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Sect. B: Organic Chemistry including Medicinal Chemistry Total visitors: 1,310 since 20-11-07 |
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VOL. 46B |
NUMBER 11 |
NOVEmber 2007 |
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CONTENTS |
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Papers |
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1815 |
Guanidino
substituted isoindolones as novel glycoprotein IIb-IIIa receptor antagonists |
Design
and synthesis of potent new GP IIb-IIIa receptor antagonist. Compound with R1
= R2 = OCH2COOEt and X = O showed IC50 =
0.025 mM. Our study also indicated possibility of
additional binding site near the central part of the molecule in the form of
H-bond donor to ligand. |
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Bansi Lal*, Ashok K Gangopadhyay, P G
Jagtap, Rajendra Tanpure, V S V V Rao, Ravindra D Gupte, |
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1833 |
Wavelength
dependent regioselective E (trans)®Z (cis) isomerization of 9-anthryldiene derivatives |
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Majjigapu Janaki
Ram Reddy, Perepogu Arun Kumar, Uppalanchi Srinivas, Vummadi Venkat Reddy, |
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1848 |
Microwave assisted synthesis of indole and furan
derivatives possessing good anti-inflammatory and analgesic activity |
A number of indole 1 and furan 2-6 derivatives
have been synthesized by condensation of indole-2- carboxylic acid with aryl
sulfonyl hydrazide and furfuryl amine with various carboxylic acids and
diacids using microwave irradiation. On anti-inflammatory and analgesic
activity screening compound 5 exhibited
good anti-inflammatory and analgesic activity. |
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Sham M Sondhi*, Shubhi Jain, Reshma Rani & Ashok Kumar |
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1855 |
A comparative crystallographic
analysis of the |
The molecular and crystal structures of
(+)-4-cholesten-3-one 1
cholesteryl chloroformate 2 and
cholesteryl-caprylate 3 have been
determined by using X-ray crystallographic and computational techniques. All
the three compounds crystallize in the monoclinic space group P21
with unit cell parameters: a=10.683(5)Å, b=7.861(2), c=14.616(2), b=105.8(2)o
for [1], a=12.294(2)Å, b=9.399(8), c=12.787(2), b=113.3(1)o
for [2] and a = 12.778(9), b = 9.201(4), c = 14.063(6)
Å, b = 93.85(4)o for [3]. The number of molecules
per unit cell in case of each structure is 2. The final R-factor for [1] is
0.054, [2] 0.077 and [3] 0.068. Besides some interesting geometrical and
structural features, all the three molecules exhibit C-H…O hydrogen bonding. |
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Rajnikant*,
Dinesh, Kamni, Bandhan Sharma, Sonam Lotus & Kewal Gupta |
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1860 |
Photocyclisations
of some 3-alkoxychromones: Substituent control on photoreactivity |
Photoreorganisations of some phenyl
substituted chromones, showing the effects of various substituents upon the
3-alkoxy moiety have been investigated. |
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Mohamad Yusuf*, Rupesh Kumar, W R
Bansal & Ritu Bala |
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1868 |
Antifungal
and Phytochemical studies of Eupatorium birmanicum DC
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Antifungal activity of the chloroform and
methanol extracts of the leaves of Eupatorium
birmanicum DC. and isolation of |
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L
Reena Devi, Th Shyamkeshor Singh & |
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Notes |
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1873 |
Synthesis and
antimicrobial screening of 5-(4,7-dimethyl-2-oxo-2H-benzopyran-6-ylazo)-2-methyl-6-morpholin-4-yl-2,3-dihydro-3H-pyrimidin-4-one and 5-(4,7-dimethyl-2-oxo-2H-benzopyran-6-ylazo)- |
A facile synthesis of
5-(4,7-dimethyl-2-oxo-2H-benzopyran-6-ylazo)-2-methyl-6-
morpholin -4-yl-2,3-dihydro
-3H-pyrimidin-4-one and 5-(4,7-dimethyl-2-oxo-2H-benzopyran-6-ylazo)-2-methyl-6-piperidin-1-yl-2,3-dihydro-3H-pyrimidin-4-one. |
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1879 |
Molecular and
crystal structure of 6α-acetoxy azadirone |
An approach
towards the single crystal structure analysis of the biologically important
limonoid, 6α-acetoxy azadirone is presented.. |
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Jibon Kotoky*, Mahendra Kalita, Gautam Kumar Sarmah
& Babulal Das |
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1883 |
Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and evaluation of bio-activity of thiazolo[3,2-b]-s-triazoles and isomeric thiazolo[2,3-c]-s-triazoles |
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Parvin Kumar, Jag Mohan & J K Makrandi* |
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1886 |
Gallium(III)
halides catalyzed, microwave enhanced, synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent free condition |
Gallium(III) halides catalyzed and microwave enhanced three component Biginelli reaction of aldehyde, 1,3-dicarbonyl compounds and urea or thiourea under solvent free conditions to afford 3,4-dihydropyrimidin-2-(1H)-ones in excellent yields is described. The present procedure for the production of dihydropyrimidinones describes the first ever catalytic activity of gallium(III) halides. This improved procedure is fairly simple, facile and environment friendly. |
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Anil Saini, Sanjay Kumar & Jagir S Sandhu*
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1890 |
The electrosynthesis of pinacols |
Electrosynthesis of pinacols by iron as
electrode in acid condition is performed. The influence of electric potential
and time on pinacol yield is explored. The optimal reaction conditions are:
electric potential 4 V, time 60 min., methanol 6 mL, hydrochloric acid (2N) 2 mL, with the yield of pinacols up
to 18-81%. |
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Yan-Jiang Bian* & Dong Sheng Bai |
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1893 |
KHSO4-SiO2-MeOH — An
efficient selective solid-supported system for deprotection of alcohols from
esters |
KHSO4-SiO2 can efficiently deprotect alcohols from esters through transesterification in methanol. |
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Amrit Goswami*, Ram |
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1896 |
Alkaloids of Sida cordifolia L |
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Ranajit
K Sutradhar *, A K M Matior Rahman Mesbah U Ahmad
& Koushik Saha |
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Authors for correspondence are indicated by (*) |
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