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Indian Journal of Chemistry |
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Sect. B: Organic Chemistry including Medicinal Chemistry |
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VOL. 46B |
NUMBER 1 |
JANUARY 2007 |
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CONTENTS |
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Papers |
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115 |
Synthesis and bronchodilatory activity of new 4-aryl-3,5-bis-(2-chlorophenyl)carbamoyl-2,6 -dimethyl-1,4-dihydropyridines and their 1-substituted analogues IPC:
Int.Cl.8 C07C |
New 1,4-DHPs have been prepared by rapid synthetic methods,
characterized and their yields and reaction times compared. They have been
screened for their bronchodilatory activity and the results are reported. |
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T Suresh, S K
Swamy & V M Reddy* |
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122 |
Synthesis of substituted and unsubstituted 5-(1,3-diaryl-1-oxopropyl)pyrimidine(1H, 3H, 5H)-2,4,6-triones IPC: Int.Cl.8
C07D |
Reactions of 1,3-diaryl-2-propene-1-ones
give the corresponding 5-(1,3-diaryl-1-oxopropyl)pyrimidine (1H,3H,5H)-2,4,6-triones
with barbituric acid under refluxing
condition without using any catalyst. |
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M Giasuddin Ahmed*, Syeda
Asghari Ahmed, S Mosaddeq Ahmed, Tazin Sultana & Md Khabir Uddin |
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126 |
Synthesis of amide derivatives of quinolone and their antimicrobial studies IPC: Int.Cl.8
C07C |
A series of
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[chloro/1-piperazinyl/4-methyl-1-piperazinyl/4-ethyl-1-piperazinyl/4-hydroxyethyl-1-piperazinyl/imidazolyl/morpholinyl]-3[N-(substituted phenyl amino)
carbo-nyl]quinoline 5a-j-11a-j have been prepared by using
substituted arylamine at C-3 position and
1-piperazine/4-methyl-1-piperazine/4-ethyl-1-piperazine/4-hydroxyethyl-1-piperazine/imidazole/morpholine
at C-7 position of newly synthesized quinolone 3. Biological profile
like antibacterial activity against four different strain viz. S.
aureus and B. subtilis (gram-positive bacteria) and E. coli
and P. aeruginosa (gram-negative bacteria) and C. albicans
(fungi) by cup plate method have been studied. |
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N B Patel*, A L
Patel & H I Chauhan |
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135 |
Synthesis of some
pyrazino, pyrimido and mercaptopyrimido annelated carbazoles using
2-hydroxymethylene-1-oxo-1,2,3,4-tetrahydrocarbazoles IPC: Int.Cl.8
C07D |
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V Sangeetha & K J
Rajendra Prasad* |
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141 |
Polymorphism in hydrazonium salt of 3,5-pyrazoledicarboxylic
acid IPC: Int.Cl.8
C07C |
Two polymorphic structures of hydrazonium monobasic
salts of 3,5-pyrazoledicarboxylic acid are described. In both instances,
one-dimensional infinite chains formed by acid molecules through
O–H∙∙∙O hydrogen bonding (1.68 Å ,177.1°; 1.71 Å ,169°) are
inter-linked by hydrazonium dications to form two-dimensional sheets. The
subtle structural difference between the two forms arises in the packing of
hydrazonium dications. In form A,
the hydrazonium dications are relatively close packed compared to those in
form B. The closest N…..N distance
between two hydrazonium dications of inversion related layers in form A is 2.03 Å whereas the closest N…..N
distance between two similar hydrazonium dications (disordered) is 4.89 Å for
form B. This account for the
higher packing fraction (78% vs 76.2%) of form A compared to form B. |
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V S Senthil Kumar, T Premkumar, Nigam P Rath
& S Govindarajan* |
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148 |
Synthesis and antimicrobial activity of
5-amino-2,7-diaryl-6-cyano-3-isonicotinamido thiazolo[4,5-b]-2,3,4,7-tetrahydropyridines,
2,7-diaryl-6-cyano-3-isonicotinamido thiazolo[4,5-b]-2,3,4,5,6,7-hexahydropyrid-5-ones,
2,7-diaryl-5-amino-3-isonicotinamido thiazolo[4,5-d][1,3]thiazines and 2,6-diaryl-3-isonicotinamido thiazolo[4,5-c] pyrazolines IPC: Int.Cl.8
C07D |
5-Amino-2,7-diaryl-6-cyano-3-isonicotinamido
thiazolo[4,5-b]-2,3,4,7-tetrahydropyridines
and 2,7-diaryl-6-cyano-3-isonicotinamido thiazolo[4,5-b]-2,3,4,5,6,7-hexahydropyrid-5-ones have been prepared by
Michael addition between a,b-unsaturated ketones and
malononitrile/ethyl cyanoacetate in the presence of excess ammonium acetate.
2,7-Diaryl-5-amino-3-isonicotinamido thiazolo[4,5-d][1,3]thiazines and 2,6-diaryl-3-isonicotinamido thiazolo[4,5-c]pyrazolines have been prepared by
cyclocondensation of a,b-unsaturated ketones with
thiourea/hydrazine hydrate, respectively. The antimicrobial activity of the
representative samples are assayed against bacteria sE. coli, B. subtilis, S. aureus and fungi A. niger, P. oryzae and F.
oxysporum at 100 mg/mL concentration. |
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Mukhtar Hussain
Khan |
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154 |
Recyclable
polymer bound Pd(0) phosphine catalyst for effecting sp2-sp2
and sp2-sp carbon-carbon coupling reactions in aqueous medium IPC: Int.Cl.8
C07D |
Aqueous Heck type coupling reactions between
aryl iodides and terminal alkenes or alkynes have been effected in good
yields using a recyclable catalyst system that consists of poly(N-isopropyl acrylamide) bound Pd(0)
phosphine and an anionic surfactant, potassium lauryl sulphate. |
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Nirmal Koshti*, Bharat Parab & Shubhangi Naik |
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160 |
Conformational studies of some N-acyl-t(3)-isopropyl-r(2),c(6)-bis(2¢-furyl)piperidin-4-ones IPC: Int.Cl.8
C07D |
The high resolution 1H and 13C
NMR spectra of four N-acyl-t(3)-isopropyl-r(2),c(6)-bis(2¢-furyl)piperidin-4-ones 1-4 have been recorded at various
temperatures and analysed. |
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A Manimekalai*, K Selvaraju & T
Maruthavanan |
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170 |
Alternate routes for the
synthesis of ibuprofen piconol IPC: Int.Cl.8
C07D |
New, improved and alternate methods for the
synthesis of ibuprofen piconol from ibuprofen and pyridine-2-methanol have
been demonstrated with different carboxyl activating groups |
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C M Haricharan Raju, C Vijay Anand, P K
Dubey & Palle V R Acharyulu* |
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173 |
Two
new terpenes from the lichen Parmelia
perlata IPC: Int.Cl.8
C07D |
The lichen Parmelia perlata
an important drug used in Indian systems of medicine has yielded a new
lanost-2-en type triterpene, named parmelanostene and a new labdane type
diterpenoid, named permelabdone, identified on the basis of spectroscopic
studies as 29, 30-nordimethyl-lanost-2-en 1 and 2¢-methoxyphenyl-19-[4a,8b,10b-trimethyl-9-(13-methyl butyl)-decahydronapthalen-4-yl]-20-methoxyenzoate 2, respectively. The
compounds showed antibacterial activity against S. aureus and E. coli. |
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S Tarique Abdullah, Hinna Hamid,
Mohammed Ali, S H Ansari &
M Sarwar Alam* |
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177 |
QSAR studies of cytotoxic acridine
5,7-diones : A comparative study using P-VSA descriptors and topological
descriptors IPC: Int.Cl.8
C07D |
A comparative QSAR analysis of a series of cytotoxic
acridine 5,7-diones was performed using topological descriptors and a novel
set of P-VSA descriptors. |
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N S Hari Narayana Moorthy, C
Karthikeyan & Piyush Trivedi* |
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185 |
Synthesis and
primary cytotoxicity evaluation of new diaryltriazenes |
A series of triazenes derived from 5-(4-aminophenyl)-2,4-dihydro–4-substituted-3H-1,2,4-triazole-3-thiones 1a-c, aminoglutethimide or paraaminobenzoic acid have been synthesized for in vitro anticancer properties. |
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S Unsalan & S Rollas* |
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192 |
Phototransformation of 16a,17a-epoxy-3b-hydroxypregn-5-ene-20-one to 3b-hydroxy-pregn-5-ene-16,20-dione IPC: Int.Cl.8
C07C |
UV irradiation of 16a,17a-epoxy-3b-hydroxy-pregn-5-ene-20-one
5 in a variety of solvents (benzene, acetonitrile, methanol) and in
the presence of triethylamine, pyrex glass reactor, leads to the formation of
3b-hydroxypregn-5-ene-16,20-dione
6. |
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N
Kumar Girdhar, Abdul Faruk, K Avtar Suri & M P S Ishar* |
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195 |
Microwave
accelerated synthesis of novel spiro heterocycles IPC: Int.Cl.8 C07C |
A quick and efficient method for the
synthesis of variety of spiro heterocycles containing fused triazoles,
thiazetidines, oxoazetidines, diazetidines and thiadiazoles moiety by microwave
technique as well as by classical thermal method has been described. |
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Vijay V
Dabholkar* & Sagar D Parab |
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Notes
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201 |
Synthesis of N-(3′,5′-dimethyl-4′-hydroxybenzyl)-N-tosyl-3,4-dimethoxybenzyl
amine IPC: Int.Cl.8
A61K |
Reaction of 4-benzyloxy-3,5-dimethyl benzyl
bromide 4 and N-tosyl-3,4-dimethoxy
benzyl amine 5 gave N-(4′-benzyloxy
-3′,5′-dimethylbenzyl)-N-tosyl-3,4-dimethoxybenzyl amine 6. The obtained product on
debenzylation gave N-(3′,5′-dimethyl-4′-hydroxybenzyl)-N-tosyl-3,4-dimethoxy
benzyl amine 7 in 94% yield, which
is key intermediate in the synthesis of isoindolines. |
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B China
Raju, Parvathi Neelakantan & U T Bhalerao* |
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204 |
Silica supported chromium trioxide: Microwave promoted oxidative
ring closure of a-cyano-b-thioenaminones to
isothiazoles IPC: Int.Cl.8
C07D |
Silica supported
chromium trioxide is found to be an excellent reagent for oxidative ring
closure of a-cyano-b-thioenaminones to
isothiazoles in dichloromethane at room temperature or in dry media under
microwave irradiation. |
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Manisha Mishra & Kumar K Mahalanabis* |
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207 |
Microwave assisted synthesis of N-(3-aryl-1,8-naphthyridin-2-yl)phthalimides under solvent-free conditions IPC: Int.Cl.8
C07C |
A simple, rapid and efficient method for the
synthesis of N-(3-aryl-1,8-naphthyridin-2-yl)phthalimides 3 in
solvent-free conditions under microwave irradiation has been described. |
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K Mogilaiah*
& B Sakram |
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210 |
Microwave-assisted facile synthesis of a new class of
asymmetrical diheteroarylmethanes
bearing
imidazopyridine
moieties under
solvent-free condition IPC: Int.Cl.8
C07D |
A useful approach to diheteroarylmethanes bearing imidazopyridine
moieties is described. |
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Guiyun Duan, Yawei Sun, Junzhi
Liu, Guilong Zhao,
Datong Zhang & Jianwu Wang* |
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213 |
A novel synthesis of
spiroisoxazoles via 1,3-dipolar cycloaddition of nitrile oxide to
6-arylidene-6,7,8,9-tetrahydrobenzocyclohepten-5-one IPC: Int.Cl.8
A61K |
Synthesis of a series of spiroisoxazole derivatives have been
accomplished in good yield by regioselective 1,3-dipolar cycloaddition of nitrile
oxide to 6-arylidene-3-methyl-6,7,8,9-tetrahydro-5H-benzo[a]cyclohepten-5-one.
The antimicrobial activity of these compounds have been carried out. |
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Peesapati Venkateswarlu* & Nageswara Rao Vasireddy |
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216 |
Synthesis
of novel 1,2,4-oxadiazole heterocyclic compounds contain 2-H-pyranopyridine-2-one moiety and
related compounds IPC: Int.Cl.8
C07D |
Ethyl 5-methyl-6-cyano-7-hydroxy-2-oxo-2H-pyrano
[2, 3-b] pyridine-3-carboxylate
1 and ethyl 5-methyl-6-cyano-7-chloro-2-oxo-2H-pyrano
[2, 3-b] pyridine-3-carboxylate
2 are treated with aqueous ammonia solution to afford 2H-pyrano[2,3-b] pyridine-3-carboxamide 3a-b,
which are converted to 6-carboxamidoxime2H-pyrano[2,3-b]pyridine-3-carboxamide 4a-b
and hydroxylamine on refluxing ethanol. Carboxamidoximes are treated with
various acid chlorides to obtain 1,2,4-oxadiazole derivatives 5, 6a-c.
The compound 3a was reacted with triethyl orthoformate to give
4-amino-5-methyl pyrano [3", 2':5, 6] pyrido[2,3-d] pyrimidine7-carboximde 7, 4a is allowed to
reacted N, N-dimethyl formamide dimethyl acetal under reflux N-(6-carbonyl-4-methyl-7-oxo-1,7-dihydropyrano[2,3-b]pyrazolo[4,3-e] yridine-3-yl) methanamide 8. |
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N Vasanth Kumar
& Uday C Mashelker* |
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Authors for correspondence are indicated by (*) IPC: International Patent
Classification Int.Cl8.: International
Classification, 8th Edition, 2006 |
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