japonicus. Journal of Asian Natural Products Research v. 11(9-10): p. 824-831, 2009 (Eng; 16 ref).

Two novel furostanol saponins were isolated from the fresh tubers of Ophiopogon japonicus (Liliaceae). Comprehensive spectroscopic analysis allowed the chemical structures of the compounds to be assigned as (25R)-26-(0-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranosyl)-22alp ha-hydroxyfurost-5-ene-3-O-beta-D-xylopyranosyl-(1-4)-O-alpha-L-rhamn opyranosyl-(l-2)-beta-D-glucopyranoside (1, ophiopogonin F) and (25R)-26-(O-beta-D-glucopyranosyl-(1 -6)-beta-D-glucopyranosyl)-22alpha-hydroxyfurost-5-ene-3-0-beta-D-xyl opyranosyl-(1- 4)-O-alpha-L- rhamnopyranosyl-(1-2)-beta-D-glucopyranoside (2, ophiopogonin G). The rare furostanol saponins with two glucosyl residues at C-26 position were isolated from the natural source for the first time.

2010-02-1099 Zhao, M.; Duan, J.A.; Che, C.T. (School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong) Isoflavanones and their 0-glycosides from Desmodium styracifolium. Phytochemistry v. 68(10): p. 1471-1479, 2007 (Eng; 52 ref).

Two isoflavanones (5,7-dihydroxy-2',3',4'-trimethoxy-isoflavanone and 5,7-dihydroxy-2'-methoxy-3',4'-methylenedioxy-isoflavanone), four isoflavanone O-glycosides (5,7-dihydroxy-2',3',4'-trimethoxy-isoflavanone 7-O-beta-glucopyranoside, 5, 7-dihydroxy-2'-methoxy-3',4'-methylenedioxy-isoflavanone 7-O-beta-glucopyranoside, 5,7-dihydroxy-2',4'-dimethoxy-isoflavanone 7-O-beta-glucopyranoside, and 5,7,4'-trihydroxy-2',3'-dimethoxy-isoflavanone 7-O-beta-glucopyranoside), and a coumaronochromone (3,5,7,4'-tetrahydroxy-coumaronochromone), along with 25 known compounds, were isolated from the aerial parts of Desmodium styracifolium (Fabaceae). This is for the first time isoflavanone O-glycosides were isolated from a natural source.

2010-02-1100 Zhou, S.Y.; Wang, W.G.; Li, H.M.; Zhang, R.B.; Li, H.Z.; Li, R.T. (College of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China) Schisanlactone H and sphenanthin A, new metabolites from Schisandra sphenanthera. Journal of Asian Natural Products Research v. 11(9-10): p. 860-865, 2009 (Eng; 9 ref).

From the fruits of Schisandra sphenanthera (Schisandraceae), a new 3,4-seco-lanostane triterpenoid, schisanlactone H (1), and a new monocyclofarnesane sesquiterpenoid, sphenanthin A (2), were isolated. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques.